Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction

Journal of the American Chemical Society

Volumn 134, Issue 10, 2012, Pages 4465-4468

  Buckley, Dennis L ^a   Van Molle, Inge ^c   Gareiss, Peter C ^a   Tae, Hyun Seop ^a   Michel, Julien ^a,d   Noblin, Devin J ^a   Jorgensen, William L ^a   Ciulli, Alessio ^c   Crews, Craig M ^a,b  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MODES; DRUG TARGETS; E3 LIGASE; E3 UBIQUITIN LIGASES; POTENT INHIBITOR; PROTEIN TARGETS; PROTEIN-PROTEIN INTERACTIONS; RATIONAL DESIGN; SMALL MOLECULES; SMALL-MOLECULE INHIBITORS; SUBSTRATE RECOGNITION; SUBSTRATE SPECIFICITY; UBIQUITIN LIGASES; UBIQUITINATION;

BINDING ENERGY; DRUG INTERACTIONS; LEAD COMPOUNDS; TRANSCRIPTION FACTORS;

MOLECULES;

HYPOXIA INDUCIBLE FACTOR 1ALPHA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VON HIPPEL LINDAU E3 UBIQUITIN LIGASE; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; IC 50; PROTEIN BINDING; UPREGULATION;

HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SMALL MOLECULE LIBRARIES; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84858201095     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja209924v     Document Type: Article

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