메뉴 건너뛰기




Volumn 3, Issue 8, 2012, Pages 890-903

The connection between lymphangiogenic signalling and prostaglandin biology: A missing link in the metastatic pathway

Author keywords

Angiogenesis; Aspirin; Cancer; COX 1; COX 2; Lymphangiogenesis; Lymphatics; Metastasis; NSAID; PGDH; Prostaglandin; VEGF D

Indexed keywords

CELECOXIB; DICLOFENAC; ETODOLAC; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; ROFECOXIB; VASCULOTROPIN; VASCULOTROPIN C; VASCULOTROPIN D; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; PTGS1 PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN; VEGFC PROTEIN, HUMAN;

EID: 84874811135     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.593     Document Type: Article
Times cited : (47)

References (159)
  • 1
    • 0026536653 scopus 로고
    • Cancer cell invasion and metastasis
    • Liotta LA. Cancer cell invasion and metastasis. Scientific American. 1992; 266(1992):54-63.
    • (1992) Scientific American. 1992. , vol.266 , pp. 54-63
    • Liotta, L.A.1
  • 2
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. The Lancet. 1889; 1:571-573.
    • (1889) The Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 3
    • 0004182442 scopus 로고
    • W. B. Saunders Co., Philadelphia
    • Ewing J. (1928). Neoplastic diseases: W. B. Saunders Co., Philadelphia.
    • (1928) Neoplastic diseases
    • Ewing, J.1
  • 4
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
    • Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nature RevCancer. 2003; 3(6):453-458.
    • (2003) Nature RevCancer , vol.3 , Issue.6 , pp. 453-458
    • Fidler, I.J.1
  • 5
    • 80054046700 scopus 로고    scopus 로고
    • A role for bone morphogenic protein-4 in vascular endothelial growth factor-D mediated tumor growth, metastasis and vessel remodelling
    • Farnsworth RH, Karnezis T, Shayan R, Matsumoto M, Nowell CJ, Achen MG and Stacker SA. A role for bone morphogenic protein-4 in vascular endothelial growth factor-D mediated tumor growth, metastasis and vessel remodelling. Cancer Res. 2011; 71:6547-6557.
    • (2011) Cancer Res , vol.71 , pp. 6547-6557
    • Farnsworth, R.H.1    Karnezis, T.2    Shayan, R.3    Matsumoto, M.4    Nowell, C.J.5    Achen, M.G.6    Stacker, S.A.7
  • 8
    • 79952073341 scopus 로고    scopus 로고
    • The biology of cancer metastasis
    • Fidler IJ. The biology of cancer metastasis. Semin Cancer Biol. 2011; 21(2):71.
    • (2011) Semin Cancer Biol , vol.21 , Issue.2 , pp. 71
    • Fidler, I.J.1
  • 9
    • 76749083490 scopus 로고    scopus 로고
    • Lymphangiogenesis: Molecular mechanisms and future promise
    • Tammela T and Alitalo K. Lymphangiogenesis: Molecular mechanisms and future promise. Cell. 2010; 140(4):460- 476.
    • (2010) Cell , vol.140 , Issue.4 , pp. 460-476
    • Tammela, T.1    Alitalo, K.2
  • 10
    • 25444525461 scopus 로고    scopus 로고
    • Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis
    • Cao Y. Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat Rev Cancer. 2005; 5(9):735-743.
    • (2005) Nat Rev Cancer , vol.5 , Issue.9 , pp. 735-743
    • Cao, Y.1
  • 11
    • 84858307271 scopus 로고    scopus 로고
    • Tumor lymphangiogenesis as a potential therapeutic target
    • Duong T, Koopman P and Francois M. Tumor lymphangiogenesis as a potential therapeutic target. J Oncol. 2012; 2012:204946.
    • (2012) J Oncol , vol.2012 , pp. 204946
    • Duong, T.1    Koopman, P.2    Francois, M.3
  • 12
    • 33748190835 scopus 로고    scopus 로고
    • Lymphatic vessels in cancer metastasis: bridging the gaps
    • Shayan R, Achen MG and Stacker SA. Lymphatic vessels in cancer metastasis: bridging the gaps. Carcinogenesis. 2006; 27(9):1729-1738.
    • (2006) Carcinogenesis , vol.27 , Issue.9 , pp. 1729-1738
    • Shayan, R.1    Achen, M.G.2    Stacker, S.A.3
  • 14
    • 13844265843 scopus 로고    scopus 로고
    • Focus on lymphangiogenesis in tumor metastasis
    • Achen MG, McColl BK and Stacker SA. Focus on lymphangiogenesis in tumor metastasis. Cancer Cell. 2005; 7(2):121-127.
    • (2005) Cancer Cell , vol.7 , Issue.2 , pp. 121-127
    • Achen, M.G.1    McColl, B.K.2    Stacker, S.A.3
  • 15
    • 41749093830 scopus 로고    scopus 로고
    • Molecular biology and pathology of lymphangiogenesis
    • Karpanen T and Alitalo K. Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol. 2008; 3:367-397.
    • (2008) Annu Rev Pathol , vol.3 , pp. 367-397
    • Karpanen, T.1    Alitalo, K.2
  • 16
    • 0030026897 scopus 로고    scopus 로고
    • A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
    • Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N and Alitalo K. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. The EMBO journal. 1996; 15(2):290-298.
    • (1996) The EMBO journal , vol.15 , Issue.2 , pp. 290-298
    • Joukov, V.1    Pajusola, K.2    Kaipainen, A.3    Chilov, D.4    Lahtinen, I.5    Kukk, E.6    Saksela, O.7    Kalkkinen, N.8    Alitalo, K.9
  • 17
    • 0031905861 scopus 로고    scopus 로고
    • Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk-1) and VEGF receptor 3 (Flt-4)
    • Achen MG, Jeltsch M, Kukk E, Ma-kinen T, Vitali A, Wilks AF, Alitalo K and Stacker SA. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk-1) and VEGF receptor 3 (Flt- 4). Proc Natl Acad Sci USA. 1998; 95:548-553.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 548-553
    • Achen, M.G.1    Jeltsch, M.2    Kukk, E.3    Ma-kinen, T.4    Vitali, A.5    Wilks, A.F.6    Alitalo, K.7    Stacker, S.A.8
  • 19
    • 0036306121 scopus 로고    scopus 로고
    • Vascular growth factors and lymphangiogenesis
    • Jussila L and Alitalo K. Vascular growth factors and lymphangiogenesis. Physiol Rev. 2002; 82(3):673-700.
    • (2002) Physiol Rev , vol.82 , Issue.3 , pp. 673-700
    • Jussila, L.1    Alitalo, K.2
  • 20
    • 44449133602 scopus 로고    scopus 로고
    • Molecular control of lymphatic metastasis
    • Achen MG and Stacker SA. Molecular control of lymphatic metastasis. Ann NY Acad Sci. 2008; 1131:225-234.
    • (2008) Ann NY Acad Sci , vol.1131 , pp. 225-234
    • Achen, M.G.1    Stacker, S.A.2
  • 21
    • 0033178020 scopus 로고    scopus 로고
    • The prevention of colorectal cancer by aspirin use
    • Giovannucci E. The prevention of colorectal cancer by aspirin use. Biomed Pharmacother. 1999; 53(7):303-308.
    • (1999) Biomed Pharmacother , vol.53 , Issue.7 , pp. 303-308
    • Giovannucci, E.1
  • 22
    • 78650825618 scopus 로고    scopus 로고
    • Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
    • Rothwell PM, Fowkes FG, Belch JF, Ogawa H, Warlow CP and Meade TW. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet. 2011; 377 (9759):31-41.
    • (2011) Lancet , vol.377 , Issue.9759 , pp. 31-41
    • Rothwell, P.M.1    Fowkes, F.G.2    Belch, J.F.3    Ogawa, H.4    Warlow, C.P.5    Meade, T.W.6
  • 23
    • 84863412124 scopus 로고    scopus 로고
    • Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
    • Rothwell PM, Price JF, Fowkes FG, Zanchetti A, Roncaglioni MC, Tognoni G, Lee R, Belch JF, Wilson M, Mehta Z and Meade TW. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet. 2012; 379(9826):1602-12.
    • (2012) Lancet , vol.379 , Issue.9826 , pp. 1602-1612
    • Rothwell, P.M.1    Price, J.F.2    Fowkes, F.G.3    Zanchetti, A.4    Roncaglioni, M.C.5    Tognoni, G.6    Lee, R.7    Belch, J.F.8    Wilson, M.9    Mehta, Z.10    Meade, T.W.11
  • 24
    • 84863399038 scopus 로고    scopus 로고
    • Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
    • Rothwell PM, Wilson M, Price JF, Belch JF, Meade TW and Mehta Z. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet. 2012; 379:1591-1601.
    • (2012) Lancet , vol.379 , pp. 1591-1601
    • Rothwell, P.M.1    Wilson, M.2    Price, J.F.3    Belch, J.F.4    Meade, T.W.5    Mehta, Z.6
  • 25
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: a molecular target for colorectal cancer prevention
    • Brown JR and DuBois RN. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol. 2005; 23(12):2840-2855.
    • (2005) J Clin Oncol , vol.23 , Issue.12 , pp. 2840-2855
    • Brown, J.R.1    DuBois, R.N.2
  • 26
    • 33750054757 scopus 로고    scopus 로고
    • Tumor and lymph node lymphangiogenesis--impact on cancer metastasis
    • Tobler NE and Detmar M. Tumor and lymph node lymphangiogenesis--impact on cancer metastasis. JLeukocBiol. 2006; 80(4):691-696.
    • (2006) J LeukocBiol , vol.80 , Issue.4 , pp. 691-696
    • Tobler, N.E.1    Detmar, M.2
  • 28
    • 2942677282 scopus 로고    scopus 로고
    • Crosstalk between angiogenesis and lymphangiogenesis in tumor progression
    • Scavelli C, Vacca A, Di Pietro G, Dammacco F and Ribatti D. Crosstalk between angiogenesis and lymphangiogenesis in tumor progression. Leukemia. 2004; 18(6):1054-1058.
    • (2004) Leukemia , vol.18 , Issue.6 , pp. 1054-1058
    • Scavelli, C.1    Vacca, A.2    Di Pietro, G.3    Dammacco, F.4    Ribatti, D.5
  • 29
    • 0036844702 scopus 로고    scopus 로고
    • Molecular control of lymphangiogenesis
    • Baldwin ME, Stacker SA and Achen MG. Molecular control of lymphangiogenesis. Bioessays. 2002; 24(11):1030-1040.
    • (2002) Bioessays , vol.24 , Issue.11 , pp. 1030-1040
    • Baldwin, M.E.1    Stacker, S.A.2    Achen, M.G.3
  • 31
    • 0036527585 scopus 로고    scopus 로고
    • Molecular mechanisms of lymphangiogenesis in health and disease
    • Alitalo K and Carmeliet P. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell. 2002; 1(3):219-227.
    • (2002) Cancer Cell , vol.1 , Issue.3 , pp. 219-227
    • Alitalo, K.1    Carmeliet, P.2
  • 32
    • 0036310316 scopus 로고    scopus 로고
    • The role of tumor lymphangiogenesis in metastatic spread
    • Stacker SA, Baldwin ME and Achen MG. The role of tumor lymphangiogenesis in metastatic spread. FASEB J. 2002; 16(9):922-934.
    • (2002) FASEB J , vol.16 , Issue.9 , pp. 922-934
    • Stacker, S.A.1    Baldwin, M.E.2    Achen, M.G.3
  • 33
    • 17144402207 scopus 로고    scopus 로고
    • VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
    • Hirakawa S, Kodama S, Kunstfeld R, Kajiya K, Brown LF and Detmar M. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med. 2005; 201(7):1089-1099.
    • (2005) J Exp Med , vol.201 , Issue.7 , pp. 1089-1099
    • Hirakawa, S.1    Kodama, S.2    Kunstfeld, R.3    Kajiya, K.4    Brown, L.F.5    Detmar, M.6
  • 34
    • 27544483545 scopus 로고    scopus 로고
    • Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis
    • Wong SY, Haack H, Crowley D, Barry M, Bronson RT and Hynes RO. Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. Cancer Res. 2005; 65(21):9789- 9798.
    • (2005) Cancer Res , vol.65 , Issue.21 , pp. 9789-9798
    • Wong, S.Y.1    Haack, H.2    Crowley, D.3    Barry, M.4    Bronson, R.T.5    Hynes, R.O.6
  • 36
    • 2342495793 scopus 로고    scopus 로고
    • Molecular regulation of lymphangiogenesis
    • Saharinen P and Petrova TV. Molecular regulation of lymphangiogenesis. Ann N Y Acad Sci. 2004; 1014:76-87.
    • (2004) Ann N Y Acad Sci , vol.1014 , pp. 76-87
    • Saharinen, P.1    Petrova, T.V.2
  • 37
    • 2942668041 scopus 로고    scopus 로고
    • Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation
    • Saharinen P, Tammela T, Karkkainen MJ and Alitalo K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol. 2004; 25(7):387-395.
    • (2004) Trends Immunol , vol.25 , Issue.7 , pp. 387-395
    • Saharinen, P.1    Tammela, T.2    Karkkainen, M.J.3    Alitalo, K.4
  • 38
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce JA and Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009; 9(4):239-252.
    • (2009) Nat Rev Cancer , vol.9 , Issue.4 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 39
    • 21144437844 scopus 로고    scopus 로고
    • Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
    • He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla- Herttuala S, Harding T, Jooss K, Takahashi T and Alitalo K. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res. 2005; 65(11):4739-4746.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4739-4746
    • He, Y.1    Rajantie, I.2    Pajusola, K.3    Jeltsch, M.4    Holopainen, T.5    Yla-Herttuala, S.6    Harding, T.7    Jooss, K.8    Takahashi, T.9    Alitalo, K.10
  • 40
    • 33748075460 scopus 로고    scopus 로고
    • Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications
    • Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP and Jain RK. Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Res. 2006; 66(16):8065- 8075.
    • (2006) Cancer Res , vol.66 , Issue.16 , pp. 8065-8075
    • Hoshida, T.1    Isaka, N.2    Hagendoorn, J.3    di Tomaso, E.4    Chen, Y.L.5    Pytowski, B.6    Fukumura, D.7    Padera, T.P.8    Jain, R.K.9
  • 41
    • 0032881898 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in the regulation of angiogenesis
    • Ferrara N. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney international. 1999; 56(3):794-814.
    • (1999) Kidney international , vol.56 , Issue.3 , pp. 794-814
    • Ferrara, N.1
  • 42
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP and LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003; 9(6):669-676.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 43
    • 34047175559 scopus 로고    scopus 로고
    • Targeting VEGF-A to treat cancer and age-related macular degeneration
    • Ferrara N, Mass RD, Campa C and Kim R. Targeting VEGF-A to treat cancer and age-related macular degeneration. Annu Rev Med. 2007; 58:491-504.
    • (2007) Annu Rev Med , vol.58 , pp. 491-504
    • Ferrara, N.1    Mass, R.D.2    Campa, C.3    Kim, R.4
  • 44
    • 0031213636 scopus 로고    scopus 로고
    • VEGF and EGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane
    • Oh SJ, Jeltsch MM, Birkenhager R, McCarthy JE, Weich HA, Christ B, Alitalo K and Wilting J. VEGF and EGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. Dev Biol. 1997; 188(1):96-109.
    • (1997) Dev Biol , vol.188 , Issue.1 , pp. 96-109
    • Oh, S.J.1    Jeltsch, M.M.2    Birkenhager, R.3    McCarthy, J.E.4    Weich, H.A.5    Christ, B.6    Alitalo, K.7    Wilting, J.8
  • 45
    • 0032192493 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C: a growth factor for lymphatic and blood vascular endothelial cells
    • Enholm B, Jussila L, Karkkainen M and Alitalo K. Vascular endothelial growth factor-C: a growth factor for lymphatic and blood vascular endothelial cells. Trends CardiovascMed. 1998; 8:292-297.
    • (1998) Trends CardiovascMed , vol.8 , pp. 292-297
    • Enholm, B.1    Jussila, L.2    Karkkainen, M.3    Alitalo, K.4
  • 52
    • 10344237560 scopus 로고    scopus 로고
    • Lymphangiogenic growth factors as markers of tumor metastasis
    • Stacker SA, Williams RA and Achen MG. Lymphangiogenic growth factors as markers of tumor metastasis APMIS. 2004; 112:539-549.
    • (2004) APMIS , vol.112 , pp. 539-549
    • Stacker, S.A.1    Williams, R.A.2    Achen, M.G.3
  • 53
    • 0031905861 scopus 로고    scopus 로고
    • Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
    • Achen MG, Jeltsch M, Kukk E, Makinen T, Vitali A, Wilks AF, Alitalo K and Stacker SA. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci USA. 1998; 95(2):548-553.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.2 , pp. 548-553
    • Achen, M.G.1    Jeltsch, M.2    Kukk, E.3    Makinen, T.4    Vitali, A.5    Wilks, A.F.6    Alitalo, K.7    Stacker, S.A.8
  • 60
    • 84866909298 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-D:signalling mechanisms, biology and clinical relevance
    • in press
    • Achen MG and Stacker.SA. Vascular endothelial growth factor-D:signalling mechanisms, biology and clinical relevance. Growth Factors. 2012; in press.
    • (2012) Growth Factors
    • Achen, M.G.1    Stacker, S.A.2
  • 62
    • 80051690785 scopus 로고    scopus 로고
    • Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer
    • Harris NC, Paavonen K, Davydova N, Roufail S, Sato T, Zhang YF, Karnezis T, Stacker SA and Achen MG. Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer. FASEB J. 2011; 25:2615-2625.
    • (2011) FASEB J , vol.25 , pp. 2615-2625
    • Harris, N.C.1    Paavonen, K.2    Davydova, N.3    Roufail, S.4    Sato, T.5    Zhang, Y.F.6    Karnezis, T.7    Stacker, S.A.8    Achen, M.G.9
  • 63
    • 0036083664 scopus 로고    scopus 로고
    • Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy
    • Khatib AM, Siegfried G, Chretien M, Metrakos P and Seidah NG. Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy. Am J Path. 2002; 160(6):1921-1935.
    • (2002) Am J Path , vol.160 , Issue.6 , pp. 1921-1935
    • Khatib, A.M.1    Siegfried, G.2    Chretien, M.3    Metrakos, P.4    Seidah, N.G.5
  • 67
    • 0035903330 scopus 로고    scopus 로고
    • Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
    • Kriehuber E, Breiteneder-Geleff S, Groeger M, Soleiman A, Schoppmann SF, Stingl G, Kerjaschki D and Maurer D. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J Exp Med. 2001; 194(6):797-808.
    • (2001) J Exp Med , vol.194 , Issue.6 , pp. 797-808
    • Kriehuber, E.1    Breiteneder-Geleff, S.2    Groeger, M.3    Soleiman, A.4    Schoppmann, S.F.5    Stingl, G.6    Kerjaschki, D.7    Maurer, D.8
  • 71
    • 4143135316 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer
    • Zeng Y, Opeskin K, Baldwin ME, Horvath LG, Achen MG, Stacker SA, Sutherland RL and Williams ED. Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer. Clin Cancer Res. 2004; 10(15):5137- 5144.
    • (2004) Clin Cancer Res , vol.10 , Issue.15 , pp. 5137-5144
    • Zeng, Y.1    Opeskin, K.2    Baldwin, M.E.3    Horvath, L.G.4    Achen, M.G.5    Stacker, S.A.6    Sutherland, R.L.7    Williams, E.D.8
  • 75
    • 3042826827 scopus 로고    scopus 로고
    • Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function
    • Isaka N, Padera TP, Hagendoorn J, Fukumura D and Jain RK. Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function. Cancer Res. 2004; 64(13):4400-4404.
    • (2004) Cancer Res , vol.64 , Issue.13 , pp. 4400-4404
    • Isaka, N.1    Padera, T.P.2    Hagendoorn, J.3    Fukumura, D.4    Jain, R.K.5
  • 78
    • 0037172970 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea
    • Kubo H, Cao R, Br"kenhielm E, M"kinen T, Cao Y and Alitalo K. Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2- induced lymphangiogenesis in mouse cornea. Proc Natl Acad Sci USA. 2002; 99:8868-8873.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8868-8873
    • Kubo, H.1    Cao, R.2    Br"kenhielm, E.3    M"kinen, T.4    Cao, Y.5    Alitalo, K.6
  • 81
    • 27144524895 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis
    • Bjorndahl MA, Cao R, Burton JB, Brakenhielm E, Religa P, Galter D, Wu L and Cao Y. Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis. Cancer Res. 2005; 65(20):9261-9268.
    • (2005) Cancer Res , vol.65 , Issue.20 , pp. 9261-9268
    • Bjorndahl, M.A.1    Cao, R.2    Burton, J.B.3    Brakenhielm, E.4    Religa, P.5    Galter, D.6    Wu, L.7    Cao, Y.8
  • 82
    • 33646407806 scopus 로고    scopus 로고
    • Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action
    • Cao R, Bjorndahl MA, Gallego MI, Chen S, Religa P, Hansen AJ and Cao Y. Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action. Blood. 2006; 107(9):3531-3536.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3531-3536
    • Cao, R.1    Bjorndahl, M.A.2    Gallego, M.I.3    Chen, S.4    Religa, P.5    Hansen, A.J.6    Cao, Y.7
  • 83
    • 66049154097 scopus 로고    scopus 로고
    • M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis
    • Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H and Suda T. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med. 2009; 206(5):1089-1102.
    • (2009) J Exp Med , vol.206 , Issue.5 , pp. 1089-1102
    • Kubota, Y.1    Takubo, K.2    Shimizu, T.3    Ohno, H.4    Kishi, K.5    Shibuya, M.6    Saya, H.7    Suda, T.8
  • 86
    • 67650065464 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer
    • Di JM, Zhou J, Zhou XL, Gao X, Shao CQ, Pang J, Sun QP, Zhang Y and Ruan XX. Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer. Arch Med Res. 2009; 40(4):268-275.
    • (2009) Arch Med Res , vol.40 , Issue.4 , pp. 268-275
    • Di, J.M.1    Zhou, J.2    Zhou, X.L.3    Gao, X.4    Shao, C.Q.5    Pang, J.6    Sun, Q.P.7    Zhang, Y.8    Ruan, X.X.9
  • 91
    • 84858326048 scopus 로고    scopus 로고
    • Prostaglandins in cancer cell adhesion, migration, and invasion
    • Menter DG and Dubois RN. Prostaglandins in cancer cell adhesion, migration, and invasion. Int J Cell Biol. 2012; 2012:723419.
    • (2012) Int J Cell Biol , vol.2012 , pp. 723419
    • Menter, D.G.1    Dubois, R.N.2
  • 92
    • 0037108979 scopus 로고    scopus 로고
    • COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression
    • Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS and Simmons DL. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002; 99(21):13926- 13931.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.21 , pp. 13926-13931
    • Chandrasekharan, N.V.1    Dai, H.2    Roos, K.L.3    Evanson, N.K.4    Tomsik, J.5    Elton, T.S.6    Simmons, D.L.7
  • 95
  • 97
    • 0032542763 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer
    • Hwang D, Scollard D, Byrne J and Levine E. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J Natl Cancer Inst. 1998; 90(6):455-460.
    • (1998) J Natl Cancer Inst , vol.90 , Issue.6 , pp. 455-460
    • Hwang, D.1    Scollard, D.2    Byrne, J.3    Levine, E.4
  • 99
    • 0023915232 scopus 로고
    • Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence
    • Yokoyama C, Takai T and Tanabe T. Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence. FEBS Lett. 1988; 231(2):347-351.
    • (1988) FEBS Lett , vol.231 , Issue.2 , pp. 347-351
    • Yokoyama, C.1    Takai, T.2    Tanabe, T.3
  • 100
    • 0025871150 scopus 로고
    • TIS10 a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
    • Kujubu DA, Fletcher BS, Varnum BC, Lim RW and Herschman HR. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem. 1991; 266(20):12866-12872.
    • (1991) J Biol Chem , vol.266 , Issue.20 , pp. 12866-12872
    • Kujubu, D.A.1    Fletcher, B.S.2    Varnum, B.C.3    Lim, R.W.4    Herschman, H.R.5
  • 101
    • 0026730021 scopus 로고
    • Human cyclooxygenase-2 cDNA
    • Hla T and Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A. 1992; 89(16):7384-7388.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.16 , pp. 7384-7388
    • Hla, T.1    Neilson, K.2
  • 102
    • 0037769698 scopus 로고    scopus 로고
    • Structure and function of human NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase
    • Tai HH, Ensor CM, Zhou H and Yan F. Structure and function of human NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. Adv Exp Med Biol. 2002; 507:245-250.
    • (2002) Adv Exp Med Biol , vol.507 , pp. 245-250
    • Tai, H.H.1    Ensor, C.M.2    Zhou, H.3    Yan, F.4
  • 105
    • 26444543238 scopus 로고    scopus 로고
    • Mechanisms for the prevention of gastrointestinal cancer: the role of prostaglandin E2
    • Backlund MG, Mann JR and Dubois RN. Mechanisms for the prevention of gastrointestinal cancer: the role of prostaglandin E2. Oncology. 2005; 69 Suppl 1:28-32.
    • (2005) Oncology , vol.69 , Issue.SUPPL 1 , pp. 28-32
    • Backlund, M.G.1    Mann, J.R.2    Dubois, R.N.3
  • 107
    • 84857372927 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta confers resistance to peroxisome proliferator-activated receptor gamma-induced apoptosis in colorectal cancer cells
    • Wang D, Ning W, Xie D, Guo L and DuBois RN. Peroxisome proliferator-activated receptor delta confers resistance to peroxisome proliferator-activated receptor gamma-induced apoptosis in colorectal cancer cells. Oncogene. 2012; 31(8):1013-1023.
    • (2012) Oncogene , vol.31 , Issue.8 , pp. 1013-1023
    • Wang, D.1    Ning, W.2    Xie, D.3    Guo, L.4    DuBois, R.N.5
  • 110
    • 29944434200 scopus 로고    scopus 로고
    • Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation
    • Cha YI, Kim SH, Sepich D, Buchanan FG, Solnica-Krezel L and DuBois RN. Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes Dev. 2006; 20(1):77-86.
    • (2006) Genes Dev , vol.20 , Issue.1 , pp. 77-86
    • Cha, Y.I.1    Kim, S.H.2    Sepich, D.3    Buchanan, F.G.4    Solnica-Krezel, L.5    DuBois, R.N.6
  • 112
    • 0028261042 scopus 로고
    • Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2
    • Pugh S and Thomas GA. Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2. Gut. 1994; 35(5):675-678.
    • (1994) Gut , vol.35 , Issue.5 , pp. 675-678
    • Pugh, S.1    Thomas, G.A.2
  • 114
    • 0037081178 scopus 로고    scopus 로고
    • Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice
    • Hansen-Petrik MB, McEntee MF, Jull B, Shi H, Zemel MB and Whelan J. Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice. Cancer Res. 2002; 62(2):403-408.
    • (2002) Cancer Res , vol.62 , Issue.2 , pp. 403-408
    • Hansen-Petrik, M.B.1    McEntee, M.F.2    Jull, B.3    Shi, H.4    Zemel, M.B.5    Whelan, J.6
  • 116
  • 117
    • 30044432923 scopus 로고    scopus 로고
    • Fishing for prostanoids: deciphering the developmental functions of cyclooxygenase-derived prostaglandins
    • Cha YI, Solnica-Krezel L and DuBois RN. Fishing for prostanoids: deciphering the developmental functions of cyclooxygenase-derived prostaglandins. Dev Biol. 2006; 289(2):263-272.
    • (2006) Dev Biol , vol.289 , Issue.2 , pp. 263-272
    • Cha, Y.I.1    Solnica-Krezel, L.2    DuBois, R.N.3
  • 118
    • 0034796261 scopus 로고    scopus 로고
    • Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
    • Sonoshita M, Takaku K, Sasaki N, Sugimoto Y, Ushikubi F, Narumiya S, Oshima M and Taketo MM. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat Med. 2001; 7(9):1048- 1051.
    • (2001) Nat Med , vol.7 , Issue.9 , pp. 1048-1051
    • Sonoshita, M.1    Takaku, K.2    Sasaki, N.3    Sugimoto, Y.4    Ushikubi, F.5    Narumiya, S.6    Oshima, M.7    Taketo, M.M.8
  • 120
    • 33750548053 scopus 로고    scopus 로고
    • Targeting prostaglandin E EP receptors to inhibit metastasis
    • Fulton AM, Ma X and Kundu N. Targeting prostaglandin E EP receptors to inhibit metastasis. Cancer Res. 2006; 66(20):9794-9797.
    • (2006) Cancer Res , vol.66 , Issue.20 , pp. 9794-9797
    • Fulton, A.M.1    Ma, X.2    Kundu, N.3
  • 122
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids cancer
    • Wang D and Dubois RN. Eicosanoids and cancer. Nat Rev Cancer. 2010; 10(3):181-193.
    • (2010) Nat Rev Cancer , vol.10 , Issue.3 , pp. 181-193
    • Wang, D.1    Dubois, R.N.2
  • 123
    • 17144415218 scopus 로고    scopus 로고
    • WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth
    • Wang D, Mann JR and DuBois RN. WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth. Cell Cycle. 2004; 3(12):1512-1515.
    • (2004) Cell Cycle , vol.3 , Issue.12 , pp. 1512-1515
    • Wang, D.1    Mann, J.R.2    DuBois, R.N.3
  • 124
    • 0035985272 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention
    • Davies G, Martin LA, Sacks N and Dowsett M. Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention. Ann Oncol. 2002; 13(5):669-678.
    • (2002) Ann Oncol , vol.13 , Issue.5 , pp. 669-678
    • Davies, G.1    Martin, L.A.2    Sacks, N.3    Dowsett, M.4
  • 125
    • 0036219594 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase
    • Fujiwaki R, Iida K, Kanasaki H, Ozaki T, Hata K and Miyazaki K. Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. Hum Pathol. 2002; 33(2):213-219.
    • (2002) Hum Pathol , vol.33 , Issue.2 , pp. 213-219
    • Fujiwaki, R.1    Iida, K.2    Kanasaki, H.3    Ozaki, T.4    Hata, K.5    Miyazaki, K.6
  • 126
    • 0037599444 scopus 로고    scopus 로고
    • Cyclooxygenase-2 overexpression correlates with vascular endothelial growth factor expression and tumor angiogenesis in gastric cancer
    • Joo YE, Rew JS, Seo YH, Choi SK, Kim YJ, Park CS and Kim SJ. Cyclooxygenase-2 overexpression correlates with vascular endothelial growth factor expression and tumor angiogenesis in gastric cancer. Journal of clinical gastroenterology. 2003; 37(1):28-33.
    • (2003) Journal of clinical gastroenterology , vol.37 , Issue.1 , pp. 28-33
    • Joo, Y.E.1    Rew, J.S.2    Seo, Y.H.3    Choi, S.K.4    Kim, Y.J.5    Park, C.S.6    Kim, S.J.7
  • 128
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M and DuBois RN. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 1998; 93(5):705-716.
    • (1998) Cell , vol.93 , Issue.5 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3    Sawaoka, H.4    Hori, M.5    DuBois, R.N.6
  • 129
    • 0037081194 scopus 로고    scopus 로고
    • Cyclooxygenase 2-and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps
    • Seno H, Oshima M, Ishikawa TO, Oshima H, Takaku K, Chiba T, Narumiya S and Taketo MM. Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Cancer Res. 2002; 62(2):506-511.
    • (2002) Cancer Res , vol.62 , Issue.2 , pp. 506-511
    • Seno, H.1    Oshima, M.2    Ishikawa, T.O.3    Oshima, H.4    Takaku, K.5    Chiba, T.6    Narumiya, S.7    Taketo, M.M.8
  • 130
    • 33750855287 scopus 로고    scopus 로고
    • EP2 a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival
    • Kamiyama M, Pozzi A, Yang L, DeBusk LM, Breyer RM and Lin PC. EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival. Oncogene. 2006; 25(53):7019-7028.
    • (2006) Oncogene , vol.25 , Issue.53 , pp. 7019-7028
    • Kamiyama, M.1    Pozzi, A.2    Yang, L.3    DeBusk, L.M.4    Breyer, R.M.5    Lin, P.C.6
  • 131
    • 0027371123 scopus 로고
    • Altered eicosanoid levels in human colon cancer
    • Rigas B, Goldman IS and Levine L. Altered eicosanoid levels in human colon cancer. J Lab Clin Med. 1993; 122(5):518-523.
    • (1993) J Lab Clin Med , vol.122 , Issue.5 , pp. 518-523
    • Rigas, B.1    Goldman, I.S.2    Levine, L.3
  • 132
    • 0035809312 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2
    • Hernandez GL, Volpert OV, Iniguez MA, Lorenzo E, Martinez-Martinez S, Grau R, Fresno M and Redondo JM. Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. J Exp Med. 2001; 193(5):607-620.
    • (2001) J Exp Med , vol.193 , Issue.5 , pp. 607-620
    • Hernandez, G.L.1    Volpert, O.V.2    Iniguez, M.A.3    Lorenzo, E.4    Martinez-Martinez, S.5    Grau, R.6    Fresno, M.7    Redondo, J.M.8
  • 133
    • 39749187604 scopus 로고    scopus 로고
    • Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer
    • Zhang XH, Huang DP, Guo GL, Chen GR, Zhang HX, Wan L and Chen SY. Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. BMC Cancer. 2008; 8:4.
    • (2008) BMC Cancer , vol.8 , pp. 4
    • Zhang, X.H.1    Huang, D.P.2    Guo, G.L.3    Chen, G.R.4    Zhang, H.X.5    Wan, L.6    Chen, S.Y.7
  • 135
    • 33646163924 scopus 로고    scopus 로고
    • COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer
    • Timoshenko AV, Chakraborty C, Wagner GF and Lala PK. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. Br J Cancer. 2006; 94(8):1154-1163.
    • (2006) Br J Cancer , vol.94 , Issue.8 , pp. 1154-1163
    • Timoshenko, A.V.1    Chakraborty, C.2    Wagner, G.F.3    Lala, P.K.4
  • 137
    • 1642475162 scopus 로고    scopus 로고
    • Cyclooxygenase-2 induces EP1-and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma
    • Su JL, Shih JY, Yen ML, Jeng YM, Chang CC, Hsieh CY, Wei LH, Yang PC and Kuo ML. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res. 2004; 64(2):554-564.
    • (2004) Cancer Res , vol.64 , Issue.2 , pp. 554-564
    • Su, J.L.1    Shih, J.Y.2    Yen, M.L.3    Jeng, Y.M.4    Chang, C.C.5    Hsieh, C.Y.6    Wei, L.H.7    Yang, P.C.8    Kuo, M.L.9
  • 138
  • 140
    • 1642475162 scopus 로고    scopus 로고
    • Cyclooxygenase-2 induces EP1-and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma
    • Su JL, Shih JY, Yen ML, Jeng YM, Chang CC, Hsieh CY, Wei LH, Yang PC and Kuo ML. Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res. 2004; 64(2):554-564.
    • (2004) Cancer Res , vol.64 , Issue.2 , pp. 554-564
    • Su, J.L.1    Shih, J.Y.2    Yen, M.L.3    Jeng, Y.M.4    Chang, C.C.5    Hsieh, C.Y.6    Wei, L.H.7    Yang, P.C.8    Kuo, M.L.9
  • 141
    • 0036008189 scopus 로고    scopus 로고
    • Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus
    • Coggins KG, Latour A, Nguyen MS, Audoly L, Coffman TM and Koller BH. Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. Nat Med. 2002; 8(2):91-92.
    • (2002) Nat Med , vol.8 , Issue.2 , pp. 91-92
    • Coggins, K.G.1    Latour, A.2    Nguyen, M.S.3    Audoly, L.4    Coffman, T.M.5    Koller, B.H.6
  • 142
    • 0037053689 scopus 로고    scopus 로고
    • Growth factors controlling angiogenesis and lymphangiogenesis
    • Alitalo K. Growth factors controlling angiogenesis and lymphangiogenesis. Ugeskr Laeger. 2002; 164(24):3170- 3172.
    • (2002) Ugeskr Laeger , vol.164 , Issue.24 , pp. 3170-3172
    • Alitalo, K.1
  • 143
    • 33644837942 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics
    • Ulrich CM, Bigler J and Potter JD. Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat Rev Cancer. 2006; 6(2):130- 140.
    • (2006) Nat Rev Cancer , vol.6 , Issue.2 , pp. 130-140
    • Ulrich, C.M.1    Bigler, J.2    Potter, J.D.3
  • 144
    • 77949701170 scopus 로고    scopus 로고
    • Genetic tools to tailor cancer prevention by NSAIDs
    • Ulrich CM, Bigler J and Potter JD. Genetic tools to tailor cancer prevention by NSAIDs. Discov Med. 2006; 6(32):71-74.
    • (2006) Discov Med , vol.6 , Issue.32 , pp. 71-74
    • Ulrich, C.M.1    Bigler, J.2    Potter, J.D.3
  • 145
    • 0036521678 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention
    • Chan TA. Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention. Lancet Oncol. 2002; 3(3):166-174.
    • (2002) Lancet Oncol , vol.3 , Issue.3 , pp. 166-174
    • Chan, T.A.1
  • 146
    • 0034671921 scopus 로고    scopus 로고
    • 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells
    • Shureiqi I, Chen D, Lotan R, Yang P, Newman RA, Fischer SM and Lippman SM. 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. Cancer Res. 2000; 60(24):6846-6850.
    • (2000) Cancer Res , vol.60 , Issue.24 , pp. 6846-6850
    • Shureiqi, I.1    Chen, D.2    Lotan, R.3    Yang, P.4    Newman, R.A.5    Fischer, S.M.6    Lippman, S.M.7
  • 147
    • 0023687241 scopus 로고
    • Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study
    • Kune GA, Kune S and Watson LF. Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res. 1988; 48(15):4399-4404.
    • (1988) Cancer Res , vol.48 , Issue.15 , pp. 4399-4404
    • Kune, G.A.1    Kune, S.2    Watson, L.F.3
  • 152
    • 20444453338 scopus 로고    scopus 로고
    • Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A VEGF-C) in esophageal adenocarcinoma
    • von Rahden BH, Stein HJ, Puhringer F, Koch I, Langer R, Piontek G, Siewert JR, Hofler H and Sarbia M. Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma. Cancer Res. 2005; 65(12):5038-5044.
    • (2005) Cancer Res , vol.65 , Issue.12 , pp. 5038-5044
    • von Rahden, B.H.1    Stein, H.J.2    Puhringer, F.3    Koch, I.4    Langer, R.5    Piontek, G.6    Siewert, J.R.7    Hofler, H.8    Sarbia, M.9
  • 156
    • 16844364790 scopus 로고    scopus 로고
    • PTGS2 (COX-2)-765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs
    • Ulrich CM, Whitton J, Yu JH, Sibert J, Sparks R, Potter JD and Bigler J. PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. Cancer Epidemiol Biomarkers Prev. 2005; 14(3):616-619.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , Issue.3 , pp. 616-619
    • Ulrich, C.M.1    Whitton, J.2    Yu, J.H.3    Sibert, J.4    Sparks, R.5    Potter, J.D.6    Bigler, J.7
  • 158
    • 77952242619 scopus 로고    scopus 로고
    • Vascular endothelial growth factor polymorphisms: role in response and toxicity of tyrosine kinase inhibitors
    • Vaziri SA, Kim J, Ganapathi MK and Ganapathi R. Vascular endothelial growth factor polymorphisms: role in response and toxicity of tyrosine kinase inhibitors. Curr Oncol Rep. 2010; 12(2):102-108.
    • (2010) Curr Oncol Rep , vol.12 , Issue.2 , pp. 102-108
    • Vaziri, S.A.1    Kim, J.2    Ganapathi, M.K.3    Ganapathi, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.