Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity

Journal of Combinatorial Chemistry

Volumn 12, Issue 5, 2010, Pages 676-686

  Murray, Justin K ^a   Balan, Chenera ^a   Allgeier, Alan M ^b   Kasparian, Annie ^b   Viswanadhan, Vellarkad ^a   Wilde, Christopher ^a   Allen, Jennifer R ^a   Yoder, Sean C ^b   Biddlecome, Gloria ^b   Hungate, Randall W ^a   Miranda, Les P ^a  

^a AMGEN INC   (United States)

^b Department of Hematology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDE; ENZYME INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOENZYME; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; QUINOLONE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; METABOLISM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

COMBINATORIAL CHEMISTRY TECHNIQUES; DIPEPTIDES; ENZYME INHIBITORS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISOENZYMES; MOLECULAR STRUCTURE; PROCOLLAGEN-PROLINE DIOXYGENASE; QUINOLONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956529178     PISSN: 15204766     EISSN: 15204774     Source Type: Journal    
DOI: 10.1021/cc100073a     Document Type: Article

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