Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: Implication for breast cancer osteolytic bone metastases

International Journal of Cancer

Volumn 123, Issue 5, 2008, Pages 1034-1042

  Bu, Guojun ^a   Lu, Wenyan ^b   Liu, Chia Chen ^a   Selander, Katri ^c   Yoneda, Toshiyuki ^d   Hall, Christopher ^e   Keller, Evan T ^e   Li, Yonghe ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Bone metastasis; Dkk1; OPG; Osteoblast differentiation; Wnt signaling

Indexed keywords

ANTIBODY; BETA CATENIN; DICKKOPF1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOPROTEGERIN; PROTEIN; WNT PROTEIN; WNT3A PROTEIN; DKK1 PROTEIN, HUMAN; OSTEOCLAST DIFFERENTIATION FACTOR; SIGNAL PEPTIDE; TNFSF11 PROTEIN, HUMAN; WNT3 PROTEIN;

ANIMAL CELL; ARTICLE; BONE ATROPHY; BONE METASTASIS; BREAST CANCER; CANCER CELL; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; FUNCTIONAL PROTEOMICS; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; BONE TUMOR; BREAST TUMOR; FEMALE; GENE EXPRESSION REGULATION; METABOLISM; METASTASIS; OSTEOLYSIS; PATHOLOGY; TUMOR CELL LINE; UPREGULATION;

BETA CATENIN; BONE NEOPLASMS; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-KAPPA B; OSTEOBLASTS; OSTEOLYSIS; OSTEOPROTEGERIN; RANK LIGAND; UP-REGULATION; WNT PROTEINS;

EID: 47249149740     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23625     Document Type: Article

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