The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer

Current Cancer Drug Targets

Volumn 11, Issue 9, 2011, Pages 1098-1110

  Liu, Y L ^a   Yang, H P ^a   Zhou, X D ^a   Gong, L ^a   Tang, C L ^a   Wang, H J ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bisdemethoxycurcumin; Lung neoplasms; Promoter demethylation; Wnt inhibitory factor 1

Indexed keywords

BETA CATENIN; DIDEMETHOXYCURCUMIN; DNA METHYLTRANSFERASE 1; WNT PROTEIN; WNT1 PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL TYPE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DOWN REGULATION; DRUG EFFECT; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PROTEIN EXPRESSION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CURCUMIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; MICE, SCID; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; WNT SIGNALING PATHWAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 81255166788     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800911798073041     Document Type: Article

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