-
2
-
-
76249113874
-
The mechanism of mineralization and the role of alkaline phosphatase in health and disease
-
Orimo H. The mechanism of mineralization and the role of alkaline phosphatase in health and disease. J Nippon Med Sch. 2010;77(1):4-12.
-
(2010)
J Nippon Med Sch
, vol.77
, Issue.1
, pp. 4-12
-
-
Orimo, H.1
-
3
-
-
0034284970
-
Bone resorption by osteoclasts
-
Teitelbaum SL. Bone resorption by osteoclasts. Science. 2000; 289(5484):1504-1508.
-
(2000)
Science
, vol.289
, Issue.5484
, pp. 1504-1508
-
-
Teitelbaum, S.L.1
-
4
-
-
0034285013
-
The osteoblast: A sophisticated fibroblast under central surveillance
-
Ducy P, Schinke T, Karsenty G. The osteoblast: a sophisticated fibroblast under central surveillance. Science. 2000;289(5484):1501-1504.
-
(2000)
Science
, vol.289
, Issue.5484
, pp. 1501-1504
-
-
Ducy, P.1
Schinke, T.2
Karsenty, G.3
-
5
-
-
0034618580
-
Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: Modulation of the expression by osteotropic factors and cytokines
-
Nakashima T, Kobayashi Y, Yamasaki S, et al. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem Biophys Res Commun. 2000; 275(3):768-775.
-
(2000)
Biochem Biophys Res Commun
, vol.275
, Issue.3
, pp. 768-775
-
-
Nakashima, T.1
Kobayashi, Y.2
Yamasaki, S.3
-
6
-
-
42049110350
-
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease
-
Kearns AE, Khosla S, Kostenuik PJ. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev. 2008;29(2):155-192.
-
(2008)
Endocr Rev
, vol.29
, Issue.2
, pp. 155-192
-
-
Kearns, A.E.1
Khosla, S.2
Kostenuik, P.J.3
-
7
-
-
0028035150
-
Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity
-
Martin TJ, Ng KW. Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity. J Cell Biochem. 1994;56(3): 357-366.
-
(1994)
J Cell Biochem
, vol.56
, Issue.3
, pp. 357-366
-
-
Martin, T.J.1
Ng, K.W.2
-
8
-
-
18744366041
-
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
-
Takayanagi H, Kim S, Koga T, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Developmental Cell. 2002; 3(6):889-901.
-
(2002)
Developmental Cell
, vol.3
, Issue.6
, pp. 889-901
-
-
Takayanagi, H.1
Kim, S.2
Koga, T.3
-
9
-
-
0037673945
-
Osteoclast differentiation and activation
-
Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003;423(6937):337-342.
-
(2003)
Nature
, vol.423
, Issue.6937
, pp. 337-342
-
-
Boyle, W.J.1
Simonet, W.S.2
Lacey, D.L.3
-
10
-
-
33845994375
-
Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF- κ B ligand
-
Hikita A, Yana I, Wakeyama H, et al. Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF- κ B ligand. J Biol Chem. 2006;281(48):36846-36855.
-
(2006)
J Biol Chem
, vol.281
, Issue.48
, pp. 36846-36855
-
-
Hikita, A.1
Yana, I.2
Wakeyama, H.3
-
11
-
-
21144438505
-
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL
-
Lynch CC, Hikosaka A, Acuff HB, et al. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell. 2005;7(5):485-496.
-
(2005)
Cancer Cell
, vol.7
, Issue.5
, pp. 485-496
-
-
Lynch, C.C.1
Hikosaka, A.2
Acuff, H.B.3
-
12
-
-
79957896060
-
Is RANKL shedding involved in immune cell-mediated osteoclastogenesis? Interface Oral Health Science. 2009
-
Sasano T, Suzuki O, Kanzaki H, et al. Is RANKL shedding involved in immune cell-mediated osteoclastogenesis? Interface Oral Health Science. 2009: Springer Japan; 2010:403-405.
-
(2010)
Springer Japan
, pp. 403-405
-
-
Sasano, T.1
Suzuki, O.2
Kanzaki, H.3
-
13
-
-
0023784985
-
Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts
-
Vaes G. Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts. Clin Orthop Relat Res. 1988;231: 239-271.
-
(1988)
Clin Orthop Relat Res
, vol.231
, pp. 239-271
-
-
Vaes, G.1
-
14
-
-
57449116758
-
Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited
-
Teti A, Zallone A. Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited. Bone. 2009;44(1):11-16.
-
(2009)
Bone
, vol.44
, Issue.1
, pp. 11-16
-
-
Teti, A.1
Zallone, A.2
-
15
-
-
0036197329
-
Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-beta: Enhancement by estrogen
-
Heino TJ, Hentunen TA, Vaananen HK. Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-beta: enhancement by estrogen. J Cell Biochem. 2002;85(1):185-197.
-
(2002)
J Cell Biochem
, vol.85
, Issue.1
, pp. 185-197
-
-
Heino, T.J.1
Hentunen, T.A.2
Vaananen, H.K.3
-
16
-
-
33846284505
-
Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions
-
Taylor AF, Saunders MM, Shingle DL, Cimbala JM, Zhou Z, Donahue HJ. Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions. Am J Physiol Cell Physiol. 2007;292(1):C545-C552.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
, Issue.1
, pp. 545-552
-
-
Taylor, A.F.1
Saunders, M.M.2
Shingle, D.L.3
Cimbala, J.M.4
Zhou, Z.5
Donahue, H.J.6
-
17
-
-
70349495272
-
A trabecular bone explant model of osteocyte-osteoblast co-culture for bone mechanobiology
-
Chan M, Lu X, Huo B, et al. A trabecular bone explant model of osteocyte-osteoblast co-culture for bone mechanobiology. Cell Mol Bioeng. 2009;2(3):405-415.
-
(2009)
Cell Mol Bioeng
, vol.2
, Issue.3
, pp. 405-415
-
-
Chan, M.1
Lu, X.2
Huo, B.3
-
18
-
-
58249095935
-
Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells
-
Ara T, Song L, Shimada H, et al. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res. 2009;69(1):329-337.
-
(2009)
Cancer Res
, vol.69
, Issue.1
, pp. 329-337
-
-
Ara, T.1
Song, L.2
Shimada, H.3
-
19
-
-
0031798846
-
Enhanced expression of interleukin- 6 in bone and serum of metastatic renal cell carcinoma
-
Paule B, Clerc D, Rudant C, et al. Enhanced expression of interleukin- 6 in bone and serum of metastatic renal cell carcinoma. Hum Pathol. 1998;29(4):421-424.
-
(1998)
Hum Pathol
, vol.29
, Issue.4
, pp. 421-424
-
-
Paule, B.1
Clerc, D.2
Rudant, C.3
-
20
-
-
0033305222
-
Breast cancer cells interact with osteoblasts to support osteoclast formation
-
Thomas RJ, Guise TA, Yin JJ, et al. Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology. 1999; 140(10):4451-4458.
-
(1999)
Endocrinology
, vol.140
, Issue.10
, pp. 4451-4458
-
-
Thomas, R.J.1
Guise, T.A.2
Yin, J.J.3
-
21
-
-
33750726077
-
Clinical features of metastatic bone disease and risk of skeletal morbidity
-
Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 2006;12(20):6243s-6249s.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.20
-
-
Coleman, R.E.1
-
22
-
-
0023137823
-
The clinical course of bone metastases from breast cancer
-
Coleman RE, Rubens RD. The clinical course of bone metastases from breast cancer. Br J Cancer. 1987;55(1):61-66.
-
(1987)
Br J Cancer
, vol.55
, Issue.1
, pp. 61-66
-
-
Coleman, R.E.1
Rubens, R.D.2
-
23
-
-
0033509949
-
Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival
-
DuBois SG, Kalika Y, Lukens JN, et al. Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival. J Pediatr Hematol/Oncol. 1999;21(3):181-189.
-
(1999)
J Pediatr Hematol/Oncol
, vol.21
, Issue.3
, pp. 181-189
-
-
Dubois, S.G.1
Kalika, Y.2
Lukens, J.N.3
-
24
-
-
73349127846
-
Treatment of bone metastases in lung cancer: The actual role of zoledronic acid
-
Ricciardi S, de Marinis F. Treatment of bone metastases in lung cancer: the actual role of zoledronic acid. Rev Recent Clin Trials. 2009;4(3): 205-211.
-
(2009)
Rev Recent Clin Trials
, vol.4
, Issue.3
, pp. 205-211
-
-
Ricciardi, S.1
de Marinis, F.2
-
25
-
-
0032733840
-
Genetically fluorescent melanoma bone and organ metastasis models
-
Yang M, Jiang P, An Z, et al. Genetically fluorescent melanoma bone and organ metastasis models. Clin Cancer Res. 1999;5(11):3549-3559.
-
(1999)
Clin Cancer Res
, vol.5
, Issue.11
, pp. 3549-3559
-
-
Yang, M.1
Jiang, P.2
An, Z.3
-
26
-
-
33750738067
-
Basic mechanisms responsible for osteolytic and osteoblastic bone metastases
-
Guise TA, Mohammad KS, Clines G, et al. Basic mechanisms responsible for osteolytic and osteoblastic bone metastases. Clin Cancer Res. 2006;12(20 Pt 2):6213s-6216s.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.20 PART. 2
-
-
Guise, T.A.1
Mohammad, K.S.2
Clines, G.3
-
27
-
-
0033134951
-
Skeletal metastasis of prostate adenocarcinoma in rats: Morphometric analysis and role of parathyroid hormone-related protein
-
Eric AGB, Kristiann MD, Kenneth JP, Charles CC, Thomas JR, Laurie KM. Skeletal metastasis of prostate adenocarcinoma in rats: morphometric analysis and role of parathyroid hormone-related protein. Prostate. 1999;39(3):187-197.
-
(1999)
Prostate
, vol.39
, Issue.3
, pp. 187-197
-
-
Eric, A.G.B.1
Kristiann, M.D.2
Kenneth, J.P.3
Charles, C.C.4
Thomas, J.R.5
Laurie, K.M.6
-
28
-
-
11344267803
-
Prostate cancer bone metastases promote both osteolytic and osteoblastic activity
-
Keller ET, Brown J. Prostate cancer bone metastases promote both osteolytic and osteoblastic activity. J Cell Biochem. 2004;91(4): 718-729.
-
(2004)
J Cell Biochem
, vol.91
, Issue.4
, pp. 718-729
-
-
Keller, E.T.1
Brown, J.2
-
29
-
-
4644261592
-
Mechanisms of bone metastasis
-
Roodman GD. Mechanisms of bone metastasis. N Engl J Med. 2004; 350(16):1655-1664.
-
(2004)
N Engl J Med
, vol.350
, Issue.16
, pp. 1655-1664
-
-
Roodman, G.D.1
-
30
-
-
0035010803
-
Metastatic bone disease: Clinical features, pathophysiology and treatment strategies
-
Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treat Rev. 2001;27(3): 165-176.
-
(2001)
Cancer Treat Rev
, vol.27
, Issue.3
, pp. 165-176
-
-
Coleman, R.E.1
-
31
-
-
0037085938
-
-
Taichman RS, Cooper C, Keller ET, Pienta KJ, Taichman NS, McCauley LK. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. 2002;62:1832-1837.
-
(2002)
Use of the Stromal Cell-derived Factor-1/CXCR4 Pathway In Prostate Cancer Metastasis to Bone
, vol.62
, pp. 1832-1837
-
-
Taichman, R.S.1
Cooper, C.2
Keller, E.T.3
Pienta, K.J.4
Taichman, N.S.5
McCauley, L.K.6
-
32
-
-
40949136474
-
CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone
-
Chinni SR, Yamamoto H, Dong Z, Sabbota A, Bonfil RD, Cher ML. CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone. Mol Cancer Res. 2008;6(3):446-457.
-
(2008)
Mol Cancer Res
, vol.6
, Issue.3
, pp. 446-457
-
-
Chinni, S.R.1
Yamamoto, H.2
Dong, Z.3
Sabbota, A.4
Bonfil, R.D.5
Cher, M.L.6
-
33
-
-
77949890714
-
Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain
-
Hinton CV, Avraham S, Avraham HK. Role of the CXCR4/CXCL12 signaling axis in breast cancer metastasis to the brain. Clin Exp Metastasis. 2010;27(2):97-105.
-
(2010)
Clin Exp Metastasis
, vol.27
, Issue.2
, pp. 97-105
-
-
Hinton, C.V.1
Avraham, S.2
Avraham, H.K.3
-
34
-
-
33746868899
-
Functions of CXCL12 and CXCR4 in breast cancer
-
Luker KE, Luker GD. Functions of CXCL12 and CXCR4 in breast cancer. Cancer Lett. 2006;238(1):30-41.
-
(2006)
Cancer Lett
, vol.238
, Issue.1
, pp. 30-41
-
-
Luker, K.E.1
Luker, G.D.2
-
35
-
-
70349147030
-
CXCL12/CXCR4 axis in tissue targeting and bone destruction in cancer and multiple myeloma
-
Ooi LL, Dunstan CR. CXCL12/CXCR4 axis in tissue targeting and bone destruction in cancer and multiple myeloma. J Bone Miner Res. 2009;24(7):1147-1149.
-
(2009)
J Bone Miner Res
, vol.24
, Issue.7
, pp. 1147-1149
-
-
Ooi, L.L.1
Dunstan, C.R.2
-
36
-
-
0038498102
-
NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4
-
Helbig G, Christopherson KW 2nd, Bhat-Nakshatri P, et al. NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem. 2003; 278(24):21631-21638.
-
(2003)
J Biol Chem
, vol.278
, Issue.24
, pp. 21631-21638
-
-
Helbig, G.1
Christopherson, K.W.2
Bhat-Nakshatri, P.3
-
37
-
-
77950882020
-
The CXCR4/SDF-1 chemokine axis: A potential therapeutic target for bone metastases?
-
Hirbe AC, Morgan EA, Weilbaecher KN. The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases? Curr Pharm Des. 2010;16(11):1284-1290.
-
(2010)
Curr Pharm Des
, vol.16
, Issue.11
, pp. 1284-1290
-
-
Hirbe, A.C.1
Morgan, E.A.2
Weilbaecher, K.N.3
-
38
-
-
0023037767
-
Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-sepharose
-
Hauschka PV, Mavrakos AE, Iafrati MD, Doleman SE, Klagsbrun M. Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-sepharose. J Biol Chem. 1986;261(27): 12665-12674.
-
(1986)
J Biol Chem
, vol.261
, Issue.27
, pp. 12665-12674
-
-
Hauschka, P.V.1
Mavrakos, A.E.2
Iafrati, M.D.3
Doleman, S.E.4
Klagsbrun, M.5
-
40
-
-
40649109728
-
The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer
-
Naugler WE, Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med. 2008;14(3):109-119.
-
(2008)
Trends Mol Med
, vol.14
, Issue.3
, pp. 109-119
-
-
Naugler, W.E.1
Karin, M.2
-
41
-
-
84925549112
-
The paradigm of IL-6: From basic science to medicine
-
Naka T, Nishimoto N, Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res. 2002;4 Suppl 3:S233-S242.
-
(2002)
Arthritis Res
, vol.4
, Issue.SUPPL. 3
, pp. 233-242
-
-
Naka, T.1
Nishimoto, N.2
Kishimoto, T.3
-
42
-
-
68949215504
-
Pathology of bone injury
-
Athanasou NA. Pathology of bone injury. Diagn Histopathol. 2009; 15(9):437-443.
-
(2009)
Diagn Histopathol
, vol.15
, Issue.9
, pp. 437-443
-
-
Athanasou, N.A.1
-
43
-
-
0025248775
-
Interleukin-1 induces interleukin-6 production in peripheral blood monocytes
-
Tosato G, Jones KD. Interleukin-1 induces interleukin-6 production in peripheral blood monocytes. Blood. 1990;75(6):1305-1310.
-
(1990)
Blood
, vol.75
, Issue.6
, pp. 1305-1310
-
-
Tosato, G.1
Jones, K.D.2
-
44
-
-
0028174011
-
Prostaglandin E2 stimulates the production of interleukin-6 by neonatal mouse parietal bones
-
Holt I, Davie MW, Braidman IP, Marshall MJ. Prostaglandin E2 stimulates the production of interleukin-6 by neonatal mouse parietal bones. Bone Miner. 1994;25(1):47-57.
-
(1994)
Bone Miner
, vol.25
, Issue.1
, pp. 47-57
-
-
Holt, I.1
Davie, M.W.2
Braidman, I.P.3
Marshall, M.J.4
-
45
-
-
0033617143
-
Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts
-
Eickelberg O, Pansky A, Mussmann R, et al. Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts. J Biol Chem. 1999;274(18):12933-12938.
-
(1999)
J Biol Chem
, vol.274
, Issue.18
, pp. 12933-12938
-
-
Eickelberg, O.1
Pansky, A.2
Mussmann, R.3
-
46
-
-
0028963365
-
Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF IL 6 and NF-kappa B
-
Zhang Y, Broser M, Rom W. Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF IL 6 and NF-kappa B. Proc Natl Acad Sci U S A. 1995;92(8):3632.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, Issue.8
, pp. 3632
-
-
Zhang, Y.1
Broser, M.2
Rom, W.3
-
47
-
-
0025343895
-
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
-
Libermann TA, Baltimore D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol. 1990; 10(5):2327-2334.
-
(1990)
Mol Cell Biol
, vol.10
, Issue.5
, pp. 2327-2334
-
-
Libermann, T.A.1
Baltimore, D.2
-
48
-
-
33847170583
-
Tumour necrosis factoralpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells
-
Fitzgerald DC, Meade KG, McEvoy AN, et al. Tumour necrosis factoralpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells. Vet Immunol Immunopathol. 2007;116(1-2):59-68.
-
(2007)
Vet Immunol Immunopathol
, vol.116
, Issue.1-2
, pp. 59-68
-
-
Fitzgerald, D.C.1
Meade, K.G.2
McEvoy, A.N.3
-
49
-
-
33749336430
-
Interleukin 6, a nuclear factor-kappaB target, predicts resistance to docetaxel in hormoneindependent prostate cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity
-
Domingo-Domenech J, Oliva C, Rovira A, et al. Interleukin 6, a nuclear factor-kappaB target, predicts resistance to docetaxel in hormoneindependent prostate cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity. Clin Cancer Res. 2006;12(18):5578-5586.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.18
, pp. 5578-5586
-
-
Domingo-Domenech, J.1
Oliva, C.2
Rovira, A.3
-
50
-
-
0032168152
-
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
-
Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J. 1998;334 (Pt 2):297-314.
-
(1998)
Biochem J
, vol.334
, Issue.PART. 2
, pp. 297-314
-
-
Heinrich, P.C.1
Behrmann, I.2
Muller-Newen, G.3
Schaper, F.4
Graeve, L.5
-
51
-
-
0027199126
-
IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase
-
Murakami M, Hibi M, Nakagawa N, et al. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science. 1993;260(5115):1808-1810.
-
(1993)
Science
, vol.260
, Issue.5115
, pp. 1808-1810
-
-
Murakami, M.1
Hibi, M.2
Nakagawa, N.3
-
52
-
-
39649113108
-
Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival
-
Wegiel B, Bjartell A, Culig Z, Persson JL. Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival. Int J Cancer. 2008;122(7):1521-1529.
-
(2008)
Int J Cancer
, vol.122
, Issue.7
, pp. 1521-1529
-
-
Wegiel, B.1
Bjartell, A.2
Culig, Z.3
Persson, J.L.4
-
53
-
-
54449101331
-
IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17
-
Hashizume M, Hayakawa N, Mihara M. IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. Rheumatology (Oxford). 2008;47(11):1635-1640.
-
(2008)
Rheumatology (Oxford)
, vol.47
, Issue.11
, pp. 1635-1640
-
-
Hashizume, M.1
Hayakawa, N.2
Mihara, M.3
-
54
-
-
0033516661
-
STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone
-
O'Brien CA, Gubrij I, Lin SC, Saylors RL, Manolagas SC. STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone. J Biol Chem. 1999;274(27):19301-19308.
-
(1999)
J Biol Chem
, vol.274
, Issue.27
, pp. 19301-19308
-
-
O'Brien, C.A.1
Gubrij, I.2
Lin, S.C.3
Saylors, R.L.4
Manolagas, S.C.5
-
55
-
-
31044449633
-
Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis
-
Wong PK, Quinn JM, Sims NA, van Nieuwenhuijze A, Campbell IK, Wicks IP. Interleukin-6 modulates production of T lymphocyte-derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis. Arthritis Rheum. 2006;54(1):158-168.
-
(2006)
Arthritis Rheum
, vol.54
, Issue.1
, pp. 158-168
-
-
Wong, P.K.1
Quinn, J.M.2
Sims, N.A.3
van Nieuwenhuijze, A.4
Campbell, I.K.5
Wicks, I.P.6
-
56
-
-
36248965294
-
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cellmediated pathology
-
McGeachy MJ, Bak-Jensen KS, Chen Y, et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cellmediated pathology. Nat Immunol. 2007;8(12):1390-1397.
-
(2007)
Nat Immunol
, vol.8
, Issue.12
, pp. 1390-1397
-
-
McGeachy, M.J.1
Bak-Jensen, K.S.2
Chen, Y.3
-
57
-
-
67650495415
-
IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway
-
Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H. IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med. 2009;206(7):1457-1464.
-
(2009)
J Exp Med
, vol.206
, Issue.7
, pp. 1457-1464
-
-
Wang, L.1
Yi, T.2
Kortylewski, M.3
Pardoll, D.M.4
Zeng, D.5
Yu, H.6
-
58
-
-
18444412566
-
Differential effects of interleukin-6 receptor activation on intracellular signaling and bone resorption by isolated rat osteoclasts
-
Moonga BS, Adebanjo OA, Wang HJ, et al. Differential effects of interleukin-6 receptor activation on intracellular signaling and bone resorption by isolated rat osteoclasts. J Endocrinol. 2002;173(3):395-405.
-
(2002)
J Endocrinol
, vol.173
, Issue.3
, pp. 395-405
-
-
Moonga, B.S.1
Adebanjo, O.A.2
Wang, H.J.3
-
59
-
-
18444380548
-
Postmenopausal osteoporosis and hormone replacement therapy
-
Gambacciani M, Vacca F. Postmenopausal osteoporosis and hormone replacement therapy. Minerva Med. 2004;95(6):507-520.
-
(2004)
Minerva Med
, vol.95
, Issue.6
, pp. 507-520
-
-
Gambacciani, M.1
Vacca, F.2
-
60
-
-
0035542661
-
17beta-Estradiol progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production
-
Kanda N, Watanabe S. 17beta-estradiol, progesterone, and dihydrotestosterone suppress the growth of human melanoma by inhibiting interleukin-8 production. J Invest Dermatol. 2001;117(2):274-283.
-
(2001)
J Invest Dermatol
, vol.117
, Issue.2
, pp. 274-283
-
-
Kanda, N.1
Watanabe, S.2
-
61
-
-
2642566162
-
17 beta-estradiol regulates cytokine release through modulation of CD16 expression in monocytes and monocyte-derived macrophages
-
Kramer PR, Kramer SF, Guan G. 17 beta-estradiol regulates cytokine release through modulation of CD16 expression in monocytes and monocyte-derived macrophages. Arthritis Rheum. 2004;50(6): 1967-1975.
-
(2004)
Arthritis Rheum
, vol.50
, Issue.6
, pp. 1967-1975
-
-
Kramer, P.R.1
Kramer, S.F.2
Guan, G.3
-
62
-
-
0042707678
-
Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease
-
Bendre MS, Montague DC, Peery T, Akel NS, Gaddy D, Suva LJ. Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease. Bone. 2003;33(1):28-37.
-
(2003)
Bone
, vol.33
, Issue.1
, pp. 28-37
-
-
Bendre, M.S.1
Montague, D.C.2
Peery, T.3
Akel, N.S.4
Gaddy, D.5
Suva, L.J.6
-
63
-
-
14844309301
-
Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway
-
Manna SK, Ramesh GT. Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway. J Biol Chem. 2005;280(8):7010-7021.
-
(2005)
J Biol Chem
, vol.280
, Issue.8
, pp. 7010-7021
-
-
Manna, S.K.1
Ramesh, G.T.2
-
64
-
-
48049093247
-
Differential IL-6 and VEGF secretion in adult and neonatal mesenchymal stem cells: Role of NFkB
-
Novotny NM, Markel TA, Crisostomo PR, Meldrum DR. Differential IL-6 and VEGF secretion in adult and neonatal mesenchymal stem cells: role of NFkB. Cytokine. 2008;43(2):215-219.
-
(2008)
Cytokine
, vol.43
, Issue.2
, pp. 215-219
-
-
Novotny, N.M.1
Markel, T.A.2
Crisostomo, P.R.3
Meldrum, D.R.4
-
65
-
-
30544443971
-
17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells
-
Lesmeister MJ, Jorgenson RL, Young SL, Misfeldt ML. 17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells. Reprod Biol Endocrinol. 2005;3:74.
-
(2005)
Reprod Biol Endocrinol
, vol.3
, pp. 74
-
-
Lesmeister, M.J.1
Jorgenson, R.L.2
Young, S.L.3
Misfeldt, M.L.4
-
66
-
-
0032499534
-
NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha
-
Bhat-Nakshatri P, Newton TR, Goulet R Jr, Nakshatri H. NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha. Proc Natl Acad Sci U S A. 1998;95(12):6971-6976.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.12
, pp. 6971-6976
-
-
Bhat-Nakshatri, P.1
Newton, T.R.2
Goulet Jr., R.3
Nakshatri, H.4
-
67
-
-
0035943676
-
Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3
-
Wang LH, Yang XY, Mihalic K, Xiao W, Li D, Farrar WL. Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3. J Biol Chem. 2001;276(34):31839-31844.
-
(2001)
J Biol Chem
, vol.276
, Issue.34
, pp. 31839-31844
-
-
Wang, L.H.1
Yang, X.Y.2
Mihalic, K.3
Xiao, W.4
Li, D.5
Farrar, W.L.6
-
68
-
-
0036260603
-
Testosterone stimulates proliferation and inhibits interleukin-6 production of normal and hereditary gingival fibromatosis fibroblasts
-
Coletta RD, Reynolds MA, Martelli-Junior H, Graner E, Almeida OP, Sauk JJ. Testosterone stimulates proliferation and inhibits interleukin-6 production of normal and hereditary gingival fibromatosis fibroblasts. Oral Microbiol Immunol. 2002;17(3):186-192.
-
(2002)
Oral Microbiol Immunol
, vol.17
, Issue.3
, pp. 186-192
-
-
Coletta, R.D.1
Reynolds, M.A.2
Martelli-Junior, H.3
Graner, E.4
Almeida, O.P.5
Sauk, J.J.6
-
69
-
-
59849114732
-
Testosterone, bone and osteoporosis
-
Tuck SP, Francis RM. Testosterone, bone and osteoporosis. Front Horm Res. 2009;37:123-132.
-
(2009)
Front Horm Res
, vol.37
, pp. 123-132
-
-
Tuck, S.P.1
Francis, R.M.2
-
70
-
-
0034045441
-
Testosterone suppresses the response of the hypothalamic-pituitary-adrenal axis to interleukin-6
-
Papadopoulos AD, Wardlaw SL. Testosterone suppresses the response of the hypothalamic-pituitary-adrenal axis to interleukin-6. Neuroimmunomodulation. 2000;8(1):39-44.
-
(2000)
Neuroimmunomodulation
, vol.8
, Issue.1
, pp. 39-44
-
-
Papadopoulos, A.D.1
Wardlaw, S.L.2
-
71
-
-
5444245835
-
Prevention and management of osteoporosis in women with breast cancer and men with prostate cancer
-
Hershman D, Narayanan R. Prevention and management of osteoporosis in women with breast cancer and men with prostate cancer. Curr Oncol Rep. 2004;6(4):277-284.
-
(2004)
Curr Oncol Rep
, vol.6
, Issue.4
, pp. 277-284
-
-
Hershman, D.1
Narayanan, R.2
-
72
-
-
0028810948
-
Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin
-
Barille S, Collette M, Bataille R, Amiot M. Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin. Blood. 1995;86(8):3151-3159.
-
(1995)
Blood
, vol.86
, Issue.8
, pp. 3151-3159
-
-
Barille, S.1
Collette, M.2
Bataille, R.3
Amiot, M.4
-
73
-
-
39449138376
-
Interactions between microenvironment and cancer cells in two animal models of bone metastasis
-
Blouin S, Basle MF, Chappard D. Interactions between microenvironment and cancer cells in two animal models of bone metastasis. Br J Cancer. 2008;98(4):809-815.
-
(2008)
Br J Cancer
, vol.98
, Issue.4
, pp. 809-815
-
-
Blouin, S.1
Basle, M.F.2
Chappard, D.3
-
74
-
-
34948859456
-
Increased Dickkopf-1 expression in breast cancer bone metastases
-
Voorzanger-Rousselot N, Goehrig D, Journe F, et al. Increased Dickkopf-1 expression in breast cancer bone metastases. Br J Cancer. 2007;97(7):964-970.
-
(2007)
Br J Cancer
, vol.97
, Issue.7
, pp. 964-970
-
-
Voorzanger-Rousselot, N.1
Goehrig, D.2
Journe, F.3
-
75
-
-
54549093635
-
Oral squamous cell carcinomas stimulate osteoclast differentiation
-
Deyama Y, Tei K, Yoshimura Y, et al. Oral squamous cell carcinomas stimulate osteoclast differentiation. Oncol Rep. 2008;20(3):663-668.
-
(2008)
Oncol Rep
, vol.20
, Issue.3
, pp. 663-668
-
-
Deyama, Y.1
Tei, K.2
Yoshimura, Y.3
-
76
-
-
36549049974
-
Metastatic breast cancer induces an osteoblast inflammatory response
-
Kinder M, Chislock E, Bussard KM, Shuman L, Mastro AM. Metastatic breast cancer induces an osteoblast inflammatory response. Exp Cell Res. 2008;314(1):173-183.
-
(2008)
Exp Cell Res
, vol.314
, Issue.1
, pp. 173-183
-
-
Kinder, M.1
Chislock, E.2
Bussard, K.M.3
Shuman, L.4
Mastro, A.M.5
-
77
-
-
70849087652
-
Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer
-
Chen YC, Sosnoski DM, Gandhi UH, Novinger LJ, Prabhu KS, Mastro AM. Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer. Carcinogenesis. 2009;30(11): 1941-1948.
-
(2009)
Carcinogenesis
, vol.30
, Issue.11
, pp. 1941-1948
-
-
Chen, Y.C.1
Sosnoski, D.M.2
Gandhi, U.H.3
Novinger, L.J.4
Prabhu, K.S.5
Mastro, A.M.6
-
78
-
-
62649173106
-
Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts
-
Mizutani K, Sud S, Pienta KJ. Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts. J Cell Biochem. 2009;106(4): 563-569.
-
(2009)
J Cell Biochem
, vol.106
, Issue.4
, pp. 563-569
-
-
Mizutani, K.1
Sud, S.2
Pienta, K.J.3
-
79
-
-
0037265995
-
Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism
-
Kudo O, Sabokbar A, Pocock A, Itonaga I, Fujikawa Y, Athanasou NA. Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. Bone. 2003;32(1):1-7.
-
(2003)
Bone
, vol.32
, Issue.1
, pp. 1-7
-
-
Kudo, O.1
Sabokbar, A.2
Pocock, A.3
Itonaga, I.4
Fujikawa, Y.5
Athanasou, N.A.6
-
80
-
-
34548401627
-
Clinical development of anti-RANKL therapy
-
Schwarz EM, Ritchlin CT. Clinical development of anti-RANKL therapy. Arthritis Res Ther. 2007;9 Suppl 1:S7.
-
(2007)
Arthritis Res Ther
, vol.9
, Issue.SUPPL. 1
-
-
Schwarz, E.M.1
Ritchlin, C.T.2
-
81
-
-
3042714222
-
Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity
-
Lee KM, Kang BS, Lee HL, et al. Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity. Eur J Neurosci. 2004;19(12):3375-3381.
-
(2004)
Eur J Neurosci
, vol.19
, Issue.12
, pp. 3375-3381
-
-
Lee, K.M.1
Kang, B.S.2
Lee, H.L.3
-
82
-
-
0029671291
-
Prostaglandin E2 stimulates osteoclast-like cell formation and boneresorbing activity via osteoblasts: Role of cAMP-dependent protein kinase
-
Kaji H, Sugimoto T, Kanatani M, Fukase M, Kumegawa M, Chihara K. Prostaglandin E2 stimulates osteoclast-like cell formation and boneresorbing activity via osteoblasts: role of cAMP-dependent protein kinase. J Bone Miner Res. 1996;11(1):62-71.
-
(1996)
J Bone Miner Res
, vol.11
, Issue.1
, pp. 62-71
-
-
Kaji, H.1
Sugimoto, T.2
Kanatani, M.3
Fukase, M.4
Kumegawa, M.5
Chihara, K.6
-
83
-
-
0025313227
-
IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release
-
Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol. 1990;144(11): 4226-4230.
-
(1990)
J Immunol
, vol.144
, Issue.11
, pp. 4226-4230
-
-
Kurihara, N.1
Bertolini, D.2
Suda, T.3
Akiyama, Y.4
Roodman, G.D.5
-
84
-
-
0031021187
-
Effects of antioxidant enzyme modulations on interleukin-1-induced nuclear factor kappa B activation
-
Renard P, Zachary MD, Bougelet C, et al. Effects of antioxidant enzyme modulations on interleukin-1-induced nuclear factor kappa B activation. Biochem Pharmacol. 1997;53(2):149-160.
-
(1997)
Biochem Pharmacol
, vol.53
, Issue.2
, pp. 149-160
-
-
Renard, P.1
Zachary, M.D.2
Bougelet, C.3
-
85
-
-
38649109161
-
An overview of prognostic factors for long-term survivors of breast cancer
-
Soerjomataram I, Louwman MW, Ribot JG, Roukema JA, Coebergh JW. An overview of prognostic factors for long-term survivors of breast cancer. Breast Cancer Res Treat. 2008;107(3):309-330.
-
(2008)
Breast Cancer Res Treat
, vol.107
, Issue.3
, pp. 309-330
-
-
Soerjomataram, I.1
Louwman, M.W.2
Ribot, J.G.3
Roukema, J.A.4
Coebergh, J.W.5
-
86
-
-
41149166182
-
Prostate-specific antigen and prostate cancer: Prediction, detection and monitoring
-
Lilja H, Ulmert D, Vickers AJ. Prostate-specific antigen and prostate cancer: prediction, detection and monitoring. Nat Rev Cancer. 2008; 8(4):268-278.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.4
, pp. 268-278
-
-
Lilja, H.1
Ulmert, D.2
Vickers, A.J.3
-
87
-
-
36849069347
-
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
-
Harris L, Fritsche H, Mennel R, et al. American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol. 2007;25(33):5287-5312.
-
(2007)
J Clin Oncol
, vol.25
, Issue.33
, pp. 5287-5312
-
-
Harris, L.1
Fritsche, H.2
Mennel, R.3
-
89
-
-
33947414063
-
Significance of interleukin-6 (IL-6) in breast cancer (review)
-
Knüpfer H, Preiß R. Significance of interleukin-6 (IL-6) in breast cancer (review). Breast Cancer Res Treat. 2007;102(2):129-135.
-
(2007)
Breast Cancer Res Treat
, vol.102
, Issue.2
, pp. 129-135
-
-
Knüpfer, H.1
Preiß, R.2
-
90
-
-
33846519859
-
Interleukin 6 is associated with cachexia in patients with prostate cancer
-
Kuroda K, Nakashima J, Kanao K, et al. Interleukin 6 is associated with cachexia in patients with prostate cancer. Urology. 2007; 69(1):113-117.
-
(2007)
Urology
, vol.69
, Issue.1
, pp. 113-117
-
-
Kuroda, K.1
Nakashima, J.2
Kanao, K.3
-
91
-
-
65549159745
-
Serum interleukin-6 in patients with metastatic bone disease: Correlation with cystatin C
-
Tumminello FM, Badalamenti G, Incorvaia L, Fulfaro F, D'Amico C, Leto G. Serum interleukin-6 in patients with metastatic bone disease: correlation with cystatin C. Med Oncol. 2008;26(1):10-15.
-
(2008)
Med Oncol
, vol.26
, Issue.1
, pp. 10-15
-
-
Tumminello, F.M.1
Badalamenti, G.2
Incorvaia, L.3
Fulfaro, F.4
D'amico, C.5
Leto, G.6
-
92
-
-
16344365813
-
The prognostic significance of plasma interleukin-6 levels in patients with metastatic hormonerefractory prostate cancer: Results from cancer and leukemia group B 9480
-
George DJ, Halabi S, Shepard TF, et al. The prognostic significance of plasma interleukin-6 levels in patients with metastatic hormonerefractory prostate cancer: results from cancer and leukemia group B 9480. Clin Cancer Res. 2005;11(5):1815-1820.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.5
, pp. 1815-1820
-
-
George, D.J.1
Halabi, S.2
Shepard, T.F.3
-
93
-
-
52149115150
-
Prognostic value of serum level of interleukin-6 and interleukin-8 in metastatic breast cancer patients
-
Ahmed OI, Adel AM, Diab DR, Gobran NS. Prognostic value of serum level of interleukin-6 and interleukin-8 in metastatic breast cancer patients. Egypt J Immunol. 2006;13(2):61-68.
-
(2006)
Egypt J Immunol
, vol.13
, Issue.2
, pp. 61-68
-
-
Ahmed, O.I.1
Adel, A.M.2
Diab, D.R.3
Gobran, N.S.4
-
94
-
-
0037455841
-
Circulating interleukin-6 predicts survival in patients with metastatic breast cancer
-
Roberto S, Sara J, Ina B, et al. Circulating interleukin-6 predicts survival in patients with metastatic breast cancer. Int J Cancer. 2003; 103(5):642-646.
-
(2003)
Int J Cancer
, vol.103
, Issue.5
, pp. 642-646
-
-
Roberto, S.1
Sara, J.2
Ina, B.3
-
95
-
-
0035667565
-
Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis
-
Shariat SF, Andrews B, Kattan MW, Kim J, Wheeler TM, Slawin KM. Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis. Urology. 2001; 58(6):1008-1015.
-
(2001)
Urology
, vol.58
, Issue.6
, pp. 1008-1015
-
-
Shariat, S.F.1
Andrews, B.2
Kattan, M.W.3
Kim, J.4
Wheeler, T.M.5
Slawin, K.M.6
-
96
-
-
1642392553
-
Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression
-
Shariat SF, Kattan MW, Traxel E, et al. Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression. Clin Cancer Res. 2004;10(6):1992-1999.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.6
, pp. 1992-1999
-
-
Shariat, S.F.1
Kattan, M.W.2
Traxel, E.3
-
97
-
-
0026689535
-
Evidence for the involvement of interleukin 6 in experimental cancer cachexia
-
Strassmann G, Fong M, Kenney JS, Jacob CO. Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J Clin Invest. 1992;89(5):1681-1684.
-
(1992)
J Clin Invest
, vol.89
, Issue.5
, pp. 1681-1684
-
-
Strassmann, G.1
Fong, M.2
Kenney, J.S.3
Jacob, C.O.4
-
98
-
-
0028820721
-
Interleukin-6: A candidate mediator of human prostate cancer morbidity
-
Twillie DA, Eisenberger MA, Carducci MA, Hseih WS, Kim WY, Simons JW. Interleukin-6: a candidate mediator of human prostate cancer morbidity. Urology. 1995;45(3):542-549.
-
(1995)
Urology
, vol.45
, Issue.3
, pp. 542-549
-
-
Twillie, D.A.1
Eisenberger, M.A.2
Carducci, M.A.3
Hseih, W.S.4
Kim, W.Y.5
Simons, J.W.6
-
99
-
-
12344305118
-
Steep elevation of blood interleukin-6 (IL-6) associated only with late stages of cachexia in cancer patients
-
Iwase S, Murakami T, Saito Y, Nakagawa K. Steep elevation of blood interleukin-6 (IL-6) associated only with late stages of cachexia in cancer patients. Eur Cytokine Netw. 2004;15(4):312-316.
-
(2004)
Eur Cytokine Netw
, vol.15
, Issue.4
, pp. 312-316
-
-
Iwase, S.1
Murakami, T.2
Saito, Y.3
Nakagawa, K.4
-
100
-
-
58949088029
-
Overt bone marrow metastasis from early gastric cancer
-
Kang SH, Kim JI, Moon HS, et al. Overt bone marrow metastasis from early gastric cancer. Endoscopy. 2008;40 Suppl 2: E34-E35.
-
(2008)
Endoscopy
, vol.40
, Issue.SUPPL. 2
, pp. 34-35
-
-
Kang, S.H.1
Kim, J.I.2
Moon, H.S.3
-
102
-
-
18544364182
-
Clinical significance of interleukin-6 (IL-6) in the spread of gastric cancer: Role of IL-6 as a prognostic factor
-
Ashizawa T, Okada R, Suzuki Y, et al. Clinical significance of interleukin-6 (IL-6) in the spread of gastric cancer: role of IL-6 as a prognostic factor. Gastric Cancer. 2005;8(2):124-131.
-
(2005)
Gastric Cancer
, vol.8
, Issue.2
, pp. 124-131
-
-
Ashizawa, T.1
Okada, R.2
Suzuki, Y.3
-
103
-
-
0036847022
-
Circulating levels of interleukin-6 soluble receptor predict rates of bone loss in patients with primary hyperparathyroidism
-
Nakchbandi IA, Mitnick MA, Lang R, Gundberg C, Kinder B, Insogna K. Circulating levels of interleukin-6 soluble receptor predict rates of bone loss in patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2002;87(11):4946-4951.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, Issue.11
, pp. 4946-4951
-
-
Nakchbandi, I.A.1
Mitnick, M.A.2
Lang, R.3
Gundberg, C.4
Kinder, B.5
Insogna, K.6
-
104
-
-
84055171636
-
The soluble interleukin 6 receptor: Generation and role in inflammation and cancer
-
Dec
-
Chalaris A, Garbers C, Rabe B, Rose-John S, Scheller J. The soluble interleukin 6 receptor: generation and role in inflammation and cancer. Eur J Cell Biol. Epub 2010 Dec 7.
-
(2010)
Eur J Cell Biol. Epub
, pp. 7
-
-
Chalaris, A.1
Garbers, C.2
Rabe, B.3
Rose-John, S.4
Scheller, J.5
-
105
-
-
1642578987
-
IL-6 trans-signaling: The heat is on
-
Rose-John S, Neurath MF. IL-6 trans-signaling: the heat is on. Immunity. 2004;20(1):2-4.
-
(2004)
Immunity
, vol.20
, Issue.1
, pp. 2-4
-
-
Rose-John, S.1
Neurath, M.F.2
-
106
-
-
44949130806
-
Signaling molecules: The pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer
-
Atreya R, Neurath MF. Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer. Curr Drug Targets. 2008;9(5): 369-374.
-
(2008)
Curr Drug Targets
, vol.9
, Issue.5
, pp. 369-374
-
-
Atreya, R.1
Neurath, M.F.2
-
107
-
-
77954516047
-
Lack of knowledge: Breast cancer and the soluble interleukin-6 receptor
-
Knupfer H, Preiss R. Lack of knowledge: breast cancer and the soluble interleukin-6 receptor. Breast Care (Basel). 2010;5(3):177-180.
-
(2010)
Breast Care (Basel)
, vol.5
, Issue.3
, pp. 177-180
-
-
Knupfer, H.1
Preiss, R.2
-
108
-
-
77449146168
-
Interleukin-6 trans- signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells
-
Santer FR, Malinowska K, Culig Z, Cavarretta IT. Interleukin-6 trans- signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells. Endocr Relat Cancer. 2009;17(1):241-253.
-
(2009)
Endocr Relat Cancer
, vol.17
, Issue.1
, pp. 241-253
-
-
Santer, F.R.1
Malinowska, K.2
Culig, Z.3
Cavarretta, I.T.4
-
109
-
-
59349118505
-
Change in markers of bone metabolism with chemotherapy for advanced prostate cancer: Interleukin-6 response is a potential early indicator of response to therapy
-
Woods Ignatoski KM, Friedman J, Escara-Wilke J, et al. Change in markers of bone metabolism with chemotherapy for advanced prostate cancer: interleukin-6 response is a potential early indicator of response to therapy. J Interferon Cytokine Res. 2008;29(2):105-112.
-
(2008)
J Interferon Cytokine Res
, vol.29
, Issue.2
, pp. 105-112
-
-
Woods Ignatoski, K.M.1
Friedman, J.2
Escara-Wilke, J.3
-
110
-
-
33746877876
-
Paclitaxel (Taxol) upregulates expression of functional interleukin-6 in human ovarian cancer cells through multiple signaling pathways
-
Wang TH, Chan YH, Chen CW, et al. Paclitaxel (Taxol) upregulates expression of functional interleukin-6 in human ovarian cancer cells through multiple signaling pathways. Oncogene. 2006;25(35): 4857-4866.
-
(2006)
Oncogene
, vol.25
, Issue.35
, pp. 4857-4866
-
-
Wang, T.H.1
Chan, Y.H.2
Chen, C.W.3
-
111
-
-
64249115346
-
Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality
-
Stark JR, Li H, Kraft P, et al. Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality. Int J Cancer. 2009;124(11):2683-2689.
-
(2009)
Int J Cancer
, vol.124
, Issue.11
, pp. 2683-2689
-
-
Stark, J.R.1
Li, H.2
Kraft, P.3
-
112
-
-
79957891103
-
SWOG S0354: A phase II trial of CNTO328, a monoclonal antibody against interleukin-6 (IL-6), in chemotherapy pretreated patients (pts) with castration-resistant prostate cancer (CRPC)
-
Pinski JK, Goldman B, Dorff T, et al. SWOG S0354: a phase II trial of CNTO328, a monoclonal antibody against interleukin-6 (IL-6), in chemotherapy pretreated patients (pts) with castration-resistant prostate cancer (CRPC). J Clin Oncol. 2009;27(15S):5143.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15
, pp. 5143
-
-
Pinski, J.K.1
Goldman, B.2
Dorff, T.3
-
113
-
-
23844481408
-
Mechanisms of drug resistance in cancer chemotherapy
-
Luqmani YA. Mechanisms of drug resistance in cancer chemotherapy. Med Princ Pract. 2005;14 Suppl 1:35-48.
-
(2005)
Med Princ Pract
, vol.14
, Issue.SUPPL. 1
, pp. 35-48
-
-
Luqmani, Y.A.1
-
115
-
-
33750728891
-
Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: Results of cancer and leukemia group B trial 159806
-
Rincon M, Broadwater G, Harris L, et al. Interleukin-6, multidrug resistance protein-1 expression and response to paclitaxel in women with metastatic breast cancer: results of cancer and leukemia group B trial 159806. Breast Cancer Res Treat. 2006;100(3): 301-308.
-
(2006)
Breast Cancer Res Treat
, vol.100
, Issue.3
, pp. 301-308
-
-
Rincon, M.1
Broadwater, G.2
Harris, L.3
-
116
-
-
0033988528
-
Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines
-
Chung TD, Yu JJ, Kong TA, Spiotto MT, Lin JM. Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines. Prostate. 2000;42(1):1-7.
-
(2000)
Prostate
, vol.42
, Issue.1
, pp. 1-7
-
-
Chung, T.D.1
Yu, J.J.2
Kong, T.A.3
Spiotto, M.T.4
Lin, J.M.5
-
117
-
-
22144438698
-
IL-6, its receptors and its relationship with bcl-2 and bax proteins in infiltrating and in situ human breast carcinoma
-
Garcia-Tunon I, Ricote M, Ruiz A, Fraile B, Paniagua R, Royuela M. IL-6, its receptors and its relationship with bcl-2 and bax proteins in infiltrating and in situ human breast carcinoma. Histopathology. 2005;47(1):82-89.
-
(2005)
Histopathology
, vol.47
, Issue.1
, pp. 82-89
-
-
Garcia-Tunon, I.1
Ricote, M.2
Ruiz, A.3
Fraile, B.4
Paniagua, R.5
Royuela, M.6
-
118
-
-
57849119717
-
A primer of bone metastases management in breast cancer patients
-
Petrut B, Trinkaus M, Simmons C, Clemons M. A primer of bone metastases management in breast cancer patients. Curr Oncol. 2008; 15(Suppl 1):S50-S57.
-
(2008)
Curr Oncol
, vol.15
, Issue.SUPPL. 1
, pp. 50-57
-
-
Petrut, B.1
Trinkaus, M.2
Simmons, C.3
Clemons, M.4
-
119
-
-
0033663602
-
Management of bone metastases
-
Coleman RE. Management of bone metastases. Oncologist. 2000; 5(6):463-470.
-
(2000)
Oncologist
, vol.5
, Issue.6
, pp. 463-470
-
-
Coleman, R.E.1
-
120
-
-
51349134454
-
Actemra poised to launch IL-6 inhibitors
-
Melton L, Coombs A. Actemra poised to launch IL-6 inhibitors. Nat Biotechnol. 2008;26(9):957-959.
-
(2008)
Nat Biotechnol
, vol.26
, Issue.9
, pp. 957-959
-
-
Melton, L.1
Coombs, A.2
-
121
-
-
68849107757
-
Antitumor effect of humanized anti-interleukin-6 receptor antibody (tocilizumab) on glioma cell proliferation
-
Kudo M, Jono H, Shinriki S, et al. Antitumor effect of humanized anti-interleukin-6 receptor antibody (tocilizumab) on glioma cell proliferation. J Neurosurg. 2009;111(2):219-225.
-
(2009)
J Neurosurg
, vol.111
, Issue.2
, pp. 219-225
-
-
Kudo, M.1
Jono, H.2
Shinriki, S.3
-
122
-
-
33847084044
-
Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor
-
Yoshio-Hoshino N, Adachi Y, Aoki C, Pereboev A, Curiel DT, Nishimoto N. Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor. Cancer Res. 2007;67(3):871-875.
-
(2007)
Cancer Res
, vol.67
, Issue.3
, pp. 871-875
-
-
Yoshio-Hoshino, N.1
Adachi, Y.2
Aoki, C.3
Pereboev, A.4
Curiel, D.T.5
Nishimoto, N.6
-
123
-
-
67349104400
-
Interleukin-6 as a key player in systemic inflammation and joint destruction
-
Fonseca JESM, Canhão H, Choy E. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev. 2009; 8(7):538-542.
-
(2009)
Autoimmun Rev
, vol.8
, Issue.7
, pp. 538-542
-
-
Fonseca, J.E.S.M.1
Canhão, H.2
Choy, E.3
-
125
-
-
77649172209
-
Pharmacokinetic and pharmacodynamic modeling of an anti-interleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma
-
Puchalski T, Prabhakar U, Jiao Q, Berns B, Davis HM. Pharmacokinetic and pharmacodynamic modeling of an anti-interleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma. Clin Cancer Res. 2010;16(5):1652-1661.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.5
, pp. 1652-1661
-
-
Puchalski, T.1
Prabhakar, U.2
Jiao, Q.3
Berns, B.4
Davis, H.M.5
-
126
-
-
77957995258
-
A Phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer
-
Rossi JF, Negrier S, James ND, et al. A Phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer. Br J Cancer. 2010;103(8):1154-1162.
-
(2010)
Br J Cancer
, vol.103
, Issue.8
, pp. 1154-1162
-
-
Rossi, J.F.1
Negrier, S.2
James, N.D.3
-
127
-
-
77954085082
-
A phase II multicenter study of CNTO 328, an anti-IL-6 monoclonal antibody, in patients (pts) with relapsed or refractory multiple myeloma (MM)
-
Meeting Abstracts
-
Voorhees PM, Manges RF, Somlo G, et al. A phase II multicenter study of CNTO 328, an anti-IL-6 monoclonal antibody, in patients (pts) with relapsed or refractory multiple myeloma (MM). J Clin Oncol (Meeting Abstracts). 2009;27(15S):8527.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15
, pp. 8527
-
-
Voorhees, P.M.1
Manges, R.F.2
Somlo, G.3
-
128
-
-
3843139682
-
CNTO 328, a monoclonal antibody to IL-6, inhibits human tumor-induced cachexia in nude mice
-
Zaki MH, Nemeth JA, Trikha M. CNTO 328, a monoclonal antibody to IL-6, inhibits human tumor-induced cachexia in nude mice. Int J Cancer. 2004;111(4):592-595.
-
(2004)
Int J Cancer
, vol.111
, Issue.4
, pp. 592-595
-
-
Zaki, M.H.1
Nemeth, J.A.2
Trikha, M.3
-
129
-
-
33645514605
-
Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgenindependent phenotype in orchiectomized mice
-
Wallner L, Dai J, Escara-Wilke J, et al. Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgenindependent phenotype in orchiectomized mice. Cancer Res. 2006; 66(6):3087-3095.
-
(2006)
Cancer Res
, vol.66
, Issue.6
, pp. 3087-3095
-
-
Wallner, L.1
Dai, J.2
Escara-Wilke, J.3
-
130
-
-
79956160855
-
The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a Phase I study
-
Feb
-
Karkera J, Steiner H, Li W, et al. The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a Phase I study. Prostate. Epub 2011 Feb 14.
-
(2011)
Prostate Epub
, pp. 14
-
-
Karkera, J.1
Steiner, H.2
Li, W.3
-
131
-
-
77953091816
-
-
Dorff TB, Goldman B, Pinski JK, et al. Clinical and correlative results of SWOG S0354: a Phase II trial of CNTO328 (Siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer. Clin Cancer Res. 2010;16(11):3028-3034.
-
Clinical and Correlative Results of SWOG S0354: A Phase II Trial of CNTO328 (Siltuximab), a Monoclonal Antibody Against Interleukin-6, In Chemotherapy-pretreated Patients With Castration-resistant Prostate Cancer. Clin Cancer Res. 2010;16(11):3028-3034
-
-
Dorff, T.B.1
Goldman, B.2
Pinski, J.K.3
-
132
-
-
34147174947
-
Pharma consolidates its grip on post-antibody landscape
-
Sheridan C. Pharma consolidates its grip on post-antibody landscape. Nat Biotechnol. 2007;25(4):365-366.
-
(2007)
Nat Biotechnol
, vol.25
, Issue.4
, pp. 365-366
-
-
Sheridan, C.1
-
133
-
-
28644436100
-
Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains
-
Silverman J, Liu Q, Bakker A, et al. Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains. Nat Biotechnol. 2005;23(12):1556-1561.
-
(2005)
Nat Biotechnol
, vol.23
, Issue.12
, pp. 1556-1561
-
-
Silverman, J.1
Liu, Q.2
Bakker, A.3
-
134
-
-
34250021892
-
11th annual inflammatory and immune diseases drug discovery and development summit
-
Braddock M. 11th annual inflammatory and immune diseases drug discovery and development summit. Expert Opin Investig Drugs. 2007;16:909-917.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 909-917
-
-
Braddock, M.1
-
135
-
-
0025183151
-
Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice
-
Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW. Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest. 1990;86(2):592-599.
-
(1990)
J Clin Invest
, vol.86
, Issue.2
, pp. 592-599
-
-
Brandt, S.J.1
Bodine, D.M.2
Dunbar, C.E.3
Nienhuis, A.W.4
-
136
-
-
60849102193
-
Development of novel protein scaffolds as alternatives to whole antibodies for imaging and therapy: Status on discovery research and clinical validation
-
Wurch T, Lowe P, Caussanel V, Bes C, Beck A, Corvaia N. Development of novel protein scaffolds as alternatives to whole antibodies for imaging and therapy: status on discovery research and clinical validation. Curr Pharm Biotechnol. 2008;9:502-509.
-
(2008)
Curr Pharm Biotechnol
, vol.9
, pp. 502-509
-
-
Wurch, T.1
Lowe, P.2
Caussanel, V.3
Bes, C.4
Beck, A.5
Corvaia, N.6
-
137
-
-
67649872364
-
Engineered protein scaffolds as next-generation antibody therapeutics
-
Gebauer M, Skerra A. Engineered protein scaffolds as next-generation antibody therapeutics. Curr Opin Chem Biol. 2009;13(3):245-255.
-
(2009)
Curr Opin Chem Biol
, vol.13
, Issue.3
, pp. 245-255
-
-
Gebauer, M.1
Skerra, A.2
|