메뉴 건너뛰기




Volumn 359, Issue 26, 2008, Pages 2814-

Molecular basis of metastasis

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR;

EID: 58149102321     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMra0805239     Document Type: Review
Times cited : (866)

References (70)
  • 1
    • 57749087908 scopus 로고    scopus 로고
    • DeVita VT Jr, Lawrence TS, Rosenberg SA, eds, 8th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins
    • DeVita VT Jr, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg's Cancer: principles & practice of oncology. 8th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins, 2008.
    • (2008) DeVita, Hellman, and Rosenberg's Cancer: Principles & practice of oncology
  • 3
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003;3:453-8.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 4
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006;127:679-95.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 5
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002;2:563-72.
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 6
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases
    • Luzzi KJ, MacDonald IC, Schmidt EE, et al. Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol 1998;153:865-73.
    • (1998) Am J Pathol , vol.153 , pp. 865-873
    • Luzzi, K.J.1    MacDonald, I.C.2    Schmidt, E.E.3
  • 7
    • 33845656738 scopus 로고    scopus 로고
    • Acetylation of the p53 DNA-binding domain regulates apoptosis induction
    • Sykes SM, Mellert HS, Holbert MA, et al. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 2006;24:841-51.
    • (2006) Mol Cell , vol.24 , pp. 841-851
    • Sykes, S.M.1    Mellert, H.S.2    Holbert, M.A.3
  • 8
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science 2008;319:1352-5.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 9
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouysségur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006;441:437-43.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouysségur, J.1    Dayan, F.2    Mazure, N.M.3
  • 10
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability
    • Bristow RG, Hill RP. Hypoxia and metabolism: hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008;8:180-92.
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 11
    • 36849021771 scopus 로고    scopus 로고
    • Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    • Higgins DF, Kimura K, Bernhardt WM, et al. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 2007;117:3810-20.
    • (2007) J Clin Invest , vol.117 , pp. 3810-3820
    • Higgins, D.F.1    Kimura, K.2    Bernhardt, W.M.3
  • 12
    • 33646365644 scopus 로고    scopus 로고
    • Lysyl oxidase is essential for hypoxia-induced metastasis
    • Erler JT, Bennewith KL, Nicolau M, et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 2006;440:1222-6.
    • (2006) Nature , vol.440 , pp. 1222-1226
    • Erler, J.T.1    Bennewith, K.L.2    Nicolau, M.3
  • 13
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003;425:307-11.
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 14
    • 33646045010 scopus 로고    scopus 로고
    • Clarke MF, Fuller M. Stem cells and cancer: two faces of Eve. Cell 2006;124:1111-5.
    • Clarke MF, Fuller M. Stem cells and cancer: two faces of Eve. Cell 2006;124:1111-5.
  • 15
    • 42349093952 scopus 로고    scopus 로고
    • Cancer stem cells: Implications for the progression and treatment of metastatic disease
    • Croker AK, Allan AL. Cancer stem cells: implications for the progression and treatment of metastatic disease. J Cell Mol Med 2008;12:374-90.
    • (2008) J Cell Mol Med , vol.12 , pp. 374-390
    • Croker, A.K.1    Allan, A.L.2
  • 16
    • 23844513413 scopus 로고    scopus 로고
    • Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis
    • Kucia M, Reca R, Miekus K, et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005;23:879-94.
    • (2005) Stem Cells , vol.23 , pp. 879-894
    • Kucia, M.1    Reca, R.2    Miekus, K.3
  • 17
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the premetastatic niche
    • Kaplan RN, Riba RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the premetastatic niche. Nature 2005;438:820-7.
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3
  • 18
    • 40349098612 scopus 로고    scopus 로고
    • Migratory neighbors and distant invaders: Tumor-associated niche cells
    • Wels J, Kaplan RN, Rafii S, Lyden D. Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev 2008;22:559-74.
    • (2008) Genes Dev , vol.22 , pp. 559-574
    • Wels, J.1    Kaplan, R.N.2    Rafii, S.3    Lyden, D.4
  • 19
    • 0032510494 scopus 로고    scopus 로고
    • A causal role for E-cadherin in the transition from adenoma to carcinoma
    • Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 1998;392:190-3.
    • (1998) Nature , vol.392 , pp. 190-193
    • Perl, A.K.1    Wilgenbus, P.2    Dahl, U.3    Semb, H.4    Christofori, G.5
  • 20
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-54.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 21
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A, Pérez-Moreno MA, Rodrigo I, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000;2:76-83.
    • (2000) Nat Cell Biol , vol.2 , pp. 76-83
    • Cano, A.1    Pérez-Moreno, M.A.2    Rodrigo, I.3
  • 22
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004;117:927-39.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 23
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1alpha promotes metastasis
    • Yang MH, Wu MZ, Chiou SH, et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008;10:295-305.
    • (2008) Nat Cell Biol , vol.10 , pp. 295-305
    • Yang, M.H.1    Wu, M.Z.2    Chiou, S.H.3
  • 24
    • 0034601487 scopus 로고    scopus 로고
    • Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000;406:532-5. [Erratum, Nature 2001;411:974.]
    • Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000;406:532-5. [Erratum, Nature 2001;411:974.]
  • 25
    • 24344486013 scopus 로고    scopus 로고
    • RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
    • Hakem A, Sanchez-Sweatman O, You-Ten A, et al. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 2005;19:1974-9.
    • (2005) Genes Dev , vol.19 , pp. 1974-1979
    • Hakem, A.1    Sanchez-Sweatman, O.2    You-Ten, A.3
  • 26
    • 33745288277 scopus 로고    scopus 로고
    • Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene
    • Kim M, Gans JD, Nogueira C, et al. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell 2006;125:1269-81.
    • (2006) Cell , vol.125 , pp. 1269-1281
    • Kim, M.1    Gans, J.D.2    Nogueira, C.3
  • 27
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002;2:161-74.
    • (2002) Nat Rev Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 28
    • 34648815810 scopus 로고    scopus 로고
    • Emerging roles of proteases in tumour suppression
    • López-Otin C, Matrisian LM. Emerging roles of proteases in tumour suppression. Nat Rev Cancer 2007;7:800-8.
    • (2007) Nat Rev Cancer , vol.7 , pp. 800-808
    • López-Otin, C.1    Matrisian, L.M.2
  • 29
    • 36148994693 scopus 로고    scopus 로고
    • The other side of MMPs: Protective roles in tumor progression
    • Martin MD, Matrisian LM. The other side of MMPs: protective roles in tumor progression. Cancer Metastasis Rev 2007;26:717-24.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 717-724
    • Martin, M.D.1    Matrisian, L.M.2
  • 30
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003;3:537-49.
    • (2003) Cancer Cell , vol.3 , pp. 537-549
    • Kang, Y.1    Siegel, P.M.2    Shu, W.3
  • 31
    • 13444268127 scopus 로고    scopus 로고
    • Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors
    • Minn AJ, Kang Y, Serganova I, et al. Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest 2005;115:44-55.
    • (2005) J Clin Invest , vol.115 , pp. 44-55
    • Minn, A.J.1    Kang, Y.2    Serganova, I.3
  • 32
    • 38049115129 scopus 로고    scopus 로고
    • Endogenous human microRNAs that suppress breast cancer metastasis
    • Tavazoie SF, Alarcón C, Oskarsson T, et al. Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008;451:147-52.
    • (2008) Nature , vol.451 , pp. 147-152
    • Tavazoie, S.F.1    Alarcón, C.2    Oskarsson, T.3
  • 33
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006;66:605-12.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 34
    • 20444412646 scopus 로고    scopus 로고
    • Therapeutic targeting of the tumor microenvironment
    • Joyce JA. Therapeutic targeting of the tumor microenvironment. Cancer Cell 2005;7:513-20.
    • (2005) Cancer Cell , vol.7 , pp. 513-520
    • Joyce, J.A.1
  • 35
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005;121:335-48.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3
  • 36
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006;124:263-6.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 37
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    • Padua D, Zhang XH, Wang Q, et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008;133:66-77.
    • (2008) Cell , vol.133 , pp. 66-77
    • Padua, D.1    Zhang, X.H.2    Wang, Q.3
  • 38
    • 27644546807 scopus 로고    scopus 로고
    • Brain metastases: Epidemiology and pathophysiology
    • Gavrilovic IT, Posner JB. Brain metastases: epidemiology and pathophysiology. J Neurooncol 2005;75:5-14.
    • (2005) J Neurooncol , vol.75 , pp. 5-14
    • Gavrilovic, I.T.1    Posner, J.B.2
  • 39
    • 0033511159 scopus 로고    scopus 로고
    • Pulmonary metastases from soft tissue sarcoma: Analysis of patterns of diseases and postmetastasis survival
    • Billingsley KG, Burt ME, Jara E, et al. Pulmonary metastases from soft tissue sarcoma: analysis of patterns of diseases and postmetastasis survival. Ann Surg 1999;229:602-10.
    • (1999) Ann Surg , vol.229 , pp. 602-610
    • Billingsley, K.G.1    Burt, M.E.2    Jara, E.3
  • 40
    • 33645834966 scopus 로고    scopus 로고
    • Metastatic patterns in adenocarcinoma
    • Hess KR, Varadhachary GR, Taylor SH, et al. Metastatic patterns in adenocarcinoma. Cancer 2006;106:1624-33.
    • (2006) Cancer , vol.106 , pp. 1624-1633
    • Hess, K.R.1    Varadhachary, G.R.2    Taylor, S.H.3
  • 42
    • 33846815517 scopus 로고    scopus 로고
    • Significance, detection and markers of disseminated breast cancer cells
    • Lacroix M. Significance, detection and markers of disseminated breast cancer cells. Endocr Relat Cancer 2006;13:1033-67.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 1033-1067
    • Lacroix, M.1
  • 43
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. Lancet 1889;1:571-3.
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 44
    • 11144357298 scopus 로고    scopus 로고
    • The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
    • Khanna C, Wan X, Bose S, et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 2004;10:182-6.
    • (2004) Nat Med , vol.10 , pp. 182-186
    • Khanna, C.1    Wan, X.2    Bose, S.3
  • 45
    • 34547926839 scopus 로고    scopus 로고
    • LKB1 modulates lung cancer differentiation and metastasis
    • Ji H, Ramsey MR, Hayes DN, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007;448:807-10.
    • (2007) Nature , vol.448 , pp. 807-810
    • Ji, H.1    Ramsey, M.R.2    Hayes, D.N.3
  • 46
    • 23144461051 scopus 로고    scopus 로고
    • Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature 2005;436:518-24.
    • Minn AJ, Gupta GP, Siegel PM, et al. Genes that mediate breast cancer metastasis to lung. Nature 2005;436:518-24.
  • 47
    • 33846058844 scopus 로고    scopus 로고
    • The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis
    • Wang J, Loberg R, Taichman RS. The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis. Cancer Metastasis Rev 2006;25:573-87.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 573-587
    • Wang, J.1    Loberg, R.2    Taichman, R.S.3
  • 48
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007;8:341-52.
    • (2007) Nat Rev Genet , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 49
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 51
    • 0023790913 scopus 로고
    • Genetic evidence for progressive selection and overgrowth of primary tumors by metastatic cell subpopulations
    • Waghorne C, Thomas M, Lagarde A, Kerbel RS, Breitman ML. Genetic evidence for progressive selection and overgrowth of primary tumors by metastatic cell subpopulations. Cancer Res 1988;48:6109-14.
    • (1988) Cancer Res , vol.48 , pp. 6109-6114
    • Waghorne, C.1    Thomas, M.2    Lagarde, A.3    Kerbel, R.S.4    Breitman, M.L.5
  • 52
    • 34147220392 scopus 로고    scopus 로고
    • Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
    • Gupta GP, Nguyen DX, Chiang AC, et al. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 2007;446:765-70.
    • (2007) Nature , vol.446 , pp. 765-770
    • Gupta, G.P.1    Nguyen, D.X.2    Chiang, A.C.3
  • 53
    • 37649001973 scopus 로고    scopus 로고
    • ID genes mediate tumor reinitiation during breast cancer lung metastasis
    • Gupta GP, Perk J, Acharyya S, et al. ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A 2007;104:19506-11.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19506-19511
    • Gupta, G.P.1    Perk, J.2    Acharyya, S.3
  • 54
    • 44449084242 scopus 로고    scopus 로고
    • Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response
    • Swarbrick A, Roy E, Allen T, Bishop JM. Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response. Proc Natl Acad Sci U S A 2008;105:5402-7.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5402-5407
    • Swarbrick, A.1    Roy, E.2    Allen, T.3    Bishop, J.M.4
  • 55
    • 0037206022 scopus 로고    scopus 로고
    • Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer
    • Klein CA, Blankenstein TJ, Schmidt-Kittler O, et al. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 2002;360:683-9.
    • (2002) Lancet , vol.360 , pp. 683-689
    • Klein, C.A.1    Blankenstein, T.J.2    Schmidt-Kittler, O.3
  • 56
    • 0038271868 scopus 로고    scopus 로고
    • From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression
    • Schmidt-Kittler O, Ragg T, Daskalakis A, et al. From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A 2003;100:7737-42.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7737-7742
    • Schmidt-Kittler, O.1    Ragg, T.2    Daskalakis, A.3
  • 57
    • 37349079197 scopus 로고    scopus 로고
    • Systemic spread is an early step in breast cancer
    • Hüsemann Y, Geigl JB, Schubert F, et al. Systemic spread is an early step in breast cancer. Cancer Cell 2008;13:58-68.
    • (2008) Cancer Cell , vol.13 , pp. 58-68
    • Hüsemann, Y.1    Geigl, J.B.2    Schubert, F.3
  • 58
    • 33748931283 scopus 로고    scopus 로고
    • The problem of cancer dormancy: Understanding the basic mechanisms and identifying therapeutic opportunities
    • Aguirre-Ghiso JA. The problem of cancer dormancy: understanding the basic mechanisms and identifying therapeutic opportunities. Cell Cycle 2006;5:1740-3.
    • (2006) Cell Cycle , vol.5 , pp. 1740-1743
    • Aguirre-Ghiso, J.A.1
  • 59
    • 33746807641 scopus 로고    scopus 로고
    • Is cancer a disease of self-seeding?
    • Norton L, Massagué J. Is cancer a disease of self-seeding? Nat Med 2006;12:875-8.
    • (2006) Nat Med , vol.12 , pp. 875-878
    • Norton, L.1    Massagué, J.2
  • 60
    • 34147211281 scopus 로고    scopus 로고
    • Lung metastasis genes couple breast tumor size and metastatic spread
    • Minn AJ, Gupta GP, Padua D, et al. Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A 2007;104:6740-5.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6740-6745
    • Minn, A.J.1    Gupta, G.P.2    Padua, D.3
  • 62
    • 33748693297 scopus 로고    scopus 로고
    • Validation and clinical utility of a 70-gene prognostic signature for women with nodenegative breast cancer
    • Buyse M, Loi S, van't Veer L, et al. Validation and clinical utility of a 70-gene prognostic signature for women with nodenegative breast cancer. J Natl Cancer Inst 2006;98:1183-92.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1183-1192
    • Buyse, M.1    Loi, S.2    van't Veer, L.3
  • 63
    • 33746910265 scopus 로고    scopus 로고
    • Concordance among gene-expression-based predictors for breast cancer
    • Fan C, Oh DS, Wessels L, et al. Concordance among gene-expression-based predictors for breast cancer. N Engl J Med 2006;355:560-9.
    • (2006) N Engl J Med , vol.355 , pp. 560-569
    • Fan, C.1    Oh, D.S.2    Wessels, L.3
  • 64
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver MJ, He YD, van't Veer LJ, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002;347:1999-2009.
    • (2002) N Engl J Med , vol.347 , pp. 1999-2009
    • van de Vijver, M.J.1    He, Y.D.2    van't Veer, L.J.3
  • 65
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van't Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002;415:530-6.
    • (2002) Nature , vol.415 , pp. 530-536
    • van't Veer, L.J.1    Dai, H.2    van de Vijver, M.J.3
  • 66
    • 19344363035 scopus 로고    scopus 로고
    • Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds
    • Chang HY, Sneddon JB, Alizadeh AA, et al. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol 2004;2(2):e7.
    • (2004) PLoS Biol , vol.2 , Issue.2
    • Chang, H.Y.1    Sneddon, J.B.2    Alizadeh, A.A.3
  • 67
    • 33644551073 scopus 로고    scopus 로고
    • Gene expression programs in response to hypoxia: Cell type specificity and prognostic significance in human cancers
    • Chi JT, Wang Z, Nuyten DS, et al. Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med 2006;3(3):e47.
    • (2006) PLoS Med , vol.3 , Issue.3
    • Chi, J.T.1    Wang, Z.2    Nuyten, D.S.3
  • 68
    • 33748093767 scopus 로고    scopus 로고
    • Linking oncogenic pathways with therapeutic opportunities
    • Bild AH, Potti A, Nevins JR. Linking oncogenic pathways with therapeutic opportunities. Nat Rev Cancer 2006;6:735-41.
    • (2006) Nat Rev Cancer , vol.6 , pp. 735-741
    • Bild, A.H.1    Potti, A.2    Nevins, J.R.3
  • 69
    • 31144459985 scopus 로고    scopus 로고
    • Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    • Bild AH, Yao G, Chang JT, et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006;439:353-7.
    • (2006) Nature , vol.439 , pp. 353-357
    • Bild, A.H.1    Yao, G.2    Chang, J.T.3
  • 70
    • 34447555782 scopus 로고    scopus 로고
    • Mining gene expression profiles: Expression signatures as cancer phenotypes
    • Nevins JR, Potti A. Mining gene expression profiles: expression signatures as cancer phenotypes. Nat Rev Genet 2007;8:601-9.
    • (2007) Nat Rev Genet , vol.8 , pp. 601-609
    • Nevins, J.R.1    Potti, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.