메뉴 건너뛰기




Volumn 47, Issue 3, 2012, Pages 306-314

Induction of a mesenchymal expression program in lung epithelial cells by Wingless protein (Wnt)/β-catenin requires the presence of c-Jun N-terminal kinase-1 (JNK1)

Author keywords

Epithelial to mesenchymal transition; Epithelium; Fibrosis; Lung; Wnt3a

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; BINDING PROTEIN; CALVASCULIN; CARG BOX BINDING FACTOR A; MESSENGER RNA; PROTEIN ZO1; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE 1; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; VIMENTIN; WNT1 PROTEIN; WNT3A PROTEIN;

EID: 84865805629     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0297OC     Document Type: Article
Times cited : (28)

References (47)
  • 2
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • DOI 10.1016/j.ceb.2003.10.006
    • Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003;15:740-746. (Pubitemid 37487967)
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.6 , pp. 740-746
    • Thiery, J.P.1
  • 3
    • 79953761687 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase 1 promotes transforming growth factor- Beta1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of SMAD3
    • Velden JL, Alcorn JF, Guala AS, Badura EC, Janssen-Heininger YM. C-Jun N-terminal kinase 1 promotes transforming growth factor- beta1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of SMAD3. Am J Respir Cell Mol Biol 2010;44:571-581.
    • (2010) Am J Respir Cell Mol Biol , vol.44 , pp. 571-581
    • Velden, J.L.1    Alcorn, J.F.2    Guala, A.S.3    Badura, E.C.4    Janssen-Heininger, Y.M.5
  • 6
    • 41549108935 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Aberrant recapitulation of developmental programs?
    • Selman M, Pardo A, Kaminski N. Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med 2008;5:e62.
    • (2008) PLoS Med , vol.5
    • Selman, M.1    Pardo, A.2    Kaminski, N.3
  • 9
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-Catenin, and Cadherin pathways
    • DOI 10.1126/science.1094291
    • Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004;303:1483-1487. (Pubitemid 38314410)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 10
    • 0036860704 scopus 로고    scopus 로고
    • The Wnt signalling pathway
    • DOI 10.1242/jcs.00089
    • Huelsken J, Behrens J. The Wnt signalling pathway. J Cell Sci 2002;115: 3977-3978. (Pubitemid 35446796)
    • (2002) Journal of Cell Science , vol.115 , Issue.21 , pp. 3977-3978
    • Huelsken, J.1    Behrens, J.2
  • 11
    • 0037155691 scopus 로고    scopus 로고
    • Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    • DOI 10.1016/S0092-8674(02)00685-2
    • Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X. Control of beta-catenin phosphorylation/degradation by a dualkinase mechanism. Cell 2002;108:837-847. (Pubitemid 34327534)
    • (2002) Cell , vol.108 , Issue.6 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.-H.5    Tan, Y.6    Zhang, Z.7    Lin, X.8    He, X.9
  • 13
    • 0033517102 scopus 로고    scopus 로고
    • Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
    • DOI 10.1093/emboj/18.15.4233
    • Li L, Yuan H, Weaver CD, Mao J, Farr GH III, Sussman DJ, Jonkers J, Kimelman D, Wu D. Axin and FRAT1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J 1999;18:4233-4240. (Pubitemid 29364125)
    • (1999) EMBO Journal , vol.18 , Issue.15 , pp. 4233-4240
    • Li, L.1    Yuan, H.2    Weaver, C.D.3    Mao, J.4    Farr III, G.H.5    Sussman, D.J.6    Jonkers, J.7    Kimelman, D.8    Wu, D.9
  • 14
    • 28644448036 scopus 로고    scopus 로고
    • Cell biology: Relays at the membrane
    • Nusse R. Cell biology: relays at the membrane. Nature 2005;438:747-749.
    • (2005) Nature , vol.438 , pp. 747-749
    • Nusse, R.1
  • 15
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • DOI 10.1146/annurev.cellbio.20.010403.113126
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810. (Pubitemid 39488658)
    • (2004) Annual Review of Cell and Developmental Biology , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 16
    • 0032504052 scopus 로고    scopus 로고
    • Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
    • DOI 10.1016/S0092-8674(00)81226-X
    • Boutros M, Paricio N, Strutt DI, Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and Wingless signaling. Cell 1998;94:109-118. (Pubitemid 28347474)
    • (1998) Cell , vol.94 , Issue.1 , pp. 109-118
    • Boutros, M.1    Paricio, N.2    Strutt, D.I.3    Mlodzik, M.4
  • 17
    • 39049142759 scopus 로고    scopus 로고
    • o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells
    • DOI 10.1242/jcs.021964
    • Bikkavilli RK, Feigin ME, Malbon CC. G alpha O mediates Wnt-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells. J Cell Sci 2008;121:234-245. (Pubitemid 351232664)
    • (2008) Journal of Cell Science , vol.121 , Issue.2 , pp. 234-245
    • Bikkavilli, R.K.1    Feigin, M.E.2    Malbon, C.C.3
  • 19
    • 0020459632 scopus 로고
    • Continuous multiplication of rabbit tracheal epithelial cells in a defined, hormone-supplemented medium
    • Wu R, Smith D. Continuous multiplication of rabbit tracheal epithelial cells in a defined, hormone-supplemented medium. In Vitro 1982;18: 800-812. (Pubitemid 13166487)
    • (1982) In Vitro , vol.18 , Issue.9 , pp. 800-812
    • Wu, R.1    Smith, D.2
  • 20
    • 0030823559 scopus 로고    scopus 로고
    • Mouse lung epithelial cell lines - Tools for the study of differentiation and the neoplastic phenotype
    • DOI 10.1016/S0300-483X(97)00108-X, PII S0300483X9700108X
    • Malkinson AM, Dwyer-Nield LD, Rice PL, Dinsdale D. Mouse lung epithelial cell lines: tools for the study of differentiation and the neoplastic phenotype. Toxicology 1997;123:53-100. (Pubitemid 27414556)
    • (1997) Toxicology , vol.123 , Issue.1-2 , pp. 53-100
    • Malkinson, A.M.1    Dwyer-Nield, L.D.2    Rice, P.L.3    Dinsdale, D.4
  • 21
    • 0344373791 scopus 로고    scopus 로고
    • Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements
    • DOI 10.1016/S0960-9822(03)00240-9
    • Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol 2003;13:680-685. (Pubitemid 36453318)
    • (2003) Current Biology , vol.13 , Issue.8 , pp. 680-685
    • Veeman, M.T.1    Slusarski, D.C.2    Kaykas, A.3    Louie, S.H.4    Moon, R.T.5
  • 22
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: Potential role in idiopathic pulmonary fibrosis
    • Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 2005;166:1321-1332. (Pubitemid 40586504)
    • (2005) American Journal of Pathology , vol.166 , Issue.5 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3    Nicholson, A.G.4    Crandall, E.D.5    Du, B.R.M.6    Borok, Z.7
  • 25
    • 22644443940 scopus 로고    scopus 로고
    • The origin of vimentin expression in invasive breast cancer: Epithelial- mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?
    • DOI 10.1002/path.1797
    • Korsching E, Packeisen J, Liedtke C, Hungermann D, Wulfing P, van Diest PJ, Brandt B, Boecker W, Buerger H. The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential? J Pathol 2005;206:451-457. (Pubitemid 41025348)
    • (2005) Journal of Pathology , vol.206 , Issue.4 , pp. 451-457
    • Korsching, E.1    Packeisen, J.2    Liedtke, C.3    Hungermann, D.4    Wulfing, P.5    Van Diest, P.J.6    Brandt, B.7    Boecker, W.8    Buerger, H.9
  • 26
    • 33744924735 scopus 로고    scopus 로고
    • Role of epithelial cells in idiopathic pulmonary fibrosis: From innocent targets to serial killers
    • DOI 10.1513/pats.200601-003TK
    • Selman M, Pardo A. Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc Am Thorac Soc 2006;3:364-372. (Pubitemid 43845414)
    • (2006) Proceedings of the American Thoracic Society , vol.3 , Issue.4 , pp. 364-372
    • Selman, M.1    Pardo, A.2
  • 27
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • DOI 10.1172/JCI200320530
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003;112:1776-1784. (Pubitemid 38063698)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.12 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 32
    • 77949351029 scopus 로고    scopus 로고
    • New insights into epithelial-mesenchymal transition in kidney fibrosis
    • Liu Y. New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 2010;21:212-222.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 212-222
    • Liu, Y.1
  • 35
    • 33845491219 scopus 로고    scopus 로고
    • Smad4 cooperates with lymphoid enhancer-binding factor 1/T cell-specific factor to increase c-myc expression in the absense of TGF-beta signaling
    • DOI 10.1073/pnas.0604773103
    • Lim SK, Hoffmann FM. SMAD4 cooperates with lymphoid enhancer- binding factor 1/T cell-specific factor to increase c-myc expression in the absence of TGF-beta signaling. Proc Natl Acad Sci USA 2006;103: 18580-18585. (Pubitemid 44913453)
    • (2006) Proceedings of the National Academy of Sciences of the United States of America , vol.103 , Issue.49 , pp. 18580-18585
    • Lim, S.K.1    Hoffmann, F.M.2
  • 36
    • 55849119491 scopus 로고    scopus 로고
    • The gene expression profile induced by Wnt-3a in NIH 3T3 fibroblasts
    • Chen S, McLean S, Carter DE, Leask A. The gene expression profile induced by Wnt-3a in NIH 3T3 fibroblasts. J Cell Commun Signal 2007;1:175-183.
    • (2007) J Cell Commun Signal , vol.1 , pp. 175-183
    • Chen, S.1    McLean, S.2    Carter, D.E.3    Leask, A.4
  • 37
    • 75149193602 scopus 로고    scopus 로고
    • Interaction of Wingless protein (Wnt), transforming growth factor-beta1, and hyaluronan production in fetal and postnatal fibroblasts
    • Carre AL, James AW, MacLeod L, Kong W, Kawai K, Longaker MT, Lorenz HP. Interaction of Wingless protein (Wnt), transforming growth factor-beta1, and hyaluronan production in fetal and postnatal fibroblasts. Plast Reconstr Surg 2010;125:74-88.
    • (2010) Plast Reconstr Surg , vol.125 , pp. 74-88
    • Carre, A.L.1    James, A.W.2    MacLeod, L.3    Kong, W.4    Kawai, K.5    Longaker, M.T.6    Lorenz, H.P.7
  • 38
    • 60849098434 scopus 로고    scopus 로고
    • Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial SMAD signaling to cell contacts
    • Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, Chapman HA. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial SMAD signaling to cell contacts. J Cell Biol 2009;184: 309-322.
    • (2009) J Cell Biol , vol.184 , pp. 309-322
    • Kim, Y.1    Kugler, M.C.2    Wei, Y.3    Kim, K.K.4    Li, X.5    Brumwell, A.N.6    Chapman, H.A.7
  • 39
    • 84863229401 scopus 로고    scopus 로고
    • Interactions between beta-catenin and transforming growth factor-beta signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)
    • Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, et al. Interactions between beta-catenin and transforming growth factor-beta signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J Biol Chem 2012;287:7026-7038.
    • (2012) J Biol Chem , vol.287 , pp. 7026-7038
    • Zhou, B.1    Liu, Y.2    Kahn, M.3    Ann, D.K.4    Han, A.5    Wang, H.6    Nguyen, C.7    Flodby, P.8    Zhong, Q.9    Krishnaveni, M.S.10
  • 40
    • 79956200232 scopus 로고    scopus 로고
    • Wnt3a induces myofibroblast differentiation by upregulating TGF-beta signaling through SMAD2 in a beta-catenin-dependent manner
    • Carthy JM, Garmaroudi FS, Luo Z, McManus BM. Wnt3a induces myofibroblast differentiation by upregulating TGF-beta signaling through SMAD2 in a beta-catenin-dependent manner. PLoS ONE 2011;6:e19809.
    • (2011) PLoS ONE , vol.6
    • Carthy, J.M.1    Garmaroudi, F.S.2    Luo, Z.3    McManus, B.M.4
  • 42
    • 77954763443 scopus 로고    scopus 로고
    • Wnt/Frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts
    • Laeremans H, Rensen SS, Ottenheijm HC, Smits JF, Blankesteijn WM. Wnt/Frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts. Cardiovasc Res 2010;87:514-523.
    • (2010) Cardiovasc Res , vol.87 , pp. 514-523
    • Laeremans, H.1    Rensen, S.S.2    Ottenheijm, H.C.3    Smits, J.F.4    Blankesteijn, W.M.5
  • 43
    • 24644478136 scopus 로고    scopus 로고
    • Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    • DOI 10.1038/nature03914
    • Nateri AS, Spencer-Dene B, Behrens A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 2005;437:281-285. (Pubitemid 41294493)
    • (2005) Nature , vol.437 , Issue.7056 , pp. 281-285
    • Nateri, A.S.1    Spencer-Dene, B.2    Behrens, A.3
  • 44
    • 41949105179 scopus 로고    scopus 로고
    • Rac1 Activation Controls Nuclear Localization of beta-catenin during Canonical Wnt Signaling
    • DOI 10.1016/j.cell.2008.01.052, PII S0092867408002791
    • Wu X, Tu X, Joeng KS, Hilton MJ, Williams DA, Long F. Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 2008;133:340-353. (Pubitemid 351508298)
    • (2008) Cell , vol.133 , Issue.2 , pp. 340-353
    • Wu, X.1    Tu, X.2    Joeng, K.S.3    Hilton, M.J.4    Williams, D.A.5    Long, F.6
  • 45
    • 70350554238 scopus 로고    scopus 로고
    • JNK phosphorylates betacatenin and regulates adherens junctions
    • Lee MH, Koria P, Qu J, Andreadis ST. JNK phosphorylates betacatenin and regulates adherens junctions. FASEB J 2009;23: 3874-3883.
    • (2009) FASEB J , vol.23 , pp. 3874-3883
    • Lee, M.H.1    Koria, P.2    Qu, J.3    Andreadis, S.T.4
  • 46
    • 41549133557 scopus 로고    scopus 로고
    • Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction
    • DOI 10.1083/jcb.200710050
    • Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, Li L. Nuclear Dvl, c-Jun, betacatenin, and TCF form a complex leading to stabilization of betacatenin- TCF interaction. J Cell Biol 2008;180:1087-1100. (Pubitemid 351468467)
    • (2008) Journal of Cell Biology , vol.180 , Issue.6 , pp. 1087-1100
    • Gan, X.-Q.1    Wang, J.-Y.2    Xi, Y.3    Wu, Z.-L.4    Li, Y.-P.5    Li, L.6
  • 47
    • 34249336416 scopus 로고    scopus 로고
    • Physical and functional cooperation between AP-1 and beta-catenin for the regulation of TCF-dependent genes
    • DOI 10.1038/sj.onc.1210133, PII 1210133
    • Toualbi K, Guller MC, Mauriz JL, Labalette C, Buendia MA, Mauviel A, Bernuau D. Physical and functional cooperation between AP-1 and beta-catenin for the regulation of TCF-dependent genes. Oncogene 2007;26:3492-3502. (Pubitemid 46816752)
    • (2007) Oncogene , vol.26 , Issue.24 , pp. 3492-3502
    • Toualbi, K.1    Guller, M.C.2    Mauriz, J.-L.3    Labalette, C.4    Buendia, M.-A.5    Mauviel, A.6    Bernuau, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.