Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 20, 2010, Pages 6125-6128

  Conejo Garcia, Ana ^a   McDonough, Michael A ^a   Loenarz, Christoph ^a   McNeill, Luke A ^a   Hewitson, Kirsty S ^a   Ge, Wei ^a   Liénard, Benoît M ^a   Schofield, Christopher J ^a   Clifton, Ian J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

2 Oxoglutarate analogue; Factor inhibiting hypoxia inducible factor; Hydroxamic acid; Hypoxic response; Oxygenase

Indexed keywords

2 OXOGLUTARIC ACID; ASPARTIC ACID; HYDROXAMIC ACID DERIVATIVE; HYPOXIA INDUCIBLE FACTOR; IRON; IRON BINDING PROTEIN; IRON CHELATING AGENT; PYRIDINE 2,4 DICARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; ENZYME ACTIVE SITE;

BINDING SITES; CATALYTIC DOMAIN; HUMANS; KETOGLUTARIC ACIDS; MODELS, MOLECULAR; PROTEIN BINDING; REPRESSOR PROTEINS;

EID: 77956914248     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.032     Document Type: Article

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