Chemokines and chemokine receptors: An overview

Frontiers in Bioscience

Volumn 14, Issue 2, 2009, Pages 540-551

  Bonecchi, Raffaella ^a,b   Galliera, Emanuela ^b   Borroni, Elena M ^a,b   Corsi, Massimiliano M ^b   Locati, Massimo ^a,b   Mantovani, Alberto ^a,b  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Chemokine; Chemokine receptor; Inflammation; Review

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR;

ANIMAL; HOMEOSTASIS; HUMAN; PHYSIOLOGY; REVIEW;

ANIMALS; CHEMOKINES; HOMEOSTASIS; HUMANS; RECEPTORS, CHEMOKINE;

EID: 63849337259     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3261     Document Type: Article

References (57)

1. A. D. Luster: Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med., 338(7), 436-45(1998) (Pubitemid 28135672)
2. M. Baggiolini, B. Dewald and B. Moser: Human chemokines: an update. Annu Rev Immunol, 15, 675-705(1997) (Pubitemid 27169296)
3. M. Locati and P. M. Murphy: Chemokines and chemokine receptors: biology and clinical relevance in inflammation and AIDS. Annu Rev Med, 50, 425-40(1999) (Pubitemid 29117076)
4. R. Colobran, R. Pujol-Borrell, M. P. Armengol and M. Juan: The chemokine network. I. How the genomic organization of chemokines contains clues for deciphering their functional complexity. Clin Exp Immunol, 148(2), 208-17(2007) (Pubitemid 46587590)
5. K. Bacon, M. Baggiolini, H. Broxmeyer, R. Horuk, I. Lindley, A. Mantovani, K. Maysushima, P. Murphy, H. Nomiyama, J. Oppenheim, A. Rot, T. Schall, M. Tsang, R. Thorpe, J. Van Damme, M. Wadhwa, O. Yoshie, A. Zlotnik and K. Zoon: Chemokine/chemokine receptor nomenclature. J Interferon Cytokine Res, 22(10), 1067-8(2002)
6. P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim and C. A. Power: International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev, 52(1), 145-76. (2000) (Pubitemid 30127598)
7. A. Mantovani: The chemokine system: redundancy for robust outputs. Immunol Today, 20(6), 254-7. (1999) (Pubitemid 29258161)
8. A. Mantovani, A. Sica, S. Sozzani, P. Allavena, A. Vecchi and M. Locati: The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol, 25(12), 677-86(2004) (Pubitemid 39457982)
9. J. A. Hedrick, A. Helms, A. Vicari and A. Zlotnik: Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10. Blood, 91(11), 4242-7(1998) (Pubitemid 28261988)
10. S. Struyf, M. D. Burdick, P. Proost, J. Van Damme and R. M. Strieter: Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. Circ Res, 95(9), 855-7(2004) (Pubitemid 39434999)
11. P. Perrier, F. O. Martinez, M. Locati, G. Bianchi, M. Nebuloni, G. Vago, F. Bazzoni, S. Sozzani, P. Allavena and A. Mantovani: Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13. J Immunol, 172(11), 7031-42(2004) (Pubitemid 38669145)
12. R. Bonecchi, G. Bianchi, P. P. Bordignon, D. D'Ambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P. A. Gray, A. Mantovani and F. Sinigaglia: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med, 187(1), 129-34(1998) (Pubitemid 28044828)
13. D. Rossi and A. Zlotnik: The biology of chemokines and their receptors. Annu Rev Immunol, 18, 217-42(2000)
14. C. R. Mackay: Chemokines: immunology's high impact factors. Nat Immunol, 2(2), 95-101. (2001) (Pubitemid 33707925)
15. Z. Johnson, A. E. Proudfoot and T. M. Handel: Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention. Cytokine Growth Factor Rev, 16(6), 625-36(2005) (Pubitemid 41509199)
16. S. Lira: Lessons from gene modified mice. Forum (Genova), 9(4), 286-98(1999)
17. S. Struyf, P. Proost and J. Van Damme: Regulation of the immune response by the interaction of chemokines and proteases. Adv Immunol, 81, 1-44(2003) (Pubitemid 38009040)
18. R. Bonecchi, M. Locati, E. Galliera, M. Vulcano, M. Sironi, A. M. Fra, M. Gobbi, A. Vecchi, S. Sozzani, B. Haribabu, J. Van Damme and A. Mantovani: Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor. J Immunol, 172(8), 4972-6(2004) (Pubitemid 38456423)
19. M. Detheux, L. Standker, J. Vakili, J. Munch, U. Forssmann, K. Adermann, S. Pohlmann, G. Vassart, F. Kirchhoff, M. Parmentier and W. G. Forssmann: Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR) 1 and CCR5 agonist with anti-HIV properties. J Exp Med, 192(10), 1501-8(2000)
20. S. Sozzani, P. Allavena, G. D'Amico, W. Luini, G. Bianchi, M. Kataura, T. Imai, O. Yoshie, R. Bonecchi and A. Mantovani: Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties. J Immunol, 161(3), 1083-6(1998) (Pubitemid 28380531)
21. M. Thelen: Dancing to the tune of chemokines. Nat Immunol, 2(2), 129-34. (2001) (Pubitemid 33707930)
22. G. D'Amico, G. Frascaroli, G. Bianchi, P. Transidico, A. Doni, A. Vecchi, S. Sozzani, P. Allavena and A. Mantovani: Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys. Nat Immunol, 1(5), 387-91. (2000)
23. A. Mantovani, R. Bonecchi and M. Locati: Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat Rev Immunol, 6(12), 907-18(2006) (Pubitemid 44851733)
24. M. Locati, Y. M. Torre, E. Galliera, R. Bonecchi, H. Bodduluri, G. Vago, A. Vecchi and A. Mantovani: Silent chemoattractant receptors: D6 as a decoy and scavenger receptor for inflammatory CC chemokines. Cytokine Growth Factor Rev, 16(6), 679-86(2005) (Pubitemid 41505523)
25. R. J. Nibbs, E. Kriehuber, P. D. Ponath, D. Parent, S. Qin, J. D. Campbell, A. Henderson, D. Kerjaschki, D. Maurer, G. J. Graham and A. Rot: The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. Am J Pathol, 158(3), 867-77. (2001) (Pubitemid 32221780)
26. Y. Martinez de la Torre, C. Buracchi, E. M. Borroni, J. Dupor, R. Bonecchi, M. Nebuloni, F. Pasqualini, A. Doni, E. Lauri, C. Agostinis, R. Bulla, D. N. Cook, B. Haribabu, P. Meroni, D. Rukavina, L. Vago, F. Tedesco, A. Vecchi, S. A. Lira, M. Locati and A. Mantovani: Protection against inflammation-and autoantibody-caused fetal loss by the chemokine decoy receptor D6. Proc Natl Acad Sci U S A, 104(7), 2319-24(2007) (Pubitemid 46391395)
27. A. M. Fra, M. Locati, K. Otero, M. Sironi, P. Signorelli, M. L. Massardi, M. Gobbi, A. Vecchi, S. Sozzani and A. Mantovani: Cutting Edge: Scavenging of Inflammatory CC Chemokines by the Promiscuous Putatively Silent Chemokine Receptor D6. J Immunol, 170(5), 2279-2282(2003) (Pubitemid 36245612)
28. E. Galliera, V. R. Jala, J. O. Trent, R. Bonecchi, P. Signorelli, R. J. Lefkowitz, A. Mantovani, M. Locati and B. Haribabu: beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. J Biol Chem, 279(24), 25590-7(2004) (Pubitemid 38756820)
29. M. Weber, E. Blair, C. V. Simpson, M. O'Hara, P. E. Blackburn, A. Rot, G. J. Graham and R. J. Nibbs: The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines. Mol Biol Cell, 15(5), 2492-508(2004) (Pubitemid 38580663)
30. T. Jamieson, D. N. Cook, R. J. Nibbs, A. Rot, C. Nixon, P. McLean, A. Alcami, S. A. Lira, M. Wiekowski and G. J. Graham: The chemokine receptor D6 limits the inflammatory response in vivo. Nat Immunol, 6(4), 403-11(2005) (Pubitemid 41716781)
31. Y. Martinez de la Torre, M. Locati, C. Buracchi, J. Dupor, D. N. Cook, R. Bonecchi, M. Nebuloni, D. Rukavina, L. Vago, A. Vecchi, S. A. Lira and A. Mantovani: Increased inflammation in mice deficient for the chemokine decoy receptor D6. Eur J Immunol, 35(5), 1342-6(2005) (Pubitemid 40691415)
32. L. Liu, G. J. Graham, A. Damodaran, T. Hu, S. A. Lira, M. Sasse, C. Canasto-Chibuque, D. N. Cook and R. M. Ransohoff: Cutting Edge: The silent chemokine receptor D6 is required for generating T cell responses that mediate experimental autoimmune encephalomyelitis. J Immunol, 177(1), 17-21(2006) (Pubitemid 43939108)
33. M. Locati, R. Bonecchi and M. M. Corsi: Chemokines and their receptors: roles in specific clinical conditions and measurement in the clinical laboratory. Am J Clin Pathol, 123 Suppl, S82-95 (2005)
34. F. Sallusto and C. R. Mackay: Chemoattractants and their receptors in homeostasis and inflammation. Curr Opin Immunol, 16(6), 724-31(2004) (Pubitemid 39423660)
35. A. Harada, N. Sekido, T. Akahoshi, T. Wada, N. Mukaida and K. Matsushima: Essential involvement of interleukin-8(IL-8) in acute inflammation. J Leukoc Biol, 56(5), 559-64(1994) (Pubitemid 24348812)
36. R. Bertini, M. Allegretti, C. Bizzarri, A. Moriconi, M. Locati, G. Zampella, M. N. Cervellera, V. Di Cioccio, M. C. Cesta, E. Galliera, F. O. Martinez, R. Di Bitondo, G. Troiani, V. Sabbatini, G. D'Anniballe, R. Anacardio, J. C. Cutrin, B. Cavalieri, F. Mainiero, R. Strippoli, P. Villa, M. Di Girolamo, F. Martin, M. Gentile, A. Santoni, D. Corda, G. Poli, A. Mantovani, P. Ghezzi and F. Colotta: Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A, 101(32), 11791-6(2004) (Pubitemid 39095373)
37. W. J. Karpus and R. M. Ransohoff: Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis. J Immunol, 161(6), 2667-71(1998) (Pubitemid 28425682)
38. J. Gosling, S. Slaymaker, L. Gu, S. Tseng, C. H. Zlot, S. G. Young, B. J. Rollins and I. F. Charo: MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B. J Clin Invest, 103(6), 773-8(1999) (Pubitemid 29152622)
39. P. C. Fulkerson, C. A. Fischetti, M. L. McBride, L. M. Hassman, S. P. Hogan and M. E. Rothenberg: A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc Natl Acad Sci U S A, 103(44), 16418-23(2006) (Pubitemid 44715211)
40. B. M. Saunders and W. J. Britton: Life and death in the granuloma: immunopathology of tuberculosis. Immunol Cell Biol, 85(2), 103-11(2007) (Pubitemid 46398725)
41. A. L. Miller, C. Gerard, M. Schaller, A. D. Gruber, A. A. Humbles and N. W. Lukacs: Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection. J Immunol, 176(4), 2562-7(2006) (Pubitemid 43201708)
42. B. Ma, W. Liu, R. J. Homer, P. J. Lee, A. J. Coyle, J. M. Lora, C. G. Lee and J. A. Elias: Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol, 176(8), 4968-78(2006)
43. K. Blease, B. Mehrad, T. J. Standiford, N. W. Lukacs, J. Gosling, L. Boring, I. F. Charo, S. L. Kunkel and C. M. Hogaboam: Enhanced pulmonary allergic responses to Aspergillus in CCR2-/-mice. J Immunol, 165(5), 2603-11(2000) (Pubitemid 30660707)
44. Y. Zhou, T. Kurihara, R. P. Ryseck, Y. Yang, C. Ryan, J. Loy, G. Warr and R. Bravo: Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J Immunol, 160(8), 4018-25(1998) (Pubitemid 28176111)
45. A. Alcami: Viral mimicry of cytokines, chemokines and their receptors. Nat Rev Immunol, 3(1), 36-50(2003) (Pubitemid 37328698)
46. K. K. Jensen and S. A. Lira: Chemokines and Kaposi's sarcoma. Semin Cancer Biol, 14(3), 187-94(2004) (Pubitemid 38586744)
47. P. Lusso: HIV and the chemokine system: 10 years later. Embo J, 25(3), 447-56(2006)
48. A. M. Tsibris and D. R. Kuritzkes: Chemokine antagonists as therapeutics: focus on HIV-1. Annu Rev Med, 58, 445-59(2007) (Pubitemid 46706526)
49. S. J. O'Brien and J. P. Moore: The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol Rev, 177, 99-111(2000)
50. J. K. Lim, W. G. Glass, D. H. McDermott and P. M. Murphy: CCR5: no longer a "good for nothing" gene-chemokine control of West Nile virus infection. Trends Immunol, 27(7), 308-12(2006) (Pubitemid 43963479)
51. A. Rot: Contribution of Duffy antigen to chemokine function. Cytokine Growth Factor Rev, 16(6), 687-94(2005) (Pubitemid 41505524)
52. R. M. Strieter, M. D. Burdick, B. N. Gomperts, J. A. Belperio and M. P. Keane: CXC chemokines in angiogenesis. Cytokine Growth Factor Rev, 16(6), 593-609(2005) (Pubitemid 41505519)
53. P. Romagnani, L. Lasagni, F. Annunziato, M. Serio and S. Romagnani: CXC chemokines: the regulatory link between inflammation and angiogenesis. Trends Immunol, 25(4), 201-9(2004) (Pubitemid 38372168)
54. A. Zlotnik: Chemokines and cancer. Int J Cancer, 119(9), 2026-9(2006) (Pubitemid 44423657)
55. F. Balkwill: Cancer and the chemokine network. Nat Rev Cancer, 4(7), 540-50(2004) (Pubitemid 38868623)
56. H. Kulbe, N. R. Levinson, F. Balkwill and J. L. Wilson: The chemokine network in cancer-much more than directing cell movement. Int J Dev Biol, 48(5-6), 489-96(2004) (Pubitemid 39360399)
57. F. Balkwill: The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol, 14(3), 171-9(2004) (Pubitemid 38586742)