메뉴 건너뛰기




Volumn 91, Issue 4, 2013, Pages 411-429

The metastasis-promoting roles of tumor-associated immune cells

Author keywords

Immune cell; Inflammation; Metastasis; Stroma; Tumor microenvironment

Indexed keywords

CYTOKINE; GROWTH FACTOR; PROTEINASE;

EID: 84879604746     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-013-1021-5     Document Type: Review
Times cited : (293)

References (225)
  • 1
    • 77549085849 scopus 로고    scopus 로고
    • Lymphocytes in cancer development: Polarization towards pro-tumor immunity
    • 20005150 1:CAS:528:DC%2BC3cXivFKgsrY%3D 10.1016/j.cytogfr.2009.11.002
    • Ruffell B, DeNardo DG, Affara NI, Coussens LM (2010) Lymphocytes in cancer development: polarization towards pro-tumor immunity. Cytokine Growth Factor Rev 21:3-10
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 3-10
    • Ruffell, B.1    Denardo, D.G.2    Affara, N.I.3    Coussens, L.M.4
  • 2
    • 0038069515 scopus 로고    scopus 로고
    • MHC class i antigens, immune surveillance, and tumor immune escape
    • 12704644 1:CAS:528:DC%2BD3sXjs1yhs7w%3D 10.1002/jcp.10290
    • Garcia-Lora A, Algarra I, Garrido F (2003) MHC class I antigens, immune surveillance, and tumor immune escape. J Cell Physiol 195:346-355
    • (2003) J Cell Physiol , vol.195 , pp. 346-355
    • Garcia-Lora, A.1    Algarra, I.2    Garrido, F.3
  • 3
    • 33847650413 scopus 로고    scopus 로고
    • Cancer immunosurveillance, immunoediting and inflammation: Independent or interdependent processes?
    • 17292599 1:CAS:528:DC%2BD2sXisleiu7c%3D 10.1016/j.coi.2007.02.001
    • Bui JD, Schreiber RD (2007) Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes? Curr Opin Immunol 19:203-208
    • (2007) Curr Opin Immunol , vol.19 , pp. 203-208
    • Bui, J.D.1    Schreiber, R.D.2
  • 4
    • 30144443269 scopus 로고    scopus 로고
    • Paradoxical roles of the immune system during cancer development
    • 16397525 10.1038/nrc1782 1:CAS:528:DC%2BD28Xht1Ggtw%3D%3D
    • de Visser KE, Eichten A, Coussens LM (2006) Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6:24-37
    • (2006) Nat Rev Cancer , vol.6 , pp. 24-37
    • De Visser, K.E.1    Eichten, A.2    Coussens, L.M.3
  • 5
    • 43749102276 scopus 로고    scopus 로고
    • Immune surveillance: A balance between protumor and antitumor immunity
    • 18308558 1:CAS:528:DC%2BD1cXmsVartLc%3D 10.1016/j.gde.2007.12.007
    • Ostrand-Rosenberg S (2008) Immune surveillance: a balance between protumor and antitumor immunity. Curr Opin Genet Dev 18:11-18
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 11-18
    • Ostrand-Rosenberg, S.1
  • 6
    • 80054899779 scopus 로고    scopus 로고
    • Phenotypic and functional plasticity of cells of innate immunity: Macrophages, mast cells and neutrophils
    • 22012443 1:CAS:528:DC%2BC3MXhtlChtrnE 10.1038/ni.2109
    • Galli SJ, Borregaard N, Wynn TA (2011) Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol 12:1035-1044
    • (2011) Nat Immunol , vol.12 , pp. 1035-1044
    • Galli, S.J.1    Borregaard, N.2    Wynn, T.A.3
  • 7
    • 84862683651 scopus 로고    scopus 로고
    • Helper T cell diversity and plasticity
    • 22341735 1:CAS:528:DC%2BC38XisFyjtLo%3D 10.1016/j.coi.2012.01.014
    • Nakayamada S, Takahashi H, Kanno Y, O'Shea JJ (2012) Helper T cell diversity and plasticity. Curr Opin Immunol 24:297-302
    • (2012) Curr Opin Immunol , vol.24 , pp. 297-302
    • Nakayamada, S.1    Takahashi, H.2    Kanno, Y.3    O'Shea, J.J.4
  • 8
    • 84879076366 scopus 로고    scopus 로고
    • The split nature of tumor-infiltrating leukocytes: Implications for cancer surveillance and immunotherapy
    • 22934263 10.4161/onci.20068
    • Lanca T, Silva-Santos B (2012) The split nature of tumor-infiltrating leukocytes: implications for cancer surveillance and immunotherapy. Oncoimmunology 1:717-725
    • (2012) Oncoimmunology , vol.1 , pp. 717-725
    • Lanca, T.1    Silva-Santos, B.2
  • 9
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • 19279573 1:CAS:528:DC%2BD1MXivFCjsLg%3D 10.1038/nrc2618
    • Joyce JA, Pollard JW (2009) Microenvironmental regulation of metastasis. Nat Rev Cancer 9:239-252
    • (2009) Nat Rev Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 10
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • 19945376 1:CAS:528:DC%2BC3cXksFWltA%3D%3D 10.1016/j.cell.2009.11.007
    • Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139:871-890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 11
    • 80054093580 scopus 로고    scopus 로고
    • Chronic inflammation and immunologic-based constraints in malignant disease
    • 21995576 10.2217/imt.11.113
    • Lowe DB, Storkus WJ (2011) Chronic inflammation and immunologic-based constraints in malignant disease. Immunotherapy 3:1265-1274
    • (2011) Immunotherapy , vol.3 , pp. 1265-1274
    • Lowe, D.B.1    Storkus, W.J.2
  • 12
    • 79953327275 scopus 로고    scopus 로고
    • Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization
    • 1:CAS:528:DC%2BC3MXktVSgt7o%3D 10.1002/ijc.26032
    • Erez N, Coussens LM (2011) Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization. Int J Cancer J Int Du Cancer 128:2536-2544
    • (2011) Int J Cancer J Int du Cancer , vol.128 , pp. 2536-2544
    • Erez, N.1    Coussens, L.M.2
  • 13
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • 3537791 1:STN:280:DyaL2s%2FmsV2mtw%3D%3D 10.1056/NEJM198612253152606
    • Dvorak HF (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315:1650-1659
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 14
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • 18650914 1:CAS:528:DC%2BD1cXovV2mtbg%3D 10.1038/nature07205
    • Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436-444
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 15
    • 70349292140 scopus 로고    scopus 로고
    • Colitis-associated cancer: The role of T cells in tumor development
    • 19495757 1:CAS:528:DC%2BD1MXhtFent7zM 10.1007/s00281-009-0161-8
    • Waldner MJ, Neurath MF (2009) Colitis-associated cancer: the role of T cells in tumor development. Semin Immunopathol 31:249-256
    • (2009) Semin Immunopathol , vol.31 , pp. 249-256
    • Waldner, M.J.1    Neurath, M.F.2
  • 16
    • 59449085264 scopus 로고    scopus 로고
    • Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, long-term foe
    • 1:CAS:528:DC%2BD1MXlvFeksg%3D%3D 10.1158/1078-0432.CCR-08-0149
    • Aggarwal BB, Vijayalekshmi RV, Sung B (2009) Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res Off J Am Assoc Cancer Res 15:425-430
    • (2009) Clin Cancer Res off J Am Assoc Cancer Res , vol.15 , pp. 425-430
    • Aggarwal, B.B.1    Vijayalekshmi, R.V.2    Sung, B.3
  • 17
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • 16724054 1:CAS:528:DC%2BD28XkvVyrsrw%3D 10.1038/nature04870
    • Karin M (2006) Nuclear factor-kappaB in cancer development and progression. Nature 441:431-436
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 18
    • 69949120571 scopus 로고    scopus 로고
    • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17T cell responses
    • 19701202 1:CAS:528:DC%2BD1MXhtVersbvJ 10.1038/nm.2015
    • Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F et al (2009) A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17T cell responses. Nat Med 15:1016-1022
    • (2009) Nat Med , vol.15 , pp. 1016-1022
    • Wu, S.1    Rhee, K.J.2    Albesiano, E.3    Rabizadeh, S.4    Wu, X.5    Yen, H.R.6    Huso, D.L.7    Brancati, F.L.8    Wick, E.9    McAllister, F.10
  • 19
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • 11229684 1:CAS:528:DC%2BD3MXhsVKltb0%3D 10.1016/S0140-6736(00)04046-0
    • Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357:539-545
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 20
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • 20303878 1:CAS:528:DC%2BC3cXlsVSgu7g%3D 10.1016/j.cell.2010.01.025
    • Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883-899
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 21
    • 34948852371 scopus 로고    scopus 로고
    • Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
    • 17906636 1:CAS:528:DC%2BD2sXhtFagsbzF 10.1038/nm1649
    • Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, Evan GI (2007) Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med 13:1211-1218
    • (2007) Nat Med , vol.13 , pp. 1211-1218
    • Soucek, L.1    Lawlor, E.R.2    Soto, D.3    Shchors, K.4    Swigart, L.B.5    Evan, G.I.6
  • 22
    • 7944223098 scopus 로고    scopus 로고
    • Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
    • 10.1016/j.ccr.2004.09.028 15542429 1:CAS:528:DC%2BD2cXhtVGlurvE 10.1016/j.ccr.2004.09.028
    • Sparmann A, Bar-Sagi D (2004) Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 6:447-458. doi: 10.1016/j.ccr.2004.09.028
    • (2004) Cancer Cell , vol.6 , pp. 447-458
    • Sparmann, A.1    Bar-Sagi, D.2
  • 23
    • 3543102542 scopus 로고    scopus 로고
    • Inflammation and necrosis promote tumour growth
    • 15286730 1:CAS:528:DC%2BD2cXmtFWktrg%3D 10.1038/nri1415
    • Vakkila J, Lotze MT (2004) Inflammation and necrosis promote tumour growth. Nat Rev Immunol 4:641-648
    • (2004) Nat Rev Immunol , vol.4 , pp. 641-648
    • Vakkila, J.1    Lotze, M.T.2
  • 24
    • 33947259319 scopus 로고    scopus 로고
    • Immunosuppressive strategies that are mediated by tumor cells
    • 17134371 1:CAS:528:DC%2BD2sXltlagu7c%3D 10.1146/annurev.immunol.25. 022106.141609
    • Rabinovich GA, Gabrilovich D, Sotomayor EM (2007) Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25:267-296
    • (2007) Annu Rev Immunol , vol.25 , pp. 267-296
    • Rabinovich, G.A.1    Gabrilovich, D.2    Sotomayor, E.M.3
  • 25
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • 19197294 1:CAS:528:DC%2BD1MXhsFeqsbw%3D 10.1038/nri2506
    • Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162-174
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 26
    • 77955549860 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: More mechanisms for inhibiting antitumor immunity
    • 10.1007/s00262-010-0855-8
    • Ostrand-Rosenberg S (2010) Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity. Cancer Immunol Immunother CII 59:1593-1600
    • (2010) Cancer Immunol Immunother , vol.259 , pp. 1593-1600
    • Ostrand-Rosenberg, S.1
  • 29
    • 28644445445 scopus 로고    scopus 로고
    • Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    • 16288283 1:CAS:528:DC%2BD2MXht1yisr3I 10.1038/nm1325
    • Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mule J, Kerr WG et al (2005) Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 11:1314-1321
    • (2005) Nat Med , vol.11 , pp. 1314-1321
    • Kortylewski, M.1    Kujawski, M.2    Wang, T.3    Wei, S.4    Zhang, S.5    Pilon-Thomas, S.6    Niu, G.7    Kay, H.8    Mule, J.9    Kerr, W.G.10
  • 30
    • 79956131523 scopus 로고    scopus 로고
    • Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4(+) T cells to T-regulatory cells
    • 21444674 1:CAS:528:DC%2BC3MXmtVGlt7w%3D 10.1158/0008-5472.CAN-10-4316
    • Olkhanud PB, Damdinsuren B, Bodogai M, Gress RE, Sen R, Wejksza K, Malchinkhuu E, Wersto RP, Biragyn A (2011) Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4(+) T cells to T-regulatory cells. Cancer Res 71:3505-3515
    • (2011) Cancer Res , vol.71 , pp. 3505-3515
    • Olkhanud, P.B.1    Damdinsuren, B.2    Bodogai, M.3    Gress, R.E.4    Sen, R.5    Wejksza, K.6    Malchinkhuu, E.7    Wersto, R.P.8    Biragyn, A.9
  • 31
    • 77956111527 scopus 로고    scopus 로고
    • Convergent pathways of macrophage polarization: The role of B cells
    • 20623553 1:CAS:528:DC%2BC3cXpsF2rtr4%3D 10.1002/eji.201040736
    • Sica A, Porta C, Riboldi E, Locati M (2010) Convergent pathways of macrophage polarization: the role of B cells. Eur J Immunol 40:2131-2133
    • (2010) Eur J Immunol , vol.40 , pp. 2131-2133
    • Sica, A.1    Porta, C.2    Riboldi, E.3    Locati, M.4
  • 32
    • 33947494918 scopus 로고    scopus 로고
    • Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    • 17255343 10.2353/ajpath.2007.060761
    • Harrell MI, Iritani BM, Ruddell A (2007) Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am J Pathol 170:774-786
    • (2007) Am J Pathol , vol.170 , pp. 774-786
    • Harrell, M.I.1    Iritani, B.M.2    Ruddell, A.3
  • 33
    • 80051484018 scopus 로고    scopus 로고
    • B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma
    • 21847366 1:CAS:528:DC%2BC3MXhtFCku77N
    • Ruddell A, Harrell MI, Furuya M, Kirschbaum SB, Iritani BM (2011) B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma. Neoplasia 13:748-757
    • (2011) Neoplasia , vol.13 , pp. 748-757
    • Ruddell, A.1    Harrell, M.I.2    Furuya, M.3    Kirschbaum, S.B.4    Iritani, B.M.5
  • 34
    • 84864720683 scopus 로고    scopus 로고
    • + T cell response to a murine Burkitt's-like B cell lymphoma
    • 22880059 1:CAS:528:DC%2BC38XhtFyrurfE 10.1371/journal.pone.0042635
    • + T cell response to a murine Burkitt's-like B cell lymphoma. PLoS One 7:e42635
    • (2012) PLoS One , vol.7 , pp. 42635
    • Bjordahl, R.L.1    Gapin, L.2    Marrack, P.3    Refaeli, Y.4
  • 35
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • 12490959 1:CAS:528:DC%2BD38XpsFygtb4%3D 10.1038/nature01322
    • Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860-867
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 36
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    • 18432192 1:CAS:528:DC%2BD1cXmvVGmsL8%3D 10.1038/nature06905
    • Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M (2008) NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453:807-811
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3    Akassoglou, K.4    Zinkernagel, A.S.5    Nizet, V.6    Johnson, R.S.7    Haddad, G.G.8    Karin, M.9
  • 37
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • 19262571 1:CAS:528:DC%2BD1MXis1Chtb0%3D 10.1038/nrc2620
    • Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9:265-273
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 38
    • 67651005404 scopus 로고    scopus 로고
    • EMT: When epithelial cells decide to become mesenchymal-like cells
    • 19487817 1:CAS:528:DC%2BD1MXntVCjtrw%3D 10.1172/JCI39675
    • Kalluri R (2009) EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 119:1417-1419
    • (2009) J Clin Invest , vol.119 , pp. 1417-1419
    • Kalluri, R.1
  • 39
    • 0035904231 scopus 로고    scopus 로고
    • E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity
    • 11564756 1:CAS:528:DC%2BD3MXntVGgt7c%3D 10.1083/jcb.200104036
    • Stockinger A, Eger A, Wolf J, Beug H, Foisner R (2001) E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol 154:1185-1196
    • (2001) J Cell Biol , vol.154 , pp. 1185-1196
    • Stockinger, A.1    Eger, A.2    Wolf, J.3    Beug, H.4    Foisner, R.5
  • 40
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • 15294153 1:CAS:528:DC%2BD2cXmslKrs7w%3D 10.1016/j.cell.2004.07.011
    • Kang Y, Massague J (2004) Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118:277-279
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massague, J.2
  • 41
    • 84867886641 scopus 로고    scopus 로고
    • Inflammation linking EMT and cancer stem cells
    • 22766510 1:CAS:528:DC%2BC38XpvFCkurw%3D 10.1016/j.oraloncology.2012.06. 005
    • Zhou C, Liu J, Tang Y, Liang X (2012) Inflammation linking EMT and cancer stem cells. Oral Oncol 48:1068-1075
    • (2012) Oral Oncol , vol.48 , pp. 1068-1075
    • Zhou, C.1    Liu, J.2    Tang, Y.3    Liang, X.4
  • 42
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • 21436443 1:CAS:528:DC%2BC3MXjs1Cgtbo%3D 10.1126/science.1203543
    • Chaffer CL, Weinberg RA (2011) A perspective on cancer cell metastasis. Science 331:1559-1564
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 43
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • 20531305 1:CAS:528:DC%2BC3cXntVSrur0%3D 10.1038/onc.2010.215
    • Singh A, Settleman J (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29:4741-4751
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 44
    • 70450142560 scopus 로고    scopus 로고
    • Inflammation and EMT: An alliance towards organ fibrosis and cancer progression
    • 20049734 1:CAS:528:DC%2BD1MXhsVSltL%2FJ 10.1002/emmm.200900043
    • Lopez-Novoa JM, Nieto MA (2009) Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med 1:303-314
    • (2009) EMBO Mol Med , vol.1 , pp. 303-314
    • Lopez-Novoa, J.M.1    Nieto, M.A.2
  • 46
    • 0029662049 scopus 로고    scopus 로고
    • TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • 8843198 1:CAS:528:DyaK28Xmt1KnurY%3D 10.1101/gad.10.19.2462
    • Oft M, Peli J, Rudaz C, Schwarz H, Beug H, Reichmann E (1996) TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 10:2462-2477
    • (1996) Genes Dev , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 47
    • 0037572319 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    • 12802055 1:CAS:528:DC%2BD3sXktFKiuro%3D 10.1091/mbc.E02-09-0583
    • Bates RC, Mercurio AM (2003) Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell 14:1790-1800
    • (2003) Mol Biol Cell , vol.14 , pp. 1790-1800
    • Bates, R.C.1    Mercurio, A.M.2
  • 49
    • 84870933589 scopus 로고    scopus 로고
    • CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFalpha
    • Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan ZR, Roberts AI, Zhang L, Zheng B et al (2012) CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFalpha. Cell Stem Cell 11:812-824
    • (2012) Cell Stem Cell , vol.11 , pp. 812-824
    • Ren, G.1    Zhao, X.2    Wang, Y.3    Zhang, X.4    Chen, X.5    Xu, C.6    Yuan, Z.R.7    Roberts, A.I.8    Zhang, L.9    Zheng, B.10
  • 50
    • 65349092794 scopus 로고    scopus 로고
    • Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    • 19411070 1:CAS:528:DC%2BD1MXmvVGitrs%3D 10.1016/j.ccr.2009.03.016
    • Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP (2009) Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 15:416-428
    • (2009) Cancer Cell , vol.15 , pp. 416-428
    • Wu, Y.1    Deng, J.2    Rychahou, P.G.3    Qiu, S.4    Evers, B.M.5    Zhou, B.P.6
  • 51
    • 77954030498 scopus 로고    scopus 로고
    • NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells
    • 20350779 1:CAS:528:DC%2BC3cXotVWlu7o%3D 10.1016/j.canlet.2010.03.003
    • Maier HJ, Schmidt-Strassburger U, Huber MA, Wiedemann EM, Beug H, Wirth T (2010) NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett 295:214-228
    • (2010) Cancer Lett , vol.295 , pp. 214-228
    • Maier, H.J.1    Schmidt-Strassburger, U.2    Huber, M.A.3    Wiedemann, E.M.4    Beug, H.5    Wirth, T.6
  • 52
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • 15448698 1:CAS:528:DC%2BD2cXnvFGqs7o%3D 10.1038/ncb1173
    • Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6:931-940
    • (2004) Nat Cell Biol , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6    Hung, M.C.7
  • 53
  • 54
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • 19851315 1:CAS:528:DC%2BD1MXhtlSjur%2FP 10.1038/nrc2734
    • Yu H, Pardoll D, Jove R (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9:798-809
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 55
    • 69249221254 scopus 로고    scopus 로고
    • Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    • 19581928 1:CAS:528:DC%2BD1MXotF2qsLo%3D 10.1038/onc.2009.180
    • Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, Ramirez N, Oberyszyn TM, Hall BM (2009) Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 28:2940-2947
    • (2009) Oncogene , vol.28 , pp. 2940-2947
    • Sullivan, N.J.1    Sasser, A.K.2    Axel, A.E.3    Vesuna, F.4    Raman, V.5    Ramirez, N.6    Oberyszyn, T.M.7    Hall, B.M.8
  • 56
    • 60649089997 scopus 로고    scopus 로고
    • Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells
    • 19249678 1:CAS:528:DC%2BD1MXltFSmtbg%3D 10.1016/j.ccr.2009.01.023
    • Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y (2009) Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 15:195-206
    • (2009) Cancer Cell , vol.15 , pp. 195-206
    • Kudo-Saito, C.1    Shirako, H.2    Takeuchi, T.3    Kawakami, Y.4
  • 58
    • 12144266241 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition
    • 15631989 1:CAS:528:DC%2BD2MXltlSqtg%3D%3D 10.1083/jcb.200409067
    • Bachelder RE, Yoon SO, Franci C, de Herreros AG, Mercurio AM (2005) Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol 168:29-33
    • (2005) J Cell Biol , vol.168 , pp. 29-33
    • Bachelder, R.E.1    Yoon, S.O.2    Franci, C.3    De Herreros, A.G.4    Mercurio, A.M.5
  • 59
    • 33846828787 scopus 로고    scopus 로고
    • NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2
    • 16862183 1:CAS:528:DC%2BD2sXhtFGmurs%3D 10.1038/sj.onc.1209808
    • Chua HL, Bhat-Nakshatri P, Clare SE, Morimiya A, Badve S, Nakshatri H (2007) NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 26:711-724
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5    Nakshatri, H.6
  • 62
    • 79952845386 scopus 로고    scopus 로고
    • The role of B-RAF mutations in melanoma and the induction of EMT via dysregulation of the NF-kappaB/Snail/RKIP/PTEN circuit
    • 1:CAS:528:DC%2BC3cXhtVyjs7vF 10.1177/1947601910373795
    • Lin K, Baritaki S, Militello L, Malaponte G, Bevelacqua Y, Bonavida B (2010) The role of B-RAF mutations in melanoma and the induction of EMT via dysregulation of the NF-kappaB/Snail/RKIP/PTEN circuit. Genes & Cancer 1:409-420
    • (2010) Genes & Cancer , vol.1 , pp. 409-420
    • Lin, K.1    Baritaki, S.2    Militello, L.3    Malaponte, G.4    Bevelacqua, Y.5    Bonavida, B.6
  • 63
    • 70349973076 scopus 로고    scopus 로고
    • Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: Pivotal roles of Snail repression and RKIP induction
    • 19633685 1:CAS:528:DC%2BD1MXovFyltrw%3D 10.1038/onc.2009.214
    • Baritaki S, Chapman A, Yeung K, Spandidos DA, Palladino M, Bonavida B (2009) Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. Oncogene 28:3573-3585
    • (2009) Oncogene , vol.28 , pp. 3573-3585
    • Baritaki, S.1    Chapman, A.2    Yeung, K.3    Spandidos, D.A.4    Palladino, M.5    Bonavida, B.6
  • 64
    • 78650179541 scopus 로고    scopus 로고
    • Involvement of NF-kappaB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells
    • 20798686 10.1038/cdd.2010.103 1:CAS:528:DC%2BC3cXhsFGgsLvE
    • Li QQ, Chen ZQ, Cao XX, Xu JD, Xu JW, Chen YY, Wang WJ, Chen Q, Tang F, Liu XP et al (2011) Involvement of NF-kappaB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells. Cell Death Differ 18:16-25
    • (2011) Cell Death Differ , vol.18 , pp. 16-25
    • Li, Q.Q.1    Chen, Z.Q.2    Cao, X.X.3    Xu, J.D.4    Xu, J.W.5    Chen, Y.Y.6    Wang, W.J.7    Chen, Q.8    Tang, F.9    Liu, X.P.10    Xu, Z.D.11
  • 65
    • 0031183766 scopus 로고    scopus 로고
    • The role of nuclear factor-kappa B in cytokine gene regulation
    • 9224203 1:CAS:528:DyaK2sXksF2ktL8%3D 10.1165/ajrcmb.17.1.f132
    • Blackwell TS, Christman JW (1997) The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 17:3-9
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 3-9
    • Blackwell, T.S.1    Christman, J.W.2
  • 66
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • 18662538 1:CAS:528:DC%2BD1cXptlaltbk%3D 10.1016/j.cell.2008.07.001
    • Massague J (2008) TGFbeta in cancer. Cell 134:215-230
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 67
    • 84866334922 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial-mesenchymal transition: A link between cancer and inflammation
    • 22627188 1:CAS:528:DC%2BC38XhtlOju7bL 10.1016/j.semcancer.2012.05.004
    • Fuxe J, Karlsson MC (2012) TGF-beta-induced epithelial-mesenchymal transition: a link between cancer and inflammation. Semin Cancer Biol 22:455-461
    • (2012) Semin Cancer Biol , vol.22 , pp. 455-461
    • Fuxe, J.1    Karlsson, M.C.2
  • 68
    • 81255205399 scopus 로고    scopus 로고
    • Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    • 22094253 1:CAS:528:DC%2BC3MXhsFSktLnJ 10.1016/j.ccr.2011.09.009
    • Labelle M, Begum S, Hynes RO (2011) Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20:576-590
    • (2011) Cancer Cell , vol.20 , pp. 576-590
    • Labelle, M.1    Begum, S.2    Hynes, R.O.3
  • 69
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • 17186030 1:CAS:528:DC%2BD28XhtlCht7fE 10.1038/nri1995
    • Yu H, Kortylewski M, Pardoll D (2007) Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 7:41-51
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 70
    • 67649966600 scopus 로고    scopus 로고
    • TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation
    • 20141610 10.1111/j.1582-4934.2008.00647.x
    • Sullivan DE, Ferris M, Nguyen H, Abboud E, Brody AR (2009) TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation. J Cell Mol Med 13:1866-1876
    • (2009) J Cell Mol Med , vol.13 , pp. 1866-1876
    • Sullivan, D.E.1    Ferris, M.2    Nguyen, H.3    Abboud, E.4    Brody, A.R.5
  • 72
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
    • 12665527 1:CAS:528:DC%2BD3sXkt1Wit7g%3D 10.1074/jbc.M211304200
    • Peinado H, Quintanilla M, Cano A (2003) Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278:21113-21123
    • (2003) J Biol Chem , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 75
    • 0036674213 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration
    • 12118074 1:CAS:528:DC%2BD38XmsFarsr4%3D
    • Bakin AV, Rinehart C, Tomlinson AK, Arteaga CL (2002) p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115:3193-3206
    • (2002) J Cell Sci , vol.115 , pp. 3193-3206
    • Bakin, A.V.1    Rinehart, C.2    Tomlinson, A.K.3    Arteaga, C.L.4
  • 76
    • 0034906821 scopus 로고    scopus 로고
    • TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
    • 11483955 1:CAS:528:DC%2BD3MXmtFensL8%3D 10.1038/35087019
    • Perlman R, Schiemann WP, Brooks MW, Lodish HF, Weinberg RA (2001) TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol 3:708-714
    • (2001) Nat Cell Biol , vol.3 , pp. 708-714
    • Perlman, R.1    Schiemann, W.P.2    Brooks, M.W.3    Lodish, H.F.4    Weinberg, R.A.5
  • 77
  • 78
    • 0037461958 scopus 로고    scopus 로고
    • Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: Implications in liver tumor formation
    • 12545162 1:CAS:528:DC%2BD3sXlsV2lug%3D%3D 10.1038/sj.onc.1206132
    • Arsura M, Panta GR, Bilyeu JD, Cavin LG, Sovak MA, Oliver AA, Factor V, Heuchel R, Mercurio F, Thorgeirsson SS et al (2003) Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation. Oncogene 22:412-425
    • (2003) Oncogene , vol.22 , pp. 412-425
    • Arsura, M.1    Panta, G.R.2    Bilyeu, J.D.3    Cavin, L.G.4    Sovak, M.A.5    Oliver, A.A.6    Factor, V.7    Heuchel, R.8    Mercurio, F.9    Thorgeirsson, S.S.10    Sonenshein, G.E.11
  • 79
    • 77649261101 scopus 로고    scopus 로고
    • TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI
    • 1:CAS:528:DC%2BC3cXisFems7w%3D
    • Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, Howe PH (2010) TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. NatureCell Biology 12:286-293
    • (2010) NatureCell Biology , vol.12 , pp. 286-293
    • Chaudhury, A.1    Hussey, G.S.2    Ray, P.S.3    Jin, G.4    Fox, P.L.5    Howe, P.H.6
  • 80
    • 40449092814 scopus 로고    scopus 로고
    • Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression
    • 18316610 1:CAS:528:DC%2BD1cXislagu7w%3D 10.1158/0008-5472.CAN-07-3094
    • Neil JR, Schiemann WP (2008) Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer Res 68:1462-1470
    • (2008) Cancer Res , vol.68 , pp. 1462-1470
    • Neil, J.R.1    Schiemann, W.P.2
  • 81
    • 0042303832 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways
    • 12853969 1:CAS:528:DC%2BD3sXlt1Cktbs%3D 10.1038/sj.onc.1206478
    • Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG (2003) Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways. Oncogene 22:4314-4332
    • (2003) Oncogene , vol.22 , pp. 4314-4332
    • Park, J.I.1    Lee, M.G.2    Cho, K.3    Park, B.J.4    Chae, K.S.5    Byun, D.S.6    Ryu, B.K.7    Park, Y.K.8    Chi, S.G.9
  • 82
    • 56749095797 scopus 로고    scopus 로고
    • Transcriptional regulation of cell polarity in EMT and cancer
    • 19029937 1:CAS:528:DC%2BD1cXhsVWhurvF 10.1038/onc.2008.346
    • Moreno-Bueno G, Portillo F, Cano A (2008) Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 27:6958-6969
    • (2008) Oncogene , vol.27 , pp. 6958-6969
    • Moreno-Bueno, G.1    Portillo, F.2    Cano, A.3
  • 84
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • 17508028 1:CAS:528:DC%2BD2sXls1Kjs70%3D 10.1038/nrc2131
    • Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7:415-428
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 85
    • 77955349641 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells
    • 20513670 1:CAS:528:DC%2BC3cXpvFWqsLo%3D 10.1093/carcin/bgq108
    • Natsuizaka M, Ohashi S, Wong GS, Ahmadi A, Kalman RA, Budo D, Klein-Szanto AJ, Herlyn M, Diehl JA, Nakagawa H (2010) Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells. Carcinogenesis 31:1344-1353
    • (2010) Carcinogenesis , vol.31 , pp. 1344-1353
    • Natsuizaka, M.1    Ohashi, S.2    Wong, G.S.3    Ahmadi, A.4    Kalman, R.A.5    Budo, D.6    Klein-Szanto, A.J.7    Herlyn, M.8    Diehl, J.A.9    Nakagawa, H.10
  • 86
    • 77956928318 scopus 로고    scopus 로고
    • AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling
    • 20581862 1:CAS:528:DC%2BC3cXnvFyktb0%3D 10.1038/onc.2010.258
    • Kong B, Michalski CW, Hong X, Valkovskaya N, Rieder S, Abiatari I, Streit S, Erkan M, Esposito I, Friess H et al (2010) AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling. Oncogene 29:5146-5158
    • (2010) Oncogene , vol.29 , pp. 5146-5158
    • Kong, B.1    Michalski, C.W.2    Hong, X.3    Valkovskaya, N.4    Rieder, S.5    Abiatari, I.6    Streit, S.7    Erkan, M.8    Esposito, I.9    Friess, H.10    Kleeff, J.11
  • 87
    • 78650359160 scopus 로고    scopus 로고
    • Homeoprotein Six1 increases TGF-beta type i receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth
    • 21056993 1:CAS:528:DC%2BC3cXhsFGrtL%2FJ 10.1158/0008-5472.CAN-10-1354
    • Micalizzi DS, Wang CA, Farabaugh SM, Schiemann WP, Ford HL (2010) Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer Res 70:10371-10380
    • (2010) Cancer Res , vol.70 , pp. 10371-10380
    • Micalizzi, D.S.1    Wang, C.A.2    Farabaugh, S.M.3    Schiemann, W.P.4    Ford, H.L.5
  • 88
    • 77954956544 scopus 로고    scopus 로고
    • Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas
    • 20498632 1:CAS:528:DC%2BC3cXmsVWnur0%3D 10.1038/onc.2010.169
    • Braun J, Hoang-Vu C, Dralle H, Huttelmaier S (2010) Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. Oncogene 29:4237-4244
    • (2010) Oncogene , vol.29 , pp. 4237-4244
    • Braun, J.1    Hoang-Vu, C.2    Dralle, H.3    Huttelmaier, S.4
  • 89
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • 18411277 1:CAS:528:DC%2BD1cXmtlynsbc%3D 10.1074/jbc.C800074200
    • Korpal M, Lee ES, Hu G, Kang Y (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283:14910-14914
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 91
    • 79955954699 scopus 로고    scopus 로고
    • An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
    • 21411626 1:CAS:528:DC%2BC3MXntFSjt7s%3D 10.1091/mbc.E11-02-0103
    • Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY et al (2011) An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell 22:1686-1698
    • (2011) Mol Biol Cell , vol.22 , pp. 1686-1698
    • Gregory, P.A.1    Bracken, C.P.2    Smith, E.3    Bert, A.G.4    Wright, J.A.5    Roslan, S.6    Morris, M.7    Wyatt, L.8    Farshid, G.9    Lim, Y.Y.10
  • 92
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • 18483486 1:CAS:528:DC%2BD1cXmsFykt7Y%3D 10.1038/embor.2008.74
    • Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, Brabletz T (2008) A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 9:582-589
    • (2008) EMBO Rep , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6    Brabletz, T.7
  • 93
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • 18381893 1:CAS:528:DC%2BD1cXksVGktL4%3D 10.1101/gad.1640608
    • Park SM, Gaur AB, Lengyel E, Peter ME (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22:894-907
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 94
    • 34347266556 scopus 로고    scopus 로고
    • MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
    • 17363372 1:CAS:528:DC%2BD2sXkvVynsLk%3D 10.1074/jbc.M611393200
    • Zhu S, Si ML, Wu H, Mo YY (2007) MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 282:14328-14336
    • (2007) J Biol Chem , vol.282 , pp. 14328-14336
    • Zhu, S.1    Si, M.L.2    Wu, H.3    Mo, Y.Y.4
  • 95
    • 55849123946 scopus 로고    scopus 로고
    • MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    • 18794355 1:CAS:528:DC%2BD1cXhsVSnurfJ 10.1128/MCB.00941-08
    • Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ (2008) MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 28:6773-6784
    • (2008) Mol Cell Biol , vol.28 , pp. 6773-6784
    • Kong, W.1    Yang, H.2    He, L.3    Zhao, J.J.4    Coppola, D.5    Dalton, W.S.6    Cheng, J.Q.7
  • 96
    • 33846643454 scopus 로고    scopus 로고
    • Cysteine cathepsins and the cutting edge of cancer invasion
    • 17245112 1:CAS:528:DC%2BD2sXnvFygsbc%3D 10.4161/cc.6.1.3669
    • Gocheva V, Joyce JA (2007) Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle 6:60-64
    • (2007) Cell Cycle , vol.6 , pp. 60-64
    • Gocheva, V.1    Joyce, J.A.2
  • 97
    • 1542604677 scopus 로고    scopus 로고
    • Cysteine proteases as disease markers
    • 1:CAS:528:DC%2BD2cXitFChsLk%3D 10.1016/j.cccn.2003.12.016
    • Berdowska I (2004) Cysteine proteases as disease markers. Clin Chim Acta Int J Clin Chem 342:41-69
    • (2004) Clin Chim Acta Int J Clin Chem , vol.342 , pp. 41-69
    • Berdowska, I.1
  • 98
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • 20371345 1:CAS:528:DC%2BC3cXlsVSgtb4%3D 10.1016/j.cell.2010.03.015
    • Kessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:52-67
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 99
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • 15882617 1:CAS:528:DC%2BD2MXktlSiu7w%3D 10.1016/j.cell.2005.02.034
    • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-348
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 101
    • 0034721666 scopus 로고    scopus 로고
    • MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    • 11081634 1:CAS:528:DC%2BD3cXnvF2ksLg%3D 10.1016/S0092-8674(00)00139-2
    • Coussens LM, Tinkle CL, Hanahan D, Werb Z (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103:481-490
    • (2000) Cell , vol.103 , pp. 481-490
    • Coussens, L.M.1    Tinkle, C.L.2    Hanahan, D.3    Werb, Z.4
  • 102
    • 41649116240 scopus 로고    scopus 로고
    • Plasticity in tumor-promoting inflammation: Impairment of macrophage recruitment evokes a compensatory neutrophil response
    • 18392134 1:CAS:528:DC%2BD1cXltleiurg%3D
    • Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE, Hanahan D (2008) Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia 10:329-340
    • (2008) Neoplasia , vol.10 , pp. 329-340
    • Pahler, J.C.1    Tazzyman, S.2    Erez, N.3    Chen, Y.Y.4    Murdoch, C.5    Nozawa, H.6    Lewis, C.E.7    Hanahan, D.8
  • 103
    • 77349109251 scopus 로고    scopus 로고
    • Mast cell tryptase promotes breast cancer migration and invasion
    • 20126998 1:CAS:528:DC%2BC3cXjtlGrsbs%3D
    • Xiang M, Gu Y, Zhao F, Lu H, Chen S, Yin L (2010) Mast cell tryptase promotes breast cancer migration and invasion. Oncol Rep 23:615-619
    • (2010) Oncol Rep , vol.23 , pp. 615-619
    • Xiang, M.1    Gu, Y.2    Zhao, F.3    Lu, H.4    Chen, S.5    Yin, L.6
  • 104
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • 16439202 1:CAS:528:DC%2BD28Xht1KktLo%3D 10.1016/j.cell.2006.01.007
    • Condeelis J, Pollard JW (2006) Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124:263-266
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 107
    • 0141720342 scopus 로고    scopus 로고
    • Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
    • 12925691 1:CAS:528:DC%2BD3sXms1Wntbg%3D
    • Li Y, Yang J, Dai C, Wu C, Liu Y (2003) Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 112:503-516
    • (2003) J Clin Invest , vol.112 , pp. 503-516
    • Li, Y.1    Yang, J.2    Dai, C.3    Wu, C.4    Liu, Y.5
  • 108
    • 0036233040 scopus 로고    scopus 로고
    • Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    • 11967021 1:CAS:528:DC%2BD38XjvFWhsr0%3D 10.1046/j.1523-1755.2002.00333.x
    • Strutz F, Zeisberg M, Ziyadeh FN, Yang CQ, Kalluri R, Muller GA, Neilson EG (2002) Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 61:1714-1728
    • (2002) Kidney Int , vol.61 , pp. 1714-1728
    • Strutz, F.1    Zeisberg, M.2    Ziyadeh, F.N.3    Yang, C.Q.4    Kalluri, R.5    Muller, G.A.6    Neilson, E.G.7
  • 110
    • 76149146398 scopus 로고    scopus 로고
    • IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    • 20080943 1:CAS:528:DC%2BC3cXhsFeitrY%3D 10.1101/gad.1874010
    • Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall AL, Berman T, Joyce JA (2010) IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 24:241-255
    • (2010) Genes Dev , vol.24 , pp. 241-255
    • Gocheva, V.1    Wang, H.W.2    Gadea, B.B.3    Shree, T.4    Hunter, K.E.5    Garfall, A.L.6    Berman, T.7    Joyce, J.A.8
  • 112
    • 34247274248 scopus 로고    scopus 로고
    • Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin
    • 17377533 1:CAS:528:DC%2BD2sXjslOlsLk%3D 10.1038/nature05656
    • Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M (2007) Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature 446:690-694
    • (2007) Nature , vol.446 , pp. 690-694
    • Luo, J.L.1    Tan, W.2    Ricono, J.M.3    Korchynskyi, O.4    Zhang, M.5    Gonias, S.L.6    Cheresh, D.A.7    Karin, M.8
  • 113
    • 78650988139 scopus 로고    scopus 로고
    • Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice
    • 20818432 1:CAS:528:DC%2BC3cXhtFWksrjP 10.1038/onc.2010.387
    • Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Muller S, Follo M, Peters C, Reinheckel T (2011) Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice. Oncogene 30:54-64
    • (2011) Oncogene , vol.30 , pp. 54-64
    • Sevenich, L.1    Werner, F.2    Gajda, M.3    Schurigt, U.4    Sieber, C.5    Muller, S.6    Follo, M.7    Peters, C.8    Reinheckel, T.9
  • 114
    • 36349007731 scopus 로고    scopus 로고
    • Cathepsin e prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface
    • 18006832 1:CAS:528:DC%2BD2sXhtlSlsL%2FM 10.1158/0008-5472.CAN-07-2048
    • Kawakubo T, Okamoto K, Iwata J, Shin M, Okamoto Y, Yasukochi A, Nakayama KI, Kadowaki T, Tsukuba T, Yamamoto K (2007) Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Cancer Res 67:10869-10878
    • (2007) Cancer Res , vol.67 , pp. 10869-10878
    • Kawakubo, T.1    Okamoto, K.2    Iwata, J.3    Shin, M.4    Okamoto, Y.5    Yasukochi, A.6    Nakayama, K.I.7    Kadowaki, T.8    Tsukuba, T.9    Yamamoto, K.10
  • 115
    • 67650495415 scopus 로고    scopus 로고
    • IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway
    • 19564351 1:CAS:528:DC%2BD1MXos1eis7k%3D 10.1084/jem.20090207
    • Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H (2009) IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med 206:1457-1464
    • (2009) J Exp Med , vol.206 , pp. 1457-1464
    • Wang, L.1    Yi, T.2    Kortylewski, M.3    Pardoll, D.M.4    Zeng, D.5    Yu, H.6
  • 116
    • 67651160649 scopus 로고    scopus 로고
    • CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • 19647220 1:CAS:528:DC%2BD1MXhsVCjsrfJ 10.1016/j.ccr.2009.06.018
    • DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM (2009) CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16:91-102
    • (2009) Cancer Cell , vol.16 , pp. 91-102
    • Denardo, D.G.1    Barreto, J.B.2    Andreu, P.3    Vasquez, L.4    Tawfik, D.5    Kolhatkar, N.6    Coussens, L.M.7
  • 117
    • 58149269348 scopus 로고    scopus 로고
    • Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
    • 19122641 1:CAS:528:DC%2BD1MXhtVGhsA%3D%3D 10.1038/nature07623
    • Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M (2009) Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457:102-106
    • (2009) Nature , vol.457 , pp. 102-106
    • Kim, S.1    Takahashi, H.2    Lin, W.W.3    Descargues, P.4    Grivennikov, S.5    Kim, Y.6    Luo, J.L.7    Karin, M.8
  • 118
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • 19308067 1:CAS:528:DC%2BD1MXjsFSrsr4%3D 10.1038/nrc2622
    • Nguyen DX, Bos PD, Massague J (2009) Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9:274-284
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 119
    • 41149178781 scopus 로고    scopus 로고
    • The tumor cell-host organ interface in the early onset of metastatic organ colonisation
    • 18058027 1:CAS:528:DC%2BD1cXmtFyhur4%3D 10.1007/s10585-007-9130-6
    • Gassmann P, Haier J (2008) The tumor cell-host organ interface in the early onset of metastatic organ colonisation. Clin Exp Metastasis 25:171-181
    • (2008) Clin Exp Metastasis , vol.25 , pp. 171-181
    • Gassmann, P.1    Haier, J.2
  • 120
    • 4544224979 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression
    • 15380520 1:CAS:528:DC%2BD2cXot1KisL8%3D 10.1016/j.ccr.2004.08.012
    • Luo JL, Maeda S, Hsu LC, Yagita H, Karin M (2004) Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell 6:297-305
    • (2004) Cancer Cell , vol.6 , pp. 297-305
    • Luo, J.L.1    Maeda, S.2    Hsu, L.C.3    Yagita, H.4    Karin, M.5
  • 121
    • 42549167207 scopus 로고    scopus 로고
    • Fusion of tumour cells with bone marrow-derived cells: A unifying explanation for metastasis
    • 18385683 1:CAS:528:DC%2BD1cXltVGlur8%3D 10.1038/nrc2371
    • Pawelek JM, Chakraborty AK (2008) Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis. Nat Rev Cancer 8:377-386
    • (2008) Nat Rev Cancer , vol.8 , pp. 377-386
    • Pawelek, J.M.1    Chakraborty, A.K.2
  • 122
    • 3142592165 scopus 로고    scopus 로고
    • Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis
    • 15031212 1:CAS:528:DC%2BD2cXlvFSnt7Y%3D 10.1182/blood-2004-02-0434
    • Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin SR (2004) Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood 104:397-401
    • (2004) Blood , vol.104 , pp. 397-401
    • Camerer, E.1    Qazi, A.A.2    Duong, D.N.3    Cornelissen, I.4    Advincula, R.5    Coughlin, S.R.6
  • 123
    • 9244265563 scopus 로고    scopus 로고
    • Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation
    • 15574768 1:CAS:528:DC%2BD2cXhtVCjs73I 10.1158/0008-5472.CAN-04-2078
    • Im JH, Fu W, Wang H, Bhatia SK, Hammer DA, Kowalska MA, Muschel RJ (2004) Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res 64:8613-8619
    • (2004) Cancer Res , vol.64 , pp. 8613-8619
    • Im, J.H.1    Fu, W.2    Wang, H.3    Bhatia, S.K.4    Hammer, D.A.5    Kowalska, M.A.6    Muschel, R.J.7
  • 124
    • 34347385401 scopus 로고    scopus 로고
    • Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms
    • 17371949 1:CAS:528:DC%2BD2sXnsVaisL8%3D 10.1182/blood-2007-01-065995
    • Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL (2007) Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms. Blood 110:133-141
    • (2007) Blood , vol.110 , pp. 133-141
    • Palumbo, J.S.1    Talmage, K.E.2    Massari, J.V.3    La Jeunesse, C.M.4    Flick, M.J.5    Kombrinck, K.W.6    Hu, Z.7    Barney, K.A.8    Degen, J.L.9
  • 125
    • 10844222440 scopus 로고    scopus 로고
    • Platelet-cancer interactions: Mechanisms and pharmacology of tumour cell-induced platelet aggregation
    • 15492016 1:CAS:528:DC%2BD2cXhtFGmurjO 10.1038/sj.bjp.0706013
    • Jurasz P, Alonso-Escolano D, Radomski MW (2004) Platelet-cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation. Br J Pharmacol 143:819-826
    • (2004) Br J Pharmacol , vol.143 , pp. 819-826
    • Jurasz, P.1    Alonso-Escolano, D.2    Radomski, M.W.3
  • 128
    • 68349101949 scopus 로고    scopus 로고
    • Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms
    • 1:CAS:528:DC%2BD1MXovVelsLc%3D 10.1002/ijc.24409
    • McDonald B, Spicer J, Giannais B, Fallavollita L, Brodt P, Ferri LE (2009) Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms. Int J Cancer J Int du Cancer 125:1298-1305
    • (2009) Int J Cancer J Int du Cancer , vol.125 , pp. 1298-1305
    • McDonald, B.1    Spicer, J.2    Giannais, B.3    Fallavollita, L.4    Brodt, P.5    Ferri, L.E.6
  • 129
    • 0042023405 scopus 로고    scopus 로고
    • Neutrophils influence melanoma adhesion and migration under flow conditions
    • 1:CAS:528:DC%2BD3sXms1Squ7Y%3D 10.1002/ijc.11297
    • Slattery MJ, Dong C (2003) Neutrophils influence melanoma adhesion and migration under flow conditions. Int J Cancer J International du Cancer 106:713-722
    • (2003) Int J Cancer J International du Cancer , vol.106 , pp. 713-722
    • Slattery, M.J.1    Dong, C.2
  • 130
    • 15444376600 scopus 로고    scopus 로고
    • Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation
    • 15601752 1:CAS:528:DC%2BD2MXjtlOqur0%3D 10.1152/ajpcell.00439.2004
    • Slattery MJ, Liang S, Dong C (2005) Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation. Am J Physiol Cell Physiol 288:C831-C839
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Slattery, M.J.1    Liang, S.2    Dong, C.3
  • 131
    • 84865107210 scopus 로고    scopus 로고
    • Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells
    • 22751466 1:CAS:528:DC%2BC38XhtF2rtr3I 10.1158/0008-5472.CAN-11-2393
    • Spicer JD, McDonald B, Cools-Lartigue JJ, Chow SC, Giannias B, Kubes P, Ferri LE (2012) Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. Cancer Res 72:3919-3927
    • (2012) Cancer Res , vol.72 , pp. 3919-3927
    • Spicer, J.D.1    McDonald, B.2    Cools-Lartigue, J.J.3    Chow, S.C.4    Giannias, B.5    Kubes, P.6    Ferri, L.E.7
  • 132
    • 33750083649 scopus 로고    scopus 로고
    • Cellular basis of cancer metastasis: A review of fundamentals and new advances
    • 16730054 1:CAS:528:DC%2BD2sXhtVOjtrY%3D 10.1016/j.acthis.2006.03.008
    • Oppenheimer SB (2006) Cellular basis of cancer metastasis: a review of fundamentals and new advances. Acta Histochem 108:327-334
    • (2006) Acta Histochem , vol.108 , pp. 327-334
    • Oppenheimer, S.B.1
  • 133
    • 34447120196 scopus 로고    scopus 로고
    • The role of vascular cell adhesion molecule-1 in tumor immune evasion
    • 17616653 1:CAS:528:DC%2BD2sXnsVyqsLw%3D 10.1158/0008-5472.CAN-07-1543
    • Wu TC (2007) The role of vascular cell adhesion molecule-1 in tumor immune evasion. Cancer Res 67:6003-6006
    • (2007) Cancer Res , vol.67 , pp. 6003-6006
    • Wu, T.C.1
  • 135
    • 80054725681 scopus 로고    scopus 로고
    • Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs
    • 22014578 1:CAS:528:DC%2BC3MXhtlKrtrfN 10.1016/j.ccr.2011.08.025
    • Chen Q, Zhang XH, Massague J (2011) Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20:538-549
    • (2011) Cancer Cell , vol.20 , pp. 538-549
    • Chen, Q.1    Zhang, X.H.2    Massague, J.3
  • 136
    • 83455208311 scopus 로고    scopus 로고
    • VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging alpha4beta1-positive osteoclast progenitors
    • 22137794 1:CAS:528:DC%2BC3MXhs1Cit77P 10.1016/j.ccr.2011.11.002
    • Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M, Yan J, Hua Y, Tiede BJ, Haffty BG et al (2011) VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging alpha4beta1-positive osteoclast progenitors. Cancer Cell 20:701-714
    • (2011) Cancer Cell , vol.20 , pp. 701-714
    • Lu, X.1    Mu, E.2    Wei, Y.3    Riethdorf, S.4    Yang, Q.5    Yuan, M.6    Yan, J.7    Hua, Y.8    Tiede, B.J.9    Haffty, B.G.10
  • 137
    • 67349256382 scopus 로고    scopus 로고
    • Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells
    • 19136936 1:CAS:528:DC%2BD1MXks1ygsbc%3D 10.1038/cdd.2008.190
    • Kochetkova M, Kumar S, McColl SR (2009) Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells. Cell Death Differ 16:664-673
    • (2009) Cell Death Differ , vol.16 , pp. 664-673
    • Kochetkova, M.1    Kumar, S.2    McColl, S.R.3
  • 138
    • 44449109524 scopus 로고    scopus 로고
    • Lymphatic vessel activation in cancer
    • 18519976 1:CAS:528:DC%2BD1cXotFait7w%3D 10.1196/annals.1413.021
    • Das S, Skobe M (2008) Lymphatic vessel activation in cancer. Ann N Y Acad Sci 1131:235-241
    • (2008) Ann N y Acad Sci , vol.1131 , pp. 235-241
    • Das, S.1    Skobe, M.2
  • 139
    • 2942668041 scopus 로고    scopus 로고
    • Lymphatic vasculature: Development, molecular regulation and role in tumor metastasis and inflammation
    • 15207507 1:CAS:528:DC%2BD2cXltVKjtb0%3D 10.1016/j.it.2004.05.003
    • Saharinen P, Tammela T, Karkkainen MJ, Alitalo K (2004) Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 25:387-395
    • (2004) Trends Immunol , vol.25 , pp. 387-395
    • Saharinen, P.1    Tammela, T.2    Karkkainen, M.J.3    Alitalo, K.4
  • 140
    • 33846044750 scopus 로고    scopus 로고
    • Bone marrow cells in the 'pre-metastatic niche': Within bone and beyond
    • 17186383 10.1007/s10555-006-9036-9
    • Kaplan RN, Psaila B, Lyden D (2006) Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer Metastasis Rev 25:521-529
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 521-529
    • Kaplan, R.N.1    Psaila, B.2    Lyden, D.3
  • 142
    • 77955384579 scopus 로고    scopus 로고
    • Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung
    • 20631080 1:CAS:528:DC%2BC3cXpsVCntLo%3D 10.1158/0008-5472.CAN-10-0706
    • Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, Geng Y, Gray JW, Moses HL, Yang L (2010) Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res 70:6139-6149
    • (2010) Cancer Res , vol.70 , pp. 6139-6149
    • Yan, H.H.1    Pickup, M.2    Pang, Y.3    Gorska, A.E.4    Li, Z.5    Chytil, A.6    Geng, Y.7    Gray, J.W.8    Moses, H.L.9    Yang, L.10
  • 143
    • 67650995905 scopus 로고    scopus 로고
    • Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells
    • 19567680 1:CAS:528:DC%2BD1MXosV2mt78%3D 10.1158/0008-5472.CAN-08-4619
    • Olkhanud PB, Baatar D, Bodogai M, Hakim F, Gress R, Anderson RL, Deng J, Xu M, Briest S, Biragyn A (2009) Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells. Cancer Res 69:5996-6004
    • (2009) Cancer Res , vol.69 , pp. 5996-6004
    • Olkhanud, P.B.1    Baatar, D.2    Bodogai, M.3    Hakim, F.4    Gress, R.5    Anderson, R.L.6    Deng, J.7    Xu, M.8    Briest, S.9    Biragyn, A.10
  • 144
    • 33751504690 scopus 로고    scopus 로고
    • Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
    • 17128264 1:CAS:528:DC%2BD28Xht1Kju7rL 10.1038/ncb1507
    • Hiratsuka S, Watanabe A, Aburatani H, Maru Y (2006) Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 8:1369-1375
    • (2006) Nat Cell Biol , vol.8 , pp. 1369-1375
    • Hiratsuka, S.1    Watanabe, A.2    Aburatani, H.3    Maru, Y.4
  • 147
    • 77954563464 scopus 로고    scopus 로고
    • Hypoxia, inflammation, and the tumor microenvironment in metastatic disease
    • 20393783 1:CAS:528:DC%2BC3cXlslWgtrg%3D 10.1007/s10555-010-9224-5
    • Finger EC, Giaccia AJ (2010) Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev 29:285-293
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 285-293
    • Finger, E.C.1    Giaccia, A.J.2
  • 149
    • 55349148665 scopus 로고    scopus 로고
    • The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma
    • 18974152 1:CAS:528:DC%2BD1cXhtlSkur3J 10.1158/0008-5472.CAN-08-1810
    • Marchesi F, Piemonti L, Fedele G, Destro A, Roncalli M, Albarello L, Doglioni C, Anselmo A, Doni A, Bianchi P et al (2008) The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Cancer Res 68:9060-9069
    • (2008) Cancer Res , vol.68 , pp. 9060-9069
    • Marchesi, F.1    Piemonti, L.2    Fedele, G.3    Destro, A.4    Roncalli, M.5    Albarello, L.6    Doglioni, C.7    Anselmo, A.8    Doni, A.9    Bianchi, P.10
  • 150
    • 34247521438 scopus 로고    scopus 로고
    • Priming the 'soil' for breast cancer metastasis: The pre-metastatic niche
    • 17473366 1:CAS:528:DC%2BD2sXksVCjt78%3D
    • Psaila B, Kaplan RN, Port ER, Lyden D (2006) Priming the 'soil' for breast cancer metastasis: the pre-metastatic niche. Breast Dis 26:65-74
    • (2006) Breast Dis , vol.26 , pp. 65-74
    • Psaila, B.1    Kaplan, R.N.2    Port, E.R.3    Lyden, D.4
  • 151
    • 79952070774 scopus 로고    scopus 로고
    • The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts
    • 21251983 1:CAS:528:DC%2BC3MXjs1Crtbs%3D 10.1016/j.semcancer.2011.01.002
    • Peinado H, Lavotshkin S, Lyden D (2011) The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Semin Cancer Biol 21:139-146
    • (2011) Semin Cancer Biol , vol.21 , pp. 139-146
    • Peinado, H.1    Lavotshkin, S.2    Lyden, D.3
  • 152
    • 80053974912 scopus 로고    scopus 로고
    • Roles of metalloproteases in metastatic niche
    • 21707518 1:CAS:528:DC%2BC3MXhsVWhsr3F 10.2174/156652411797536705
    • Rucci N, Sanita P, Angelucci A (2011) Roles of metalloproteases in metastatic niche. Curr Mol Med 11:609-622
    • (2011) Curr Mol Med , vol.11 , pp. 609-622
    • Rucci, N.1    Sanita, P.2    Angelucci, A.3
  • 153
  • 154
    • 1642535552 scopus 로고    scopus 로고
    • Inhibition of cytokine-induced microvascular arrest of tumor cells by recombinant endostatin prevents experimental hepatic melanoma metastasis
    • 14729638 1:CAS:528:DC%2BD2cXkslyktA%3D%3D 10.1158/0008-5472.CAN-03-1829
    • Mendoza L, Valcarcel M, Carrascal T, Egilegor E, Salado C, Sim BK, Vidal-Vanaclocha F (2004) Inhibition of cytokine-induced microvascular arrest of tumor cells by recombinant endostatin prevents experimental hepatic melanoma metastasis. Cancer Res 64:304-310
    • (2004) Cancer Res , vol.64 , pp. 304-310
    • Mendoza, L.1    Valcarcel, M.2    Carrascal, T.3    Egilegor, E.4    Salado, C.5    Sim, B.K.6    Vidal-Vanaclocha, F.7
  • 156
    • 0242352506 scopus 로고    scopus 로고
    • FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3′-inositol phosphatase, PTEN
    • 14607277 1:CAS:528:DC%2BD3sXos1Olsb0%3D 10.1016/S0898-6568(03)00113-X
    • Brown KS, Blair D, Reid SD, Nicholson EK, Harnett MM (2004) FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3′-inositol phosphatase, PTEN. Cell Signal 16:71-80
    • (2004) Cell Signal , vol.16 , pp. 71-80
    • Brown, K.S.1    Blair, D.2    Reid, S.D.3    Nicholson, E.K.4    Harnett, M.M.5
  • 158
    • 70350381008 scopus 로고    scopus 로고
    • Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone
    • 19720836 1:CAS:528:DC%2BD1MXht1Cmt7vJ 10.1074/jbc.M109.035899
    • Lu X, Kang Y (2009) Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem 284:29087-29096
    • (2009) J Biol Chem , vol.284 , pp. 29087-29096
    • Lu, X.1    Kang, Y.2
  • 159
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • 12154351 1:CAS:528:DC%2BD38XlslGqsLo%3D 10.1038/nrc867
    • Mundy GR (2002) Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2:584-593
    • (2002) Nat Rev Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 160
    • 77950690023 scopus 로고    scopus 로고
    • Interleukin-6 in bone metastasis and cancer progression
    • 20335016 1:CAS:528:DC%2BC3cXkvFKqtrs%3D 10.1016/j.ejca.2010.02.026
    • Ara T, Declerck YA (2010) Interleukin-6 in bone metastasis and cancer progression. Eur J Cancer 46:1223-1231
    • (2010) Eur J Cancer , vol.46 , pp. 1223-1231
    • Ara, T.1    Declerck, Y.A.2
  • 161
    • 33846049299 scopus 로고    scopus 로고
    • NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
    • 17159986 1:CAS:528:DC%2BD2sXhvFWjug%3D%3D 10.1038/nm1519
    • Park BK, Zhang H, Zeng Q, Dai J, Keller ET, Giordano T, Gu K, Shah V, Pei L, Zarbo RJ et al (2007) NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat Med 13:62-69
    • (2007) Nat Med , vol.13 , pp. 62-69
    • Park, B.K.1    Zhang, H.2    Zeng, Q.3    Dai, J.4    Keller, E.T.5    Giordano, T.6    Gu, K.7    Shah, V.8    Pei, L.9    Zarbo, R.J.10
  • 164
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • 19308069 1:CAS:528:DC%2BD1MXjsFSrsr8%3D 10.1038/nrc2627
    • Klein CA (2009) Parallel progression of primary tumours and metastases. Nat Rev Cancer 9:302-312
    • (2009) Nat Rev Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 165
    • 80053157914 scopus 로고    scopus 로고
    • Unravelling the complexity of metastasis - Molecular understanding and targeted therapies
    • 21941285 1:CAS:528:DC%2BC3MXht1ajurvF 10.1038/nrc3125
    • Sethi N, Kang Y (2011) Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer 11:735-748
    • (2011) Nat Rev Cancer , vol.11 , pp. 735-748
    • Sethi, N.1    Kang, Y.2
  • 166
    • 84860432909 scopus 로고    scopus 로고
    • The pro-metastatic role of bone marrow-derived cells: A focus on MSCs and regulatory T cells
    • 22473297 1:CAS:528:DC%2BC38XkvFSqtrk%3D 10.1038/embor.2012.41
    • Koh BI, Kang Y (2012) The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells. EMBO Rep 13:412-422
    • (2012) EMBO Rep , vol.13 , pp. 412-422
    • Koh, B.I.1    Kang, Y.2
  • 167
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • 18039110 1:CAS:528:DC%2BD28XktVOitb0%3D 10.1146/annurev.pathol.1.110304. 100224
    • Tlsty TD, Coussens LM (2006) Tumor stroma and regulation of cancer development. Annu Rev Pathol 1:119-150
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 168
    • 84870547819 scopus 로고    scopus 로고
    • Cell-extrinsic consequences of epithelial stress: Activation of protumorigenic tissue phenotypes: BCR
    • 23216814 1:CAS:528:DC%2BC3sXjslyqsr4%3D 10.1186/bcr3368
    • Fordyce CA, Patten KT, Fessenden TB, Defilippis R, Hwang ES, Zhao J, Tlsty TD (2012) Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes: BCR. Breast Cancer Res 14:R155
    • (2012) Breast Cancer Res , vol.14 , pp. 155
    • Fordyce, C.A.1    Patten, K.T.2    Fessenden, T.B.3    Defilippis, R.4    Hwang, E.S.5    Zhao, J.6    Tlsty, T.D.7
  • 169
    • 70949103794 scopus 로고    scopus 로고
    • Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model
    • 19956757 10.1371/journal.pone.0007965 1:CAS:528:DC%2BD1MXhsVyktrrL
    • Liao D, Luo Y, Markowitz D, Xiang R, Reisfeld RA (2009) Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS One 4:e7965
    • (2009) PLoS One , vol.4 , pp. 7965
    • Liao, D.1    Luo, Y.2    Markowitz, D.3    Xiang, R.4    Reisfeld, R.A.5
  • 170
    • 50849117485 scopus 로고    scopus 로고
    • Mesenchymal stem cells in cancer
    • 18493880 10.1007/s12015-008-9030-4
    • Stagg J (2008) Mesenchymal stem cells in cancer. Stem Cell Rev 4:119-124
    • (2008) Stem Cell Rev , vol.4 , pp. 119-124
    • Stagg, J.1
  • 172
    • 79951841819 scopus 로고    scopus 로고
    • Concise review: Dissecting a discrepancy in the literature: Do mesenchymal stem cells support or suppress tumor growth?
    • 21280155 1:CAS:528:DC%2BC3MXjvFSltrw%3D 10.1002/stem.559
    • Klopp AH, Gupta A, Spaeth E, Andreeff M, Marini F 3rd (2011) Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth? Stem Cells 29:11-19
    • (2011) Stem Cells , vol.29 , pp. 11-19
    • Klopp, A.H.1    Gupta, A.2    Spaeth, E.3    Andreeff, M.4    Marini III, F.5
  • 173
    • 49249129381 scopus 로고    scopus 로고
    • The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury
    • 18192235 1:CAS:528:DC%2BD1cXmtFKlur0%3D 10.1634/stemcells.2007-0737
    • Oh JY, Kim MK, Shin MS, Lee HJ, Ko JH, Wee WR, Lee JH (2008) The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells 26:1047-1055
    • (2008) Stem Cells , vol.26 , pp. 1047-1055
    • Oh, J.Y.1    Kim, M.K.2    Shin, M.S.3    Lee, H.J.4    Ko, J.H.5    Wee, W.R.6    Lee, J.H.7
  • 177
    • 78650337010 scopus 로고    scopus 로고
    • Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis
    • 21159629 1:CAS:528:DC%2BC3cXhsFGrt7rK 10.1158/0008-5472.CAN-10-1254
    • Goldstein RH, Reagan MR, Anderson K, Kaplan DL, Rosenblatt M (2010) Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis. Cancer Res 70:10044-10050
    • (2010) Cancer Res , vol.70 , pp. 10044-10050
    • Goldstein, R.H.1    Reagan, M.R.2    Anderson, K.3    Kaplan, D.L.4    Rosenblatt, M.5
  • 178
    • 67650468207 scopus 로고    scopus 로고
    • Genomic predictors of outcome and treatment response in breast cancer
    • 19537843 1:CAS:528:DC%2BD1MXpvFehtrs%3D 10.1007/BF03256317
    • Dunn L, Demichele A (2009) Genomic predictors of outcome and treatment response in breast cancer. Mol Diagn Ther 13:73-90
    • (2009) Mol Diagn Ther , vol.13 , pp. 73-90
    • Dunn, L.1    Demichele, A.2
  • 179
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • 15485625 1:CAS:528:DC%2BD2cXpvVygt7k%3D 10.1016/j.immuni.2004.08.018
    • Kolls JK, Linden A (2004) Interleukin-17 family members and inflammation. Immunity 21:467-476
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 180
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • 17201677 1:CAS:528:DC%2BD2sXltlans7s%3D 10.1146/annurev.immunol.25. 022106.141557
    • Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821-852
    • (2007) Annu Rev Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 182
    • 2342468719 scopus 로고    scopus 로고
    • Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts
    • 15134897 1:CAS:528:DC%2BD2cXjvVeqsLs%3D 10.1016/j.imlet.2004.01.014
    • Numasaki M, Lotze MT, Sasaki H (2004) Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts. Immunol Lett 93:39-43
    • (2004) Immunol Lett , vol.93 , pp. 39-43
    • Numasaki, M.1    Lotze, M.T.2    Sasaki, H.3
  • 183
    • 18044377011 scopus 로고    scopus 로고
    • Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells
    • 15860217 1:CAS:528:DC%2BD2MXjs1ClsrY%3D 10.1016/j.imlet.2004.11.012
    • Takahashi H, Numasaki M, Lotze MT, Sasaki H (2005) Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells. Immunol Lett 98:189-193
    • (2005) Immunol Lett , vol.98 , pp. 189-193
    • Takahashi, H.1    Numasaki, M.2    Lotze, M.T.3    Sasaki, H.4
  • 187
    • 69349095364 scopus 로고    scopus 로고
    • Anticancer strategies involving the vasculature
    • 19424102 1:CAS:528:DC%2BD1MXnslKks78%3D 10.1038/nrclinonc.2009.52
    • Heath VL, Bicknell R (2009) Anticancer strategies involving the vasculature. Nat Rev Clin Oncol 6:395-404
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 395-404
    • Heath, V.L.1    Bicknell, R.2
  • 188
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • 15637262 1:CAS:528:DC%2BD2MXnvFar 10.1126/science.1104819
    • Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307:58-62
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 189
    • 65949096075 scopus 로고    scopus 로고
    • Complexity of tumor vasculature in clear cell renal cell carcinoma
    • 19402071 1:CAS:528:DC%2BD1MXmtVOksbk%3D 10.1002/cncr.24238
    • Qian CN, Huang D, Wondergem B, Teh BT (2009) Complexity of tumor vasculature in clear cell renal cell carcinoma. Cancer 115:2282-2289
    • (2009) Cancer , vol.115 , pp. 2282-2289
    • Qian, C.N.1    Huang, D.2    Wondergem, B.3    Teh, B.T.4
  • 190
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • 17114237 1:CAS:528:DC%2BD28Xht1KnsL%2FI 10.1158/0008-5472.CAN-06-1278
    • Lin EY, Li JF, Gnatovskiy L, Deng Y, Zhu L, Grzesik DA, Qian H, Xue XN, Pollard JW (2006) Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 66:11238-11246
    • (2006) Cancer Res , vol.66 , pp. 11238-11246
    • Lin, E.Y.1    Li, J.F.2    Gnatovskiy, L.3    Deng, Y.4    Zhu, L.5    Grzesik, D.A.6    Qian, H.7    Xue, X.N.8    Pollard, J.W.9
  • 191
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • 16169466 10.1016/j.ccr.2005.08.002 1:CAS:528:DC%2BD2MXhtV2gt7vM
    • De Palma M, Venneri MA, Galli R, Sergi Sergi L, Politi LS, Sampaolesi M, Naldini L (2005) Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8:211-226
    • (2005) Cancer Cell , vol.8 , pp. 211-226
    • De Palma, M.1    Venneri, M.A.2    Galli, R.3    Sergi Sergi, L.4    Politi, L.S.5    Sampaolesi, M.6    Naldini, L.7
  • 192
    • 33747602354 scopus 로고    scopus 로고
    • Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
    • 16891410 1:CAS:528:DC%2BD28Xos1OjurY%3D 10.1073/pnas.0601807103
    • Nozawa H, Chiu C, Hanahan D (2006) Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci USA 103:12493-12498
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12493-12498
    • Nozawa, H.1    Chiu, C.2    Hanahan, D.3
  • 193
    • 70349782389 scopus 로고    scopus 로고
    • An overview of small-molecule inhibitors of VEGFR signaling
    • 19736552 1:CAS:528:DC%2BD1MXhtFyntbbI 10.1038/nrclinonc.2009.130
    • Ivy SP, Wick JY, Kaufman BM (2009) An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 6:569-579
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 194
    • 55849107422 scopus 로고    scopus 로고
    • Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice
    • 18776941 1:CAS:528:DC%2BD1cXht1ChsrrE 10.1172/JCI35213
    • Kujawski M, Kortylewski M, Lee H, Herrmann A, Kay H, Yu H (2008) Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J Clin Invest 118:3367-3377
    • (2008) J Clin Invest , vol.118 , pp. 3367-3377
    • Kujawski, M.1    Kortylewski, M.2    Lee, H.3    Herrmann, A.4    Kay, H.5    Yu, H.6
  • 196
  • 197
    • 34548798765 scopus 로고    scopus 로고
    • Tie2-expressing monocytes and tumor angiogenesis: Regulation by hypoxia and angiopoietin-2
    • 17875679 1:CAS:528:DC%2BD2sXhtVCit7%2FE 10.1158/0008-5472.CAN-07-1684
    • Lewis CE, De Palma M, Naldini L (2007) Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. Cancer Res 67:8429-8432
    • (2007) Cancer Res , vol.67 , pp. 8429-8432
    • Lewis, C.E.1    De Palma, M.2    Naldini, L.3
  • 198
    • 80055009377 scopus 로고    scopus 로고
    • Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease
    • 21924227 1:CAS:528:DC%2BC3MXhsFCmu7nJ 10.1016/j.ajpath.2011.07.029
    • Capobianco A, Monno A, Cottone L, Venneri MA, Biziato D, Di Puppo F, Ferrari S, De Palma M, Manfredi AA, Rovere-Querini P (2011) Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease. Am J Pathol 179:2651-2659
    • (2011) Am J Pathol , vol.179 , pp. 2651-2659
    • Capobianco, A.1    Monno, A.2    Cottone, L.3    Venneri, M.A.4    Biziato, D.5    Di Puppo, F.6    Ferrari, S.7    De Palma, M.8    Manfredi, A.A.9    Rovere-Querini, P.10
  • 200
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    • 11689883 1:CAS:528:DC%2BD3MXotlKltLY%3D 10.1038/nm1101-1194
    • Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L et al (2001) Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7:1194-1201
    • (2001) Nat Med , vol.7 , pp. 1194-1201
    • Lyden, D.1    Hattori, K.2    Dias, S.3    Costa, C.4    Blaikie, P.5    Butros, L.6    Chadburn, A.7    Heissig, B.8    Marks, W.9    Witte, L.10
  • 201
  • 202
    • 77954551165 scopus 로고    scopus 로고
    • Why not treat human cancer with interleukin-1 blockade?
    • 20422276 1:CAS:528:DC%2BC3cXlslWgtrk%3D 10.1007/s10555-010-9229-0
    • Dinarello C (2010) Why not treat human cancer with interleukin-1 blockade? Cancer Metastasis Rev 29:317-329
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 317-329
    • Dinarello, C.1
  • 203
    • 84873129546 scopus 로고    scopus 로고
    • CTLA-4 blockade in tumor models: An overview of preclinical and translational research
    • 23390376
    • Grosso JF, Jure-Kunkel MN (2013) CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun 13:5
    • (2013) Cancer Immun , vol.13 , pp. 5
    • Grosso, J.F.1    Jure-Kunkel, M.N.2
  • 205
    • 84856862354 scopus 로고    scopus 로고
    • PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer
    • 22306905 1:CAS:528:DC%2BC38XhslOltLo%3D 10.1097/CJI.0b013e318247a4e7
    • Dulos J, Carven GJ, van Boxtel SJ, Evers S, Driessen-Engels LJ, Hobo W, Gorecka MA, de Haan AF, Mulders P, Punt CJ et al (2012) PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer. J Immunother 35:169-178
    • (2012) J Immunother , vol.35 , pp. 169-178
    • Dulos, J.1    Carven, G.J.2    Van Boxtel, S.J.3    Evers, S.4    Driessen-Engels, L.J.5    Hobo, W.6    Gorecka, M.A.7    De Haan, A.F.8    Mulders, P.9    Punt, C.J.10
  • 206
    • 84865316603 scopus 로고    scopus 로고
    • Immunomodulating antibodies in the treatment of metastatic melanoma: The experience with anti-CTLA-4, anti-CD137, and anti-PD1
    • 22524673 1:CAS:528:DC%2BC38Xht1ajsrnO 10.3109/1547691X.2012.678021
    • Simeone E, Ascierto PA (2012) Immunomodulating antibodies in the treatment of metastatic melanoma: the experience with anti-CTLA-4, anti-CD137, and anti-PD1. J Immunotoxicol 9:241-247
    • (2012) J Immunotoxicol , vol.9 , pp. 241-247
    • Simeone, E.1    Ascierto, P.A.2
  • 207
    • 81255138488 scopus 로고    scopus 로고
    • Ipilimumab: An anti-CTLA-4 antibody for metastatic melanoma
    • 1:CAS:528:DC%2BC3MXhsVKht73J 10.1158/1078-0432.CCR-11-1595
    • Lipson EJ, Drake CG (2011) Ipilimumab: an anti-CTLA-4 antibody for metastatic melanoma. Clin Cancer Res Off J Am Assoc Cancer Res 17:6958-6962
    • (2011) Clin Cancer Res off J Am Assoc Cancer Res , vol.17 , pp. 6958-6962
    • Lipson, E.J.1    Drake, C.G.2
  • 208
    • 84874811135 scopus 로고    scopus 로고
    • The connection between lymphangiogenic signalling and prostaglandin biology: A missing link in the metastatic pathway
    • 23097685
    • Karnezis T, Shayan R, Fox S, Achen MG, Stacker SA (2012) The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway. Oncotarget 3:893-906
    • (2012) Oncotarget , vol.3 , pp. 893-906
    • Karnezis, T.1    Shayan, R.2    Fox, S.3    Achen, M.G.4    Stacker, S.A.5
  • 209
    • 84864538653 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and melanoma
    • 22632752 1:CAS:528:DC%2BC38XhsVKku7rM 10.2174/138161212802083680
    • Sanz-Motilva V, Martorell-Calatayud A, Nagore E (2012) Non-steroidal anti-inflammatory drugs and melanoma. Curr Pharm Des 18:3966-3978
    • (2012) Curr Pharm des , vol.18 , pp. 3966-3978
    • Sanz-Motilva, V.1    Martorell-Calatayud, A.2    Nagore, E.3
  • 210
    • 32644470964 scopus 로고    scopus 로고
    • Colon cancer - Understanding how NSAIDs work
    • 16481647 1:CAS:528:DC%2BD28XhsVWqsbs%3D 10.1056/NEJMcibr055457
    • Clevers H (2006) Colon cancer - understanding how NSAIDs work. N Engl J Med 354:761-763
    • (2006) N Engl J Med , vol.354 , pp. 761-763
    • Clevers, H.1
  • 211
    • 52049121633 scopus 로고    scopus 로고
    • Antimetastatic effect of an orally active heparin derivative on experimentally induced metastasis
    • 1:CAS:528:DC%2BD1cXlsFSjs78%3D 10.1158/1078-0432.CCR-07-0641
    • Lee DY, Park K, Kim SK, Park RW, Kwon IC, Kim SY, Byun Y (2008) Antimetastatic effect of an orally active heparin derivative on experimentally induced metastasis. Clin Cancer Res Off J Am Assoc Cancer Res 14:2841-2849
    • (2008) Clin Cancer Res off J Am Assoc Cancer Res , vol.14 , pp. 2841-2849
    • Lee, D.Y.1    Park, K.2    Kim, S.K.3    Park, R.W.4    Kwon, I.C.5    Kim, S.Y.6    Byun, Y.7
  • 212
    • 84867752187 scopus 로고    scopus 로고
    • Myeloid cells in tumor inflammation
    • 22938502 10.1186/2045-824X-4-14
    • Schmid MC, Varner JA (2012) Myeloid cells in tumor inflammation. Vascular cell 4:14
    • (2012) Vascular Cell , vol.4 , pp. 14
    • Schmid, M.C.1    Varner, J.A.2
  • 213
    • 84867792293 scopus 로고    scopus 로고
    • UPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation
    • 23060546 1:CAS:528:DC%2BC38Xhs1ygtbvK
    • Ilkovitch D, Carrio R, Lopez DM (2012) uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation. Anticancer Res 32:4263-4270
    • (2012) Anticancer Res , vol.32 , pp. 4263-4270
    • Ilkovitch, D.1    Carrio, R.2    Lopez, D.M.3
  • 214
    • 84866939221 scopus 로고    scopus 로고
    • PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cells
    • 23017139 1:CAS:528:DC%2BC38XhsVeiurrL 10.3109/08820139.2012.695417
    • Obermajer N, Wong JL, Edwards RP, Odunsi K, Moysich K, Kalinski P (2012) PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cells. Immunol Invest 41:635-657
    • (2012) Immunol Invest , vol.41 , pp. 635-657
    • Obermajer, N.1    Wong, J.L.2    Edwards, R.P.3    Odunsi, K.4    Moysich, K.5    Kalinski, P.6
  • 215
    • 84868125342 scopus 로고    scopus 로고
    • Significance of IL-6 in the transition of hormone-resistant prostate cancer and the induction of myeloid-derived suppressor cells
    • 1:CAS:528:DC%2BC38XhsFKgtb%2FJ 10.1007/s00109-012-0916-x
    • Wu CT, Hsieh CC, Lin CC, Chen WC, Hong JH, Chen MF (2012) Significance of IL-6 in the transition of hormone-resistant prostate cancer and the induction of myeloid-derived suppressor cells. J Mol Med (Berl) 90:1343-1355
    • (2012) J Mol Med (Berl) , vol.90 , pp. 1343-1355
    • Wu, C.T.1    Hsieh, C.C.2    Lin, C.C.3    Chen, W.C.4    Hong, J.H.5    Chen, M.F.6
  • 216
    • 84862076074 scopus 로고    scopus 로고
    • Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release
    • 22529296 1:CAS:528:DC%2BC38Xnt1ais7g%3D 10.4049/jimmunol.1103553
    • Jayaraman P, Parikh F, Lopez-Rivera E, Hailemichael Y, Clark A, Ma G, Cannan D, Ramacher M, Kato M, Overwijk WW et al (2012) Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol 188:5365-5376
    • (2012) J Immunol , vol.188 , pp. 5365-5376
    • Jayaraman, P.1    Parikh, F.2    Lopez-Rivera, E.3    Hailemichael, Y.4    Clark, A.5    Ma, G.6    Cannan, D.7    Ramacher, M.8    Kato, M.9    Overwijk, W.W.10
  • 217
    • 80053336355 scopus 로고    scopus 로고
    • Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor
    • 21980263 1:CAS:528:DC%2BC3MXhtlCjsrbN 10.1371/journal.pbio.1001162
    • Toh B, Wang X, Keeble J, Sim WJ, Khoo K, Wong WC, Kato M, Prevost-Blondel A, Thiery JP, Abastado JP (2011) Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol 9:e1001162
    • (2011) PLoS Biol , vol.9 , pp. 1001162
    • Toh, B.1    Wang, X.2    Keeble, J.3    Sim, W.J.4    Khoo, K.5    Wong, W.C.6    Kato, M.7    Prevost-Blondel, A.8    Thiery, J.P.9    Abastado, J.P.10
  • 218
    • 84874391326 scopus 로고    scopus 로고
    • Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious?
    • 22754792 10.4161/onci.19401
    • Facciabene A, Santoro S, Coukos G (2012) Know thy enemy: why are tumor-infiltrating regulatory T cells so deleterious? Oncoimmunology 1:575-577
    • (2012) Oncoimmunology , vol.1 , pp. 575-577
    • Facciabene, A.1    Santoro, S.2    Coukos, G.3
  • 220
    • 62449250053 scopus 로고    scopus 로고
    • Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome
    • 19244125 1:CAS:528:DC%2BD1MXisFSrtbg%3D 10.1158/0008-5472.CAN-08-2360
    • Gobert M, Treilleux I, Bendriss-Vermare N, Bachelot T, Goddard-Leon S, Arfi V, Biota C, Doffin AC, Durand I, Olive D et al (2009) Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 69:2000-2009
    • (2009) Cancer Res , vol.69 , pp. 2000-2009
    • Gobert, M.1    Treilleux, I.2    Bendriss-Vermare, N.3    Bachelot, T.4    Goddard-Leon, S.5    Arfi, V.6    Biota, C.7    Doffin, A.C.8    Durand, I.9    Olive, D.10
  • 221
    • 69249242897 scopus 로고    scopus 로고
    • The yin-yang of tumor-associated neutrophils
    • 19732714 1:CAS:528:DC%2BD1MXhsVChs7rK 10.1016/j.ccr.2009.08.014
    • Mantovani A (2009) The yin-yang of tumor-associated neutrophils. Cancer Cell 16:173-174
    • (2009) Cancer Cell , vol.16 , pp. 173-174
    • Mantovani, A.1
  • 223
    • 84860484044 scopus 로고    scopus 로고
    • Tumor-associated neutrophils: Friend or foe?
    • 22425643 1:CAS:528:DC%2BC38Xmt1yit7w%3D 10.1093/carcin/bgs123
    • Fridlender ZG, Albelda SM (2012) Tumor-associated neutrophils: friend or foe? Carcinogenesis 33:949-955
    • (2012) Carcinogenesis , vol.33 , pp. 949-955
    • Fridlender, Z.G.1    Albelda, S.M.2
  • 224
    • 79251577730 scopus 로고    scopus 로고
    • The platelet contribution to cancer progression
    • 1:CAS:528:DC%2BC3MXjtVSgsr0%3D 10.1111/j.1538-7836.2010.04131.x
    • Bambace NM, Holmes CE (2011) The platelet contribution to cancer progression. J Thromb Haemostasis JTH 9:237-249
    • (2011) J Thromb Haemostasis JTH , vol.9 , pp. 237-249
    • Bambace, N.M.1    Holmes, C.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.