메뉴 건너뛰기




Volumn 32, Issue 7, 2013, Pages 380-396

Skeletal metastasis: Treatments, mouse models, and the Wnt signaling

Author keywords

Cancer; Mouse models; Skeletal metastasis; Therapy; Wnt signaling

Indexed keywords

ABIRATERONE ACETATE; ALENDRONIC ACID; ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; BALICATIB; BISPHOSPHONIC ACID DERIVATIVE; CABOZANTINIB; DENOSUMAB; ETIDRONIC ACID; GONADORELIN AGONIST; IBANDRONIC ACID; KI 26894; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; ODANACATIB; PAMIDRONIC ACID; PARATHYROID HORMONE RELATED PROTEIN; RADIOPHARMACEUTICAL AGENT; RADIUM 223; RECLASE; RISEDRONIC ACID; SCATTER FACTOR RECEPTOR; SEOCALCITOL; TAMOXIFEN; TAMOXIFEN CITRATE; TILUDRONIC ACID; TRANSFORMING GROWTH FACTOR BETA; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; WNT PROTEIN; ZOLEDRONIC ACID;

EID: 84879807719     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.012.10218     Document Type: Review
Times cited : (32)

References (216)
  • 1
    • 0003964363 scopus 로고    scopus 로고
    • Atlanta: American Cancer Society, Inc
    • Cancer facts & figures. Atlanta: American Cancer Society, Inc, 2011.
    • (2011) Cancer Facts & Figures
  • 2
    • 33645834966 scopus 로고    scopus 로고
    • Metastatic patterns in adenocarcinoma
    • Hess KR, Varadhachary GR, Taylor SH, et al. Metastatic patterns in adenocarcinoma. Cancer, 2006,106:1624-1633.
    • (2006) Cancer , vol.106 , pp. 1624-1633
    • Hess, K.R.1    Varadhachary, G.R.2    Taylor, S.H.3
  • 3
    • 79951770973 scopus 로고    scopus 로고
    • The hospital burden of disease associated with bone metastases and skeletal-related events in patients with breast cancer, lung cancer, or prostate cancer in spain
    • Pockett RD, Castellano D, McEwan P, et al. The hospital burden of disease associated with bone metastases and skeletal-related events in patients with breast cancer, lung cancer, or prostate cancer in spain. Eur J Cancer Care (Engl), 2010,19:755-760.
    • (2010) Eur J Cancer Care (Engl) , vol.19 , pp. 755-760
    • Pockett, R.D.1    Castellano, D.2    McEwan, P.3
  • 4
    • 80053978532 scopus 로고    scopus 로고
    • Matrix-embedded cells control osteoclast formation
    • Xiong J, Onal M, Jilka RL, et al. Matrix-embedded cells control osteoclast formation. Nat Med, 2011,17:1235-1241.
    • (2011) Nat Med , vol.17 , pp. 1235-1241
    • Xiong, J.1    Onal, M.2    Jilka, R.L.3
  • 5
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer, 2009,9:274-284.
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 6
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet, 2007,8:341-352.
    • (2007) Nat Rev Genet , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 7
    • 58149102321 scopus 로고    scopus 로고
    • Molecular basis of metastasis
    • Chiang AC, Massague J. Molecular basis of metastasis. N Engl J Med, 2008,359:2814-2823.
    • (2008) N Engl J Med , vol.359 , pp. 2814-2823
    • Chiang, A.C.1    Massague, J.2
  • 8
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. Lancet, 1889,1:571-573.
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 9
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer, 2002,2:584-593.
    • (2002) Nat Rev Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 10
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell, 2003,3:537-549.
    • (2003) Cancer Cell , vol.3 , pp. 537-549
    • Kang, Y.1    Siegel, P.M.2    Shu, W.3
  • 11
    • 79958037582 scopus 로고    scopus 로고
    • Bone metastasis in prostate cancer: Emerging therapeutic strategies
    • Sturge J, Caley MP, Waxman J. Bone metastasis in prostate cancer: emerging therapeutic strategies. Nat Rev Clin Oncol, 2011,8:357-368.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 357-368
    • Sturge, J.1    Caley, M.P.2    Waxman, J.3
  • 12
    • 0034659963 scopus 로고    scopus 로고
    • Biochemical markers and skeletal metastases
    • Demers LM, Costa L, Lipton A. Biochemical markers and skeletal metastases. Cancer, 2000,88:2919-2926.
    • (2000) Cancer , vol.88 , pp. 2919-2926
    • Demers, L.M.1    Costa, L.2    Lipton, A.3
  • 13
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Muller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature, 2001,410:50-56.
    • (2001) Nature , vol.410 , pp. 50-56
    • Muller, A.1    Homey, B.2    Soto, H.3
  • 14
    • 33845769269 scopus 로고    scopus 로고
    • Expression and activation of alpha v beta 3 integrins by sdf-1/cxc12 increases the aggressiveness of prostate cancer cells
    • Sun YX, Fang M, Wang J, et al. Expression and activation of alpha v beta 3 integrins by sdf-1/cxc12 increases the aggressiveness of prostate cancer cells. Prostate, 2007,67:61-73.
    • (2007) Prostate , vol.67 , pp. 61-73
    • Sun, Y.X.1    Fang, M.2    Wang, J.3
  • 15
    • 0025093971 scopus 로고
    • Organpreference of metastasis. The role of endothelial cell adhesion molecules
    • Pauli BU, Augustin-Voss HG, el-Sabban ME, et al. Organpreference of metastasis. The role of endothelial cell adhesion molecules. Cancer Metastasis Rev, 1990,9:175-189.
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 175-189
    • Pauli, B.U.1    Augustin-Voss, H.G.2    El-Sabban, M.E.3
  • 16
    • 21344452789 scopus 로고    scopus 로고
    • Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases
    • Kelly T, Suva LJ, Huang Y, et al. Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases. Cancer Res, 2005,65:5778-5784.
    • (2005) Cancer Res , vol.65 , pp. 5778-5784
    • Kelly, T.1    Suva, L.J.2    Huang, Y.3
  • 17
    • 44649088833 scopus 로고    scopus 로고
    • Systemic endocrine instigation of indolent tumor growth requires osteopontin
    • McAllister SS, Gifford AM, Greiner AL, et al. Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell, 2008,133:994-1005.
    • (2008) Cell , vol.133 , pp. 994-1005
    • McAllister, S.S.1    Gifford, A.M.2    Greiner, A.L.3
  • 18
    • 21144438505 scopus 로고    scopus 로고
    • Mmp-7 promotes prostate cancer-induced osteolysis via the solubilization of rankl
    • Lynch CC, Hikosaka A, Acuff HB, et al. Mmp-7 promotes prostate cancer-induced osteolysis via the solubilization of rankl. Cancer Cell, 2005,7:485-496.
    • (2005) Cancer Cell , vol.7 , pp. 485-496
    • Lynch, C.C.1    Hikosaka, A.2    Acuff, H.B.3
  • 20
    • 79953331206 scopus 로고    scopus 로고
    • Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow
    • Shiozawa Y, Pedersen EA, Havens AM, et al. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Invest, 2011,121:1298-1312.
    • (2011) J Clin Invest , vol.121 , pp. 1298-1312
    • Shiozawa, Y.1    Pedersen, E.A.2    Havens, A.M.3
  • 21
    • 77953229266 scopus 로고    scopus 로고
    • Skeletal related events, bone metastasis and survival of prostate cancer: A population based cohort study in denmark (1999 to 2007)
    • Norgaard M, Jensen AO, Jacobsen JB, et al. Skeletal related events, bone metastasis and survival of prostate cancer: a population based cohort study in denmark (1999 to 2007). J Urol, 2010,184:162-167.
    • (2010) J Urol , vol.184 , pp. 162-167
    • Norgaard, M.1    Jensen, A.O.2    Jacobsen, J.B.3
  • 22
    • 0034085989 scopus 로고    scopus 로고
    • Metastatic patterns of prostate cancer: An autopsy study of 1,589 patients
    • Bubendorf L, Schopfer A, Wagner U, et al. Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol, 2000,31:578-583.
    • (2000) Hum Pathol , vol.31 , pp. 578-583
    • Bubendorf, L.1    Schopfer, A.2    Wagner, U.3
  • 23
    • 78751646840 scopus 로고    scopus 로고
    • Incidence of bone metastases and skeletal-related events in breast cancer patients: A population-based cohort study in denmark
    • Jensen AO, Jacobsen JB, Norgaard M, et al. Incidence of bone metastases and skeletal-related events in breast cancer patients: a population-based cohort study in denmark. BMC Cancer, 2011,11:29.
    • (2011) BMC Cancer , vol.11 , pp. 29
    • Jensen, A.O.1    Jacobsen, J.B.2    Norgaard, M.3
  • 24
    • 0030998840 scopus 로고    scopus 로고
    • Metastatic pattern at autopsy in non-resectable adenocarcinoma of the lung- a study from a cohort of 259 consecutive patients treated with chemotherapy
    • Stenbygaard LE, Sorensen JB, Olsen JE. Metastatic pattern at autopsy in non-resectable adenocarcinoma of the lung- a study from a cohort of 259 consecutive patients treated with chemotherapy. Acta Oncol, 1997,36:301-306.
    • (1997) Acta Oncol , vol.36 , pp. 301-306
    • Stenbygaard, L.E.1    Sorensen, J.B.2    Olsen, J.E.3
  • 25
    • 0020606340 scopus 로고
    • Breast carcinoma: Pattern of metastasis at autopsy
    • Lee YT. Breast carcinoma: pattern of metastasis at autopsy. J Surg Oncol, 1983,23:175-180.
    • (1983) J Surg Oncol , vol.23 , pp. 175-180
    • Lee, Y.T.1
  • 26
    • 84856969525 scopus 로고    scopus 로고
    • Endoprosthetic treatment is more durable for pathologic proximal femur fractures
    • Steensma M, Boland PJ, Morris CD, et al. Endoprosthetic treatment is more durable for pathologic proximal femur fractures. Clin Orthop Relat Res, 2012,470:920-926.
    • (2012) Clin Orthop Relat Res , vol.470 , pp. 920-926
    • Steensma, M.1    Boland, P.J.2    Morris, C.D.3
  • 28
    • 2342455761 scopus 로고    scopus 로고
    • The scandinavian sarcoma group skeletal metastasis register. Survival after surgery for bone metastases in the pelvis and extremities
    • Hansen BH, Keller J, Laitinen M, et al. The scandinavian sarcoma group skeletal metastasis register. Survival after surgery for bone metastases in the pelvis and extremities. Acta Orthop Scand Suppl, 2004,75:11-15.
    • (2004) Acta Orthop Scand Suppl , vol.75 , pp. 11-15
    • Hansen, B.H.1    Keller, J.2    Laitinen, M.3
  • 29
    • 0029553336 scopus 로고
    • Successful treatment of solitary extracranial metastases from non-small cell lung cancer
    • Luketich JD, Martini N, Ginsberg RJ, et al. Successful treatment of solitary extracranial metastases from non-small cell lung cancer. Ann Thorac Surg, 1995,60:1609-1611.
    • (1995) Ann Thorac Surg , vol.60 , pp. 1609-1611
    • Luketich, J.D.1    Martini, N.2    Ginsberg, R.J.3
  • 30
    • 84862624969 scopus 로고    scopus 로고
    • Surgical treatment of skeletal metastases in 31 melanoma patients
    • Wedin R, Falkenius J, Weiss RJ, et al. Surgical treatment of skeletal metastases in 31 melanoma patients. Acta Orthop Belg, 2012,78:246-253.
    • (2012) Acta Orthop Belg , vol.78 , pp. 246-253
    • Wedin, R.1    Falkenius, J.2    Weiss, R.J.3
  • 31
    • 34547797305 scopus 로고    scopus 로고
    • Patient survival after surgery for osseous metastases from renal cell carcinoma
    • Lin PP, Mirza AN, Lewis VO, et al. Patient survival after surgery for osseous metastases from renal cell carcinoma. J Bone Joint Surg Am, 2007,89:1794-1801.
    • (2007) J Bone Joint Surg Am , vol.89 , pp. 1794-1801
    • Lin, P.P.1    Mirza, A.N.2    Lewis, V.O.3
  • 32
    • 0030026313 scopus 로고    scopus 로고
    • Predictors of survival in malignant tumors of the sternum
    • discussion 105-106
    • Martini N, Huvos AG, Burt ME, et al. Predictors of survival in malignant tumors of the sternum. J Thorac Cardiovasc Surg, 1996,111:96-105; discussion 105-106.
    • (1996) J Thorac Cardiovasc Surg , vol.111 , pp. 96-105
    • Martini, N.1    Huvos, A.G.2    Burt, M.E.3
  • 33
    • 84861376759 scopus 로고    scopus 로고
    • Radiotherapy of bone metastasis in breast cancer patients-current approaches
    • Feyer PC, Steingraeber M. Radiotherapy of bone metastasis in breast cancer patients-current approaches. Breast Care (Basel), 2012,7:108-112.
    • (2012) Breast Care (Basel) , vol.7 , pp. 108-112
    • Feyer, P.C.1    Steingraeber, M.2
  • 34
    • 5444266552 scopus 로고    scopus 로고
    • Pain control by ionizing radiation of bone metastasis
    • Vakaet LA, Boterberg T. Pain control by ionizing radiation of bone metastasis. Int J Dev Biol, 2004,48:599-606.
    • (2004) Int J Dev Biol , vol.48 , pp. 599-606
    • Vakaet, L.A.1    Boterberg, T.2
  • 35
    • 0029085851 scopus 로고
    • Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: Final results from a prospective trial
    • Maranzano E, Latini P. Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial. Int J Radiat Oncol Biol Phys, 1995,32:959-967.
    • (1995) Int J Radiat Oncol Biol Phys , vol.32 , pp. 959-967
    • Maranzano, E.1    Latini, P.2
  • 36
    • 84903674514 scopus 로고    scopus 로고
    • Treating spinal bone metastasis with image-guided, high-dose radiation
    • Yamada Y. Treating spinal bone metastasis with image-guided, high-dose radiation. Varian Medical Systems, 2008:1-4.
    • (2008) Varian Medical Systems , pp. 1-4
    • Yamada, Y.1
  • 37
    • 84859860003 scopus 로고    scopus 로고
    • Marginal recurrence requiring salvage radiotherapy after stereotactic body radio-therapy for spinal metastases
    • Koyfman SA, Djemil T, Burdick MJ, et al. Marginal recurrence requiring salvage radiotherapy after stereotactic body radio-therapy for spinal metastases. Int J Radiat Oncol Biol Phys, 2012,83:297-302.
    • (2012) Int J Radiat Oncol Biol Phys , vol.83 , pp. 297-302
    • Koyfman, S.A.1    Djemil, T.2    Burdick, M.J.3
  • 38
    • 84860150328 scopus 로고    scopus 로고
    • Alpha particles as radiopharmaceuticals in the treatment of bone metastases: Mechanism of action of radium-223 chloride (alpharadin) and radiation protection
    • Cheetham PJ, Petrylak DP. Alpha particles as radiopharmaceuticals in the treatment of bone metastases: Mechanism of action of radium-223 chloride (alpharadin) and radiation protection. Oncology (Williston Park), 2012,26:330-337, 341.
    • (2012) Oncology (Williston Park) , vol.26
    • Cheetham, P.J.1    Petrylak, D.P.2
  • 40
    • 53449095783 scopus 로고    scopus 로고
    • Systemic chemotherapy and new experimental approaches in the treatment of metastatic prostate cancer
    • Sternberg CN. Systemic chemotherapy and new experimental approaches in the treatment of metastatic prostate cancer. Ann Oncol, 2008,19 Suppl 7:vii91-95.
    • (2008) Ann Oncol , vol.19 , Issue.7 SUPPL.
    • Sternberg, C.N.1
  • 41
    • 84860496863 scopus 로고    scopus 로고
    • Recent developments in treatments targeting castration-resistant prostate cancer bone metastases
    • Loriot Y, Massard C, Fizazi K. Recent developments in treatments targeting castration-resistant prostate cancer bone metastases. Ann Oncol, 2012,23:1085-1094.
    • (2012) Ann Oncol , vol.23 , pp. 1085-1094
    • Loriot, Y.1    Massard, C.2    Fizazi, K.3
  • 42
    • 36748999529 scopus 로고    scopus 로고
    • The natural history of men treated with deferred androgen deprivation therapy in whom metastatic prostate cancer developed following radical prostatectomy
    • discussion 161-152
    • Makarov DV, Humphreys EB, Mangold LA, et al. The natural history of men treated with deferred androgen deprivation therapy in whom metastatic prostate cancer developed following radical prostatectomy. J Urol, 2008,179:156-161; discussion 161-152.
    • (2008) J Urol , vol.179 , pp. 156-161
    • Makarov, D.V.1    Humphreys, E.B.2    Mangold, L.A.3
  • 43
    • 3042784503 scopus 로고    scopus 로고
    • Hormonal impact of the 17alpha-hydroxylase/c(17,20)-lyase inhibitor abiraterone acetate (cb7630) in patients with prostate cancer
    • O'Donnell A, Judson I, Dowsett M, et al. Hormonal impact of the 17alpha-hydroxylase/c(17,20)-lyase inhibitor abiraterone acetate (cb7630) in patients with prostate cancer. Br J Cancer, 2004,90:2317-2325.
    • (2004) Br J Cancer , vol.90 , pp. 2317-2325
    • O'Donnell, A.1    Judson, I.2    Dowsett, M.3
  • 44
    • 79957443342 scopus 로고    scopus 로고
    • Abiraterone and increased survival in metastatic prostate cancer
    • de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med, 2011,364:1995-2005.
    • (2011) N Engl J Med , vol.364 , pp. 1995-2005
    • de Bono, J.S.1    Logothetis, C.J.2    Molina, A.3
  • 45
    • 84863393126 scopus 로고    scopus 로고
    • Effects of abiraterone acetate on androgen signaling in castrate-resistant prostate cancer in bone
    • Efstathiou E, Titus M, Tsavachidou D, et al. Effects of abiraterone acetate on androgen signaling in castrate-resistant prostate cancer in bone. J Clin Oncol, 2012,30:637-643.
    • (2012) J Clin Oncol , vol.30 , pp. 637-643
    • Efstathiou, E.1    Titus, M.2    Tsavachidou, D.3
  • 46
    • 0041307303 scopus 로고    scopus 로고
    • A novel method of generating prostate cancer metastases from orthotopic implants
    • Corey E, Quinn JE, Vessella RL. A novel method of generating prostate cancer metastases from orthotopic implants. Prostate, 2003,56:110-114.
    • (2003) Prostate , vol.56 , pp. 110-114
    • Corey, E.1    Quinn, J.E.2    Vessella, R.L.3
  • 47
    • 77955374098 scopus 로고    scopus 로고
    • Update on estrogens and the skeleton
    • Khosla S. Update on estrogens and the skeleton. J Clin Endocrinol Metab, 2010,95:3569-3577.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3569-3577
    • Khosla, S.1
  • 48
    • 11844252588 scopus 로고    scopus 로고
    • Risk of fracture after androgen deprivation for prostate cancer
    • Shahinian VB, Kuo YF, Freeman JL, et al. Risk of fracture after androgen deprivation for prostate cancer. N Engl J Med, 2005,352:154-164.
    • (2005) N Engl J Med , vol.352 , pp. 154-164
    • Shahinian, V.B.1    Kuo, Y.F.2    Freeman, J.L.3
  • 49
    • 32944481493 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone agonists and fracture risk: A claims-based cohort study of men with nonmetastatic prostate cancer
    • Smith MR, Lee WC, Brandman J, et al. Gonadotropin-releasing hormone agonists and fracture risk: a claims-based cohort study of men with nonmetastatic prostate cancer. J Clin Oncol, 2005,23:7897-7903.
    • (2005) J Clin Oncol , vol.23 , pp. 7897-7903
    • Smith, M.R.1    Lee, W.C.2    Brandman, J.3
  • 50
    • 3242781731 scopus 로고    scopus 로고
    • Clinical implications of the osteoprotegerin/rankl/rank system for bone and vascular diseases
    • Hofbauer LC, Schoppet M. Clinical implications of the osteoprotegerin/rankl/rank system for bone and vascular diseases. JAMA, 2004,292:490-495.
    • (2004) JAMA , vol.292 , pp. 490-495
    • Hofbauer, L.C.1    Schoppet, M.2
  • 51
    • 33745249570 scopus 로고    scopus 로고
    • Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: The nsabp Study of Tamoxifen and Raloxifene (star) P-2 trial
    • Vogel VG, Costantino JP, Wickerham DL, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the nsabp Study of Tamoxifen and Raloxifene (star) P-2 trial. JAMA, 2006,295:2727-2741.
    • (2006) JAMA , vol.295 , pp. 2727-2741
    • Vogel, V.G.1    Costantino, J.P.2    Wickerham, D.L.3
  • 52
    • 10644283864 scopus 로고    scopus 로고
    • Continuing outcomes relevant to Evista: Breast cancer incidence in postmeno pausal osteoporotic women in a randomized trial of raloxifene
    • Martino S, Cauley JA, Barrett-Connor E, et al. Continuing outcomes relevant to Evista: breast cancer incidence in postmeno pausal osteoporotic women in a randomized trial of raloxifene. J Natl Cancer Inst, 2004,96:1751-1761.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1751-1761
    • Martino, S.1    Cauley, J.A.2    Barrett-Connor, E.3
  • 53
    • 0031977199 scopus 로고    scopus 로고
    • Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of gtp-binding proteins, including Ras
    • Luckman SP, Hughes DE, Coxon FP, et al. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of gtp-binding proteins, including Ras. J Bone Miner Res, 1998,13:581-589.
    • (1998) J Bone Miner Res , vol.13 , pp. 581-589
    • Luckman, S.P.1    Hughes, D.E.2    Coxon, F.P.3
  • 54
    • 71949095197 scopus 로고    scopus 로고
    • The science and practice of bone health in oncology: Managing bone loss and metastasis in patients with solid tumors
    • quiz S30
    • Lipton A, Uzzo R, Amato RJ, et al. The science and practice of bone health in oncology: managing bone loss and metastasis in patients with solid tumors. J Natl Compr Canc Netw, 2009,7 Suppl 7:S1-29; quiz S30.
    • (2009) J Natl Compr Canc Netw , vol.7 , Issue.7 SUPPL.
    • Lipton, A.1    Uzzo, R.2    Amato, R.J.3
  • 55
    • 51349163043 scopus 로고    scopus 로고
    • Bisphosphonates: Mechanism of action and role in clinical practice
    • Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc, 2008,83:1032-1045.
    • (2008) Mayo Clin Proc , vol.83 , pp. 1032-1045
    • Drake, M.T.1    Clarke, B.L.2    Khosla, S.3
  • 56
    • 33646816025 scopus 로고    scopus 로고
    • Bisphosphonate induces apoptosis and inhibits pro-osteoclastic gene expression in prostate cancer cells
    • Asahi H, Mizokami A, Miwa S, et al. Bisphosphonate induces apoptosis and inhibits pro-osteoclastic gene expression in prostate cancer cells. Int J Urol, 2006,13:593-600.
    • (2006) Int J Urol , vol.13 , pp. 593-600
    • Asahi, H.1    Mizokami, A.2    Miwa, S.3
  • 57
    • 10744229392 scopus 로고    scopus 로고
    • Approval summary for zoledronic acid for treatment of multiple myeloma and cancer bone metastases
    • Ibrahim A, Scher N, Williams G, et al. Approval summary for zoledronic acid for treatment of multiple myeloma and cancer bone metastases. Clin Cancer Res, 2003,9:2394-2399.
    • (2003) Clin Cancer Res , vol.9 , pp. 2394-2399
    • Ibrahim, A.1    Scher, N.2    Williams, G.3
  • 58
    • 80052842611 scopus 로고    scopus 로고
    • Atypical subtrochanteric femoral fractures in patients with skeletal malignant involvement treated with intravenous bisphosphonates
    • Puhaindran ME, Farooki A, Steensma MR, et al. Atypical subtrochanteric femoral fractures in patients with skeletal malignant involvement treated with intravenous bisphosphonates. J Bone Joint Surg Am, 2011,93:1235-1242.
    • (2011) J Bone Joint Surg Am , vol.93 , pp. 1235-1242
    • Puhaindran, M.E.1    Farooki, A.2    Steensma, M.R.3
  • 59
    • 0344664559 scopus 로고    scopus 로고
    • Zoledronic acid: A new parenteral bisphosphonate
    • Li EC, Davis LE. Zoledronic acid: a new parenteral bisphosphonate. Clin Ther, 2003,25:2669-2708.
    • (2003) Clin Ther , vol.25 , pp. 2669-2708
    • Li, E.C.1    Davis, L.E.2
  • 60
    • 84858002781 scopus 로고    scopus 로고
    • Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass
    • Guan M, Yao W, Liu R, et al. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat Med, 2012,18:456-462.
    • (2012) Nat Med , vol.18 , pp. 456-462
    • Guan, M.1    Yao, W.2    Liu, R.3
  • 61
    • 3342982829 scopus 로고    scopus 로고
    • A single-dose placebo-controlled study of amg 162, a fully human monoclonal antibody to rankl, in postmenopausal women
    • Bekker PJ, Holloway DL, Rasmussen AS, et al. A single-dose placebo-controlled study of amg 162, a fully human monoclonal antibody to rankl, in postmenopausal women. J Bone Miner Res, 2004,19:1059-1066.
    • (2004) J Bone Miner Res , vol.19 , pp. 1059-1066
    • Bekker, P.J.1    Holloway, D.L.2    Rasmussen, A.S.3
  • 62
    • 79952360832 scopus 로고    scopus 로고
    • Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study
    • Fizazi K, Carducci M, Smith M, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet, 2011,377:813-822.
    • (2011) Lancet , vol.377 , pp. 813-822
    • Fizazi, K.1    Carducci, M.2    Smith, M.3
  • 63
    • 67649791971 scopus 로고    scopus 로고
    • Denosumab treatment of prostate cancer with bone metastases and increased urine n-telopeptide levels after therapy with intravenous bisphosphonates: Results of a randomized phase ii trial
    • discussion 515-506
    • Fizazi K, Bosserman L, Gao G, et al. Denosumab treatment of prostate cancer with bone metastases and increased urine n-telopeptide levels after therapy with intravenous bisphosphonates: results of a randomized phase ii trial. J Urol, 2009,182:509-515; discussion 515-506.
    • (2009) J Urol , vol.182 , pp. 509-515
    • Fizazi, K.1    Bosserman, L.2    Gao, G.3
  • 64
    • 83255193295 scopus 로고    scopus 로고
    • Economic evaluation of denosumab compared with zoledronic acid in hormone-refractory prostate cancer patients with bone metastases
    • Xie J, Namjoshi M, Wu EQ, et al. Economic evaluation of denosumab compared with zoledronic acid in hormone-refractory prostate cancer patients with bone metastases. J Manag Care Pharm, 2011,17:621-643.
    • (2011) J Manag Care Pharm , vol.17 , pp. 621-643
    • Xie, J.1    Namjoshi, M.2    Wu, E.Q.3
  • 65
    • 40949099444 scopus 로고    scopus 로고
    • Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate
    • Lenart BA, Lorich DG, Lane JM. Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med, 2008,358:1304-1306.
    • (2008) N Engl J Med , vol.358 , pp. 1304-1306
    • Lenart, B.A.1    Lorich, D.G.2    Lane, J.M.3
  • 66
    • 84879813150 scopus 로고    scopus 로고
    • Fda panel rejects denosumab against bone metastasis in prostate cancer
    • Available at
    • Mechcatie E. Fda panel rejects denosumab against bone metastasis in prostate cancer. Internal Medicine News, 2012. Available at: http://www.internalmedicinenews.com/single-view/fda-panel-rejects-denosumab-against-bone-metastasis-inprostate-cancer/839e175a56.html
    • (2012) Internal Medicine News
    • Mechcatie, E.1
  • 67
    • 37449004858 scopus 로고    scopus 로고
    • Rankl acts directly on rank-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes
    • Armstrong AP, Miller RE, Jones JC, et al. Rankl acts directly on rank-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes. Prostate, 2008,68:92-104.
    • (2008) Prostate , vol.68 , pp. 92-104
    • Armstrong, A.P.1    Miller, R.E.2    Jones, J.C.3
  • 68
    • 41149094679 scopus 로고    scopus 로고
    • Inhibition of rankl blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis
    • Canon JR, Roudier M, Bryant R, et al. Inhibition of rankl blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Clin Exp Metastasis, 2008,25:119-129.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 119-129
    • Canon, J.R.1    Roudier, M.2    Bryant, R.3
  • 69
    • 0344844468 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in bone
    • Zhang J, Dai J, Yao Z, et al. Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in bone. Cancer Res, 2003,63:7883-7890.
    • (2003) Cancer Res , vol.63 , pp. 7883-7890
    • Zhang, J.1    Dai, J.2    Yao, Z.3
  • 70
    • 77953026275 scopus 로고    scopus 로고
    • Inhibition of rankl increases the anti-tumor effect of the egfr inhibitor panitumumab in a murine model of bone metastasis
    • Canon J, Bryant R, Roudier M, et al. Inhibition of rankl increases the anti-tumor effect of the egfr inhibitor panitumumab in a murine model of bone metastasis. Bone, 2010,46: 1613-1619.
    • (2010) Bone , vol.46 , pp. 1613-1619
    • Canon, J.1    Bryant, R.2    Roudier, M.3
  • 71
    • 77953726348 scopus 로고    scopus 로고
    • Combined therapy with the rankl inhibitor rank-fc and rhapo2l/trail/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis
    • Holland PM, Miller R, Jones J, et al. Combined therapy with the rankl inhibitor rank-fc and rhapo2l/trail/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis. Cancer Biol Ther, 2010,9:539-550.
    • (2010) Cancer Biol Ther , vol.9 , pp. 539-550
    • Holland, P.M.1    Miller, R.2    Jones, J.3
  • 72
    • 35448959223 scopus 로고    scopus 로고
    • A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden
    • Le Gall C, Bellahcene A, Bonnelye E, et al. A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden. Cancer Res, 2007,67:9894-9902.
    • (2007) Cancer Res , vol.67 , pp. 9894-9902
    • Le Gall, C.1    Bellahcene, A.2    Bonnelye, E.3
  • 73
    • 45049083216 scopus 로고    scopus 로고
    • Drug-induced morphea: Report of a case induced by balicatib and review of the literature
    • Peroni A, Zini A, Braga V, et al. Drug-induced morphea: report of a case induced by balicatib and review of the literature. J Am Acad Dermatol, 2008,59:125-129.
    • (2008) J Am Acad Dermatol , vol.59 , pp. 125-129
    • Peroni, A.1    Zini, A.2    Braga, V.3
  • 74
    • 79952278967 scopus 로고    scopus 로고
    • The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: Results of a 4-week, double-blind, randomized, controlled trial
    • Jensen AB, Wynne C, Ramirez G, et al. The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: results of a 4-week, double-blind, randomized, controlled trial. Clin Breast Cancer, 2010,10:452-458.
    • (2010) Clin Breast Cancer , vol.10 , pp. 452-458
    • Jensen, A.B.1    Wynne, C.2    Ramirez, G.3
  • 75
    • 84863229642 scopus 로고    scopus 로고
    • Cathepsin B inhibition limits bone metastasis in breast cancer
    • Withana NP, Blum G, Sameni M, et al. Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res, 2012,72:1199-1209.
    • (2012) Cancer Res , vol.72 , pp. 1199-1209
    • Withana, N.P.1    Blum, G.2    Sameni, M.3
  • 76
    • 53449091768 scopus 로고    scopus 로고
    • Tumor expressed pthrp facilitates prostate cancer-induced osteoblastic lesions
    • Liao J, Li X, Koh AJ, et al. Tumor expressed pthrp facilitates prostate cancer-induced osteoblastic lesions. Int J Cancer, 2008,123:2267-2278.
    • (2008) Int J Cancer , vol.123 , pp. 2267-2278
    • Liao, J.1    Li, X.2    Koh, A.J.3
  • 77
    • 67651174455 scopus 로고    scopus 로고
    • Eb1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells
    • Bhatia V, Saini MK, Shen X, et al. Eb1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells. Mol Cancer Ther, 2009,8:1787-1798.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1787-1798
    • Bhatia, V.1    Saini, M.K.2    Shen, X.3
  • 78
    • 54049099247 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2
    • Alonso V, de Gortazar AR, Ardura JA, et al. Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2. J Cell Physiol, 2008,217:717-727.
    • (2008) J Cell Physiol , vol.217 , pp. 717-727
    • Alonso, V.1    de Gortazar, A.R.2    Ardura, J.A.3
  • 79
    • 84055191098 scopus 로고    scopus 로고
    • Pthrp drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target
    • Li J, Karaplis AC, Huang DC, et al. Pthrp drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target. J Clin Invest, 2011,121:4655-4669.
    • (2011) J Clin Invest , vol.121 , pp. 4655-4669
    • Li, J.1    Karaplis, A.C.2    Huang, D.C.3
  • 80
    • 10144241022 scopus 로고    scopus 로고
    • Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis
    • Guise TA, Yin JJ, Taylor SD, et al. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest, 1996,98:1544-1549.
    • (1996) J Clin Invest , vol.98 , pp. 1544-1549
    • Guise, T.A.1    Yin, J.J.2    Taylor, S.D.3
  • 81
    • 0029813935 scopus 로고    scopus 로고
    • An experimental model of bone metastasis by human lung cancer cells: The role of parathyroid hormone-related protein in bone metastasis
    • Iguchi H, Tanaka S, Ozawa Y, et al. An experimental model of bone metastasis by human lung cancer cells: the role of parathyroid hormone-related protein in bone metastasis. Cancer Res, 1996,56:4040-4043.
    • (1996) Cancer Res , vol.56 , pp. 4040-4043
    • Iguchi, H.1    Tanaka, S.2    Ozawa, Y.3
  • 82
    • 27944458779 scopus 로고    scopus 로고
    • Humanized monoclonal antibody against parathyroid hormone-related protein suppresses osteolytic bone metastasis of human breast cancer cells derived from mda-mb-231
    • Saito H, Tsunenari T, Onuma E, et al. Humanized monoclonal antibody against parathyroid hormone-related protein suppresses osteolytic bone metastasis of human breast cancer cells derived from mda-mb-231. Anticancer Res, 2005,25:3817-3823.
    • (2005) Anticancer Res , vol.25 , pp. 3817-3823
    • Saito, H.1    Tsunenari, T.2    Onuma, E.3
  • 83
    • 78349307345 scopus 로고    scopus 로고
    • Metastasis and bone loss: Advancing treatment and prevention
    • Coleman RE, Lipton A, Roodman GD, et al. Metastasis and bone loss: advancing treatment and prevention. Cancer Treat Rev, 2010,36:615-620.
    • (2010) Cancer Treat Rev , vol.36 , pp. 615-620
    • Coleman, R.E.1    Lipton, A.2    Roodman, G.D.3
  • 84
    • 80052203143 scopus 로고    scopus 로고
    • Tgf-beta/smad/gli2 signaling axis in cancer progression and metastasis
    • Javelaud D, Alexaki VI, Dennler S, et al. Tgf-beta/smad/gli2 signaling axis in cancer progression and metastasis. Cancer Res, 2011,71:5606-5610.
    • (2011) Cancer Res , vol.71 , pp. 5606-5610
    • Javelaud, D.1    Alexaki, V.I.2    Dennler, S.3
  • 85
    • 0344780198 scopus 로고    scopus 로고
    • Transforming growth factor beta (tgf-beta) levels in the conditioned media of human bone cells: Relationship to donor age, bone volume, and concentration of tgf-beta in human bone matrix in vivo
    • Bismar H, Kloppinger T, Schuster EM, et al. Transforming growth factor beta (tgf-beta) levels in the conditioned media of human bone cells: relationship to donor age, bone volume, and concentration of tgf-beta in human bone matrix in vivo. Bone, 1999,24:565-569.
    • (1999) Bone , vol.24 , pp. 565-569
    • Bismar, H.1    Kloppinger, T.2    Schuster, E.M.3
  • 86
    • 2542488254 scopus 로고
    • Purification and characterization of two cartilage-inducing factors from bovine demineralized bone
    • Seyedin SM, Thomas TC, Thompson AY, et al. Purification and characterization of two cartilage-inducing factors from bovine demineralized bone. Proc Natl Acad Sci U S A, 1985,82:2267-2271.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 2267-2271
    • Seyedin, S.M.1    Thomas, T.C.2    Thompson, A.Y.3
  • 87
    • 67650506105 scopus 로고    scopus 로고
    • Tgf-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
    • Tang Y, Wu X, Lei W, et al. Tgf-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med, 2009,15:757-765.
    • (2009) Nat Med , vol.15 , pp. 757-765
    • Tang, Y.1    Wu, X.2    Lei, W.3
  • 88
    • 26444506000 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 to the bone
    • Janssens K, ten Dijke P, Janssens S, et al. Transforming growth factor-beta1 to the bone. Endocr Rev, 2005,26:743-774.
    • (2005) Endocr Rev , vol.26 , pp. 743-774
    • Janssens, K.1    ten Dijke, P.2    Janssens, S.3
  • 89
    • 24644487312 scopus 로고    scopus 로고
    • Tgf-beta and epithelial-to-mesenchymal transitions
    • Zavadil J, Bottinger EP. Tgf-beta and epithelial-to-mesenchymal transitions. Oncogene, 2005,24:5764-5774.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 90
    • 33751328068 scopus 로고    scopus 로고
    • Ki26894, a novel transforming growth factor-beta type i receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line
    • Ehata S, Hanyu A, Fujime M, et al. Ki26894, a novel transforming growth factor-beta type i receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line. Cancer Sci, 2007,98:127-133.
    • (2007) Cancer Sci , vol.98 , pp. 127-133
    • Ehata, S.1    Hanyu, A.2    Fujime, M.3
  • 91
    • 0032918414 scopus 로고    scopus 로고
    • Tgf-beta signaling blockade inhibits pthrp secretion by breast cancer cells and bone metastases development
    • Yin JJ, Selander K, Chirgwin JM, et al. Tgf-beta signaling blockade inhibits pthrp secretion by breast cancer cells and bone metastases development. J Clin Invest, 1999,103:197-206.
    • (1999) J Clin Invest , vol.103 , pp. 197-206
    • Yin, J.J.1    Selander, K.2    Chirgwin, J.M.3
  • 92
    • 80052182957 scopus 로고    scopus 로고
    • Tgf-beta1 expression as a biomarker of poor prognosis in prostate cancer
    • Reis ST, Pontes-Junior J, Antunes AA, et al. Tgf-beta1 expression as a biomarker of poor prognosis in prostate cancer. Clinics (Sao Paulo), 2011,66:1143-1147.
    • (2011) Clinics (Sao Paulo) , vol.66 , pp. 1143-1147
    • Reis, S.T.1    Pontes-Junior, J.2    Antunes, A.A.3
  • 93
    • 84856977508 scopus 로고    scopus 로고
    • Effect of transforming growth factor beta (tgf-beta) receptor i kinase inhibitor on prostate cancer bone growth
    • Wan X, Li ZG, Yingling JM, et al. Effect of transforming growth factor beta (tgf-beta) receptor i kinase inhibitor on prostate cancer bone growth. Bone, 2012,50:695-703.
    • (2012) Bone , vol.50 , pp. 695-703
    • Wan, X.1    Li, Z.G.2    Yingling, J.M.3
  • 94
    • 84865237178 scopus 로고    scopus 로고
    • Systemic delivery of oncolytic adenoviruses targeting transforming growth factor-beta inhibits established bone metastasis in a prostate cancer mouse model
    • Hu Z, Gupta J, Zhang Z, et al. Systemic delivery of oncolytic adenoviruses targeting transforming growth factor-beta inhibits established bone metastasis in a prostate cancer mouse model. Hum Gene Ther, 2012,23:871-882.
    • (2012) Hum Gene Ther , vol.23 , pp. 871-882
    • Hu, Z.1    Gupta, J.2    Zhang, Z.3
  • 95
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (xl184), a novel met and vegfr2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
    • Yakes FM, Chen J, Tan J, et al. Cabozantinib (xl184), a novel met and vegfr2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011,10:2298-2308.
    • (2011) Mol Cancer Ther , vol.10 , pp. 2298-2308
    • Yakes, F.M.1    Chen, J.2    Tan, J.3
  • 96
    • 84863704553 scopus 로고    scopus 로고
    • Suppression of tumor invasion and metastasis by concurrent inhibition of c-met and vegf signaling in pancreatic neuroendocrine tumors
    • Sennino B, Ishiguro-Oonuma T, Wei Y, et al. Suppression of tumor invasion and metastasis by concurrent inhibition of c-met and vegf signaling in pancreatic neuroendocrine tumors. Cancer Discov, 2012,2:270-287.
    • (2012) Cancer Discov , vol.2 , pp. 270-287
    • Sennino, B.1    Ishiguro-Oonuma, T.2    Wei, Y.3
  • 97
    • 84865681662 scopus 로고    scopus 로고
    • Prostate cancer: Promising results with cabozantinibg, abiraterone, and degarelix
    • Laino C. Prostate cancer: promising results with cabozantinibg, abiraterone, and degarelix. Oncology Times, 2011,8:9-10.
    • (2011) Oncology Times , vol.8 , pp. 9-10
    • Laino, C.1
  • 98
    • 84855717694 scopus 로고    scopus 로고
    • Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases
    • Hussein O, Tiedemann K, Murshed M, et al. Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases. Cancer Lett, 2012,314:176-184.
    • (2012) Cancer Lett , vol.314 , pp. 176-184
    • Hussein, O.1    Tiedemann, K.2    Murshed, M.3
  • 99
    • 33745257077 scopus 로고    scopus 로고
    • Inhibition of protein kinase c-Src reduces the incidence of breast cancer metastases and increases survival in mice: Implications for therapy
    • Rucci N, Recchia I, Angelucci A, et al. Inhibition of protein kinase c-Src reduces the incidence of breast cancer metastases and increases survival in mice: implications for therapy. J Pharmacol Exp Ther, 2006,318:161-172.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 161-172
    • Rucci, N.1    Recchia, I.2    Angelucci, A.3
  • 100
    • 80155159982 scopus 로고    scopus 로고
    • Recent developments in treatment stratification for metastatic breast cancer
    • Barton S, Swanton C. Recent developments in treatment stratification for metastatic breast cancer. Drugs, 2011,71:2099-2113.
    • (2011) Drugs , vol.71 , pp. 2099-2113
    • Barton, S.1    Swanton, C.2
  • 101
    • 78049463805 scopus 로고    scopus 로고
    • Future directions of bone-targeted therapy for metastatic breast cancer
    • Onishi T, Hayashi N, Theriault RL, et al. Future directions of bone-targeted therapy for metastatic breast cancer. Nat Rev Clin Oncol, 2010,7:641-651.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 641-651
    • Onishi, T.1    Hayashi, N.2    Theriault, R.L.3
  • 102
    • 84855614042 scopus 로고    scopus 로고
    • Evolution of treatment options for patients with crpc and bone metastases: Bone-targeted agents that go beyond palliation of symptoms to improve overall survival
    • Rove KO, Crawford ED. Evolution of treatment options for patients with crpc and bone metastases: bone-targeted agents that go beyond palliation of symptoms to improve overall survival. Oncology (Williston Park), 2011, 25:1362-1370, 1375-1381, 1387.
    • (2011) Oncology (Williston Park) , vol.25
    • Rove, K.O.1    Crawford, E.D.2
  • 103
    • 84855406013 scopus 로고    scopus 로고
    • Beyond trastuzumab: Novel therapeutic strategies in her2-positive metastatic breast cancer
    • Tsang RY, Finn RS. Beyond trastuzumab: novel therapeutic strategies in her2-positive metastatic breast cancer. Br J Cancer, 2012,106:6-13.
    • (2012) Br J Cancer , vol.106 , pp. 6-13
    • Tsang, R.Y.1    Finn, R.S.2
  • 105
    • 33646533771 scopus 로고    scopus 로고
    • Roles and regulation of wnt signaling and betacatenin in prostate cancer
    • Verras M, Sun Z. Roles and regulation of wnt signaling and betacatenin in prostate cancer. Cancer Lett, 2006,237:22-32.
    • (2006) Cancer Lett , vol.237 , pp. 22-32
    • Verras, M.1    Sun, Z.2
  • 107
    • 34047265189 scopus 로고    scopus 로고
    • Inactivation of apc in the mouse prostate causes prostate carcinoma
    • Bruxvoort KJ, Charbonneau HM, Giambernardi TA, et al. Inactivation of apc in the mouse prostate causes prostate carcinoma. Cancer Res, 2007,67:2490-2496.
    • (2007) Cancer Res , vol.67 , pp. 2490-2496
    • Bruxvoort, K.J.1    Charbonneau, H.M.2    Giambernardi, T.A.3
  • 108
    • 79955479314 scopus 로고    scopus 로고
    • Wnt/beta-catenin activation promotes prostate tumor progression in a mouse model
    • Yu X, Wang Y, DeGraff DJ, et al. Wnt/beta-catenin activation promotes prostate tumor progression in a mouse model. Oncogene, 2011,30:1868-1879.
    • (2011) Oncogene , vol.30 , pp. 1868-1879
    • Yu, X.1    Wang, Y.2    Degraff, D.J.3
  • 109
    • 67649948804 scopus 로고    scopus 로고
    • Wnt signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics
    • Bisson I, Prowse DM. Wnt signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics. Cell Res, 2009,19:683-697.
    • (2009) Cell Res , vol.19 , pp. 683-697
    • Bisson, I.1    Prowse, D.M.2
  • 110
    • 4444326415 scopus 로고    scopus 로고
    • Up-regulation of wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: Potential pathogenetic and prognostic implications
    • Chen G, Shukeir N, Potti A, et al. Up-regulation of wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications. Cancer, 2004,101:1345-1356.
    • (2004) Cancer , vol.101 , pp. 1345-1356
    • Chen, G.1    Shukeir, N.2    Potti, A.3
  • 111
    • 77956290679 scopus 로고    scopus 로고
    • Fzd4 as a mediator of erg oncogene-induced wnt signaling and epithelial-to-mesenchymal transition in human prostate cancer cells
    • Gupta S, Iljin K, Sara H, et al. Fzd4 as a mediator of erg oncogene-induced wnt signaling and epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res, 2010,70:6735-6745.
    • (2010) Cancer Res , vol.70 , pp. 6735-6745
    • Gupta, S.1    Iljin, K.2    Sara, H.3
  • 112
    • 24744439747 scopus 로고    scopus 로고
    • Prostate cancer cells promote osteoblastic bone metastases through wnts
    • Hall CL, Bafico A, Dai J, et al. Prostate cancer cells promote osteoblastic bone metastases through wnts. Cancer Res, 2005,65:7554-7560.
    • (2005) Cancer Res , vol.65 , pp. 7554-7560
    • Hall, C.L.1    Bafico, A.2    Dai, J.3
  • 113
    • 50949117119 scopus 로고    scopus 로고
    • Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis
    • Hall CL, Daignault SD, Shah RB, et al. Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis. Prostate, 2008,68:1396-1404.
    • (2008) Prostate , vol.68 , pp. 1396-1404
    • Hall, C.L.1    Daignault, S.D.2    Shah, R.B.3
  • 114
    • 77949428236 scopus 로고    scopus 로고
    • Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
    • Uysal-Onganer P, Kawano Y, Caro M, et al. Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells. Mol Cancer, 2010,9:55.
    • (2010) Mol Cancer , vol.9 , pp. 55
    • Uysal-Onganer, P.1    Kawano, Y.2    Caro, M.3
  • 115
    • 67149111600 scopus 로고    scopus 로고
    • The wnt co-receptor lrp6 is required for normal mouse mammary gland development
    • Lindvall C, Zylstra CR, Evans N, et al. The wnt co-receptor lrp6 is required for normal mouse mammary gland development. PLoS One, 2009,4:e5813.
    • (2009) PLoS One , vol.4
    • Lindvall, C.1    Zylstra, C.R.2    Evans, N.3
  • 116
    • 54249086214 scopus 로고    scopus 로고
    • The mammary progenitor marker cd61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
    • Vaillant F, Asselin-Labat ML, Shackleton M, et al. The mammary progenitor marker cd61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res, 2008,68:7711-7717.
    • (2008) Cancer Res , vol.68 , pp. 7711-7717
    • Vaillant, F.1    Asselin-Labat, M.L.2    Shackleton, M.3
  • 117
    • 77953183234 scopus 로고    scopus 로고
    • Wnt/ beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    • Khramtsov AI, Khramtsova GF, Tretiakova M, et al. Wnt/ beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am J Pathol, 2010,176:2911-2920.
    • (2010) Am J Pathol , vol.176 , pp. 2911-2920
    • Khramtsov, A.I.1    Khramtsova, G.F.2    Tretiakova, M.3
  • 118
    • 84887212573 scopus 로고    scopus 로고
    • Mmtv-wnt1 and -deltan89beta-catenin induce canonical signaling in distinct progenitors and differentially activate hedgehog signaling within mammary tumors
    • Teissedre B, Pinderhughes A, Incassati A, et al. Mmtv-wnt1 and -deltan89beta-catenin induce canonical signaling in distinct progenitors and differentially activate hedgehog signaling within mammary tumors. PLoS One, 2009,4:e4537.
    • (2009) PLoS One , vol.4
    • Teissedre, B.1    Pinderhughes, A.2    Incassati, A.3
  • 119
    • 0024162530 scopus 로고
    • Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    • Tsukamoto AS, Grosschedl R, Guzman RC, et al. Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell, 1988,55:619-625.
    • (1988) Cell , vol.55 , pp. 619-625
    • Tsukamoto, A.S.1    Grosschedl, R.2    Guzman, R.C.3
  • 120
    • 67650496215 scopus 로고    scopus 로고
    • A novel lung metastasis signature links wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer
    • DiMeo TA, Anderson K, Phadke P, et al. A novel lung metastasis signature links wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res, 2009,69:5364-5373.
    • (2009) Cancer Res , vol.69 , pp. 5364-5373
    • Dimeo, T.A.1    Anderson, K.2    Phadke, P.3
  • 121
    • 79952358403 scopus 로고    scopus 로고
    • Beta-catenin-independent wnt signaling in basal-like breast cancer and brain metastasis
    • Klemm F, Bleckmann A, Siam L, et al. Beta-catenin-independent wnt signaling in basal-like breast cancer and brain metastasis. Carcinogenesis, 2011,32:434-442.
    • (2011) Carcinogenesis , vol.32 , pp. 434-442
    • Klemm, F.1    Bleckmann, A.2    Siam, L.3
  • 122
    • 79959686754 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in normal and cancer stem cells
    • Valkenburg KC, Graveel CR, Zylstra-Diegel CR, et al. Wnt/beta-catenin signaling in normal and cancer stem cells. Cancers, 2011,3:2050-2079.
    • (2011) Cancers , vol.3 , pp. 2050-2079
    • Valkenburg, K.C.1    Graveel, C.R.2    Zylstra-Diegel, C.R.3
  • 123
    • 67649662201 scopus 로고    scopus 로고
    • Wnt/tcf signaling through lef1 and hoxb9 mediates lung adenocarcinoma metastasis
    • Nguyen DX, Chiang AC, Zhang XH, et al. Wnt/tcf signaling through lef1 and hoxb9 mediates lung adenocarcinoma metastasis. Cell, 2009,138:51-62.
    • (2009) Cell , vol.138 , pp. 51-62
    • Nguyen, D.X.1    Chiang, A.C.2    Zhang, X.H.3
  • 124
    • 84859436026 scopus 로고    scopus 로고
    • Wnt3 gene expression promotes tumor progression in non-small cell lung cancer
    • Nakashima N, Liu D, Huang CL, et al. Wnt3 gene expression promotes tumor progression in non-small cell lung cancer. Lung Cancer, 2012,76:228-234.
    • (2012) Lung Cancer , vol.76 , pp. 228-234
    • Nakashima, N.1    Liu, D.2    Huang, C.L.3
  • 125
    • 81255166788 scopus 로고    scopus 로고
    • The hypomethylation agent bisdemethoxycurcumin acts on the wif-1 promoter, inhibits the canonical wnt pathway and induces apoptosis in human non-small-cell lung cancer
    • Liu YL, Yang HP, Zhou XD, et al. The hypomethylation agent bisdemethoxycurcumin acts on the wif-1 promoter, inhibits the canonical wnt pathway and induces apoptosis in human non-small-cell lung cancer. Curr Cancer Drug Targets, 2011,11:1098-1110.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 1098-1110
    • Liu, Y.L.1    Yang, H.P.2    Zhou, X.D.3
  • 126
    • 79955496473 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
    • Pacheco-Pinedo EC, Durham AC, Stewart KM, et al. Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J Clin Invest,121:1935-1945.
    • J Clin Invest , vol.121 , pp. 1935-1945
    • Pacheco-Pinedo, E.C.1    Durham, A.C.2    Stewart, K.M.3
  • 127
    • 78149463483 scopus 로고    scopus 로고
    • Cigarette smoke induces c/ebp-beta-mediated activation of mir-31 in normal human respiratory epithelia and lung cancer cells
    • Xi S, Yang M, Tao Y, et al. Cigarette smoke induces c/ebp-beta-mediated activation of mir-31 in normal human respiratory epithelia and lung cancer cells. PLoS One, 2010,5:e13764.
    • (2010) PLoS One , vol.5
    • Xi, S.1    Yang, M.2    Tao, Y.3
  • 128
    • 33846972636 scopus 로고    scopus 로고
    • Eating bone or adding it: The wnt pathway decides
    • Goldring SR, Goldring MB. Eating bone or adding it: the wnt pathway decides. Nat Med, 2007,13:133-134.
    • (2007) Nat Med , vol.13 , pp. 133-134
    • Goldring, S.R.1    Goldring, M.B.2
  • 129
    • 20444376156 scopus 로고    scopus 로고
    • Essential role of beta-catenin in postnatal bone acquisition
    • Holmen SL, Zylstra CR, Mukherjee A, et al. Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem, 2005,280:21162-21168.
    • (2005) J Biol Chem , vol.280 , pp. 21162-21168
    • Holmen, S.L.1    Zylstra, C.R.2    Mukherjee, A.3
  • 130
    • 77953407742 scopus 로고    scopus 로고
    • Osteocyte wnt/beta-catenin signaling is required for normal bone homeostasis
    • Kramer I, Halleux C, Keller H, et al. Osteocyte wnt/beta-catenin signaling is required for normal bone homeostasis. Mol Cell Biol, 2010,30:3071-3085.
    • (2010) Mol Cell Biol , vol.30 , pp. 3071-3085
    • Kramer, I.1    Halleux, C.2    Keller, H.3
  • 131
    • 79958171733 scopus 로고    scopus 로고
    • Lrp5 functions in bone to regulate bone mass
    • Cui Y, Niziolek PJ, MacDonald BT, et al. Lrp5 functions in bone to regulate bone mass. Nat Med, 2011,17:684-691.
    • (2011) Nat Med , vol.17 , pp. 684-691
    • Cui, Y.1    Niziolek, P.J.2    Macdonald, B.T.3
  • 132
    • 13444295117 scopus 로고    scopus 로고
    • Decreased bmd and limb deformities in mice carrying mutations in both lrp5 and lrp6
    • Holmen SL, Giambernardi TA, Zylstra CR, et al. Decreased bmd and limb deformities in mice carrying mutations in both lrp5 and lrp6. J Bone Miner Res, 2004,19:2033-2040.
    • (2004) J Bone Miner Res , vol.19 , pp. 2033-2040
    • Holmen, S.L.1    Giambernardi, T.A.2    Zylstra, C.R.3
  • 133
    • 77952989890 scopus 로고    scopus 로고
    • Wnt proteins promote bone regeneration
    • Minear S, Leucht P, Jiang J, et al. Wnt proteins promote bone regeneration. Sci Transl Med, 2010,2:29ra30.
    • (2010) Sci Transl Med , vol.2
    • Minear, S.1    Leucht, P.2    Jiang, J.3
  • 134
    • 77953695990 scopus 로고    scopus 로고
    • The wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
    • Yee DS, Tang Y, Li X, et al. The wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Mol Cancer, 2010,9:162.
    • (2010) Mol Cancer , vol.9 , pp. 162
    • Yee, D.S.1    Tang, Y.2    Li, X.3
  • 135
    • 79958201891 scopus 로고    scopus 로고
    • Knockdown of beta-catenin through shrna cause a reversal of emt and metastatic phenotypes induced by hif-1alpha
    • Zhao JH, Luo Y, Jiang YG, et al. Knockdown of beta-catenin through shrna cause a reversal of emt and metastatic phenotypes induced by hif-1alpha. Cancer Invest, 2011,29:377-382.
    • (2011) Cancer Invest , vol.29 , pp. 377-382
    • Zhao, J.H.1    Luo, Y.2    Jiang, Y.G.3
  • 136
    • 48649090754 scopus 로고    scopus 로고
    • Prostate cancer induces bone metastasis through wnt-induced bone morphogenetic protein-dependent and independent mechanisms
    • Dai J, Hall CL, Escara-Wilke J, et al. Prostate cancer induces bone metastasis through wnt-induced bone morphogenetic protein-dependent and independent mechanisms. Cancer Res, 2008,68:5785-5794.
    • (2008) Cancer Res , vol.68 , pp. 5785-5794
    • Dai, J.1    Hall, C.L.2    Escara-Wilke, J.3
  • 137
    • 79952403539 scopus 로고    scopus 로고
    • Dickkopf-1 (dkk-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases
    • Thudi NK, Martin CK, Murahari S, et al. Dickkopf-1 (dkk-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases. Prostate, 2011,71:615-625.
    • (2011) Prostate , vol.71 , pp. 615-625
    • Thudi, N.K.1    Martin, C.K.2    Murahari, S.3
  • 138
    • 38549095978 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein 5 (lrp5) mediates the prostate cancer-induced formation of new bone
    • Li ZG, Yang J, Vazquez ES, et al. Low-density lipoprotein receptor-related protein 5 (lrp5) mediates the prostate cancer-induced formation of new bone. Oncogene, 2008,27:596-603.
    • (2008) Oncogene , vol.27 , pp. 596-603
    • Li, Z.G.1    Yang, J.2    Vazquez, E.S.3
  • 139
    • 47249149740 scopus 로고    scopus 로고
    • Breast cancer-derived dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: Implication for breast cancer osteolytic bone metastases
    • Bu G, Lu W, Liu CC, et al. Breast cancer-derived dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. Int J Cancer, 2008,123:1034-1042.
    • (2008) Int J Cancer , vol.123 , pp. 1034-1042
    • Bu, G.1    Lu, W.2    Liu, C.C.3
  • 140
    • 34948859456 scopus 로고    scopus 로고
    • Increased dickkopf-1 expression in breast cancer bone metastases
    • Voorzanger-Rousselot N, Goehrig D, Journe F, et al. Increased dickkopf-1 expression in breast cancer bone metastases. Br J Cancer, 2007,97:964-970.
    • (2007) Br J Cancer , vol.97 , pp. 964-970
    • Voorzanger-Rousselot, N.1    Goehrig, D.2    Journe, F.3
  • 141
    • 74049105681 scopus 로고    scopus 로고
    • Wnt signaling enhances breast cancer cell motility and blockade of the wnt pathway by sfrp1 suppresses mda-mb-231 xenograft growth
    • Matsuda Y, Schlange T, Oakeley EJ, et al. Wnt signaling enhances breast cancer cell motility and blockade of the wnt pathway by sfrp1 suppresses mda-mb-231 xenograft growth. Breast Cancer Res, 2009,11:R32.
    • (2009) Breast Cancer Res , vol.11
    • Matsuda, Y.1    Schlange, T.2    Oakeley, E.J.3
  • 142
    • 84865805629 scopus 로고    scopus 로고
    • Induction of a mesenchymal expression program in lung epithelial cells by wnt/ beta-catenin requires the presence of c-jun n-terminal kinase 1
    • van der Velden JL, Guala AS, Leggett SE, et al. Induction of a mesenchymal expression program in lung epithelial cells by wnt/ beta-catenin requires the presence of c-jun n-terminal kinase 1. Am J Respir Cell Mol Biol, 2012,47:306-314.
    • (2012) Am J Respir Cell Mol Biol , vol.47 , pp. 306-314
    • van der Velden, J.L.1    Guala, A.S.2    Leggett, S.E.3
  • 143
    • 4344570800 scopus 로고    scopus 로고
    • Inhibition of wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells
    • You L, He B, Xu Z, et al. Inhibition of wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene, 2004,23:6170-6174.
    • (2004) Oncogene , vol.23 , pp. 6170-6174
    • You, L.1    He, B.2    Xu, Z.3
  • 144
    • 84862207240 scopus 로고    scopus 로고
    • Three decades of wnts: A personal perspective on how a scientific field developed
    • Nusse R, Varmus H. Three decades of wnts: a personal perspective on how a scientific field developed. EMBO J, 2012,31:2670-2684.
    • (2012) EMBO J , vol.31 , pp. 2670-2684
    • Nusse, R.1    Varmus, H.2
  • 145
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature, 2005,434:843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 147
    • 33749254672 scopus 로고    scopus 로고
    • Wnt signaling regulates the invasion capacity of human mesenchymal stem cells
    • Neth P, Ciccarella M, Egea V, et al. Wnt signaling regulates the invasion capacity of human mesenchymal stem cells. Stem Cells, 2006,24:1892-1903.
    • (2006) Stem Cells , vol.24 , pp. 1892-1903
    • Neth, P.1    Ciccarella, M.2    Egea, V.3
  • 148
    • 68949154567 scopus 로고    scopus 로고
    • The wnt receptor, lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage
    • Badders NM, Goel S, Clark RJ, et al. The wnt receptor, lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One, 2009,4:e6594.
    • (2009) PLoS One , vol.4
    • Badders, N.M.1    Goel, S.2    Clark, R.J.3
  • 149
    • 76349104842 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer a549 cells
    • Teng Y, Wang X, Wang Y, et al. Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer a549 cells. Biochem Biophys Res Commun, 2010,392:373-379.
    • (2010) Biochem Biophys Res Commun , vol.392 , pp. 373-379
    • Teng, Y.1    Wang, X.2    Wang, Y.3
  • 150
    • 33846193290 scopus 로고    scopus 로고
    • The many ways of wnt in cancer
    • Polakis P. The many ways of wnt in cancer. Curr Opin Genet Dev, 2007,17:45-51.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 45-51
    • Polakis, P.1
  • 151
    • 58249122326 scopus 로고    scopus 로고
    • Small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer
    • Chen B, Dodge ME, Tang W, et al. Small molecule-mediated disruption of wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol, 2009,5:100-107.
    • (2009) Nat Chem Biol , vol.5 , pp. 100-107
    • Chen, B.1    Dodge, M.E.2    Tang, W.3
  • 152
    • 0027368963 scopus 로고
    • Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein
    • van den Heuvel M, Harryman-Samos C, Klingensmith J, et al. Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J, 1993,12:5293-5302.
    • (1993) EMBO J , vol.12 , pp. 5293-5302
    • van den Heuvel, M.1    Harryman-Samos, C.2    Klingensmith, J.3
  • 153
    • 84903665447 scopus 로고    scopus 로고
    • Changing the practice of medicine
    • Fishman MC. Changing the practice of medicine. Novartis, 2010.
    • (2010) Novartis
    • Fishman, M.C.1
  • 154
    • 33751530490 scopus 로고    scopus 로고
    • Mining the wnt pathway for cancer therapeutics
    • Barker N, Clevers H. Mining the wnt pathway for cancer therapeutics. Nat Rev Drug Discov, 2006,5:997-1014.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 155
    • 4344584730 scopus 로고    scopus 로고
    • Wnt and beta-catenin signalling: Diseases and therapies
    • Moon RT, Kohn AD, De Ferrari GV, et al. Wnt and beta-catenin signalling: diseases and therapies. Nat Rev Genet, 2004,5:691-701.
    • (2004) Nat Rev Genet , vol.5 , pp. 691-701
    • Moon, R.T.1    Kohn, A.D.2    de Ferrari, G.V.3
  • 156
    • 84862170024 scopus 로고    scopus 로고
    • Drugging wnt signalling in cancer
    • Polakis P. Drugging wnt signalling in cancer. EMBO J, 2012,31:3375.
    • (2012) EMBO J , vol.31 , pp. 3375
    • Polakis, P.1
  • 157
    • 67650431302 scopus 로고    scopus 로고
    • Anti-dkk1 mab (bhq880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T, et al. Anti-dkk1 mab (bhq880) as a potential therapeutic agent for multiple myeloma. Blood, 2009,114:371-379.
    • (2009) Blood , vol.114 , pp. 371-379
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3
  • 158
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of dkk1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • Yaccoby S, Ling W, Zhan F, et al. Antibody-based inhibition of dkk1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood, 2007,109:2106-2111.
    • (2007) Blood , vol.109 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3
  • 159
    • 76949086190 scopus 로고    scopus 로고
    • Downregulation of dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of wnt/beta-catenin signaling
    • Zhou XL, Qin XR, Zhang XD, et al. Downregulation of dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of wnt/beta-catenin signaling. Acta Pharmacol Sin, 2010,31:202-210.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 202-210
    • Zhou, X.L.1    Qin, X.R.2    Zhang, X.D.3
  • 160
    • 80053561248 scopus 로고    scopus 로고
    • Choosing a mouse model: Experimental biology in context-the utility and limitations of mouse models of breast cancer
    • Borowsky AD. Choosing a mouse model: experimental biology in context-the utility and limitations of mouse models of breast cancer. Cold Spring Harb Perspect Biol, 2011,3:a009670.
    • (2011) Cold Spring Harb Perspect Biol , vol.3
    • Borowsky, A.D.1
  • 161
    • 79953272413 scopus 로고    scopus 로고
    • Pre-clinical mouse models of human prostate cancer and their utility in drug discovery
    • Chapter 14:Unit 14
    • Park SI, Kim SJ, McCauley LK, et al. Pre-clinical mouse models of human prostate cancer and their utility in drug discovery. Curr Protoc Pharmacol, 2010,Chapter 14:Unit 14 15.
    • (2010) Curr Protoc Pharmacol , pp. 15
    • Park, S.I.1    Kim, S.J.2    McCauley, L.K.3
  • 162
    • 0345060457 scopus 로고    scopus 로고
    • Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice
    • Onn A, Isobe T, Itasaka S, et al. Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice. Clin Cancer Res, 2003,9:5532-5539.
    • (2003) Clin Cancer Res , vol.9 , pp. 5532-5539
    • Onn, A.1    Isobe, T.2    Itasaka, S.3
  • 163
    • 0032789883 scopus 로고    scopus 로고
    • Characterization of a highly metastatic, orthotopic lung cancer model in the nude rat
    • Howard RB, Mullen JB, Pagura ME, et al. Characterization of a highly metastatic, orthotopic lung cancer model in the nude rat. Clin Exp Metastasis, 1999,17:157-162.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 157-162
    • Howard, R.B.1    Mullen, J.B.2    Pagura, M.E.3
  • 164
    • 0242607821 scopus 로고    scopus 로고
    • New targets for therapy in prostate cancer: Modulation of stromal-epithelial interactions
    • Chung LW, Hsieh CL, Law A, et al. New targets for therapy in prostate cancer: modulation of stromal-epithelial interactions. Urology, 2003,62:44-54.
    • (2003) Urology , vol.62 , pp. 44-54
    • Chung, L.W.1    Hsieh, C.L.2    Law, A.3
  • 165
    • 0030223057 scopus 로고    scopus 로고
    • Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice
    • Pettaway CA, Pathak S, Greene G, et al. Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice. Clin Cancer Res, 1996,2:1627-1636.
    • (1996) Clin Cancer Res , vol.2 , pp. 1627-1636
    • Pettaway, C.A.1    Pathak, S.2    Greene, G.3
  • 166
    • 0028272478 scopus 로고
    • Androgen-independent cancer progression and bone metastasis in the lncap model of human prostate cancer
    • Thalmann GN, Anezinis PE, Chang SM, et al. Androgen-independent cancer progression and bone metastasis in the lncap model of human prostate cancer. Cancer Res, 1994,54:2577-2581.
    • (1994) Cancer Res , vol.54 , pp. 2577-2581
    • Thalmann, G.N.1    Anezinis, P.E.2    Chang, S.M.3
  • 167
    • 0034234571 scopus 로고    scopus 로고
    • Lncap progression model of human prostate cancer: Androgen-independence and osseous metastasis
    • Thalmann GN, Sikes RA, Wu TT, et al. Lncap progression model of human prostate cancer: androgen-independence and osseous metastasis. Prostate, 2000,44:91-103.
    • (2000) Prostate , vol.44 , pp. 91-103
    • Thalmann, G.N.1    Sikes, R.A.2    Wu, T.T.3
  • 168
    • 0031849770 scopus 로고    scopus 로고
    • Establishing human prostate cancer cell xenografts in bone: Induction of osteoblastic reaction by prostate-specific antigen-producing tumors in athymic and scid/bg mice using lncap and lineage-derived metastatic sublines
    • Wu TT, Sikes RA, Cui Q, et al. Establishing human prostate cancer cell xenografts in bone: induction of osteoblastic reaction by prostate-specific antigen-producing tumors in athymic and scid/bg mice using lncap and lineage-derived metastatic sublines. Int J Cancer, 1998,77:887-894.
    • (1998) Int J Cancer , vol.77 , pp. 887-894
    • Wu, T.T.1    Sikes, R.A.2    Cui, Q.3
  • 169
    • 17444419735 scopus 로고    scopus 로고
    • New model for the induction of osteoblastic bone metastases in rat
    • Liepe K, Geidel H, Haase M, et al. New model for the induction of osteoblastic bone metastases in rat. Anticancer Res, 2005,25:1067-1073.
    • (2005) Anticancer Res , vol.25 , pp. 1067-1073
    • Liepe, K.1    Geidel, H.2    Haase, M.3
  • 170
    • 0033561535 scopus 로고    scopus 로고
    • Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone
    • Nemeth JA, Harb JF, Barroso U Jr, et al. Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone. Cancer Res, 1999,59:1987-1993.
    • (1999) Cancer Res , vol.59 , pp. 1987-1993
    • Nemeth, J.A.1    Harb, J.F.2    Barroso Jr., U.3
  • 171
    • 0035266413 scopus 로고    scopus 로고
    • Establishment of a novel species-and tissue-specific metastasis model of human prostate cancer in humanized non-obese diabetic/severe combined immunodeficient mice engrafted with human adult lung and bone
    • Yonou H, Yokose T, Kamijo T, et al. Establishment of a novel species-and tissue-specific metastasis model of human prostate cancer in humanized non-obese diabetic/severe combined immunodeficient mice engrafted with human adult lung and bone. Cancer Res, 2001,61:2177-2182.
    • (2001) Cancer Res , vol.61 , pp. 2177-2182
    • Yonou, H.1    Yokose, T.2    Kamijo, T.3
  • 172
    • 0029076829 scopus 로고
    • Species-specific metastasis of human tumor cells in the severe combined immunodeficiency mouse engrafted with human tissue
    • Shtivelman E, Namikawa R. Species-specific metastasis of human tumor cells in the severe combined immunodeficiency mouse engrafted with human tissue. Proc Natl Acad Sci U S A, 1995,92:4661-4665.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4661-4665
    • Shtivelman, E.1    Namikawa, R.2
  • 173
    • 0035002361 scopus 로고    scopus 로고
    • Development of an animal model for prostate cancer cell metastasis to adult human bone
    • Tsingotjidou AS, Zotalis G, Jackson KR, et al. Development of an animal model for prostate cancer cell metastasis to adult human bone. Anticancer Res, 2001,21:971-978.
    • (2001) Anticancer Res , vol.21 , pp. 971-978
    • Tsingotjidou, A.S.1    Zotalis, G.2    Jackson, K.R.3
  • 176
    • 23744449975 scopus 로고    scopus 로고
    • In vivo models of prostate cancer metastasis to bone
    • Singh AS, Figg WD. In vivo models of prostate cancer metastasis to bone. J Urol, 2005,174:820-826.
    • (2005) J Urol , vol.174 , pp. 820-826
    • Singh, A.S.1    Figg, W.D.2
  • 177
    • 11144229621 scopus 로고    scopus 로고
    • Approval summary: Docetaxel in combination with prednisone for the treatment of androgen-independent hormone-refractory prostate cancer
    • Dagher R, Li N, Abraham S, et al. Approval summary: docetaxel in combination with prednisone for the treatment of androgen-independent hormone-refractory prostate cancer. Clin Cancer Res, 2004,10:8147-8151.
    • (2004) Clin Cancer Res , vol.10 , pp. 8147-8151
    • Dagher, R.1    Li, N.2    Abraham, S.3
  • 179
    • 84864066561 scopus 로고    scopus 로고
    • Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: Final results from the egf104900 study
    • Blackwell KL, Burstein HJ, Storniolo AM, et al. Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the egf104900 study. J Clin Oncol, 2012,31:2585-2592.
    • (2012) J Clin Oncol , vol.31 , pp. 2585-2592
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 180
    • 84860705365 scopus 로고    scopus 로고
    • Sipuleucel-t for the treatment of metastatic prostate cancer: Promise and challenges
    • Paller CJ, Antonarakis E. Sipuleucel-t for the treatment of metastatic prostate cancer: promise and challenges. Hum Vaccin Immunother, 2012,8:509-519.
    • (2012) Hum Vaccin Immunother , vol.8 , pp. 509-519
    • Paller, C.J.1    Antonarakis, E.2
  • 181
    • 84859765119 scopus 로고    scopus 로고
    • Trastuzumab and gemcitabine in pretreated her2 overexpressing metastatic breast cancer patients: Retrospective analysis of our series
    • Di Lauro V, Torrisi E, Bidoli E, et al. Trastuzumab and gemcitabine in pretreated her2 overexpressing metastatic breast cancer patients: retrospective analysis of our series. J Oncol, 2012,2012:198412.
    • (2012) J Oncol , vol.2012 , pp. 198412
    • Di Lauro, V.1    Torrisi, E.2    Bidoli, E.3
  • 182
    • 73949098659 scopus 로고    scopus 로고
    • Multinational, double-blind, phase iii study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: The sparc trial
    • Sternberg CN, Petrylak DP, Sartor O, et al. Multinational, double-blind, phase iii study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: the sparc trial. J Clin Oncol, 2009,27:5431-5438.
    • (2009) J Clin Oncol , vol.27 , pp. 5431-5438
    • Sternberg, C.N.1    Petrylak, D.P.2    Sartor, O.3
  • 183
    • 84860176719 scopus 로고    scopus 로고
    • A phase ii multicenter study of two different dosages of pemetrexed given in combination with cyclophosphamide as first-line treatment in patients with locally advanced or metastatic breast cancer
    • Dittrich C, Solska E, Manikhas A, et al. A phase ii multicenter study of two different dosages of pemetrexed given in combination with cyclophosphamide as first-line treatment in patients with locally advanced or metastatic breast cancer. Cancer Invest, 2012,30:309-316.
    • (2012) Cancer Invest , vol.30 , pp. 309-316
    • Dittrich, C.1    Solska, E.2    Manikhas, A.3
  • 184
    • 84862855020 scopus 로고    scopus 로고
    • Safety and efficacy of bevacizumab combined with taxanes in the first-line treatment of metastatic breast cancer: Athena study-france
    • Hardy-Bessard AC, Delva R, Pivot X, et al. Safety and efficacy of bevacizumab combined with taxanes in the first-line treatment of metastatic breast cancer: Athena study-france. Bull Cancer, 2012,99:609-618.
    • (2012) Bull Cancer , vol.99 , pp. 609-618
    • Hardy-Bessard, A.C.1    Delva, R.2    Pivot, X.3
  • 185
    • 58149335533 scopus 로고    scopus 로고
    • Phase ii trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment group and mayo clinic trial n0336
    • Moreno-Aspitia A, Morton RF, Hillman DW, et al. Phase ii trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment group and mayo clinic trial n0336. J Clin Oncol, 2009,27:11-15.
    • (2009) J Clin Oncol , vol.27 , pp. 11-15
    • Moreno-Aspitia, A.1    Morton, R.F.2    Hillman, D.W.3
  • 186
    • 80054052140 scopus 로고    scopus 로고
    • Experience in the use of sunitinib given as a single agent in metastatic chemoresistant and castration-resistant prostate cancer patients
    • Castellano D, Gonzalez-Larriba JL, Anton-Aparicio LM, et al. Experience in the use of sunitinib given as a single agent in metastatic chemoresistant and castration-resistant prostate cancer patients. Expert Opin Pharmacother, 2011,12:2433-2439.
    • (2011) Expert Opin Pharmacother , vol.12 , pp. 2433-2439
    • Castellano, D.1    Gonzalez-Larriba, J.L.2    Anton-Aparicio, L.M.3
  • 187
    • 51049121618 scopus 로고    scopus 로고
    • Rank ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis
    • Miller RE, Roudier M, Jones J, et al. Rank ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis. Mol Cancer Ther, 2008,7:2160-2169.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2160-2169
    • Miller, R.E.1    Roudier, M.2    Jones, J.3
  • 188
    • 0037439916 scopus 로고    scopus 로고
    • Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma
    • Vanderkerken K, De Leenheer E, Shipman C, et al. Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Res, 2003,63:287-289.
    • (2003) Cancer Res , vol.63 , pp. 287-289
    • Vanderkerken, K.1    de Leenheer, E.2    Shipman, C.3
  • 189
    • 84055193418 scopus 로고    scopus 로고
    • Crizotinib: In locally advanced or metastatic non-small cell lung cancer
    • Curran MP. Crizotinib: in locally advanced or metastatic non-small cell lung cancer. Drugs, 2012,72:99-107.
    • (2012) Drugs , vol.72 , pp. 99-107
    • Curran, M.P.1
  • 190
    • 0043236062 scopus 로고    scopus 로고
    • 1alpha,25-dihydroxyvitamin d(3) (calcitriol) and its analogue, 19-nor-1alpha,25(oh)(2)d(2), potentiate the effects of ionising radiation on human prostate cancer cells
    • Dunlap N, Schwartz GG, Eads D, et al. 1alpha,25-dihydroxyvitamin d(3) (calcitriol) and its analogue, 19-nor-1alpha,25(oh)(2)d(2), potentiate the effects of ionising radiation on human prostate cancer cells. Br J Cancer, 2003,89:746-753.
    • (2003) Br J Cancer , vol.89 , pp. 746-753
    • Dunlap, N.1    Schwartz, G.G.2    Eads, D.3
  • 191
    • 0038276041 scopus 로고    scopus 로고
    • The combination of a potent vitamin d3 analog, eb 1089, with ionizing radiation reduces tumor growth and induces apoptosis of mcf-7 breast tumor xenografts in nude mice
    • Sundaram S, Sea A, Feldman S, et al. The combination of a potent vitamin d3 analog, eb 1089, with ionizing radiation reduces tumor growth and induces apoptosis of mcf-7 breast tumor xenografts in nude mice. Clin Cancer Res, 2003,9:2350-2356.
    • (2003) Clin Cancer Res , vol.9 , pp. 2350-2356
    • Sundaram, S.1    Sea, A.2    Feldman, S.3
  • 192
    • 77958056316 scopus 로고    scopus 로고
    • A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes
    • Jones MD, Liu JC, Barthel TK, et al. A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes. Clin Cancer Res, 2010,16:4978-4989.
    • (2010) Clin Cancer Res , vol.16 , pp. 4978-4989
    • Jones, M.D.1    Liu, J.C.2    Barthel, T.K.3
  • 193
    • 66149127277 scopus 로고    scopus 로고
    • Bortezomib induces osteoblast differentiation via wnt-independent activation of beta-catenin/ tcf signaling
    • Qiang YW, Hu B, Chen Y, et al. Bortezomib induces osteoblast differentiation via wnt-independent activation of beta-catenin/ tcf signaling. Blood, 2009,113:4319-4330.
    • (2009) Blood , vol.113 , pp. 4319-4330
    • Qiang, Y.W.1    Hu, B.2    Chen, Y.3
  • 194
    • 34347244905 scopus 로고    scopus 로고
    • Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: A randomised, multicentre, placebo-controlled phase ii study
    • Nilsson S, Franzen L, Parker C, et al. Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: A randomised, multicentre, placebo-controlled phase ii study. Lancet Oncol, 2007,8:587-594.
    • (2007) Lancet Oncol , vol.8 , pp. 587-594
    • Nilsson, S.1    Franzen, L.2    Parker, C.3
  • 195
    • 84862127924 scopus 로고    scopus 로고
    • Detection of previously unidentified metastatic disease as a leading cause of screening failure in a phase iii trial of zibotentan versus placebo in patients with nonmetastatic, castration resistant prostate cancer
    • Yu EY, Miller K, Nelson J, et al. Detection of previously unidentified metastatic disease as a leading cause of screening failure in a phase iii trial of zibotentan versus placebo in patients with nonmetastatic, castration resistant prostate cancer. J Urol, 2012,188:103-109.
    • (2012) J Urol , vol.188 , pp. 103-109
    • Yu, E.Y.1    Miller, K.2    Nelson, J.3
  • 196
    • 73149110553 scopus 로고    scopus 로고
    • Abt-888 confers broad in vivo activity in combination with temozolomide in diverse tumors
    • Palma JP, Wang YC, Rodriguez LE, et al. Abt-888 confers broad in vivo activity in combination with temozolomide in diverse tumors. Clin Cancer Res, 2009,15:7277-7290.
    • (2009) Clin Cancer Res , vol.15 , pp. 7277-7290
    • Palma, J.P.1    Wang, Y.C.2    Rodriguez, L.E.3
  • 197
    • 79960788405 scopus 로고    scopus 로고
    • Cilengitide inhibits metastatic bone colonization in a nude rat model
    • Bretschi M, Merz M, Komljenovic D, et al. Cilengitide inhibits metastatic bone colonization in a nude rat model. Oncol Rep, 2011,26:843-851.
    • (2011) Oncol Rep , vol.26 , pp. 843-851
    • Bretschi, M.1    Merz, M.2    Komljenovic, D.3
  • 198
    • 1642576127 scopus 로고    scopus 로고
    • Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer
    • Boffa DJ, Luan F, Thomas D, et al. Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer. Clin Cancer Res, 2004,10:293-300.
    • (2004) Clin Cancer Res , vol.10 , pp. 293-300
    • Boffa, D.J.1    Luan, F.2    Thomas, D.3
  • 199
    • 77953844482 scopus 로고    scopus 로고
    • Mtor signaling in cancer cell motility and tumor metastasis
    • Zhou H, Huang S. Mtor signaling in cancer cell motility and tumor metastasis. Crit Rev Eukaryot Gene Expr, 2010,20:1-16.
    • (2010) Crit Rev Eukaryot Gene Expr , vol.20 , pp. 1-16
    • Zhou, H.1    Huang, S.2
  • 200
    • 78650304107 scopus 로고    scopus 로고
    • Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis
    • Lynch CC. Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis. Bone, 2011,48:44-53.
    • (2011) Bone , vol.48 , pp. 44-53
    • Lynch, C.C.1
  • 201
    • 0035144531 scopus 로고    scopus 로고
    • A matrix metalloproteinase inhibitor, batimastat, retards the development of osteolytic bone metastases by mda-mb-231 human breast cancer cells in balb c nu/nu mice
    • Lee J, Weber M, Mejia S, et al. A matrix metalloproteinase inhibitor, batimastat, retards the development of osteolytic bone metastases by mda-mb-231 human breast cancer cells in balb c nu/nu mice. Eur J Cancer, 2001,37:106-113.
    • (2001) Eur J Cancer , vol.37 , pp. 106-113
    • Lee, J.1    Weber, M.2    Mejia, S.3
  • 202
    • 84856869451 scopus 로고    scopus 로고
    • Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of rankl signaling
    • Sung B, Oyajobi BO, Aggarwal BB. Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of rankl signaling. Mol Cancer Ther, 2011,11:350-359.
    • (2011) Mol Cancer Ther , vol.11 , pp. 350-359
    • Sung, B.1    Oyajobi, B.O.2    Aggarwal, B.B.3
  • 203
    • 79957888198 scopus 로고    scopus 로고
    • Clinical significance of interleukin (il)-6 in cancer metastasis to bone: Potential of anti-il-6 therapies
    • Tawara K, Oxford JT, Jorcyk CL. Clinical significance of interleukin (il)-6 in cancer metastasis to bone: potential of anti-il-6 therapies. Cancer Manag Res, 2011,3:177-189.
    • (2011) Cancer Manag Res , vol.3 , pp. 177-189
    • Tawara, K.1    Oxford, J.T.2    Jorcyk, C.L.3
  • 204
    • 77950690023 scopus 로고    scopus 로고
    • Interleukin-6 in bone metastasis and cancer progression
    • Ara T, Declerck YA. Interleukin-6 in bone metastasis and cancer progression. Eur J Cancer, 2010,46:1223-1231.
    • (2010) Eur J Cancer , vol.46 , pp. 1223-1231
    • Ara, T.1    Declerck, Y.A.2
  • 205
    • 77957727888 scopus 로고    scopus 로고
    • Inhibiting activin-a signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo
    • Chantry AD, Heath D, Mulivor AW, et al. Inhibiting activin-a signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo. J Bone Miner Res, 2010,25:2633-2646.
    • (2010) J Bone Miner Res , vol.25 , pp. 2633-2646
    • Chantry, A.D.1    Heath, D.2    Mulivor, A.W.3
  • 206
    • 0141651848 scopus 로고    scopus 로고
    • Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral gpiib/iiia antagonist xv454
    • Amirkhosravi A, Mousa SA, Amaya M, et al. Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral gpiib/iiia antagonist xv454. Thromb Haemost, 2003,90:549-554.
    • (2003) Thromb Haemost , vol.90 , pp. 549-554
    • Amirkhosravi, A.1    Mousa, S.A.2    Amaya, M.3
  • 207
    • 15244351844 scopus 로고    scopus 로고
    • Platelets and metastasis revisited: A novel fatty link
    • Gupta GP, Massague J. Platelets and metastasis revisited: a novel fatty link. J Clin Invest, 2004,114:1691-1693.
    • (2004) J Clin Invest , vol.114 , pp. 1691-1693
    • Gupta, G.P.1    Massague, J.2
  • 208
    • 73949153978 scopus 로고    scopus 로고
    • Wnt modulators in the biotech pipeline
    • Rey JP, Ellies DL. Wnt modulators in the biotech pipeline. Dev Dyn, 2010,239:102-114.
    • (2010) Dev Dyn , vol.239 , pp. 102-114
    • Rey, J.P.1    Ellies, D.L.2
  • 209
    • 58249105072 scopus 로고    scopus 로고
    • Novel wnt antagonists target porcupine and axin
    • Yeh JR, Peterson RT. Novel wnt antagonists target porcupine and axin. Nat Chem Biol, 2009,5:74-75.
    • (2009) Nat Chem Biol , vol.5 , pp. 74-75
    • Yeh, J.R.1    Peterson, R.T.2
  • 210
    • 84903680850 scopus 로고    scopus 로고
    • Inhibition of tumorigenesis driven by different wnt proteins requires blockade of distinct ligand-binding regions by lrp6 antibodies
    • Ettenberg SA, Charlat O, Daley MP, et al. Inhibition of tumorigenesis driven by different wnt proteins requires blockade of distinct ligand-binding regions by lrp6 antibodies. Proc Natl Acad Sci U S A.
    • Proc Natl Acad Sci U S A
    • Ettenberg, S.A.1    Charlat, O.2    Daley, M.P.3
  • 211
    • 0026064309 scopus 로고
    • A review of its pharma-cological properties and therapeutic efficacy in resorptive bone disease
    • Fitton A, McTavish D. Pamidronate. A review of its pharma-cological properties and therapeutic efficacy in resorptive bone disease. Drugs, 1991,41:289-318.
    • (1991) Drugs , vol.41 , pp. 289-318
    • Fitton, A.1    Pamidronate, M.D.2
  • 212
    • 0028846051 scopus 로고
    • Effects of oral alendronate and intranasal salmon calcitonin on bone mass and biochemical markers of bone turnover in postmenopausal women with osteoporosis
    • Adami S, Passeri M, Ortolani S, et al. Effects of oral alendronate and intranasal salmon calcitonin on bone mass and biochemical markers of bone turnover in postmenopausal women with osteoporosis. Bone, 1995,17:383-390.
    • (1995) Bone , vol.17 , pp. 383-390
    • Adami, S.1    Passeri, M.2    Ortolani, S.3
  • 213
    • 0017587282 scopus 로고
    • Sodium etidronate in the treatment of paget's disease of bone. A study of long-term results
    • Khairi MR, Altman RD, DeRosa GP, et al. Sodium etidronate in the treatment of paget's disease of bone. A study of long-term results. Ann Intern Med, 1977,87:656-663.
    • (1977) Ann Intern Med , vol.87 , pp. 656-663
    • Khairi, M.R.1    Altman, R.D.2    Derosa, G.P.3
  • 214
    • 0037273932 scopus 로고    scopus 로고
    • Effect of daily and intermittent use of ibandronate on bone mass and bone turnover in postmenopausal osteoporosis: A review of three phase ii studies
    • Schimmer RC, Bauss F. Effect of daily and intermittent use of ibandronate on bone mass and bone turnover in postmenopausal osteoporosis: a review of three phase ii studies. Clin Ther, 2003,25:19-34.
    • (2003) Clin Ther , vol.25 , pp. 19-34
    • Schimmer, R.C.1    Bauss, F.2
  • 215
    • 0031855640 scopus 로고    scopus 로고
    • Risedronate
    • discussion 92
    • Goa KL, Balfour JA. Risedronate. Drugs Aging, 1998,13:83-91; discussion 92.
    • (1998) Drugs Aging , vol.13 , pp. 83-91
    • Goa, K.L.1    Balfour, J.A.2
  • 216
    • 0030918039 scopus 로고    scopus 로고
    • Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts
    • Murakami H, Takahashi N, Tanaka S, et al. Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts. Bone, 1997,20:399-404.
    • (1997) Bone , vol.20 , pp. 399-404
    • Murakami, H.1    Takahashi, N.2    Tanaka, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.