Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 14, 2011, Pages 4325-4328

  Kwon, Hyuk Sung ^a,b   Choi, Yien Kyoung ^a   Kim, Jeong Won ^a   Park, Yong Keun ^b   Yang, Eun Gyeong ^a   Ahn, Dae Ro ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

Author keywords

HIF 1 ; Hypoxia; Peptide inhibitors; PHD2; Substrate analog peptides

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; LEVO 3,4 DEHYDROPROLINE; LEVO 4 THIOPROLINE; LEVO PIPERIDINE 2 CARBOXYLIC ACID; LEVO TRANS 4 FLUOROPROLINE; LEVO TRANS 4 HYDROXYPROLINE; OXYGENASE INHIBITOR; PEPTIDE DERIVATIVE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE DERIVATIVE; PROLYL HYDROXYLASE DOMAIN 2 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; ENZYME SUBSTRATE; FLUORESCENCE POLARIZATION; PROTEIN DOMAIN; PROTEIN MODIFICATION;

AMINO ACID SEQUENCE; ENZYME INHIBITORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PEPTIDES; PROCOLLAGEN-PROLINE DIOXYGENASE; SUBSTRATE SPECIFICITY;

EID: 79959869553     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.050     Document Type: Article

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