-
1
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438:967-74.
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
2
-
-
47949089077
-
VEGF-targeted therapy: Mechanisms of antitumour activity
-
Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of antitumour activity. Nat Rev Cancer 2008;8:579-91.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
3
-
-
0033822622
-
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
-
Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2000;2:306-14.
-
(2000)
Neoplasia
, vol.2
, pp. 306-314
-
-
Rubenstein, J.L.1
Kim, J.2
Ozawa, T.3
Zhang, M.4
Westphal, M.5
Deen, D.F.6
-
4
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005;8:299-309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
5
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009;15:232-9.
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
6
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15:220-31.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
Vinals, F.6
-
7
-
-
0038172576
-
Cancer: Out of air is not out of action
-
Bottaro DP, Liotta LA. Cancer: out of air is not out of action. Nature 2003;423:593-5.
-
(2003)
Nature
, vol.423
, pp. 593-595
-
-
Bottaro, D.P.1
Liotta, L.A.2
-
8
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003;3:347-61.
-
(2003)
Cancer Cell
, vol.3
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
Mazzone, M.4
Giordano, S.5
Comoglio, P.M.6
-
9
-
-
34848855124
-
The MET receptor tyrosine kinase in invasion and metastasis
-
Benvenuti S, Comoglio PM. The MET receptor tyrosine kinase in invasion and metastasis. J Cell Physiol 2007;213:316-25.
-
(2007)
J Cell Physiol
, vol.213
, pp. 316-325
-
-
Benvenuti, S.1
Comoglio, P.M.2
-
10
-
-
78649420006
-
MET signalling: Principles and functions in development, organ regeneration and cancer
-
Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol 2010;11:834-48.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 834-848
-
-
Trusolino, L.1
Bertotti, A.2
Comoglio, P.M.3
-
11
-
-
69149089019
-
Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer
-
Graveel CR, DeGroot JD, Su Y, Koeman J, Dykema K, Leung S, et al. Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer. Proc Natl Acad Sci U S A 2009;106:12909-14.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 12909-12914
-
-
Graveel, C.R.1
DeGroot, J.D.2
Su, Y.3
Koeman, J.4
Dykema, K.5
Leung, S.6
-
12
-
-
69149108735
-
Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer
-
Ponzo MG, Lesurf R, Petkiewicz S, O'Malley FP, Pinnaduwage D, Andrulis IL, et al. Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Proc Natl Acad Sci U S A 2009;106:12903-8.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 12903-12908
-
-
Ponzo, M.G.1
Lesurf, R.2
Petkiewicz, S.3
O'Malley, F.P.4
Pinnaduwage, D.5
Andrulis, I.L.6
-
13
-
-
0032523074
-
Expression of c-met is a strong independent prognostic factor in breast carcinoma
-
Ghoussoub RA, Dillon DA, D'Aquila T, Rimm EB, Fearon ER, Rimm DL. Expression of c-met is a strong independent prognostic factor in breast carcinoma. Cancer 1998;82:1513-20.
-
(1998)
Cancer
, vol.82
, pp. 1513-1520
-
-
Ghoussoub, R.A.1
Dillon, D.A.2
D'Aquila, T.3
Rimm, E.B.4
Fearon, E.R.5
Rimm, D.L.6
-
14
-
-
58949099258
-
Prognostic significance of c-Met expression in glioblastomas
-
Kong DS, Song SY, Kim DH, Joo KM, Yoo JS, Koh JS, et al. Prognostic significance of c-Met expression in glioblastomas. Cancer 2009; 115:140-8.
-
(2009)
Cancer
, vol.115
, pp. 140-148
-
-
Kong, D.S.1
Song, S.Y.2
Kim, D.H.3
Joo, K.M.4
Yoo, J.S.5
Koh, J.S.6
-
15
-
-
33847746580
-
c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion
-
Sawada K, Radjabi AR, Shinomiya N, Kistner E, Kenny H, Becker AR, et al. c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res 2007;67:1670-9.
-
(2007)
Cancer Res
, vol.67
, pp. 1670-1679
-
-
Sawada, K.1
Radjabi, A.R.2
Shinomiya, N.3
Kistner, E.4
Kenny, H.5
Becker, A.R.6
-
16
-
-
19944399371
-
C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu
-
Lengyel E, Prechtel D, Resau JH, Gauger K, Welk A, Lindemann K, et al. C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu. Int J Cancer 2005;113:678-82.
-
(2005)
Int J Cancer
, vol.113
, pp. 678-682
-
-
Lengyel, E.1
Prechtel, D.2
Resau, J.H.3
Gauger, K.4
Welk, A.5
Lindemann, K.6
-
18
-
-
77952238683
-
Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells
-
Xu L, Nilsson MB, Saintigny P, Cascone T, Herynk MH, Du Z, et al. Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells. Oncogene 2010;29:2616-27.
-
(2010)
Oncogene
, vol.29
, pp. 2616-2627
-
-
Xu, L.1
Nilsson, M.B.2
Saintigny, P.3
Cascone, T.4
Herynk, M.H.5
Du, Z.6
-
19
-
-
79960408937
-
VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer
-
You WK, Sennino B, Williamson CW, Falcon B, Hashizume H, Yao LC, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res 2011;71:4758-68.
-
(2011)
Cancer Res
, vol.71
, pp. 4758-4768
-
-
You, W.K.1
Sennino, B.2
Williamson, C.W.3
Falcon, B.4
Hashizume, H.5
Yao, L.C.6
-
20
-
-
79955029851
-
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier
-
Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, et al. GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A 2011;108:5759-64.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 5759-5764
-
-
Cullen, M.1
Elzarrad, M.K.2
Seaman, S.3
Zudaire, E.4
Stevens, J.5
Yang, M.Y.6
-
21
-
-
67049134253
-
Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors
-
Timofeevski SL, McTigue MA, Ryan K, Cui J, Zou HY, Zhu JX, et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry. 2009;48:5339-49.
-
(2009)
Biochemistry
, vol.48
, pp. 5339-5349
-
-
Timofeevski, S.L.1
McTigue, M.A.2
Ryan, K.3
Cui, J.4
Zou, H.Y.5
Zhu, J.X.6
-
22
-
-
22944447177
-
Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: Justification for K-ras-directed therapy
-
Fleming JB, Shen GL, Holloway SE, Davis M, Brekken RA. Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy. Mol Cancer Res 2005;3:413-23.
-
(2005)
Mol Cancer Res
, vol.3
, pp. 413-423
-
-
Fleming, J.B.1
Shen, G.L.2
Holloway, S.E.3
Davis, M.4
Brekken, R.A.5
-
23
-
-
0037401065
-
Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells
-
Qian LW, Mizumoto K, Inadome N, Nagai E, Sato N, Matsumoto K, et al. Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells. Int J Cancer 2003;104:542-9.
-
(2003)
Int J Cancer
, vol.104
, pp. 542-549
-
-
Qian, L.W.1
Mizumoto, K.2
Inadome, N.3
Nagai, E.4
Sato, N.5
Matsumoto, K.6
-
24
-
-
0021888904
-
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
-
Hanahan D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 1985;315:115-22.
-
(1985)
Nature
, vol.315
, pp. 115-122
-
-
Hanahan, D.1
-
25
-
-
0033617532
-
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
-
Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 1999;284:808-12.
-
(1999)
Science
, vol.284
, pp. 808-812
-
-
Bergers, G.1
Javaherian, K.2
Lo, K.M.3
Folkman, J.4
Hanahan, D.5
-
26
-
-
33646420098
-
Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice
-
Beck AW, Luster TA, Miller AF, Holloway SE, Conner CR, Barnett CC, et al. Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice. Int J Cancer 2006;118:2639-43.
-
(2006)
Int J Cancer
, vol.118
, pp. 2639-2643
-
-
Beck, A.W.1
Luster, T.A.2
Miller, A.F.3
Holloway, S.E.4
Conner, C.R.5
Barnett, C.C.6
-
27
-
-
44849093414
-
A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities
-
Christensen JG. A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumour activities. Ann Oncol 2007;18 Suppl 10:x3-10.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 10
-
-
Christensen, J.G.1
-
28
-
-
79958803354
-
The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model
-
Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, et al. The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model. J Bone Miner Res 2011;26:1283-94.
-
(2011)
J Bone Miner Res
, vol.26
, pp. 1283-1294
-
-
Sampson, E.R.1
Martin, B.A.2
Morris, A.E.3
Xie, C.4
Schwarz, E.M.5
O'Keefe, R.J.6
-
29
-
-
80051800007
-
HGFindependent potentiation of EGFR action by c-Met
-
Dulak AM, Gubish CT, Stabile LP, Henry C, Siegfried JM. HGFindependent potentiation of EGFR action by c-Met. Oncogene 2011;30:3625-35.
-
(2011)
Oncogene
, vol.30
, pp. 3625-3635
-
-
Dulak, A.M.1
Gubish, C.T.2
Stabile, L.P.3
Henry, C.4
Siegfried, J.M.5
-
30
-
-
79959936054
-
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
-
Kurzrock R, Sherman SI, Ball DW, Forastiere AA, Cohen RB, Mehra R, et al. Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J Clin Oncol 2011;29:2660-6.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2660-2666
-
-
Kurzrock, R.1
Sherman, S.I.2
Ball, D.W.3
Forastiere, A.A.4
Cohen, R.B.5
Mehra, R.6
-
31
-
-
80053571555
-
Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): Results from a phase II randomized discontinuation trial
-
4516, Abstract
-
Hussain M, Smith MR, Sweeney C, Corn PG, Elfiky A, Gordon MS, et al. Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): Results from a phase II randomized discontinuation trial. J Clin Oncol 2011;29 Suppl: Abstract 4516.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Hussain, M.1
Smith, M.R.2
Sweeney, C.3
Corn, P.G.4
Elfiky, A.5
Gordon, M.S.6
-
32
-
-
83355166909
-
Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
-
Yakes FM, Chen J, Tan J, Yamaguchi K, Shi Y, Yu P, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther 2011;10:2298-308.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2298-2308
-
-
Yakes, F.M.1
Chen, J.2
Tan, J.3
Yamaguchi, K.4
Shi, Y.5
Yu, P.6
-
33
-
-
81855194258
-
c-Met is a marker of pancreatic cancer stem cells and therapeutic target
-
Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, et al. c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology 2011;141:2218-2227. e5.
-
(2011)
Gastroenterology
, vol.141
-
-
Li, C.1
Wu, J.J.2
Hynes, M.3
Dosch, J.4
Sarkar, B.5
Welling, T.H.6
-
34
-
-
3042548695
-
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
-
Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004;165:35-52.
-
(2004)
Am J Pathol
, vol.165
, pp. 35-52
-
-
Inai, T.1
Mancuso, M.2
Hashizume, H.3
Baffert, F.4
Haskell, A.5
Baluk, P.6
-
35
-
-
37549059613
-
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
-
Christensen JG, Zou HY, Arango ME, Li Q, Lee JH, McDonnell SR, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther 2007;6:3314-22.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3314-3322
-
-
Christensen, J.G.1
Zou, H.Y.2
Arango, M.E.3
Li, Q.4
Lee, J.H.5
McDonnell, S.R.6
-
36
-
-
0036350926
-
TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis
-
Bloomston M, Shafii A, Zervos EE, Rosemurgy AS. TIMP-1 overexpression in pancreatic cancer attenuates tumor growth, decreases implantation and metastasis, and inhibits angiogenesis. J Surg Res 2002;102:39-44.
-
(2002)
J Surg Res
, vol.102
, pp. 39-44
-
-
Bloomston, M.1
Shafii, A.2
Zervos, E.E.3
Rosemurgy, A.S.4
-
37
-
-
34347216697
-
Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness
-
Gaspar NJ, Li L, Kapoun AM, Medicherla S, Reddy M, Li G, et al. Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness. Mol Pharmacol 2007;72:152-61.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 152-161
-
-
Gaspar, N.J.1
Li, L.2
Kapoun, A.M.3
Medicherla, S.4
Reddy, M.5
Li, G.6
-
38
-
-
0034255151
-
Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases
-
Bruns CJ, Liu W, Davis DW, Shaheen RM, McConkey DJ, Wilson MR, et al. Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases. Cancer 2000;89:488-99.
-
(2000)
Cancer
, vol.89
, pp. 488-499
-
-
Bruns, C.J.1
Liu, W.2
Davis, D.W.3
Shaheen, R.M.4
McConkey, D.J.5
Wilson, M.R.6
-
39
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouyssegur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006;441:437-43.
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
40
-
-
0035947770
-
Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice
-
Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol 2001;153:1023-34.
-
(2001)
J Cell Biol
, vol.153
, pp. 1023-1034
-
-
Wang, R.1
Ferrell, L.D.2
Faouzi, S.3
Maher, J.J.4
Bishop, J.M.5
-
41
-
-
0037093106
-
Constitutive c-Met signaling through a nonautocrine mechanism promotes metastasis in a transgenic transplantation model
-
Yu Y, Merlino G. Constitutive c-Met signaling through a nonautocrine mechanism promotes metastasis in a transgenic transplantation model. Cancer Res 2002;62:2951-6.
-
(2002)
Cancer Res
, vol.62
, pp. 2951-2956
-
-
Yu, Y.1
Merlino, G.2
-
42
-
-
0034708826
-
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells
-
Jo M, Stolz DB, Esplen JE, Dorko K, Michalopoulos GK, Strom SC. Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. J Biol Chem 2000;275:8806-11.
-
(2000)
J Biol Chem
, vol.275
, pp. 8806-8811
-
-
Jo, M.1
Stolz, D.B.2
Esplen, J.E.3
Dorko, K.4
Michalopoulos, G.K.5
Strom, S.C.6
-
43
-
-
0029759716
-
Cellular adherence elicits ligandindependent activation of the Met cell-surface receptor
-
Wang R, Kobayashi R, Bishop JM. Cellular adherence elicits ligandindependent activation of the Met cell-surface receptor. Proc Natl Acad Sci U S A 1996;93:8425-30.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 8425-8430
-
-
Wang, R.1
Kobayashi, R.2
Bishop, J.M.3
-
44
-
-
76749157917
-
Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency
-
McDermott U, Pusapati RV, Christensen JG, Gray NS, Settleman J. Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency. Cancer Res 2010;70:1625-34.
-
(2010)
Cancer Res
, vol.70
, pp. 1625-1634
-
-
McDermott, U.1
Pusapati, R.V.2
Christensen, J.G.3
Gray, N.S.4
Settleman, J.5
-
45
-
-
79551559942
-
Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors
-
Qi J, McTigue MA, Rogers A, Lifshits E, Christensen JG, Janne PA, et al. Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. Cancer Res 2011;71:1081-91.
-
(2011)
Cancer Res
, vol.71
, pp. 1081-1091
-
-
Qi, J.1
McTigue, M.A.2
Rogers, A.3
Lifshits, E.4
Christensen, J.G.5
Janne, P.A.6
-
46
-
-
0036559535
-
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
-
Lopez T, Hanahan D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 2002;1:339-53.
-
(2002)
Cancer Cell
, vol.1
, pp. 339-353
-
-
Lopez, T.1
Hanahan, D.2
-
47
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008;8:592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
48
-
-
78049256779
-
Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis
-
Chun MG, Mao JH, Chiu CW, Balmain A, Hanahan D. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Proc Natl Acad Sci U S A 2010;107:17268-73.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 17268-17273
-
-
Chun, M.G.1
Mao, J.H.2
Chiu, C.W.3
Balmain, A.4
Hanahan, D.5
-
49
-
-
79961139550
-
TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions
-
Santibanez JF, Quintanilla M, Bernabeu C. TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions. Clin Sci (Lond) 2011;121:233-51.
-
(2011)
Clin Sci (Lond)
, vol.121
, pp. 233-251
-
-
Santibanez, J.F.1
Quintanilla, M.2
Bernabeu, C.3
-
50
-
-
0028318915
-
Modulation of c-MET proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones: Evidence for rapid decay of the 8 kb c-MET transcript
-
Moghul A, Lin L, Beedle A, Kanbour-Shakir A, DeFrances MC, Liu Y, et al. Modulation of c-MET proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones: evidence for rapid decay of the 8 kb c-MET transcript. Oncogene 1994;9:2045-52.
-
(1994)
Oncogene
, vol.9
, pp. 2045-2052
-
-
Moghul, A.1
Lin, L.2
Beedle, A.3
Kanbour-Shakir, A.4
DeFrances, M.C.5
Liu, Y.6
-
51
-
-
54249093237
-
Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion
-
Cheng N, Chytil A, Shyr Y, Joly A, Moses HL. Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion. Mol Cancer Res 2008;6:1521-33.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1521-1533
-
-
Cheng, N.1
Chytil, A.2
Shyr, Y.3
Joly, A.4
Moses, H.L.5
-
52
-
-
0032510494
-
A causal role for E-cadherin in the transition from adenoma to carcinoma
-
Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 1998;392:190-3.
-
(1998)
Nature
, vol.392
, pp. 190-193
-
-
Perl, A.K.1
Wilgenbus, P.2
Dahl, U.3
Semb, H.4
Christofori, G.5
-
53
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-54.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
54
-
-
65349132693
-
EMT, the cytoskeleton, and cancer cell invasion
-
Yilmaz M, Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009;28:15-33.
-
(2009)
Cancer Metastasis Rev
, vol.28
, pp. 15-33
-
-
Yilmaz, M.1
Christofori, G.2
-
55
-
-
0036513626
-
The snail superfamily of zinc-finger transcription factors
-
Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002;3:155-66.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 155-166
-
-
Nieto, M.A.1
-
56
-
-
60649116273
-
Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: Impact on local control and patient survival
-
Narayana A, Kelly P, Golfinos J, Parker E, Johnson G, Knopp E, et al. Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival. J Neurosurg 2009;110:173-80.
-
(2009)
J Neurosurg
, vol.110
, pp. 173-180
-
-
Narayana, A.1
Kelly, P.2
Golfinos, J.3
Parker, E.4
Johnson, G.5
Knopp, E.6
-
57
-
-
3142512610
-
Targeting the tumor and its microenvironment by a dualfunction decoy Met receptor
-
Michieli P, Mazzone M, Basilico C, Cavassa S, Sottile A, Naldini L, et al. Targeting the tumor and its microenvironment by a dualfunction decoy Met receptor. Cancer Cell 2004;6:61-73.
-
(2004)
Cancer Cell
, vol.6
, pp. 61-73
-
-
Michieli, P.1
Mazzone, M.2
Basilico, C.3
Cavassa, S.4
Sottile, A.5
Naldini, L.6
-
58
-
-
33745697763
-
Targeting the c-Met signaling pathway in cancer
-
Peruzzi B, Bottaro DP. Targeting the c-Met signaling pathway in cancer. Clin Cancer Res 2006;12:3657-60.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3657-3660
-
-
Peruzzi, B.1
Bottaro, D.P.2
-
59
-
-
49249100382
-
MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival
-
Jin H, Yang R, Zheng Z, Romero M, Ross J, Bou-Reslan H, et al. MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res 2008;68:4360-8.
-
(2008)
Cancer Res
, vol.68
, pp. 4360-4368
-
-
Jin, H.1
Yang, R.2
Zheng, Z.3
Romero, M.4
Ross, J.5
Bou-Reslan, H.6
-
60
-
-
75749115996
-
Axl is an essential epithelial-to-mesenchymal transitioninduced regulator of breast cancer metastasis and patient survival
-
Gjerdrum C, Tiron C, Hoiby T, Stefansson I, Haugen H, Sandal T, et al. Axl is an essential epithelial-to-mesenchymal transitioninduced regulator of breast cancer metastasis and patient survival. Proc Natl Acad Sci U S A 2010;107:1124-9.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 1124-1129
-
-
Gjerdrum, C.1
Tiron, C.2
Hoiby, T.3
Stefansson, I.4
Haugen, H.5
Sandal, T.6
-
61
-
-
70350230210
-
Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
-
Qian F, Engst S, Yamaguchi K, Yu P, Won KA, Mock L, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res 2009;69:8009-16.
-
(2009)
Cancer Res
, vol.69
, pp. 8009-8016
-
-
Qian, F.1
Engst, S.2
Yamaguchi, K.3
Yu, P.4
Won, K.A.5
Mock, L.6
-
62
-
-
71849098261
-
E7050: A dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models
-
Nakagawa T, Tohyama O, Yamaguchi A, Matsushima T, Takahashi K, Funasaka S, et al. E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models. Cancer Sci 2010;101:210-5.
-
(2010)
Cancer Sci
, vol.101
, pp. 210-215
-
-
Nakagawa, T.1
Tohyama, O.2
Yamaguchi, A.3
Matsushima, T.4
Takahashi, K.5
Funasaka, S.6
-
63
-
-
70149095573
-
Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells
-
Sulpice E, Ding S, Muscatelli-Groux B, Berge M, Han ZC, Plouet J, et al. Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells. Biol Cell 2009;101:525-39.
-
(2009)
Biol Cell
, vol.101
, pp. 525-539
-
-
Sulpice, E.1
Ding, S.2
Muscatelli-Groux, B.3
Berge, M.4
Han, Z.C.5
Plouet, J.6
-
64
-
-
25144464664
-
Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance
-
Dai C, Huh CG, Thorgeirsson SS, Liu Y. Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol 2005;167:429-36.
-
(2005)
Am J Pathol
, vol.167
, pp. 429-436
-
-
Dai, C.1
Huh, C.G.2
Thorgeirsson, S.S.3
Liu, Y.4
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