-
1
-
-
40949088023
-
Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion
-
Loor, G.; Schumacker, P.T. Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion. Cell Death Differ., 2008, 15(4), 686-690.
-
(2008)
Cell Death Differ.
, vol.15
, Issue.4
, pp. 686-690
-
-
Loor, G.1
Schumacker, P.T.2
-
2
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza, G.L. HIF-1: Mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol., 2000, 88(4), 1474-1480.
-
(2000)
J. Appl. Physiol.
, vol.88
, Issue.4
, pp. 1474-1480
-
-
Semenza, G.L.1
-
3
-
-
79953649414
-
HIF prolyl hydroxylase inhibitors for anemia
-
Muchnik, E.; Kaplan, J. HIF prolyl hydroxylase inhibitors for anemia. Expert Opin. Invest. Drugs, 2011, 20(5), 645-656.
-
(2011)
Expert Opin. Invest. Drugs
, vol.20
, Issue.5
, pp. 645-656
-
-
Muchnik, E.1
Kaplan, J.2
-
4
-
-
84870248829
-
Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis
-
Beuck, S.; Schaenzer, W.; Thevis, M. Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis. Drug Test. Anal., 2012, 4(11), 830-845.
-
(2012)
Drug Test. Anal.
, vol.4
, Issue.11
, pp. 830-845
-
-
Beuck, S.1
Schaenzer, W.2
Thevis, M.3
-
5
-
-
84899606679
-
Effects of a novel anemia treatment FG-4592 an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) on blood pressure and cholesterol in patients with chronic kidney disease
-
Bakris, G.L.; Yu, K.-H.P.; Leong, R.; Shi, W.; Lee, T.; Saikali, K.; Henry, E.; Neff, T.B. Effects of a Novel Anemia Treatment, FG-4592, an Oral Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor (HIF-PHI) on Blood Pressure and Cholesterol in Patients with Chronic Kidney Disease. J. Clin. Hypertens., 2012, 14(7), 489.
-
(2012)
J. Clin. Hypertens.
, vol.14
, Issue.7
, pp. 489
-
-
Bakris, G.L.1
Yu, K.-H.P.2
Leong, R.3
Shi, W.4
Lee, T.5
Saikali, K.6
Henry, E.7
Neff, T.B.8
-
6
-
-
84880276273
-
Evaluation of hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for hemoglobin correction and maintenance in nondialysis chronic kidney disease patients for 16 and 24 weeks
-
Besarab, A.; Belo, D.; Diamond, S.; Martin, E.; Sun, C.; Lee, T.; Saikali, K.; Franco, M.; Leong, R.; Neff, T.; Yu, P. Evaluation of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor FG-4592 for Hemoglobin Correction and Maintenance in Nondialysis Chronic Kidney Disease Patients for 16 and 24 Weeks. Nephrol. Dial. Transpl., 2012, 27(suppl 2), ii133-ii145.
-
(2012)
Nephrol. Dial. Transpl.
, vol.27
, Issue.SUPPL. 2
-
-
Besarab, A.1
Belo, D.2
Diamond, S.3
Martin, E.4
Sun, C.5
Lee, T.6
Saikali, K.7
Franco, M.8
Leong, R.9
Neff, T.10
Yu, P.11
-
7
-
-
84873080079
-
Evaluation of FG-4592, a novel oral hypoxia-inducible factor prolyl hydroxylase inhibitor, to treat anemia in hemodialysis patients
-
Provenzano, R.; Goodkin, D.; Klaus, S.; Linde, P.; Kazazi, F.; Lee, T.; Neff, T.; Yu, P. Evaluation of FG-4592, A Novel Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor, to Treat Anemia in Hemodialysis Patients. Am. J. Kidney Dis., 2011, 57(4), B80.
-
(2011)
Am. J. Kidney Dis.
, vol.57
, Issue.4
-
-
Provenzano, R.1
Goodkin, D.2
Klaus, S.3
Linde, P.4
Kazazi, F.5
Lee, T.6
Neff, T.7
Yu, P.8
-
8
-
-
70349766826
-
Beneficial pharmacodynamic effects resulting from 'complete erythropoiesis' induced by novel HIF prolyl hydroxylase inhibitors FG-2216 and FG-4592
-
Klaus, S.; Langsetmo, I.; Neff, T.; Lin, A.; Liu, D. Beneficial Pharmacodynamic Effects Resulting from 'Complete Erythropoiesis' Induced by Novel HIF Prolyl Hydroxylase Inhibitors FG-2216 and FG-4592 J. Am. Soc. Nephrol., 2008, 19, 524A.
-
(2008)
J. Am. Soc. Nephrol.
, vol.19
-
-
Klaus, S.1
Langsetmo, I.2
Neff, T.3
Lin, A.4
Liu, D.5
-
9
-
-
65449184945
-
Worldwide prevalence of anaemia WHO vitamin and mineral nutrition information system 1993-2005
-
McLean, E.; Cogswell, M.; Egli, I.; Wojdyla, D.; de, B.B. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutr, 2009, 12(4), 444-454.
-
(2009)
Public Health Nutr
, vol.12
, Issue.4
, pp. 444-454
-
-
McLean, E.1
Cogswell, M.2
Egli, I.3
Wojdyla, D.4
De, B.B.5
-
11
-
-
83955164266
-
Anaemia in low-income and middle-income countries
-
Balarajan, Y.; Ramakrishnan, U.; Ozaltin, E.; Shankar, A.H.; Subramanian, S.V. Anaemia in low-income and middle-income countries. Lancet, 2011, 378(9809), 2123-2135.
-
(2011)
Lancet
, vol.378
, Issue.9809
, pp. 2123-2135
-
-
Balarajan, Y.1
Ramakrishnan, U.2
Ozaltin, E.3
Shankar, A.H.4
Subramanian, S.V.5
-
12
-
-
34548786074
-
An update on anemia in less developed countries
-
Tolentino, K.; Friedman, J.F. An update on anemia in less developed countries. Am. J. Trop. Med. Hyg., 2007, 77(1), 44-51.
-
(2007)
Am. J. Trop. Med. Hyg.
, vol.77
, Issue.1
, pp. 44-51
-
-
Tolentino, K.1
Friedman, J.F.2
-
15
-
-
84880302853
-
-
Ed.; Lippincott Williams & Wilkins: Philadelphia
-
In: Pharmacology; Finkel, R.; Clark, M.A.; Cubeddu, L.X., Ed.; Lippincott Williams & Wilkins: Philadelphia, 2009; pp. 229-248.
-
(2009)
Pharmacology
, pp. 229-248
-
-
Finkel, R.1
Clark, M.A.2
Cubeddu, L.X.3
-
16
-
-
84874600566
-
-
Berenson, J.R., Editor; Humana Press Inc.: Totowa
-
Ludwig, H.; Oesterborg, A. In: Current Clinical Oncology: Biology and Management of Multiple Myeloma; Berenson, J.R., Editor; Humana Press Inc.: Totowa, 2004; pp. 303-318.
-
(2004)
Current Clinical Oncology: Biology and Management of Multiple Myeloma
, pp. 303-318
-
-
Ludwig, H.1
Oesterborg, A.2
-
17
-
-
49249119764
-
Erythropoiesis-stimulating agents: Benefits and risks in supportive care of cancer
-
Melosky, B.L. Erythropoiesis-stimulating agents: Benefits and risks in supportive care of cancer. Curr. Oncol., 2008, 15, S10-S15.
-
(2008)
Curr. Oncol.
, vol.15
-
-
Melosky, B.L.1
-
18
-
-
33748361586
-
Cost comparison of epoetin alpha, epoetin beta and darbepoetin alpha for cancer patients with anaemia in the clinical practice setting
-
Reichardt, B. Cost comparison of epoetin alpha, epoetin beta and darbepoetin alpha for cancer patients with anaemia in the clinical practice setting. J. Clin. Pharm. Ther., 2006, 31, 503-512.
-
(2006)
J. Clin. Pharm. Ther.
, vol.31
, pp. 503-512
-
-
Reichardt, B.1
-
19
-
-
33751002326
-
Normalization of hemoglobin level in patients with chronic kidney disease and anemia
-
Drueke, T.B.; Locatelli, F.; Clyne, N.; Eckardt, K.-U.; Macdougall, L.C.; Tsakiris, D.; Burger, H.-U.; Scherhag, A. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N. Engl. J. Med., 2006, 355, 2071-2084.
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 2071-2084
-
-
Drueke, T.B.1
Locatelli, F.2
Clyne, N.3
Eckardt, K.-U.4
Macdougall, L.C.5
Tsakiris, D.6
Burger, H.-U.7
Scherhag, A.8
-
20
-
-
33750983605
-
Correction of anemia with epoetin alfa in chronic kidney disease
-
Singh, A.K.; Szczech, L.; Tang, K.L.; Barnhart, H.; Sapp, S.; Wolfson, M.; Reddan, D. Correction of anemia with epoetin alfa in chronic kidney disease. N. Engl. J. Med., 2006, 355, 2085-2098.
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 2085-2098
-
-
Singh, A.K.1
Szczech, L.2
Tang, K.L.3
Barnhart, H.4
Sapp, S.5
Wolfson, M.6
Reddan, D.7
-
21
-
-
70949108082
-
A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
-
Pfeiffer, M.A.; Burdmann, E.A.; Chen, C.-Y.; Cooper, M.E.; De, Z.D.; Eckardt, K.-U.; Feyzi, J.M.; Ivanovich, P.; Kewalramani, R.; Levey, A.S.; Lewis, E.F.; McGill, J.B.; McMurray, J.J.V.; Parfey, P.; Parving, H.-H.; Remuzzi, G.; Singh, A.K.; Solomon, S.D.; Toto, R. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N. Engl. J. Med., 2009, 361, 2019-2032.
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 2019-2032
-
-
Pfeiffer, M.A.1
Burdmann, E.A.2
Chen, C.-Y.3
Cooper, M.E.4
De, Z.D.5
Eckardt, K.-U.6
Feyzi, J.M.7
Ivanovich, P.8
Kewalramani, R.9
Levey, A.S.10
Lewis, E.F.11
McGill, J.B.12
McMurray, J.J.V.13
Parfey, P.14
Parving, H.-H.15
Remuzzi, G.16
Singh, A.K.17
Solomon, S.D.18
Toto, R.19
-
22
-
-
70349836253
-
Erythropoiesis stimulatory agent-resistant anemia in dialysis patients: Review of causes and management
-
Kanbay, M.; Perazella, M.A.; Kasapoglu, B.; Koroglu, M.; Covic, A. Erythropoiesis stimulatory agent-resistant anemia in dialysis patients: Review of causes and management. Blood Purif, 2010, 29, 1-12.
-
(2010)
Blood Purif
, vol.29
, pp. 1-12
-
-
Kanbay, M.1
Perazella, M.A.2
Kasapoglu, B.3
Koroglu, M.4
Covic, A.5
-
23
-
-
34447542038
-
Erythropoiesisstimulating agent hyporesponsiveness
-
Johnson, D.W.; Pollock, C.A.; MacDougall, I.C. Erythropoiesisstimulating agent hyporesponsiveness. Nephrology, 2007, 12, 321-330.
-
(2007)
Nephrology
, vol.12
, pp. 321-330
-
-
Johnson, D.W.1
Pollock, C.A.2
MacDougall, I.C.3
-
24
-
-
84857371377
-
New anemia therapies: Translating novel strategies from bench to bedside
-
Macdougall, I.C. New anemia therapies: Translating novel strategies from bench to bedside. Am. J. Kidney Dis., 2012, 59(3), 444-451.
-
(2012)
Am. J. Kidney Dis.
, vol.59
, Issue.3
, pp. 444-451
-
-
Macdougall, I.C.1
-
25
-
-
77957761392
-
Inhibitors of HIF prolyl hydroxylases
-
Rabinowitz, M.H.; Barrett, T.D.; Rosen, M.D.; Venkatesan, H. Inhibitors of HIF prolyl hydroxylases. Annu. Rep. Med. Chem., 2010, 45, 123-139.
-
(2010)
Annu. Rep. Med. Chem.
, vol.45
, pp. 123-139
-
-
Rabinowitz, M.H.1
Barrett, T.D.2
Rosen, M.D.3
Venkatesan, H.4
-
26
-
-
1542754785
-
High-altitude adaptations
-
Beall, C.M. High-altitude adaptations. Lancet, 2003, 362 Suppl, s14-s15.
-
(2003)
Lancet
, vol.362
, Issue.SUPPL.
-
-
Beall, C.M.1
-
27
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza, G.L.; Wang, G.L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol., 1992, 12(12), 5447-5454.
-
(1992)
Mol. Cell. Biol.
, vol.12
, Issue.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
28
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang, G.L.; Semenza, G.L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem., 1995, 270(3), 1230-1237.
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.3
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
29
-
-
0029051439
-
Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang, G.L.; Jiang, B.-H.; Rue, E.A.; Semenza, G.L. Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U. S. A., 1995, 92, 5510-5514.
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.-H.2
Rue, E.A.3
Semenza, G.L.4
-
30
-
-
84866172766
-
HIF-1 Versus HIF-2-Is one more important than the other?
-
Loboda, A.; Jozkowicz, A.; Dulak, J. HIF-1 versus HIF-2-Is one more important than the other? Vasc. Pharmacol., 2012, 56(5-6), 245-251.
-
(2012)
Vasc. Pharmacol.
, vol.56
, Issue.5-6
, pp. 245-251
-
-
Loboda, A.1
Jozkowicz, A.2
Dulak, J.3
-
31
-
-
78650211341
-
Benzimidazole-2-pyrazole HIF Prolyl 4- hydroxylase inhibitors as oral erythropoietin secretagogues
-
Rosen, M.D.; Venkatesan, H.; Peltier, H.M.; Bembenek, S.D.; Kanelakis, K.C.; Zhao, L.X.; Leonard, B.E.; Hocutt, F.M.; Wu, X.; Palomino, H.L.; Brondstetter, T.I.; Haugh, P.V.; Cagnon, L.; Yan, W.; Liotta, L.A.; Young, A.; Mirzadegan, T.; Shankley, N.P.; Barrett, T.D.; Rabinowitz, M.H. Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues. ACS Med. Chem. Lett., 2010, 1(9), 526-529.
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, Issue.9
, pp. 526-529
-
-
Rosen, M.D.1
Venkatesan, H.2
Peltier, H.M.3
Bembenek, S.D.4
Kanelakis, K.C.5
Zhao, L.X.6
Leonard, B.E.7
Hocutt, F.M.8
Wu, X.9
Palomino, H.L.10
Brondstetter, T.I.11
Haugh, P.V.12
Cagnon, L.13
Yan, W.14
Liotta, L.A.15
Young, A.16
Mirzadegan, T.17
Shankley, N.P.18
Barrett, T.D.19
Rabinowitz, M.H.20
more..
-
32
-
-
0035917808
-
Targeting of HIF-k to the von hippel-lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola, P.; Mole, D.R.; Tian, Y.-M.; Wilson, M.I.; Gielbert, J.; Gaskell, S.J.; von, K.A.; Hebestreit, H.F.; Mukherji, M.; Schofield, C.J.; Maxwell, P.H.; Pugh, C.W.; Ratcliffe, P.J. Targeting of HIF-k to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (Washington, DC, U. S.), 2001, 292(5516), 468-472.
-
(2001)
Science (Washington, DC, U. S.
, vol.292
, Issue.5516
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.-M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Von, K.A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
33
-
-
0035917313
-
HIFα targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan, M.; Kondo, K.; Yang, H.; Kim, W.; Valiando, J.; Ohh, M.; Salic, A.; Asara, J.M.; Lane, W.S.; Kaelin, W.G., Jr. HIFα targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science (Washington, DC, U. S.), 2001, 292(5516), 464-468.
-
(2001)
Science (Washington, DC, U. S.)
, vol.292
, Issue.5516
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
34
-
-
84870929731
-
Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases
-
Smirnova, N.A.; Hushpulian, D.M.; Speer, R.E.; Gaisina, I.N.; Ratan, R.R.; Gazaryan, I.G. Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases. Biochemistry (Moscow), 2012, 77(10), 1108-1119.
-
(2012)
Biochemistry (Moscow)
, vol.77
, Issue.10
, pp. 1108-1119
-
-
Smirnova, N.A.1
Hushpulian, D.M.2
Speer, R.E.3
Gaisina, I.N.4
Ratan, R.R.5
Gazaryan, I.G.6
-
35
-
-
61449231910
-
Targeting hypoxiainducible factor-1 (HIF-1) signaling in therapeutics: Implications for the treatment of inflammatory bowel disease
-
Hirota, S.A.; Beck, P.L.; MacDonald, J.A. Targeting hypoxiainducible factor-1 (HIF-1) signaling in therapeutics: Implications for the treatment of inflammatory bowel disease. Recent Pat. Inflamm. Allergy Drug Discov., 2009, 3(1), 1-16.
-
(2009)
Recent Pat. Inflamm. Allergy Drug Discov.
, vol.3
, Issue.1
, pp. 1-16
-
-
Hirota, S.A.1
Beck, P.L.2
MacDonald, J.A.3
-
36
-
-
84865610131
-
Hypoxia-inducible factor as a therapeutic target for cardioprotection
-
Ong, S.-G.; Hausenloy, D.J. Hypoxia-inducible factor as a therapeutic target for cardioprotection. Pharmacol. Ther., 2012, 136(1), 69-81.
-
(2012)
Pharmacol. Ther.
, vol.136
, Issue.1
, pp. 69-81
-
-
Ong, S.-G.1
Hausenloy, D.J.2
-
37
-
-
78649251947
-
Cancer therapy by targeting hypoxia-inducible factor-1
-
Li, Y.; Ye, D. Cancer therapy by targeting hypoxia-inducible factor-1. Curr. Cancer Drug Targets, 2010, 10(7), 782-796.
-
(2010)
Curr. Cancer Drug Targets
, vol.10
, Issue.7
, pp. 782-796
-
-
Li, Y.1
Ye, D.2
-
38
-
-
80052929099
-
Hypoxia inducible factor-1 as a target for neurodegenerative diseases
-
Zhang, Z.; Yan, J.; Chang, Y.; Yan, S.S.D.; Shi, H. Hypoxia inducible factor-1 as a target for neurodegenerative diseases. Curr. Med. Chem., 2011, 18(28), 4335-4343.
-
(2011)
Curr. Med. Chem.
, vol.18
, Issue.28
, pp. 4335-4343
-
-
Zhang, Z.1
Yan, J.2
Chang, Y.3
Yan, S.S.D.4
Shi, H.5
-
39
-
-
27544504817
-
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
-
Hirota, K.; Semenza, G.L. Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem. Biophys. Res. Commun., 2005, 338(1), 610-616.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.338
, Issue.1
, pp. 610-616
-
-
Hirota, K.1
Semenza, G.L.2
-
40
-
-
84862798797
-
Salidroside stimulates the accumulation of HIF-1β protein resulted in the induction of EPO expression: A signaling via blocking the degradation pathway in kidney and liver cells
-
Zheng, K.Y.-Z.; Zhang, Z.-X.; Guo, A.J.-Y.; Bi, C.W.-C.; Zhu, K.Y.; Xu, S.L.; Zhan, J.Y.-X.; Lau, D.T.-W.; Dong, T.T.-X.; Choi, R.C.-Y.; Tsim, K.W.-K. Salidroside stimulates the accumulation of HIF-1β protein resulted in the induction of EPO expression: A signaling via blocking the degradation pathway in kidney and liver cells. Eur. J. Pharmacol., 2012, 679(1-3), 34-39.
-
(2012)
Eur. J. Pharmacol.
, vol.679
, Issue.1-3
, pp. 34-39
-
-
Zheng, K.Y.-Z.1
Zhang, Z.-X.2
Guo, A.J.-Y.3
Bi, C.W.-C.4
Zhu, K.Y.5
Xu, S.L.6
Zhan, J.Y.-X.7
Lau, D.T.-W.8
Dong, T.T.-X.9
Choi, R.C.-Y.10
Tsim, K.W.-K.11
-
41
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
-
Lando, D.; Peet, D.J.; Whelan, D.A.; Gorman, J.J.; Whitelaw, M.L. Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch. Science (Washington, DC, U. S.), 2002, 295(5556), 858-861.
-
(2002)
Science (Washington, DC, U. S.)
, vol.295
, Issue.5556
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
42
-
-
84861845402
-
The updated biology of hypoxia-inducible factor
-
Greer, S.N.; Metcalf, J.L.; Wang, Y.; Ohh, M. The updated biology of hypoxia-inducible factor. EMBO J., 2012, 31(11), 2448-2460.
-
(2012)
EMBO J.
, vol.31
, Issue.11
, pp. 2448-2460
-
-
Greer, S.N.1
Metcalf, J.L.2
Wang, Y.3
Ohh, M.4
-
43
-
-
79953180051
-
Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor
-
Yang, M.; Ge, W.; Chowdhury, R.; Claridge, T.D.W.; Kramer, H.B.; Schmierer, B.; McDonough, M.A.; Gong, L.; Kessler, B.M.; Ratcliffe, P.J.; Coleman, M.L.; Schofield, C.J. Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor. J. Biol. Chem., 2011, 286(9), 7648-7660.
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.9
, pp. 7648-7660
-
-
Yang, M.1
Ge, W.2
Chowdhury, R.3
Claridge, T.D.W.4
Kramer, H.B.5
Schmierer, B.6
McDonough, M.A.7
Gong, L.8
Kessler, B.M.9
Ratcliffe, P.J.10
Coleman, M.L.11
Schofield, C.J.12
-
44
-
-
67349241646
-
Gene regulation in response to graded hypoxia: The non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway
-
Dayan, F.; Monticelli, M.; Pouyssegur, J.; Pecou, E. Gene regulation in response to graded hypoxia: The non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway. J. Theor. Biol., 2009, 259(2), 304-316.
-
(2009)
J. Theor. Biol.
, vol.259
, Issue.2
, pp. 304-316
-
-
Dayan, F.1
Monticelli, M.2
Pouyssegur, J.3
Pecou, E.4
-
45
-
-
33745764163
-
Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1
-
Nagle, D.G.; Zhou, Y.-D. Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1). Curr. Pharm. Des., 2006, 12(21), 2673-2688.
-
(2006)
Curr. Pharm. Des.
, vol.12
, Issue.21
, pp. 2673-2688
-
-
Nagle, D.G.1
Zhou, Y.-D.2
-
46
-
-
0034663153
-
Epolones induce erythropoietin expression via hypoxia-inducible factor-1β activation
-
Wanner, R.M.; Spielmann, P.; Stroka, D.M.; Camenisch, G.; Camenisch, I.; Scheid, A.; Houck, D.R.; Bauer, C.; Gassmann, M.; Wenger, R.H. Epolones induce erythropoietin expression via hypoxia-inducible factor-1β activation. Blood, 2000, 96(4), 1558-1565.
-
(2000)
Blood
, vol.96
, Issue.4
, pp. 1558-1565
-
-
Wanner, R.M.1
Spielmann, P.2
Stroka, D.M.3
Camenisch, G.4
Camenisch, I.5
Scheid, A.6
Houck, D.R.7
Bauer, C.8
Gassmann, M.9
Wenger, R.H.10
-
47
-
-
80052601576
-
Isolation identification and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis
-
Hattori, H.; Okuda, K.; Murase, T.; Shigetsura, Y.; Narise, K.; Semenza, G.L.; Nagasawa, H. Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. Bioorg. Med. Chem., 2011, 19(18), 5392-5401.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, Issue.18
, pp. 5392-5401
-
-
Hattori, H.1
Okuda, K.2
Murase, T.3
Shigetsura, Y.4
Narise, K.5
Semenza, G.L.6
Nagasawa, H.7
-
48
-
-
34347334632
-
Quercetin activates an angiogenic pathway hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: A structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase
-
Jeon, H.; Kim, H.; Choi, D.; Kim, D.; Park, S.-Y.; Kim, Y.-J.; Kim, Y.M.; Jung, Y. Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: A structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase. Mol. Pharmacol., 2007, 71(6), 1676-1684.
-
(2007)
Mol. Pharmacol.
, vol.71
, Issue.6
, pp. 1676-1684
-
-
Jeon, H.1
Kim, H.2
Choi, D.3
Kim, D.4
Park, S.-Y.5
Kim, Y.-J.6
Kim, Y.M.7
Jung, Y.8
-
49
-
-
1542541381
-
Specific inhibition of hypoxia-inducible factor (HIF)-1β activation and of vascular endothelial growth factor (VEGF) production by flavonoids
-
Hasebe, Y.; Egawa, K.; Yamazaki, Y.; Kunimoto, S.; Hirai, Y.; Ida, Y.; Nose, K. Specific inhibition of hypoxia-inducible factor (HIF)-1β activation and of vascular endothelial growth factor (VEGF) production by flavonoids. Biol. Pharm. Bull., 2003, 26(10), 1379-1383.
-
(2003)
Biol. Pharm. Bull.
, vol.26
, Issue.10
, pp. 1379-1383
-
-
Hasebe, Y.1
Egawa, K.2
Yamazaki, Y.3
Kunimoto, S.4
Hirai, Y.5
Ida, Y.6
Nose, K.7
-
50
-
-
84880307794
-
Investigation of the biological properties of Cinnulin PF in the context of diabetes: Mechanistic insights by genome-wide mRNA-Seq analysis
-
Rafehi, H.; Ververis, K.; Balcerczyk, A.; Ziemann, M.; Ooi, J.; Hu, S.; Kwa, F.A.A.; Loveridge, S.J.; Georgiadis, G.T.; El-Osta, A.; Karagiannis, T.C. Investigation of the biological properties of Cinnulin PF in the context of diabetes: Mechanistic insights by genome-wide mRNA-Seq analysis. Pathobiol. Aging Age-Relat. Dis., 2012, 2, 11905.
-
(2012)
Pathobiol. Aging Age-Relat. Dis.
, vol.2
, pp. 11905
-
-
Rafehi, H.1
Ververis, K.2
Balcerczyk, A.3
Ziemann, M.4
Ooi, J.5
Hu, S.6
Kwa, F.A.A.7
Loveridge, S.J.8
Georgiadis, G.T.9
El-Osta, A.10
Karagiannis, T.C.11
-
51
-
-
11844269261
-
Hypoxia-Inducible Factor-1 Activation by (-)-Epicatechin Gallate: Potential adverse effects of cancer chemoprevention with high-dose green tea extracts
-
Zhou, Y.-D.; Kim, Y.-P.; Li, X.-C.; Baerson, S.R.; Agarwal, A.K.; Hodges, T.W.; Ferreira, D.; Nagle, D.G. Hypoxia-Inducible Factor-1 Activation by (-)-Epicatechin Gallate: Potential Adverse Effects of Cancer Chemoprevention with High-Dose Green Tea Extracts. J. Nat. Prod., 2004, 67(12), 2063-2069.
-
(2004)
J. Nat. Prod.
, vol.67
, Issue.12
, pp. 2063-2069
-
-
Zhou, Y.-D.1
Kim, Y.-P.2
Li, X.-C.3
Baerson, S.R.4
Agarwal, A.K.5
Hodges, T.W.6
Ferreira, D.7
Nagle, D.G.8
-
52
-
-
33750326701
-
Gallate the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase
-
Tsukiyama, F.; Nakai, Y.; Yoshida, M.; Tokuhara, T.; Hirota, K.; Sakai, A.; Hayashi, H.; Katsumata, T. Gallate, the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase. Biochem. Biophys. Res. Commun., 2006, 351(1), 234-239.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.351
, Issue.1
, pp. 234-239
-
-
Tsukiyama, F.1
Nakai, Y.2
Yoshida, M.3
Tokuhara, T.4
Hirota, K.5
Sakai, A.6
Hayashi, H.7
Katsumata, T.8
-
53
-
-
68349133481
-
Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2
-
Mecinovic, J.; Chowdhury, R.; Flashman, E.; Schofield, C.J. Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2. Anal. Biochem., 2009, 393(2), 215-221.
-
(2009)
Anal. Biochem.
, vol.393
, Issue.2
, pp. 215-221
-
-
Mecinovic, J.1
Chowdhury, R.2
Flashman, E.3
Schofield, C.J.4
-
54
-
-
67649980040
-
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
-
Chowdhury, R.; McDonough, M.A.; Mecinovic, J.; Loenarz, C.; Flashman, E.; Hewitson, K.S.; Domene, C.; Schofield, C.J. Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases. Structure (Cambridge, MA, U. S.), 2009, 17(7), 981-989.
-
(2009)
Structure (Cambridge, MA, U. S.)
, vol.17
, Issue.7
, pp. 981-989
-
-
Chowdhury, R.1
McDonough, M.A.2
Mecinovic, J.3
Loenarz, C.4
Flashman, E.5
Hewitson, K.S.6
Domene, C.7
Schofield, C.J.8
-
55
-
-
29844433228
-
Human metallothionein gene expression is upregulated by k-thujaplicin: Possible involvement of protein kinase C and reactive oxygen species
-
Nakano, H.; Ikenaga, S.; Aizu, T.; Kaneko, T.; Matsuzaki, Y.; Tsuchida, S.; Hanada, K.; Arima, Y. Human metallothionein gene expression is upregulated by k-thujaplicin: Possible involvement of protein kinase C and reactive oxygen species. Biol. Pharm. Bull., 2006, 29(1), 55-59.
-
(2006)
Biol. Pharm. Bull.
, vol.29
, Issue.1
, pp. 55-59
-
-
Nakano, H.1
Ikenaga, S.2
Aizu, T.3
Kaneko, T.4
Matsuzaki, Y.5
Tsuchida, S.6
Hanada, K.7
Arima, Y.8
-
56
-
-
77952745235
-
Hinokitiol activates the hypoxiainducible factor (HIF) pathway through inhibition of HIF hydroxylases
-
Lee, M.J.; Kim, J.W.; Yang, E.G. Hinokitiol activates the hypoxiainducible factor (HIF) pathway through inhibition of HIF hydroxylases. Biochem. Biophys. Res. Commun., 2010, 396(2), 370-375.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.396
, Issue.2
, pp. 370-375
-
-
Lee, M.J.1
Kim, J.W.2
Yang, E.G.3
-
57
-
-
84863060920
-
L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N-myc downstream regulated gene 1 in prostate carcinoma cells
-
Chung, L.-C.; Tsui, K.-H.; Feng, T.-H.; Lee, S.-L.; Chang, P.-L.; Juang, H.-H. L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N-myc downstream regulated gene 1 in prostate carcinoma cells. Am. J. Physiol. Cell Physiol., 2012, 302(4), C676-685.
-
(2012)
Am. J. Physiol. Cell Physiol.
, vol.302
, Issue.4
-
-
Chung, L.-C.1
Tsui, K.-H.2
Feng, T.-H.3
Lee, S.-L.4
Chang, P.-L.5
Juang, H.-H.6
-
58
-
-
79954419856
-
Traditional Chinese medicine, Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats
-
Lee, J.-J.; Hsu, W.-H.; Yen, T.-L.; Chang, N.-C.; Luo, Y.-J.; Hsiao, G.; Sheu, J.-R. Traditional Chinese medicine, Xue-Fu-Zhu-Yu decoction, potentiates tissue plasminogen activator against thromboembolic stroke in rats. J. Ethnopharmacol., 2011, 134(3), 824-830.
-
(2011)
J. Ethnopharmacol.
, vol.134
, Issue.3
, pp. 824-830
-
-
Lee, J.-J.1
Hsu, W.-H.2
Yen, T.-L.3
Chang, N.-C.4
Luo, Y.-J.5
Hsiao, G.6
Sheu, J.-R.7
-
59
-
-
77951744892
-
Merging traditional chinese medicine with modern drug discovery technologies to find novel drugs and functional foods
-
Graziose, R.; Lila, M.A.; Raskin, I. Merging traditional chinese medicine with modern drug discovery technologies to find novel drugs and functional foods. Curr. Drug Discovery Technol., 2010, 7(1), 2-12.
-
(2010)
Curr. Drug Discovery Technol.
, vol.7
, Issue.1
, pp. 2-12
-
-
Graziose, R.1
Lila, M.A.2
Raskin, I.3
-
60
-
-
42549125894
-
A chinese herbal decoction prepared from Radix Astragali and Radix Angelicae sinensis induces the expression of erythropoietin in cultured Hep3B cells
-
Gao, Q.T.; Cheung, J.K.H.; Choi, R.C.Y.; Cheung, A.W.H.; Li, J.; Jiang, Z.Y.; Duan, R.; Zhao, K.J.; Ding, A.W.; Dong, T.T.X.; Tsim, K.W.K. A chinese herbal decoction prepared from Radix Astragali and Radix Angelicae sinensis induces the expression of erythropoietin in cultured Hep3B cells. Planta Med., 2008, 74(4), 392-395.
-
(2008)
Planta Med.
, vol.74
, Issue.4
, pp. 392-395
-
-
Gao, Q.T.1
Cheung, J.K.H.2
Choi, R.C.Y.3
Cheung, A.W.H.4
Li, J.5
Jiang, Z.Y.6
Duan, R.7
Zhao, K.J.8
Ding, A.W.9
Dong, T.T.X.10
Tsim, K.W.K.11
-
61
-
-
84856242445
-
Fo Shou San an ancient herbal decoction prepared from Angelicae Sinensis Radix and Chuanxiong Rhizoma, induces erythropoietin expression: A signaling mediated by the reduced degradation of hypoxia-inducible factor in cultured liver cells
-
Bi, C.W.C.; Xu, L.; Zhang, W.L.; Zhan, J.Y.X.; Fu, Q.; Zheng, K.Y.Z.; Chen, V.P.; Lau, D.T.W.; Choi, R.C.Y.; Wang, T.J.; Dong, T.T.X.; Tsim, K.W.K. Fo Shou San, an ancient herbal decoction prepared from Angelicae Sinensis Radix and Chuanxiong Rhizoma, induces erythropoietin expression: A signaling mediated by the reduced degradation of hypoxia-inducible factor in cultured liver cells. Planta Med., 2012, 78(2), 122-127.
-
(2012)
Planta Med.
, vol.78
, Issue.2
, pp. 122-127
-
-
Bi, C.W.C.1
Xu, L.2
Zhang, W.L.3
Zhan, J.Y.X.4
Fu, Q.5
Zheng, K.Y.Z.6
Chen, V.P.7
Lau, D.T.W.8
Choi, R.C.Y.9
Wang, T.J.10
Dong, T.T.X.11
Tsim, K.W.K.12
-
62
-
-
68149131977
-
Treatment with astragali radix and angelicae radix enhances erythropoietin gene expression in the cyclophosphamide-induced anemic rat
-
Chang, M.S.; Kim, D.R.; Ko, E.B.; Choi, B.J.; Park, S.Y.; Kang, S.A.; Park, S.K. Treatment with Astragali Radix and Angelicae Radix Enhances Erythropoietin Gene Expression in the Cyclophosphamide-Induced Anemic Rat. J. Med. Food, 2009, 12(3), 637-642.
-
(2009)
J. Med. Food
, vol.12
, Issue.3
, pp. 637-642
-
-
Chang, M.S.1
Kim, D.R.2
Ko, E.B.3
Choi, B.J.4
Park, S.Y.5
Kang, S.A.6
Park, S.K.7
-
63
-
-
0033024460
-
Picroliv-A natural product protects cells and regulates the gene expression during hypoxia/reoxygenation
-
Gaddipati, J.P.; Madhavan, S.; Sidhu, G.S.; Singh, A.K.; Seth, P.; Maheshwari, R.K. Picroliv-A natural product protects cells and regulates the gene expression during hypoxia/reoxygenation. Mol. Cell. Biochem., 1999, 194(1&2), 271-281.
-
(1999)
Mol. Cell. Biochem.
, vol.194
, Issue.1-2
, pp. 271-281
-
-
Gaddipati, J.P.1
Madhavan, S.2
Sidhu, G.S.3
Singh, A.K.4
Seth, P.5
Maheshwari, R.K.6
-
64
-
-
62149124032
-
Salidroside protects cardiomyocyte against hypoxia-induced death: A HIF-1β-activated and VEGF-mediated pathway
-
Zhang, J.; Liu, A.; Hou, R.; Zhang, J.; Jia, X.; Jiang, W.; Chen, J. Salidroside protects cardiomyocyte against hypoxia-induced death: A HIF-1β-activated and VEGF-mediated pathway. Eur. J. Pharmacol., 2009, 607(1-3), 6-14.
-
(2009)
Eur. J. Pharmacol.
, vol.607
, Issue.1-3
, pp. 6-14
-
-
Zhang, J.1
Liu, A.2
Hou, R.3
Zhang, J.4
Jia, X.5
Jiang, W.6
Chen, J.7
-
65
-
-
29844457587
-
The evolution of iron chelators for the treatment of iron overload disease and cancer
-
Kalinowski, D.S.; Richardson, D.R. The evolution of iron chelators for the treatment of iron overload disease and cancer. Pharmacol. Rev., 2005, 57(4), 547-583.
-
(2005)
Pharmacol. Rev.
, vol.57
, Issue.4
, pp. 547-583
-
-
Kalinowski, D.S.1
Richardson, D.R.2
-
66
-
-
0032701242
-
Synthesis, physicochemical characterization, and biological evaluation of 2-(1'-Hydroxyalkyl)-3-hydroxypyridin-4-ones: Novel iron chelators with enhanced pFe3+ Values
-
Liu, Z.D.; Khodr, H.H.; Liu, D.Y.; Lu, S.L.; Hider, R.C. Synthesis, Physicochemical Characterization, and Biological Evaluation of 2-(1'-Hydroxyalkyl)-3-hydroxypyridin-4-ones: Novel Iron Chelators with Enhanced pFe3+ Values. J. Med. Chem., 1999, 42(23), 4814-4823.
-
(1999)
J. Med. Chem.
, vol.42
, Issue.23
, pp. 4814-4823
-
-
Liu, Z.D.1
Khodr, H.H.2
Liu, D.Y.3
Lu, S.L.4
Hider, R.C.5
-
67
-
-
0027328530
-
Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3- hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potential
-
Dobbin, P.S.; Hider, R.C.; Hall, A.D.; Taylor, P.D.; Sarpong, P.; Porter, J.B.; Xiao, G.; van, d.H.D. Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potential. J. Med. Chem., 1993, 36(17), 2448-2458.
-
(1993)
J. Med. Chem.
, vol.36
, Issue.17
, pp. 2448-2458
-
-
Dobbin, P.S.1
Hider, R.C.2
Hall, A.D.3
Taylor, P.D.4
Sarpong, P.5
Porter, J.B.6
Xiao, G.7
Van, D.H.D.8
-
68
-
-
79957710497
-
Induction of hypoxia inducible factor (HIF-1β) in rat kidneys by iron chelation with the hydroxypyridinone, CP94
-
Baek, J.H.; Reiter, C.E.N.; Manalo, D.J.; Buehler, P.W.; Hider, R.C.; Alayash, A.I. Induction of hypoxia inducible factor (HIF-1β) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochim. Biophys. Acta, Gene Regul. Mech., 2011, 1809(4-6), 262-268.
-
(2011)
Biochim. Biophys. Acta, Gene Regul. Mech.
, vol.1809
, Issue.4-6
, pp. 262-268
-
-
Baek, J.H.1
Reiter, C.E.N.2
Manalo, D.J.3
Buehler, P.W.4
Hider, R.C.5
Alayash, A.I.6
-
69
-
-
84861923067
-
Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH
-
Flagg, S.C.; Martin, C.B.; Taabazuing, C.Y.; Holmes, B.E.; Knapp, M.J. Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH). J. Inorg. Biochem., 2012, 113, 25-30.
-
(2012)
J. Inorg. Biochem.
, vol.113
, pp. 25-30
-
-
Flagg, S.C.1
Martin, C.B.2
Taabazuing, C.Y.3
Holmes, B.E.4
Knapp, M.J.5
-
70
-
-
79956324149
-
Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H- benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxiainducible factor prolyl hydroxylase inhibitor
-
Barrett, T.D.; Palomino, H.L.; Brondstetter, T.I.; Kanelakis, K.C.; Wu, X.; Haug, P.V.; Yan, W.; Young, A.; Hua, H.; Hart, J.C.; Tran, D.-T.; Venkatesan, H.; Rosen, M.D.; Peltier, H.M.; Sepassi, K.; Rizzolio, M.C.; Bembenek, S.D.; Mirzadegan, T.; Rabinowitz, M.H.; Shankley, N.P. Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H- pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxiainducible factor prolyl hydroxylase inhibitor. Mol. Pharmacol., 2011, 79(6), 910-920.
-
(2011)
Mol. Pharmacol.
, vol.79
, Issue.6
, pp. 910-920
-
-
Barrett, T.D.1
Palomino, H.L.2
Brondstetter, T.I.3
Kanelakis, K.C.4
Wu, X.5
Haug, P.V.6
Yan, W.7
Young, A.8
Hua, H.9
Hart, J.C.10
Tran, D.-T.11
Venkatesan, H.12
Rosen, M.D.13
Peltier, H.M.14
Sepassi, K.15
Rizzolio, M.C.16
Bembenek, S.D.17
Mirzadegan, T.18
Rabinowitz, M.H.19
Shankley, N.P.20
more..
-
71
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1β in normoxia
-
Berra, E.; Benizri, E.; Ginouves, A.; Volmat, V.; Roux, D.; Pouyssegur, J. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1β in normoxia. EMBO Journal, 2003, 22(16), 4082-4090.
-
(2003)
EMBO Journal
, vol.22
, Issue.16
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
72
-
-
33748786847
-
Design and synthesis of a series of novel pyrazolylpyridines as HIF 1-α prolyl hydroxylase inhibitors
-
Warshakoon, N.C.; Wu, S.; Boyer, A.; Kawamoto, R.; Renock, S.; Xu, K.; Pokross, M.; Evdokimov, A.G.; Zhou, S.; Winter, C.; Walter, R.; Mekel, M. Design and synthesis of a series of novel pyrazolylpyridines as HIF 1-α prolyl hydroxylase inhibitors. Bioorg. Med. Chem. Lett., 2006, 16, 5687-5690.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 5687-5690
-
-
Warshakoon, N.C.1
Wu, S.2
Boyer, A.3
Kawamoto, R.4
Renock, S.5
Xu, K.6
Pokross, M.7
Evdokimov, A.G.8
Zhou, S.9
Winter, C.10
Walter, R.11
Mekel, M.12
-
73
-
-
33745614894
-
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2
-
McDonough, M.A.; Li, V.; Flashman, E.; Chowdhury, R.; Mohr, C.; Lienard, B.M.R.; Zondlo, J.; Oldham, N.J.; Clifton, I.J.; Lewis, J.; McNeill, L.A.; Kurzeja, R.J.M.; Hewitson, K.S.; Yang, E.; Jordan, S.; Syed, R.S.; Schofield, C.J. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc. Natl. Acad. Sci. U. S. A., 2006, 103, 9814-9819.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 9814-9819
-
-
McDonough, M.A.1
Li, V.2
Flashman, E.3
Chowdhury, R.4
Mohr, C.5
Lienard, B.M.R.6
Zondlo, J.7
Oldham, N.J.8
Clifton, I.J.9
Lewis, J.10
McNeill, L.A.11
Kurzeja, R.J.M.12
Hewitson, K.S.13
Yang, E.14
Jordan, S.15
Syed, R.S.16
Schofield, C.J.17
-
74
-
-
33748807798
-
Structure-based Design Synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1β prolyl hydroxylase inhibitors
-
Warshakoon, N.C.; Wu, S.; Boyer, A.; Kawamoto, R.; Sheville, J.; Renock, S.; Xu, K.; Pokross, M.; Zhou, S.; Winter, C.; Walter, R.; Mekel, M.; Evdokimov, A.G. Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1β prolyl hydroxylase inhibitors. Bioorg. Med. Chem. Lett., 2006, 16, 5517-5522.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 5517-5522
-
-
Warshakoon, N.C.1
Wu, S.2
Boyer, A.3
Kawamoto, R.4
Sheville, J.5
Renock, S.6
Xu, K.7
Pokross, M.8
Zhou, S.9
Winter, C.10
Walter, R.11
Mekel, M.12
Evdokimov, A.G.13
-
75
-
-
47149109042
-
Discovery of novel hydroxy-thiazoles as HIF-k prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation
-
Tegley, C.M.; Viswanadhan, V.N.; Biswas, K.; Frohn, M.J.; Peterkin, T.A.N.; Chang, C.; Buerli, R.W.; Dao, J.H.; Veith, H.; Rogers, N.; Yoder, S.C.; Biddlecome, G.; Tagari, P.; Allen, J.R.; Hungate, R.W. Discovery of novel hydroxy-thiazoles as HIF-k prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation. Bioorg. Med. Chem. Lett., 2008, 18, 3925-3928.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 3925-3928
-
-
Tegley, C.M.1
Viswanadhan, V.N.2
Biswas, K.3
Frohn, M.J.4
Peterkin, T.A.N.5
Chang, C.6
Buerli, R.W.7
Dao, J.H.8
Veith, H.9
Rogers, N.10
Yoder, S.C.11
Biddlecome, G.12
Tagari, P.13
Allen, J.R.14
Hungate, R.W.15
-
76
-
-
51549084976
-
Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1β prolyl hydroxylase-2 inhibitors
-
Frohn, M.; Viswanadhan, V.; Pickrell, A.J.; Golden, J.E.; Muller, K.M.; Buerli, R.W.; Biddlecome, G.; Yoder, S.C.; Rogers, N.; Dao, J.H.; Hungate, R.; Allen, J.R. Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1β prolyl hydroxylase-2 inhibitors. Bioorg. Med. Chem. Lett., 2008, 18, 5023-5026.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 5023-5026
-
-
Frohn, M.1
Viswanadhan, V.2
Pickrell, A.J.3
Golden, J.E.4
Muller, K.M.5
Buerli, R.W.6
Biddlecome, G.7
Yoder, S.C.8
Rogers, N.9
Dao, J.H.10
Hungate, R.11
Allen, J.R.12
-
77
-
-
84858705244
-
Identification of novel potential HIFprolyl hydroxylase inhibitors by in silico screening
-
Teli, M.K.; Rajanikant, G.K. Identification of novel potential HIFprolyl hydroxylase inhibitors by in silico screening. Mol. Diversity, 2012, 16(1), 193-202.
-
(2012)
Mol. Diversity
, vol.16
, Issue.1
, pp. 193-202
-
-
Teli, M.K.1
Rajanikant, G.K.2
-
78
-
-
84655167719
-
Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway
-
Theriault, J.R.; Felts, A.S.; Bates, B.S.; Perez, J.R.; Palmer, M.; Gilbert, S.R.; Dawson, E.S.; Engers, J.L.; Lindsley, C.W.; Emmitte, K.A. Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway. Bioorg. Med. Chem. Lett., 2012, 22(1), 76-81.
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, Issue.1
, pp. 76-81
-
-
Theriault, J.R.1
Felts, A.S.2
Bates, B.S.3
Perez, J.R.4
Palmer, M.5
Gilbert, S.R.6
Dawson, E.S.7
Engers, J.L.8
Lindsley, C.W.9
Emmitte, K.A.10
-
79
-
-
84859799747
-
Giving anemia a boost with inhibitors of prolyl hydroxylase
-
Denny, W.A. Giving Anemia a Boost with Inhibitors of Prolyl Hydroxylase. J. Med. Chem., 2012, 55(7), 2943-2944.
-
(2012)
J. Med. Chem.
, vol.55
, Issue.7
, pp. 2943-2944
-
-
Denny, W.A.1
-
80
-
-
84859805859
-
138-Triazaspiro[4.5]decane-2,4- diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia
-
Vachal, P.; Miao, S.; Pierce, J.M.; Guiadeen, D.; Colandrea, V.J.; Wyvratt, M.J.; Salowe, S.P.; Sonatore, L.M.; Milligan, J.A.; Hajdu, R.; Gollapudi, A.; Keohane, C.A.; Lingham, R.B.; Mandala, S.M.; DeMartino, J.A.; Tong, X.; Wolff, M.; Steinhuebel, D.; Kieczykowski, G.R.; Fleitz, F.J.; Chapman, K.; Athanasopoulos, J.; Adam, G.; Akyuz, C.D.; Jena, D.K.; Lusen, J.W.; Meng, J.; Stein, B.D.; Xia, L.; Sherer, E.C.; Hale, J.J. 1,3,8-Triazaspiro[4.5]decane- 2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J. Med. Chem., 2012, 55(7), 2945-2959.
-
(2012)
J. Med. Chem.
, vol.55
, Issue.7
, pp. 2945-2959
-
-
Vachal, P.1
Miao, S.2
Pierce, J.M.3
Guiadeen, D.4
Colandrea, V.J.5
Wyvratt, M.J.6
Salowe, S.P.7
Sonatore, L.M.8
Milligan, J.A.9
Hajdu, R.10
Gollapudi, A.11
Keohane, C.A.12
Lingham, R.B.13
Mandala, S.M.14
DeMartino, J.A.15
Tong, X.16
Wolff, M.17
Steinhuebel, D.18
Kieczykowski, G.R.19
Fleitz, F.J.20
Chapman, K.21
Athanasopoulos, J.22
Adam, G.23
Akyuz, C.D.24
Jena, D.K.25
Lusen, J.W.26
Meng, J.27
Stein, B.D.28
Xia, L.29
Sherer, E.C.30
Hale, J.J.31
more..
-
81
-
-
41949093057
-
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry
-
Bugaut, A.; Jantos, K.; Wietor, J.-L.; Rodriguez, R.; Sanders, J.K.M.; Balasubramanian, S. Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry. Angew. Chem., Int. Ed., 2008, 47, 2677-2680.
-
(2008)
Angew. Chem., Int. Ed.
, vol.47
, pp. 2677-2680
-
-
Bugaut, A.1
Jantos, K.2
Wietor, J.-L.3
Rodriguez, R.4
Sanders, J.K.M.5
Balasubramanian, S.6
-
82
-
-
84863208034
-
Dynamic combinatorial chemistry employing boronic acidsboronate esters leads to potent oxygenase inhibitors
-
S6672/1-S6672/53
-
Demetriades, M.; Leung, I.K.H.; Chowdhury, R.; Chan, M.C.; McDonough, M.A.; Yeoh, K.K.; Tian, Y.-M.; Claridge, T.D.W.; Ratcliffe, P.J.; Woon, E.C.Y.; Schofield, C.J. Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors. Angew. Chem., Int. Ed., 2012, 51(27), 6672-6675, S6672/1-S6672/53.
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, Issue.27
, pp. 6672-6675
-
-
Demetriades, M.1
Leung, I.K.H.2
Chowdhury, R.3
Chan, M.C.4
McDonough, M.A.5
Yeoh, K.K.6
Tian, Y.-M.7
Claridge, T.D.W.8
Ratcliffe, P.J.9
Woon, E.C.Y.10
Schofield, C.J.11
-
83
-
-
79959869553
-
Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides
-
Kwon, H.S.; Choi, Y.K.; Kim, J.W.; Park, Y.K.; Yang, E.G.; Ahn, D.-R. Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides. Bioorg. Med. Chem. Lett., 2011, 21(14), 4325-4328.
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, Issue.14
, pp. 4325-4328
-
-
Kwon, H.S.1
Choi, Y.K.2
Kim, J.W.3
Park, Y.K.4
Yang, E.G.5
Ahn, D.-R.6
-
84
-
-
0037013658
-
Hydroxypyridinone complexes with aluminum. In vitro/vivo studies and perspectives
-
Amelia, S.M. Hydroxypyridinone complexes with aluminum. In vitro/vivo studies and perspectives. Coord. Chem. Rev., 2002, 228(2), 187-203.
-
(2002)
Coord. Chem. Rev.
, vol.228
, Issue.2
, pp. 187-203
-
-
Amelia, S.M.1
-
85
-
-
79958027022
-
Design of clinically useful macromolecular iron chelators
-
Zhou, T.; Winkelmann, G.; Dai, Z.-Y.; Hider, R.C. Design of clinically useful macromolecular iron chelators. J. Pharm. Pharmacol., 2011, 63(7), 893-903.
-
(2011)
J. Pharm. Pharmacol.
, vol.63
, Issue.7
, pp. 893-903
-
-
Zhou, T.1
Winkelmann, G.2
Dai, Z.-Y.3
Hider, R.C.4
-
86
-
-
80053203292
-
Natural products: An evolving role in future drug discovery
-
Mishra, B.B.; Tiwari, V.K. Natural products: An evolving role in future drug discovery. Eur. J. Med. Chem., 2011, 46(10), 4769-4807.
-
(2011)
Eur J. Med. Chem.
, vol.46
, Issue.10
, pp. 4769-4807
-
-
Mishra, B.B.1
Tiwari, V.K.2
-
87
-
-
77956529178
-
Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1β Prolyl Hydroxylases-1,-2, and-3 with altered selectivity
-
Murray, J.K.; Balan, C.; Allgeier, A.M.; Kasparian, A.; Viswanadhan, V.; Wilde, C.; Allen, J.R.; Yoder, S.C.; Biddlecome, G.; Hungate, R.W.; Miranda, L.P. Dipeptidyl-Quinolone Derivatives Inhibit Hypoxia Inducible Factor-1β Prolyl Hydroxylases-1,-2, and-3 with Altered Selectivity. J. Comb. Chem., 2010, 12, 676-686.
-
(2010)
J. Comb. Chem.
, vol.12
, pp. 676-686
-
-
Murray, J.K.1
Balan, C.2
Allgeier, A.M.3
Kasparian, A.4
Viswanadhan, V.5
Wilde, C.6
Allen, J.R.7
Yoder, S.C.8
Biddlecome, G.9
Hungate, R.W.10
Miranda, L.P.11
-
88
-
-
77950936168
-
Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation
-
Smirnova, N.A.; Rakhman, I.; Moroz, N.; Basso, M.; Payappilly, J.; Kazakov, S.; Hernandez-Guzman, F.; Gaisina, I.N.; Kozikowski, A.P.; Ratan, R.R.; Gazaryan, I.G. Utilization of an In Vivo Reporter for High Throughput Identification of Branched Small Molecule Regulators of Hypoxic Adaptation. Chem. Biol. (Cambridge, MA, U. S.), 2010, 17(4), 380-391.
-
(2010)
Chem. Biol. (Cambridge, MA, U. S.)
, vol.17
, Issue.4
, pp. 380-391
-
-
Smirnova, N.A.1
Rakhman, I.2
Moroz, N.3
Basso, M.4
Payappilly, J.5
Kazakov, S.6
Hernandez-Guzman, F.7
Gaisina, I.N.8
Kozikowski, A.P.9
Ratan, R.R.10
Gazaryan, I.G.11
-
89
-
-
79959977075
-
Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors
-
Thirstrup, K.; Christensen, S.; Moller, H.A.; Ritzen, A.; Bergstroem, A.-L.; Sager, T.N.; Jensen, H.S. Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors. Pharmacol. Res., 2011, 64(3), 268-273.
-
(2011)
Pharmacol. Res.
, vol.64
, Issue.3
, pp. 268-273
-
-
Thirstrup, K.1
Christensen, S.2
Moller, H.A.3
Ritzen, A.4
Bergstroem, A.-L.5
Sager, T.N.6
Jensen, H.S.7
-
90
-
-
77954837178
-
Reactivation of hepatic EPO synthesis in mice after PHD loss
-
Minamishima, Y.A.; Kaelin, W.G., Jr. Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss. Science (Washington, DC, U. S.), 2010, 329(5990), 407.
-
(2010)
Science (Washington, DC, U. S.)
, vol.329
, Issue.5990
, pp. 407
-
-
Minamishima, Y.A.1
Kaelin Jr., W.G.2
-
91
-
-
77956914248
-
Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
-
Conejo-Garcia, A.; McDonough, M.A.; Loenarz, C.; McNeill, L.A.; Hewitson, K.S.; Ge, W.; Lienard, B.M.; Schofield, C.J.; Clifton, I.J. Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Bioorg. Med. Chem. Lett., 2010, 20(20), 6125-6128.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.20
, pp. 6125-6128
-
-
Conejo-Garcia, A.1
McDonough, M.A.2
Loenarz, C.3
McNeill, L.A.4
Hewitson, K.S.5
Ge, W.6
Lienard, B.M.7
Schofield, C.J.8
Clifton, I.J.9
-
92
-
-
70350389957
-
FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins
-
(Hypoxia and Consequences)
-
Cockman, M.E.; Webb, J.D.; Ratcliffe, P.J. FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. Ann. N. Y. Acad. Sci., 2009, 1177(Hypoxia and Consequences), 9-18.
-
(2009)
Ann. N. Y. Acad. Sci.
, vol.1177
, pp. 9-18
-
-
Cockman, M.E.1
Webb, J.D.2
Ratcliffe, P.J.3
-
93
-
-
19744373474
-
Selective inhibition of factor inhibiting hypoxia-inducible factor
-
McDonough, M.A.; McNeill, L.A.; Tilliet, M.; Papamicaeel, C.A.; Chen, Q.-Y.; Banerji, B.; Hewitson, K.S.; Schofield, C.J. Selective Inhibition of Factor Inhibiting Hypoxia-Inducible Factor. J. Am. Chem. Soc., 2005, 127(21), 7680-7681.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, Issue.21
, pp. 7680-7681
-
-
McDonough, M.A.1
McNeill, L.A.2
Tilliet, M.3
Papamicaeel, C.A.4
Chen, Q.-Y.5
Banerji, B.6
Hewitson, K.S.7
Schofield, C.J.8
-
94
-
-
28044447626
-
The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by k-oxocarboxylic acids
-
Banerji, B.; Conejo-Garcia, A.; McNeill, L.A.; McDonough, M.A.; Buck, M.R.G.; Hewitson, K.S.; Oldham, N.J.; Schofield, C.J. The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by k-oxocarboxylic acids. Chem. Commun. (Cambridge, U. K.), 2005(43), 5438-5440.
-
(2005)
Chem. Commun. (Cambridge, U. K.)
, vol.43
, pp. 5438-5440
-
-
Banerji, B.1
Conejo-Garcia, A.2
McNeill, L.A.3
McDonough, M.A.4
Buck, M.R.G.5
Hewitson, K.S.6
Oldham, N.J.7
Schofield, C.J.8
-
95
-
-
77955056549
-
Crystal structures of human FIH-1 in complex with quinol family inhibitors
-
Moon, H.; Han, S.; Park, H.; Choe, J. Crystal structures of human FIH-1 in complex with quinol family inhibitors. Mol. Cells, 2010, 29(5), 471-474.
-
(2010)
Mol. Cells
, vol.29
, Issue.5
, pp. 471-474
-
-
Moon, H.1
Han, S.2
Park, H.3
Choe, J.4
-
96
-
-
72049121488
-
Structure-based virtual screening approach to the discovery of novel inhibitors of factorinhibiting HIF-1: Identification of new chelating groups for the active-site ferrous ion
-
Ko, S.; Lee, M.K.; Shin, D.; Park, H. Structure-based virtual screening approach to the discovery of novel inhibitors of factorinhibiting HIF-1: Identification of new chelating groups for the active-site ferrous ion. Bioorg. Med. Chem., 2009, 17(22), 7769-7774.
-
(2009)
Bioorg. Med. Chem.
, vol.17
, Issue.22
, pp. 7769-7774
-
-
Ko, S.1
Lee, M.K.2
Shin, D.3
Park, H.4
-
97
-
-
84858201095
-
Targeting the von hippel-lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1β interaction
-
Buckley, D.L.; Van, M.I.; Gareiss, P.C.; Tae, H.S.; Michel, J.; Noblin, D.J.; Jorgensen, W.L.; Ciulli, A.; Crews, C.M. Targeting the von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1β Interaction. J. Am. Chem. Soc., 2012, 134(10), 4465-4468.
-
(2012)
J. Am. Chem. Soc.
, vol.134
, Issue.10
, pp. 4465-4468
-
-
Buckley, D.L.1
Van, M.I.2
Gareiss, P.C.3
Tae, H.S.4
Michel, J.5
Noblin, D.J.6
Jorgensen, W.L.7
Ciulli, A.8
Crews, C.M.9
|