-
1
-
-
79958043675
-
-
National Cancer Institute: Bethesda, MD
-
Howlader, N.; Noone, A. M.; Krapcho, M.; Neyman, N.; Aminou, R.; Waldron, W. SEER Cancer Statistics Review, 1975-2008; National Cancer Institute: Bethesda, MD, 2011.
-
(2011)
SEER Cancer Statistics Review, 1975-2008
-
-
Howlader, N.1
Noone, A.M.2
Krapcho, M.3
Neyman, N.4
Aminou, R.5
Waldron, W.6
-
2
-
-
84860650725
-
Cellular senescence and cancer chemotherapy resistance
-
Gordon, R. R.; Nelson, P. S. Cellular senescence and cancer chemotherapy resistance Drug Resist. Updates 2012, 15, 123-131
-
(2012)
Drug Resist. Updates
, vol.15
, pp. 123-131
-
-
Gordon, R.R.1
Nelson, P.S.2
-
3
-
-
79952232216
-
Global cancer statistics
-
Jemal, A.; Bray, F.; Center, M. M.; Ferlay, J.; Ward, E.; Forman, D. Global cancer statistics Ca-Cancer J. Clin. 2011, 61, 69-90
-
(2011)
Ca - Cancer J. Clin.
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
4
-
-
17144398831
-
Possible future issues in the treatment of glioblastomas, with a special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis
-
Lefranc, F.; Brotchi, J.; Kiss, R. Possible future issues in the treatment of glioblastomas, with a special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis J. Clin. Oncol. 2005, 23, 2411-2422
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 2411-2422
-
-
Lefranc, F.1
Brotchi, J.2
Kiss, R.3
-
5
-
-
0038793948
-
Apoptosis and melanoma chemoresistance
-
Soengas, M. S.; Lowe, S. W. Apoptosis and melanoma chemoresistance Oncogene 2003, 22, 3138-3151
-
(2003)
Oncogene
, vol.22
, pp. 3138-3151
-
-
Soengas, M.S.1
Lowe, S.W.2
-
6
-
-
78650631315
-
Novel agents in the management of lung cancer
-
Kennedy, B.; Gargoum, F.; Bystricky, B. R.; Curran, D. M.; O'Connor, T. Novel agents in the management of lung cancer Curr. Med. Chem. 2010, 17, 4291-4325
-
(2010)
Curr. Med. Chem.
, vol.17
, pp. 4291-4325
-
-
Kennedy, B.1
Gargoum, F.2
Bystricky, B.R.3
Curran, D.M.4
O'Connor, T.5
-
7
-
-
79955423865
-
Considering temozolomide as a novel potential treatment for oesophageal cancer
-
Bruyère, C.; Lonez, C.; Duray, A.; Cludts, S.; Ruysschaert, J. M.; Saussez, S.; Yeaton, P.; Kiss, R.; Mijatovic, T. Considering temozolomide as a novel potential treatment for oesophageal cancer Cancer 2011, 117, 2004-2016
-
(2011)
Cancer
, vol.117
, pp. 2004-2016
-
-
Bruyè1
Re, C.2
Lonez, C.3
Duray, A.4
Cludts, S.5
Ruysschaert, J.M.6
Saussez, S.7
Yeaton, P.8
Kiss, R.9
Mijatovic, T.10
-
8
-
-
67650924582
-
Pancreatic cancer: Molecular pathogenesis and new therapeutic targets
-
Wong, H. H.; Lemoine, N. R. Pancreatic cancer: molecular pathogenesis and new therapeutic targets Nat. Rev. Gastroenterol. Hepatol 2009, 6, 412-422
-
(2009)
Nat. Rev. Gastroenterol. Hepatol
, vol.6
, pp. 412-422
-
-
Wong, H.H.1
Lemoine, N.R.2
-
9
-
-
77954029167
-
PET-CT for response assessment and treatment adaptation in head and neck cancer
-
Bussink, J.; van Herpen, C.; Kaanders, J.; Oyen, W. PET-CT for response assessment and treatment adaptation in head and neck cancer Lancet Oncol. 2010, 11, 661-669
-
(2010)
Lancet Oncol.
, vol.11
, pp. 661-669
-
-
Bussink, J.1
Van Herpen, C.2
Kaanders, J.3
Oyen, W.4
-
10
-
-
55949136859
-
Anoikis resistance and tumor metastasis
-
Simpson, C. D.; Anyiwe, K.; Schimmer, A. D. Anoikis resistance and tumor metastasis Cancer Lett. 2008, 272, 177-185
-
(2008)
Cancer Lett.
, vol.272
, pp. 177-185
-
-
Simpson, C.D.1
Anyiwe, K.2
Schimmer, A.D.3
-
11
-
-
55949128465
-
Anoikis: A necessary death program for anchorage-dependent cells
-
Chiarugi, P.; Giannoni, E. Anoikis: a necessary death program for anchorage-dependent cells Biochem. Pharmacol. 2008, 76, 1352-1364
-
(2008)
Biochem. Pharmacol.
, vol.76
, pp. 1352-1364
-
-
Chiarugi, P.1
Giannoni, E.2
-
12
-
-
84255210700
-
Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
-
Galluzzi, L.; Vitale, I.; Abrams, J. M.; Alnemri, E. S.; Baehrecke, E. H.; Blagosklonny, M. V.; Dawson, T. M.; Dawson, V. L.; El-Deiry, W. S.; Fulda, S.; Gottlieb, E.; Green, D. R.; Hengartner, M. O.; Kepp, O.; Knight, R. A.; Kumar, S.; Lipton, S. A.; Lu, X.; Madeo, F.; Malorni, W.; Mehlen, P.; Nunez, G.; Peter, M. E.; Piacentini, M.; Rubinsztein, D. C.; Shi, Y.; Simon, H. U.; Vandenabeele, P.; White, E.; Yuan, J.; Zhivotovsky, B.; Melino, G.; Kroemer, G. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 Cell Death Differ. 2012, 19, 107-120
-
(2012)
Cell Death Differ.
, vol.19
, pp. 107-120
-
-
Galluzzi, L.1
Vitale, I.2
Abrams, J.M.3
Alnemri, E.S.4
Baehrecke, E.H.5
Blagosklonny, M.V.6
Dawson, T.M.7
Dawson, V.L.8
El-Deiry, W.S.9
Fulda, S.10
Gottlieb, E.11
Green, D.R.12
Hengartner, M.O.13
Kepp, O.14
Knight, R.A.15
Kumar, S.16
Lipton, S.A.17
Lu, X.18
Madeo, F.19
Malorni, W.20
Mehlen, P.21
Nunez, G.22
Peter, M.E.23
Piacentini, M.24
Rubinsztein, D.C.25
Shi, Y.26
Simon, H.U.27
Vandenabeele, P.28
White, E.29
Yuan, J.30
Zhivotovsky, B.31
Melino, G.32
Kroemer, G.33
more..
-
13
-
-
33644775686
-
Targeting multidrug resistance in cancer
-
Szakacs, G.; Paterson, J. K.; Ludwig, J. A.; Booth-Genthe, C.; Gottesman, M. M. Targeting multidrug resistance in cancer Nat. Rev. Drug Discovery 2006, 5, 219-234
-
(2006)
Nat. Rev. Drug Discovery
, vol.5
, pp. 219-234
-
-
Szakacs, G.1
Paterson, J.K.2
Ludwig, J.A.3
Booth-Genthe, C.4
Gottesman, M.M.5
-
14
-
-
70349176240
-
Is resistance useless? Multidrug resistance and collateral sensitivity
-
Hall, M. D.; Handley, M. D.; Gottesman, M. M. Is resistance useless? Multidrug resistance and collateral sensitivity Trends Pharmacol. Sci. 2009, 30, 546-556
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 546-556
-
-
Hall, M.D.1
Handley, M.D.2
Gottesman, M.M.3
-
15
-
-
70350292588
-
Liposomes and nanoparticles: Nanosized vehicles for drug delivery in cancer
-
Malam, Y.; Loizidou, M.; Seifalian, A. M. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer Trends Pharmacol. Sci. 2009, 30, 592-599
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 592-599
-
-
Malam, Y.1
Loizidou, M.2
Seifalian, A.M.3
-
16
-
-
75149143363
-
ABC transporters in cancer: More than just efflux pumps
-
Fletcher, J. I.; Haber, M.; Henderson, M. J.; Norris, M. D. ABC transporters in cancer: more than just efflux pumps Nat. Rev. Cancer 2010, 10, 147-156
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 147-156
-
-
Fletcher, J.I.1
Haber, M.2
Henderson, M.J.3
Norris, M.D.4
-
17
-
-
82255192310
-
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
-
Ni Chonghaile, T.; Sarosiek, K. A.; Vo, T. T.; Ryan, J. A.; Tammareddi, A.; Moore, V. D. G.; Deng, J.; Anderson, K.; Richardson, P.; Tai, Y. T.; Mitsiades, C. S.; Matulonis, U. A.; Drapkin, R.; Stone, R.; DeAngelo, D. J.; McConkey, D. J.; Sallan, S. E.; Silverman, L.; Hirsch, M. S.; Carrasco, D. R.; Letai, A. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy Science 2011, 334, 1129-1133
-
(2011)
Science
, vol.334
, pp. 1129-1133
-
-
Ni Chonghaile, T.1
Sarosiek, K.A.2
Vo, T.T.3
Ryan, J.A.4
Tammareddi, A.5
Moore, V.D.G.6
Deng, J.7
Anderson, K.8
Richardson, P.9
Tai, Y.T.10
Mitsiades, C.S.11
Matulonis, U.A.12
Drapkin, R.13
Stone, R.14
Deangelo, D.J.15
McConkey, D.J.16
Sallan, S.E.17
Silverman, L.18
Hirsch, M.S.19
Carrasco, D.R.20
Letai, A.21
more..
-
19
-
-
84858005733
-
Acquired resistance to drugs targeting receptor tyrosine kinases
-
Rosenzweig, S. A. Acquired resistance to drugs targeting receptor tyrosine kinases Biochem. Pharmacol. 2012, 83, 1041-1048
-
(2012)
Biochem. Pharmacol.
, vol.83
, pp. 1041-1048
-
-
Rosenzweig, S.A.1
-
20
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson, T. R.; Fridlyand, J.; Yan, Y.; Penuel, E.; Burton, L.; Chan, E.; Peng, J.; Lin, E.; Wang, Y.; Sosman, J.; Ribas, A.; Li, J.; Moffat, J.; Sutherlin, D. P.; Koeppen, H.; Merchant, M.; Neve, R.; Settleman, J. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors Nature 2012, 487, 505-509
-
(2012)
Nature
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
Fridlyand, J.2
Yan, Y.3
Penuel, E.4
Burton, L.5
Chan, E.6
Peng, J.7
Lin, E.8
Wang, Y.9
Sosman, J.10
Ribas, A.11
Li, J.12
Moffat, J.13
Sutherlin, D.P.14
Koeppen, H.15
Merchant, M.16
Neve, R.17
Settleman, J.18
-
21
-
-
67649595826
-
Apoptosis and cancer: The genesis of a research field
-
Cotter, T. G. Apoptosis and cancer: the genesis of a research field Nat. Rev. Cancer 2009, 9, 501-507
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 501-507
-
-
Cotter, T.G.1
-
22
-
-
80054684146
-
Killing of tumor cells: A drama in two acts
-
Giansanti, V.; Tillhon, M.; Mazzini, G.; Prosperi, E.; Lombardi, P.; Scovassi, A. I. Killing of tumor cells: a drama in two acts Biochem. Pharmacol. 2011, 82, 1304-1310
-
(2011)
Biochem. Pharmacol.
, vol.82
, pp. 1304-1310
-
-
Giansanti, V.1
Tillhon, M.2
Mazzini, G.3
Prosperi, E.4
Lombardi, P.5
Scovassi, A.I.6
-
23
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D.; Weinberg, R. A. Hallmarks of cancer: the next generation Cell 2011, 144, 646-674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
24
-
-
79955591914
-
Recent advances in apoptosis, mitochondria and drug resistance in cancer cells
-
Indran, I. R.; Tufo, G.; Pervaiz, S.; Brenner, C. Recent advances in apoptosis, mitochondria and drug resistance in cancer cells Biochim. Biophys. Acta 2011, 1807, 735-745
-
(2011)
Biochim. Biophys. Acta
, vol.1807
, pp. 735-745
-
-
Indran, I.R.1
Tufo, G.2
Pervaiz, S.3
Brenner, C.4
-
25
-
-
84861532088
-
Killing a cancer: What are the alternatives?
-
Kreuzaler, P.; Watson, C. J. Killing a cancer: What are the alternatives? Nat. Rev. Cancer 2012, 12, 411-424
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 411-424
-
-
Kreuzaler, P.1
Watson, C.J.2
-
26
-
-
84864650304
-
Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis
-
Demers, M.; Krause, D. S.; Schatzberg, D.; Martinod, K.; Voorhees, J. R.; Fuchs, T. A.; Scadden, D. T.; Wagner, D. D. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 13076-13081
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 13076-13081
-
-
Demers, M.1
Krause, D.S.2
Schatzberg, D.3
Martinod, K.4
Voorhees, J.R.5
Fuchs, T.A.6
Scadden, D.T.7
Wagner, D.D.8
-
27
-
-
80054006775
-
Induction the cornification of squamous cancerous cells to eliminate tumor cells by promotion cell differentiation and stratum
-
Zhou, Y.; Cheng, Y.; Feng, D.; Ling, B.; Liu, P. Induction the cornification of squamous cancerous cells to eliminate tumor cells by promotion cell differentiation and stratum Med. Hypotheses 2011, 77, 763-764
-
(2011)
Med. Hypotheses
, vol.77
, pp. 763-764
-
-
Zhou, Y.1
Cheng, Y.2
Feng, D.3
Ling, B.4
Liu, P.5
-
28
-
-
84861680016
-
Regulation of myosin activation during cell-cell contact formation by Par3-LgI antagonism: Entosis without matrix detachment
-
Wan, Q.; Liu, J.; Zheng, Z.; Zhu, H.; Chu, X.; Dong, Z.; Huang, S.; Du, Q. Regulation of myosin activation during cell-cell contact formation by Par3-LgI antagonism: entosis without matrix detachment Mol. Biol. Cell 2012, 23, 2076-2091
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 2076-2091
-
-
Wan, Q.1
Liu, J.2
Zheng, Z.3
Zhu, H.4
Chu, X.5
Dong, Z.6
Huang, S.7
Du, Q.8
-
29
-
-
36248962144
-
A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion
-
Overholtzer, M.; Mailleux, A. A.; Mouneimne, G.; Normand, G.; Schnitt, S. J.; King, R. W.; Cibas, E. S.; Brugge, J. S. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion Cell 2007, 131, 966-979
-
(2007)
Cell
, vol.131
, pp. 966-979
-
-
Overholtzer, M.1
Mailleux, A.A.2
Mouneimne, G.3
Normand, G.4
Schnitt, S.J.5
King, R.W.6
Cibas, E.S.7
Brugge, J.S.8
-
30
-
-
0033815330
-
Salmonella induces macrophage death by caspase-1-dependent necrosis
-
Brennan, M. A.; Cookson, B. T. Salmonella induces macrophage death by caspase-1-dependent necrosis Mol. Microbiol. 2000, 38, 31-40
-
(2000)
Mol. Microbiol.
, vol.38
, pp. 31-40
-
-
Brennan, M.A.1
Cookson, B.T.2
-
31
-
-
58449083290
-
Pyroptosis: Host cell death and inflammation
-
Bergsbaken, T.; Fink, S. L.; Cookson, B. T. Pyroptosis: host cell death and inflammation Nat. Rev. Microbiol. 2009, 7, 99-109
-
(2009)
Nat. Rev. Microbiol.
, vol.7
, pp. 99-109
-
-
Bergsbaken, T.1
Fink, S.L.2
Cookson, B.T.3
-
32
-
-
77749260612
-
Pyroptosis - A cell death modality of its kind?
-
Kepp, O.; Galluzzi, L.; Zitvogel, L.; Kroemer, G. Pyroptosis-a cell death modality of its kind? Eur. J. Immunol. 2010, 40, 627-630
-
(2010)
Eur. J. Immunol.
, vol.40
, pp. 627-630
-
-
Kepp, O.1
Galluzzi, L.2
Zitvogel, L.3
Kroemer, G.4
-
33
-
-
82755190844
-
Anoikis: An emerging hallmark in health and diseases
-
Taddei, M. L.; Giannoni, E.; Fiaschi, T.; Chiarugi, P. Anoikis: an emerging hallmark in health and diseases J. Pathol. 2012, 226, 380-393
-
(2012)
J. Pathol.
, vol.226
, pp. 380-393
-
-
Taddei, M.L.1
Giannoni, E.2
Fiaschi, T.3
Chiarugi, P.4
-
34
-
-
84862328411
-
Novel anti-cancer compounds for developing combinatorial therapies to target anoikis-resistant tumors
-
Nagaprashantha, L.; Vartak, N.; Awasthi, S.; Awasthi, S.; Singhal, S. S. Novel anti-cancer compounds for developing combinatorial therapies to target anoikis-resistant tumors Pharm. Res. 2012, 29, 621-636
-
(2012)
Pharm. Res.
, vol.29
, pp. 621-636
-
-
Nagaprashantha, L.1
Vartak, N.2
Awasthi, S.3
Awasthi, S.4
Singhal, S.S.5
-
35
-
-
77957363101
-
Integrins as therapeutic targets: Lessons and opportunities
-
Cox, D.; Brennan, M.; Moran, N. Integrins as therapeutic targets: lessons and opportunities Nat. Rev. Drug Discovery 2010, 9, 804-820
-
(2010)
Nat. Rev. Drug Discovery
, vol.9
, pp. 804-820
-
-
Cox, D.1
Brennan, M.2
Moran, N.3
-
36
-
-
84859439673
-
Peptides for cell-selective drug delivery
-
Svensen, N.; Walton, J. G.; Bradley, M. Peptides for cell-selective drug delivery Trends Pharmacol. Sci. 2012, 33, 186-192
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 186-192
-
-
Svensen, N.1
Walton, J.G.2
Bradley, M.3
-
37
-
-
84865522116
-
Cilengitide treatment for malignant glioma: Current status and future direction
-
Kurozumi, K.; Ichikawa, T.; Onishi, M.; Fujii, K.; Date, I. Cilengitide treatment for malignant glioma: current status and future direction Neurol. Med. Chir. 2012, 52, 539-547
-
(2012)
Neurol. Med. Chir.
, vol.52
, pp. 539-547
-
-
Kurozumi, K.1
Ichikawa, T.2
Onishi, M.3
Fujii, K.4
Date, I.5
-
38
-
-
83055173043
-
Cilengitide in patients with recurrent glioblastoma: The results of NABTC 03-02, a phase II trial with measures of treatment delivery
-
Gilbert, M. R.; Kuhn, J.; Lamborn, K. R.; Lieberman, F.; Wen, P. Y.; Mehta, M.; Cloughesy, T.; Lassman, A. B.; DeAngelis, L. M.; Chang, S.; Prados, M. Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery J. Neuro-Oncol. 2012, 106, 147-153
-
(2012)
J. Neuro-Oncol.
, vol.106
, pp. 147-153
-
-
Gilbert, M.R.1
Kuhn, J.2
Lamborn, K.R.3
Lieberman, F.4
Wen, P.Y.5
Mehta, M.6
Cloughesy, T.7
Lassman, A.B.8
Deangelis, L.M.9
Chang, S.10
Prados, M.11
-
39
-
-
80655147260
-
The antiangiogenic effects of integrin alpha 5 beta 1 inhibitor (ATN-161) in vitro and in vivo
-
Wang, W.; Wang, F.; Lu, F.; Xu, S.; Hu, W.; Huang, J.; Gu, Q.; Sun, X. The antiangiogenic effects of integrin alpha 5 beta 1 inhibitor (ATN-161) in vitro and in vivo Invest. Ophthalmol. Visual Sci. 2011, 52, 7213-7220
-
(2011)
Invest. Ophthalmol. Visual Sci.
, vol.52
, pp. 7213-7220
-
-
Wang, W.1
Wang, F.2
Lu, F.3
Xu, S.4
Hu, W.5
Huang, J.6
Gu, Q.7
Sun, X.8
-
40
-
-
42249084453
-
Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): Observation of a U-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth
-
Doñate, F.; Parry, G. C.; Shaked, Y.; Hensley, H.; Guan, X.; Beck, I.; Tel-Tsur, Z.; Plunkett, M. L.; Manuia, M.; Shaw, D. E.; Kerbel, R. S.; Mazar, A. P. Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a U-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth Clin. Cancer Res. 2008, 14, 2137-2144
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 2137-2144
-
-
Doñate, F.1
Parry, G.C.2
Shaked, Y.3
Hensley, H.4
Guan, X.5
Beck, I.6
Tel-Tsur, Z.7
Plunkett, M.L.8
Manuia, M.9
Shaw, D.E.10
Kerbel, R.S.11
Mazar, A.P.12
-
41
-
-
33745240059
-
Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours
-
Cianfrocca, M. E.; Kimmel, K. A.; Gallo, J.; Cardoso, T.; Brown, M. M.; Hudes, G.; Lewis, N.; Weiner, L.; Lam, G. N.; Brown, S. C.; Shaw, D. E.; Mazar, A. P.; Cohen, R. B. Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours Br. J. Cancer 2006, 94, 1621-1626
-
(2006)
Br. J. Cancer
, vol.94
, pp. 1621-1626
-
-
Cianfrocca, M.E.1
Kimmel, K.A.2
Gallo, J.3
Cardoso, T.4
Brown, M.M.5
Hudes, G.6
Lewis, N.7
Weiner, L.8
Lam, G.N.9
Brown, S.C.10
Shaw, D.E.11
Mazar, A.P.12
Cohen, R.B.13
-
42
-
-
70350731216
-
Preclinical evaluation of the novel small-molecule integrin alpha 5 beta 1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization
-
Zahn, G.; Vossmeyer, D.; Stragies, R.; Wills, M.; Wong, C. G.; Löffler, K. U.; Adamis, A. P.; Knolle, J. Preclinical evaluation of the novel small-molecule integrin alpha 5 beta 1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization Arch. Ophthalmol. 2009, 127, 1329-1335
-
(2009)
Arch. Ophthalmol.
, vol.127
, pp. 1329-1335
-
-
Zahn, G.1
Vossmeyer, D.2
Stragies, R.3
Wills, M.4
Wong, C.G.5
Löffler, K.U.6
Adamis, A.P.7
Knolle, J.8
-
43
-
-
56249095776
-
An alpha 5 beta 1 integrin inhibitor attenuates glioma growth
-
Faerber, K.; Synowitz, M.; Zahn, G.; Vossmeyer, D.; Stragies, R.; van Rooijen, N.; Kettenmann, H. An alpha 5 beta 1 integrin inhibitor attenuates glioma growth Mol. Cell. Neurosci. 2008, 39, 579-585
-
(2008)
Mol. Cell. Neurosci.
, vol.39
, pp. 579-585
-
-
Faerber, K.1
Synowitz, M.2
Zahn, G.3
Vossmeyer, D.4
Stragies, R.5
Van Rooijen, N.6
Kettenmann, H.7
-
44
-
-
79959692800
-
Anoikis induction and metastasis suppression by a new integrin αvβ3 inhibitor in human melanoma cell line M21
-
Zhang, Y.; Yang, M.; Ji, Q.; Fan, D.; Peng, H.; Yang, C.; Xiong, D.; Zhou, Y. Anoikis induction and metastasis suppression by a new integrin αvβ3 inhibitor in human melanoma cell line M21 Invest. New Drugs 2001, 29, 666-673
-
(2001)
Invest. New Drugs
, vol.29
, pp. 666-673
-
-
Zhang, Y.1
Yang, M.2
Ji, Q.3
Fan, D.4
Peng, H.5
Yang, C.6
Xiong, D.7
Zhou, Y.8
-
45
-
-
37049031489
-
Novel quinazoline-based compounds impair prostate tumorigenesis by targeting tumor vascularity
-
Garrison, J. B.; Shaw, Y. J.; Chen, C. S.; Kyprianou, N. Novel quinazoline-based compounds impair prostate tumorigenesis by targeting tumor vascularity Cancer Res. 2007, 67, 11344-11352
-
(2007)
Cancer Res.
, vol.67
, pp. 11344-11352
-
-
Garrison, J.B.1
Shaw, Y.J.2
Chen, C.S.3
Kyprianou, N.4
-
46
-
-
79955755460
-
Conversation between apoptosis and autophagy: "is it your turn or mine?"
-
Giansanti, V.; Torriglia, A.; Scovassi, A. I. Conversation between apoptosis and autophagy: "Is it your turn or mine?" Apoptosis 2011, 16, 321-333
-
(2011)
Apoptosis
, vol.16
, pp. 321-333
-
-
Giansanti, V.1
Torriglia, A.2
Scovassi, A.I.3
-
47
-
-
67349114222
-
Programmed cell death pathways and current antitumor targets
-
Tan, M. L.; Ooi, J. P.; Ismail, N.; Moad, A. I.; Muhammad, T. S. Programmed cell death pathways and current antitumor targets Pharm. Res. 2009, 26, 1547-1560
-
(2009)
Pharm. Res.
, vol.26
, pp. 1547-1560
-
-
Tan, M.L.1
Ooi, J.P.2
Ismail, N.3
Moad, A.I.4
Muhammad, T.S.5
-
48
-
-
79956224883
-
Targeting autophagy during cancer therapy to improve clinical outcomes
-
Levy, J. M. M.; Thorburn, A. Targeting autophagy during cancer therapy to improve clinical outcomes Pharmacol. Ther. 2011, 131, 130-141
-
(2011)
Pharmacol. Ther.
, vol.131
, pp. 130-141
-
-
Levy, J.M.M.1
Thorburn, A.2
-
49
-
-
84866122688
-
Autophagy modulation as a potential therapeutic target for diverse diseases
-
Rubinsztein, D. C.; Codogno, P.; Levine, B. Autophagy modulation as a potential therapeutic target for diverse diseases Nat. Rev. Drug Discovery 2012, 11, 709-U84
-
(2012)
Nat. Rev. Drug Discovery
, vol.11
-
-
Rubinsztein, D.C.1
Codogno, P.2
Levine, B.3
-
50
-
-
79959926021
-
ATP-competitive inhibitors of mTOR: An update
-
Schenone, S.; Brullo, C.; Musumeci, F.; Radi, M.; Botta, M. ATP-competitive inhibitors of mTOR: an update Curr. Med. Chem. 2011, 18, 2995-3014
-
(2011)
Curr. Med. Chem.
, vol.18
, pp. 2995-3014
-
-
Schenone, S.1
Brullo, C.2
Musumeci, F.3
Radi, M.4
Botta, M.5
-
51
-
-
79959311967
-
Rheb/mTOR activation and regulation in cancer: Novel treatment strategies beyond rapamycin
-
Babcock, J. T.; Quilliam, L. A. Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond rapamycin Curr. Drug Targets 2011, 12, 1223-1231
-
(2011)
Curr. Drug Targets
, vol.12
, pp. 1223-1231
-
-
Babcock, J.T.1
Quilliam, L.A.2
-
52
-
-
77954739712
-
Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent
-
Geng, Y.; Kohli, L.; Klocke, B. J.; Roth, K. A. Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent Neuro-Oncology 2010, 12, 473-481
-
(2010)
Neuro-Oncology
, vol.12
, pp. 473-481
-
-
Geng, Y.1
Kohli, L.2
Klocke, B.J.3
Roth, K.A.4
-
53
-
-
33645115547
-
Adding chloroquine to conventional treatment for glioblastoma multiforme - A randomized, double-blind, placebo-controlled trial
-
Sotelo, J.; Briceño, E.; López-González, M. A. Adding chloroquine to conventional treatment for glioblastoma multiforme-a randomized, double-blind, placebo-controlled trial Ann. Intern. Med. 2006, 144, 337-343
-
(2006)
Ann. Intern. Med.
, vol.144
, pp. 337-343
-
-
Sotelo, J.1
Briceño, E.2
López-González, M.A.3
-
54
-
-
65349121788
-
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized phase III study: 5-year analysis of the EORTC-NCIC trial
-
Stupp, R.; Hegi, M. E.; Mason, W. P.; Bent, M. J. V.; Taphoorn, M. J. B.; Janzer, R. C.; Ludwin, S. K.; Allgeier, A.; Fisher, B.; Belanger, K.; Hau, P.; Brandes, A. A.; Gijtenbeek, J.; Marosi, C.; Vecht, C. J.; Mokhtari, K.; Wesseling, P.; Villa, S.; Eisenhauer, E.; Gorlia, T.; Weller, M.; Lacombe, D.; Cairncross, J. G.; Mirimanoff, R. O. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized phase III study: 5-year analysis of the EORTC-NCIC trial Lancet Oncol. 2009, 10, 459-466
-
(2009)
Lancet Oncol.
, vol.10
, pp. 459-466
-
-
Stupp, R.1
Hegi, M.E.2
Mason, W.P.3
Bent, M.J.V.4
Taphoorn, M.J.B.5
Janzer, R.C.6
Ludwin, S.K.7
Allgeier, A.8
Fisher, B.9
Belanger, K.10
Hau, P.11
Brandes, A.A.12
Gijtenbeek, J.13
Marosi, C.14
Vecht, C.J.15
Mokhtari, K.16
Wesseling, P.17
Villa, S.18
Eisenhauer, E.19
Gorlia, T.20
Weller, M.21
Lacombe, D.22
Cairncross, J.G.23
Mirimanoff, R.O.24
more..
-
55
-
-
1842865745
-
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
-
Kanzawa, T.; Germano, I. M.; Komata, T.; Ito, H.; Kondo, Y.; Kondo, S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells Cell. Death Differ. 2004, 11, 448-457
-
(2004)
Cell. Death Differ.
, vol.11
, pp. 448-457
-
-
Kanzawa, T.1
Germano, I.M.2
Komata, T.3
Ito, H.4
Kondo, Y.5
Kondo, S.6
-
56
-
-
38049027838
-
Pro-autophagic drugs: A novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas
-
Lefranc, F.; Facchini, V.; Kiss, R. Pro-autophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas Oncologist 2007, 12, 1395-1403
-
(2007)
Oncologist
, vol.12
, pp. 1395-1403
-
-
Lefranc, F.1
Facchini, V.2
Kiss, R.3
-
57
-
-
34548700597
-
Rapamycin: Something old, something new, sometimes borrowed and now renewed
-
Hartford, C. M. Rapamycin: something old, something new, sometimes borrowed and now renewed Clin. Pharmacol. Ther. 2007, 82, 381-388
-
(2007)
Clin. Pharmacol. Ther.
, vol.82
, pp. 381-388
-
-
Hartford, C.M.1
-
58
-
-
77951729433
-
FDA approval summary: Temsirolimus as treatment for advanced renal cell carcinoma
-
Kwitkowski, V. E.; Prowell, T, M.; Ibrahim, A.; Farrell, A. T.; Justice, R.; Mitchell, S. S.; Sridhara, R.; Pazdur, R. FDA approval summary: temsirolimus as treatment for advanced renal cell carcinoma Oncologist 2010, 15, 428-435
-
(2010)
Oncologist
, vol.15
, pp. 428-435
-
-
Kwitkowski, V.E.1
Prowell, T.M.2
Ibrahim, A.3
Farrell, A.T.4
Justice, R.5
Mitchell, S.S.6
Sridhara, R.7
Pazdur, R.8
-
60
-
-
33749002279
-
Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
-
Yee, K. W.; Zeng, Z.; Konopleva, M.; Verstovsek, S.; Ravandi, F.; Ferrajoli, A.; Thomas, D.; Wierda, W.; Apostolidou, E.; Albitar, M.; O'Brien, S.; Andreeff, M.; Giles, F. J. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies Clin. Cancer Res. 2006, 12, 5165-5173
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 5165-5173
-
-
Yee, K.W.1
Zeng, Z.2
Konopleva, M.3
Verstovsek, S.4
Ravandi, F.5
Ferrajoli, A.6
Thomas, D.7
Wierda, W.8
Apostolidou, E.9
Albitar, M.10
O'Brien, S.11
Andreeff, M.12
Giles, F.J.13
-
61
-
-
77955432889
-
The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma
-
Voss, V.; Senft, C.; Lang, V.; Ronellenfitsch, M. W.; Steinbach, J. P.; Seifert, V.; Kögel, D. The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma Mol. Cancer Res. 2010, 8, 1002-1016
-
(2010)
Mol. Cancer Res.
, vol.8
, pp. 1002-1016
-
-
Voss, V.1
Senft, C.2
Lang, V.3
Ronellenfitsch, M.W.4
Steinbach, J.P.5
Seifert, V.6
Kögel, D.7
-
62
-
-
57049157033
-
BCL-2 family antagonists for cancer therapy
-
Lessene, G.; Czabotar, P. E.; Colman, P. M. BCL-2 family antagonists for cancer therapy Nat. Rev. Drug Discovery 2008, 7, 989-1000
-
(2008)
Nat. Rev. Drug Discovery
, vol.7
, pp. 989-1000
-
-
Lessene, G.1
Czabotar, P.E.2
Colman, P.M.3
-
63
-
-
63149129655
-
Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy
-
Kang, M. H.; Reynolds, C. P. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy Clin. Cancer Res. 2009, 15, 1126-1132
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 1126-1132
-
-
Kang, M.H.1
Reynolds, C.P.2
-
64
-
-
0034922672
-
Oral gossypol in the treatment of patients with refractory metastatic breast cancer: A phase I/II clinical trial
-
Van Poznak, C.; Seidman, A. D.; Reidenberg, M. M.; Moasser, M. M.; Sklarin, N.; Van Zee, K.; Borgen, P.; Gollub, M.; Bacotti, D.; Yao, T. J.; Bloch, R.; Ligueros, M.; Sonenberg, M.; Norton, L.; Hudis, C. Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial Breast Cancer Res. Treat. 2001, 66, 239-248
-
(2001)
Breast Cancer Res. Treat.
, vol.66
, pp. 239-248
-
-
Van Poznak, C.1
Seidman, A.D.2
Reidenberg, M.M.3
Moasser, M.M.4
Sklarin, N.5
Van Zee, K.6
Borgen, P.7
Gollub, M.8
Bacotti, D.9
Yao, T.J.10
Bloch, R.11
Ligueros, M.12
Sonenberg, M.13
Norton, L.14
Hudis, C.15
-
65
-
-
79955745789
-
Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and-resistant lymphomas
-
Brem, E. A.; Thudium, K.; Khubchandani, S.; Tsai, P. C.; Olejniczak, S. H.; Bhat, S.; Riaz, W.; Gu, J.; Iqbal, A.; Campagna, R.; Knight, J.; Mavis, C.; Hoskin, P.; Deeb, G.; Gibbs, J. F.; Fetterly, G.; Czuczman, M. S.; Hernandez-Ilizaliturri, F. J. Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and-resistant lymphomas Br. J. Haematol. 2011, 153, 599-611
-
(2011)
Br. J. Haematol.
, vol.153
, pp. 599-611
-
-
Brem, E.A.1
Thudium, K.2
Khubchandani, S.3
Tsai, P.C.4
Olejniczak, S.H.5
Bhat, S.6
Riaz, W.7
Gu, J.8
Iqbal, A.9
Campagna, R.10
Knight, J.11
Mavis, C.12
Hoskin, P.13
Deeb, G.14
Gibbs, J.F.15
Fetterly, G.16
Czuczman, M.S.17
Hernandez-Ilizaliturri, F.J.18
-
66
-
-
84856813420
-
Obatoclax mesylate: Pharmacology and potential for therapy of hematological neoplasms
-
Joudeh, J.; Claxton, D. Obatoclax mesylate: pharmacology and potential for therapy of hematological neoplasms Expert Opin. Invest. Drugs 2012, 21, 363-373
-
(2012)
Expert Opin. Invest. Drugs
, vol.21
, pp. 363-373
-
-
Joudeh, J.1
Claxton, D.2
-
67
-
-
33644840693
-
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
-
Degterev, A.; Huang, Z.; Boyce, M.; Li, Y.; Jagtap, P.; Mizushima, N.; Cuny, G. D.; Mitchison, T. J.; Moskowitz, M. A.; Yuan, J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury Nat. Chem. Biol. 2005, 1, 112-119
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 112-119
-
-
Degterev, A.1
Huang, Z.2
Boyce, M.3
Li, Y.4
Jagtap, P.5
Mizushima, N.6
Cuny, G.D.7
Mitchison, T.J.8
Moskowitz, M.A.9
Yuan, J.10
-
68
-
-
80052173847
-
Necroptosis, necrostatins and tissue injury
-
Smith, C. C. T.; Yellon, D. M. Necroptosis, necrostatins and tissue injury J. Cell. Mol. Med. 2011, 15, 1797-1806
-
(2011)
J. Cell. Mol. Med.
, vol.15
, pp. 1797-1806
-
-
Smith, C.C.T.1
Yellon, D.M.2
-
69
-
-
34250748014
-
Shikonin circumvents cancer drug resistance by induction of a necroptotic death
-
Han, W.; Li, L.; Qiu, S.; Lu, Q.; Pan, Q.; Gu, Y.; Luo, J.; Hu, X. Shikonin circumvents cancer drug resistance by induction of a necroptotic death Mol. Cancer Ther. 2007, 6, 1641-1649
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 1641-1649
-
-
Han, W.1
Li, L.2
Qiu, S.3
Lu, Q.4
Pan, Q.5
Gu, Y.6
Luo, J.7
Hu, X.8
-
70
-
-
64249097600
-
Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo
-
Yang, H.; Zhou, P.; Huang, H.; Chen, D.; Ma, N.; Cui, C. Q.; Shen, S.; Dong, W.; Zhang, X.; Lian, W.; Wang, X.; Dou, Q. P.; Jinbao Liu, J. Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo Int. J. Cancer 2009, 124, 2450-2459
-
(2009)
Int. J. Cancer
, vol.124
, pp. 2450-2459
-
-
Yang, H.1
Zhou, P.2
Huang, H.3
Chen, D.4
Ma, N.5
Cui, C.Q.6
Shen, S.7
Dong, W.8
Zhang, X.9
Lian, W.10
Wang, X.11
Dou, Q.P.12
Jinbao Liu, J.13
-
71
-
-
58149316180
-
Naturally-occurring shikonin analogues - A class of necroptotic inducers that circumvent cancer drug resistance
-
Xuan, Y.; Hu, X. Naturally-occurring shikonin analogues-a class of necroptotic inducers that circumvent cancer drug resistance Cancer Lett. 2009, 274, 233-242
-
(2009)
Cancer Lett.
, vol.274
, pp. 233-242
-
-
Xuan, Y.1
Hu, X.2
-
72
-
-
0030729021
-
Importance of a novel oxidative mechanism for elimination of brain cholesterol - Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with O-18(2) techniques in vivo and in vitro
-
Björkhem, I.; Lütjohann, D.; Breuer, O.; Sakinis, A.; Wennmalm, Å. Importance of a novel oxidative mechanism for elimination of brain cholesterol-turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with O-18(2) techniques in vivo and in vitro J. Biol. Chem. 1997, 272, 30178-30184
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30178-30184
-
-
Björkhem, I.1
Lütjohann, D.2
Breuer, O.3
Sakinis, A.4
Wennmalm, Å.5
-
73
-
-
79960111702
-
24(S)-Hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis
-
Yamanaka, K.; Saito, Y.; Yamamori, T.; Urano, Y.; Noguchi, N. 24(S)-Hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis J. Biol. Chem. 2011, 286, 24666-24673
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 24666-24673
-
-
Yamanaka, K.1
Saito, Y.2
Yamamori, T.3
Urano, Y.4
Noguchi, N.5
-
74
-
-
84867809574
-
Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine
-
Hammerová, J.; Uldrijan, S.; Táborská, E.; Vaculová, A. H.; Slaninová, I. Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine Biol. Chem. 2012, 393, 647-658
-
(2012)
Biol. Chem.
, vol.393
, pp. 647-658
-
-
Hammerová, J.1
Uldrijan, S.2
Táborská, E.3
Vaculová, A.H.4
Slaninová, I.5
-
75
-
-
58149156276
-
3-Nitrofluoranthene (3-NF) but not 3-aminofluoranthene (3-AF) elicits apoptosis as well as programmed necrosis in Hepa1c1c7 cells
-
Asare, N.; Låg, M.; Lagadic-Gossmann, D.; Rissel, M.; Schwarze, P.; Holme, J. A. 3-Nitrofluoranthene (3-NF) but not 3-aminofluoranthene (3-AF) elicits apoptosis as well as programmed necrosis in Hepa1c1c7 cells Toxicology 2009, 255, 140-150
-
(2009)
Toxicology
, vol.255
, pp. 140-150
-
-
Asare, N.1
Låg, M.2
Lagadic-Gossmann, D.3
Rissel, M.4
Schwarze, P.5
Holme, J.A.6
-
76
-
-
34247264421
-
Structure-activity relationship study of tricyclic necroptosis inhibitors
-
Jagtap, P.; Degterev, A.; Choi, S.; Keys, H.; Yuan, J.; Cuny, G. Structure-activity relationship study of tricyclic necroptosis inhibitors J. Med. Chem. 2007, 50, 1886-1895
-
(2007)
J. Med. Chem.
, vol.50
, pp. 1886-1895
-
-
Jagtap, P.1
Degterev, A.2
Choi, S.3
Keys, H.4
Yuan, J.5
Cuny, G.6
-
77
-
-
68549106081
-
Kinesin motor proteins as targets for cancer therapy
-
Huszar, D.; Theoclitou, M. E.; Skolnik, J.; Herbst, R. Kinesin motor proteins as targets for cancer therapy Cancer Metastasis Rev. 2009, 28, 197-208
-
(2009)
Cancer Metastasis Rev.
, vol.28
, pp. 197-208
-
-
Huszar, D.1
Theoclitou, M.E.2
Skolnik, J.3
Herbst, R.4
-
78
-
-
2342563857
-
Antitumor activity of a kinesin inhibitor
-
Sakowicz, R.; Finer, J. T.; Beraud, C.; Crompton, A.; Lewis, E.; Fritsch, A.; Lee, Y.; Mak, J.; Moody, R.; Turincio, R.; Chabala, J. C.; Gonzales, P.; Roth, S.; Weitman, S.; Wood, K. W. Antitumor activity of a kinesin inhibitor Cancer Res. 2004, 64, 3276-3280
-
(2004)
Cancer Res.
, vol.64
, pp. 3276-3280
-
-
Sakowicz, R.1
Finer, J.T.2
Beraud, C.3
Crompton, A.4
Lewis, E.5
Fritsch, A.6
Lee, Y.7
Mak, J.8
Moody, R.9
Turincio, R.10
Chabala, J.C.11
Gonzales, P.12
Roth, S.13
Weitman, S.14
Wood, K.W.15
-
79
-
-
42549153290
-
Phase II, Open Label Study of SB-715992 (Ispinesib) in Subjects with Advanced or Metastatic Breast Cancer
-
San Antonio, TX, Abstract 1089
-
Miller, K.; Ng, C.; Ang, P.; Brufsky, A. M.; Lee, S. C.; Dees, E. C.; Piccart, M.; Verrill, M.; Wardley, A.; Loftiss, J.; Bal, J.; Yeoh, S.; Hodge, J.; Williams, D.; Dar, M.; Ho, P. T. C. Phase II, Open Label Study of SB-715992 (Ispinesib) in Subjects with Advanced or Metastatic Breast Cancer. Presented at the 28th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, 2005; Abstract 1089.
-
(2005)
28th Annual San Antonio Breast Cancer Symposium
-
-
Miller, K.1
Ng, C.2
Ang, P.3
Brufsky, A.M.4
Lee, S.C.5
Dees, E.C.6
Piccart, M.7
Verrill, M.8
Wardley, A.9
Loftiss, J.10
Bal, J.11
Yeoh, S.12
Hodge, J.13
Williams, D.14
Dar, M.15
Ho, P.T.C.16
-
80
-
-
84863439290
-
Phase I/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia
-
Kantarjian, H. M.; Padmanabhan, S.; Stock, W.; Tallman, M. S.; Curt, G. A.; Li, J.; Osmukhina, A.; Wu, K.; Huszar, D.; Borthukar, G.; Faderl, S.; Garcia-Manero, G.; Kadia, T.; Sankhala, K.; Odenike, O.; Altman, J. K.; Minden, M. Phase I/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia Invest. New Drugs 2012, 30, 1107-1115
-
(2012)
Invest. New Drugs
, vol.30
, pp. 1107-1115
-
-
Kantarjian, H.M.1
Padmanabhan, S.2
Stock, W.3
Tallman, M.S.4
Curt, G.A.5
Li, J.6
Osmukhina, A.7
Wu, K.8
Huszar, D.9
Borthukar, G.10
Faderl, S.11
Garcia-Manero, G.12
Kadia, T.13
Sankhala, K.14
Odenike, O.15
Altman, J.K.16
Minden, M.17
-
81
-
-
0034053130
-
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
-
Graves, P. R.; Yu, L.; Schwarz, J. K.; Gales, J.; Sausville, E. A.; O'Connor, P. M.; Worms, H. P. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01 J. Biol. Chem. 2000, 275, 5600-5605
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5600-5605
-
-
Graves, P.R.1
Yu, L.2
Schwarz, J.K.3
Gales, J.4
Sausville, E.A.5
O'Connor, P.M.6
Worms, H.P.7
-
82
-
-
0033199892
-
Inhibition of ATM and ATR kinase activity by the radiosensitizing agent caffeine
-
Sarkaria, J. N.; Busby, E. C.; Tibbetts, R. S.; Roos, R.; Taya, Y.; Karnitz, L. M.; Abraham, R. T. Inhibition of ATM and ATR kinase activity by the radiosensitizing agent caffeine Cancer Res. 1999, 59, 4375-4382
-
(1999)
Cancer Res.
, vol.59
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Busby, E.C.2
Tibbetts, R.S.3
Roos, R.4
Taya, Y.5
Karnitz, L.M.6
Abraham, R.T.7
-
83
-
-
0037069326
-
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
-
Zhao, H.; Watkins, J. L.; Helen Piwnica-Worms, H. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 14795-14800
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 14795-14800
-
-
Zhao, H.1
Watkins, J.L.2
Helen Piwnica-Worms, H.3
-
84
-
-
79651470785
-
Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
-
Ma, C. X.; Janetka, J. W.; Piwnica, W. H. Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics Trends Mol. Med. 2011, 17, 88-96
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 88-96
-
-
Ma, C.X.1
Janetka, J.W.2
Piwnica, W.H.3
-
85
-
-
52949139387
-
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA targeted therapies
-
Zabludoff, S. D.; Deng, C.; Grondine, M. R.; Sheehy, A. M.; Ashwell, S.; Caleb, B. L.; Green, S.; Haye, H. R.; Horn, C. L.; Janetka, J. W.; Liu, D.; Mouchet, E.; Ready, S.; Rosenthal, J. L.; Queva, C.; Schwartz, G. K.; Taylor, K. J.; Tse, A. N.; Walker, G. E.; White, A. M. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA targeted therapies Mol. Cancer Ther. 2008, 7, 2955-2966
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 2955-2966
-
-
Zabludoff, S.D.1
Deng, C.2
Grondine, M.R.3
Sheehy, A.M.4
Ashwell, S.5
Caleb, B.L.6
Green, S.7
Haye, H.R.8
Horn, C.L.9
Janetka, J.W.10
Liu, D.11
Mouchet, E.12
Ready, S.13
Rosenthal, J.L.14
Queva, C.15
Schwartz, G.K.16
Taylor, K.J.17
Tse, A.N.18
Walker, G.E.19
White, A.M.20
more..
-
86
-
-
77950650401
-
In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor. AZD7762
-
Mitchell, J. B.; Choudhuri, R.; Fabre, K.; Sowers, A. L.; Citrin, D.; Zabludoff, S. D.; Cook, J. A. In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor. AZD7762 Clin. Cancer Res. 2010, 16, 2076-2084
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 2076-2084
-
-
Mitchell, J.B.1
Choudhuri, R.2
Fabre, K.3
Sowers, A.L.4
Citrin, D.5
Zabludoff, S.D.6
Cook, J.A.7
-
87
-
-
77953770987
-
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair
-
Morgan, M. A.; Parsels, L. A.; Zha, L.; Parsels, J. D.; Davis, M. A.; Hassan, M. C.; Arumugarajah, S.; Hylander-Gans, L.; Morosini, D.; Simeone, D. M.; Canman, C. E.; Normolle, D. P.; Zabludoff, S. D.; Maybaum, J.; Lawrence, T. S. Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair Cancer Res. 2010, 70, 4972-4981
-
(2010)
Cancer Res.
, vol.70
, pp. 4972-4981
-
-
Morgan, M.A.1
Parsels, L.A.2
Zha, L.3
Parsels, J.D.4
Davis, M.A.5
Hassan, M.C.6
Arumugarajah, S.7
Hylander-Gans, L.8
Morosini, D.9
Simeone, D.M.10
Canman, C.E.11
Normolle, D.P.12
Zabludoff, S.D.13
Maybaum, J.14
Lawrence, T.S.15
-
88
-
-
53349156857
-
Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase
-
Blasina, A.; Hallin, J.; Chen, E.; Arango, M. E.; Kraynov, E.; Register, J.; Grant, S.; Ninkovic, S.; Chen, P.; Nichols, T.; O'Connor, P.; Anderes, K. Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase Mol. Cancer Ther. 2008, 7, 2394-2404
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 2394-2404
-
-
Blasina, A.1
Hallin, J.2
Chen, E.3
Arango, M.E.4
Kraynov, E.5
Register, J.6
Grant, S.7
Ninkovic, S.8
Chen, P.9
Nichols, T.10
O'Connor, P.11
Anderes, K.12
-
89
-
-
79955735344
-
Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening
-
Guzi, T. J.; Paruch, K.; Dwyer, M. P.; Labroli, M.; Shanahan, F.; Davis, N.; Taricani, L.; Wiswell, D.; Seghezzi, W.; Penaflor, E.; Bhagwat, B.; Wang, W.; Gu, D. L.; Hsieh, Y. S.; Lee, S.; Liu, M.; Parry, D. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening Mol. Cancer Ther. 2011, 10, 591-602
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 591-602
-
-
Guzi, T.J.1
Paruch, K.2
Dwyer, M.P.3
Labroli, M.4
Shanahan, F.5
Davis, N.6
Taricani, L.7
Wiswell, D.8
Seghezzi, W.9
Penaflor, E.10
Bhagwat, B.11
Wang, W.12
Gu, D.L.13
Hsieh, Y.S.14
Lee, S.15
Liu, M.16
Parry, D.17
-
90
-
-
84892668559
-
Ispinesib (SB-715992) a kinesin spindle protein (KSP) inhibitor has single agent activity and enhances the efficacy of standard-of-care therapies in pre-clinical models of breast cancer
-
Purcell, J. W.; Reddy, M.; Davis, J.; Samayoa, K.; Vo, C. H.; Thomsen, K.; Bean, P. A.; Wood, K. W.; Cases, S. Ispinesib (SB-715992) a kinesin spindle protein (KSP) inhibitor has single agent activity and enhances the efficacy of standard-of-care therapies in pre-clinical models of breast cancer Cancer Res. 2009, 69, 193S-193S
-
(2009)
Cancer Res.
, vol.69
-
-
Purcell, J.W.1
Reddy, M.2
Davis, J.3
Samayoa, K.4
Vo, C.H.5
Thomsen, K.6
Bean, P.A.7
Wood, K.W.8
Cases, S.9
-
91
-
-
18744377748
-
Drugging cell cycle kinases in cancer therapy
-
Blagden, S.; de Bono, J. Drugging cell cycle kinases in cancer therapy Curr. Drug Targets 2005, 6, 325-335
-
(2005)
Curr. Drug Targets
, vol.6
, pp. 325-335
-
-
Blagden, S.1
De Bono, J.2
-
92
-
-
20144373035
-
Phase i trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with fluorouracil in patients with advanced solid tumors
-
Kortmansky, J.; Shah, M. A.; Kaubisch, A.; Weyerbacher, A.; Yi, S.; Tong, W.; Sowers, R.; Gonen, M.; O'Reilly, E.; Kemeny, N.; Ilson, D. I.; Saltz, L. B.; Maki, R. G.; Kelsen, D. P.; Schwartz, G. K. Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with fluorouracil in patients with advanced solid tumors J. Clin. Oncol. 2005, 23, 1875-1884
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 1875-1884
-
-
Kortmansky, J.1
Shah, M.A.2
Kaubisch, A.3
Weyerbacher, A.4
Yi, S.5
Tong, W.6
Sowers, R.7
Gonen, M.8
O'Reilly, E.9
Kemeny, N.10
Ilson, D.I.11
Saltz, L.B.12
Maki, R.G.13
Kelsen, D.P.14
Schwartz, G.K.15
-
93
-
-
79958804691
-
Phase i clinical trial of gemcitabine (GEM) in combination with PF-00477736 (PF-736), a selective inhibitor of CHK1 kinase
-
Brega, N.; McArthur, G. A.; Britten, C.; Wong, S. G.; Wang, E.; Wilner, K. D.; Blasina, A.; Schwartz, G. K.; Gallo, J.; Tse, A. N. Phase I clinical trial of gemcitabine (GEM) in combination with PF-00477736 (PF-736), a selective inhibitor of CHK1 kinase J. Clin. Oncol. 2010, 28 (Suppl.) 3062
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.SUPPL.
, pp. 3062
-
-
Brega, N.1
McArthur, G.A.2
Britten, C.3
Wong, S.G.4
Wang, E.5
Wilner, K.D.6
Blasina, A.7
Schwartz, G.K.8
Gallo, J.9
Tse, A.N.10
-
94
-
-
79651475663
-
A phase i dose-escalation study of SCH 900776, a selective inhibitor of checkpoint kinase 1 (CHK1), in combination with gemcitabine (Gem) in subjects with advanced solid tumors
-
Daud, A.; Springett, G. M.; Mendelson, D. S.; aMunster, P. N.; Goldman, J. W.; Strosberg, J. R.; Kato, G.; Nesheiwat, T.; Isaacs, R.; Rosen, L. S. A phase I dose-escalation study of SCH 900776, a selective inhibitor of checkpoint kinase 1 (CHK1), in combination with gemcitabine (Gem) in subjects with advanced solid tumors J. Clin. Oncol. 2010, 28, 3064
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 3064
-
-
Daud, A.1
Springett, G.M.2
Mendelson, D.S.3
Amunster, P.N.4
Goldman, J.W.5
Strosberg, J.R.6
Kato, G.7
Nesheiwat, T.8
Isaacs, R.9
Rosen, L.S.10
-
95
-
-
84871234067
-
Phase i and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias
-
Karp, J. E.; Thomas, B. M.; Greer, J. M.; Sorge, C.; Gore, S. D.; Pratz, K. W.; Smith, B. D.; Flatten, K. S.; Peterson, K.; Schneider, P.; Mackey, K.; Freshwater, T.; Levis, M. J.; McDevitt, M. A.; Carraway, H. E.; Gladstone, D. E.; Showel, M. M.; Loechner, S.; Parry, D. A.; Horowitz, D. A.; Isaacs, R.; Kaufmann, S. H. Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias Clin. Cancer Res. 2012, 18, 6723-6731
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 6723-6731
-
-
Karp, J.E.1
Thomas, B.M.2
Greer, J.M.3
Sorge, C.4
Gore, S.D.5
Pratz, K.W.6
Smith, B.D.7
Flatten, K.S.8
Peterson, K.9
Schneider, P.10
Mackey, K.11
Freshwater, T.12
Levis, M.J.13
McDevitt, M.A.14
Carraway, H.E.15
Gladstone, D.E.16
Showel, M.M.17
Loechner, S.18
Parry, D.A.19
Horowitz, D.A.20
Isaacs, R.21
Kaufmann, S.H.22
more..
-
96
-
-
13844296425
-
Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells
-
Hyzy, M.; Bozko, P.; Konopa, J.; Skladanowski, A. Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells Biochem. Pharmacol. 2005, 69, 801-809
-
(2005)
Biochem. Pharmacol.
, vol.69
, pp. 801-809
-
-
Hyzy, M.1
Bozko, P.2
Konopa, J.3
Skladanowski, A.4
-
97
-
-
79960196862
-
Discovery of 4-anilinofuro[2,3- b ]quinoline derivatives as selective and orally active compounds against non-small-cell lung cancers
-
Chen, Y. W.; Chen, Y. L.; Tseng, C. H.; Liang, C. C.; Yang, C. N.; Yao, Y. C.; Lu, P. J.; Tzeng, C. C. Discovery of 4-anilinofuro[2,3- b ]quinoline derivatives as selective and orally active compounds against non-small-cell lung cancers J. Med. Chem. 2011, 54, 4446-4461
-
(2011)
J. Med. Chem.
, vol.54
, pp. 4446-4461
-
-
Chen, Y.W.1
Chen, Y.L.2
Tseng, C.H.3
Liang, C.C.4
Yang, C.N.5
Yao, Y.C.6
Lu, P.J.7
Tzeng, C.C.8
-
98
-
-
0034687754
-
An alternative, nonapoptotic form of programmed cell death
-
Sperandio, S.; Belle, I. D.; Bredesen, D. E. An alternative, nonapoptotic form of programmed cell death Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 14376-14381
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 14376-14381
-
-
Sperandio, S.1
Belle, I.D.2
Bredesen, D.E.3
-
99
-
-
69549127858
-
Bromocriptine induces parapoptosis as the main type of cell death responsible for experimental pituitary tumor shrinkage
-
Mariela Palmeri, C.; Pablo, P. J.; Liliana, D. V. S.; Silvina, G.; Lucía, D. P. A.; Humberto, M. J.; Inés, T. A. Bromocriptine induces parapoptosis as the main type of cell death responsible for experimental pituitary tumor shrinkage Toxicol. Appl. Pharmacol. 2009, 240, 55-65
-
(2009)
Toxicol. Appl. Pharmacol.
, vol.240
, pp. 55-65
-
-
Mariela Palmeri, C.1
Pablo, P.J.2
Liliana, D.V.S.3
Silvina, G.4
Lucía, D.P.A.5
Humberto, M.J.6
Inés, T.A.7
-
100
-
-
79956193429
-
A paraptosis-like cell death induced by delta-tocotrienol in human colon carcinoma SW620 cells is associated with the suppression of the Wnt signaling pathway
-
Zhang, J. S.; Li, D. M.; He, N.; Liu, Y. H.; Wang, C. H.; Jiang, S. Q.; Chen, B. Q.; Liu, J. R. A paraptosis-like cell death induced by delta-tocotrienol in human colon carcinoma SW620 cells is associated with the suppression of the Wnt signaling pathway Toxicology 2011, 285, 8-17
-
(2011)
Toxicology
, vol.285
, pp. 8-17
-
-
Zhang, J.S.1
Li, D.M.2
He, N.3
Liu, Y.H.4
Wang, C.H.5
Jiang, S.Q.6
Chen, B.Q.7
Liu, J.R.8
-
101
-
-
69049109763
-
Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: Formulation, pharmacokinetics, biodistribution and efficacy
-
Musende, A. G.; Eberding, A.; Wood, C.; Adomat, H.; Fazli, L.; Hurtado-Coll, A.; Jia, W.; Bally, M. B.; Guns, E. T. Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: formulation, pharmacokinetics, biodistribution and efficacy Cancer Chemother. Pharmacol. 2009, 64, 1085-1095
-
(2009)
Cancer Chemother. Pharmacol.
, vol.64
, pp. 1085-1095
-
-
Musende, A.G.1
Eberding, A.2
Wood, C.3
Adomat, H.4
Fazli, L.5
Hurtado-Coll, A.6
Jia, W.7
Bally, M.B.8
Guns, E.T.9
-
102
-
-
78651445610
-
Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53
-
Li, B.; Zhao, J.; Wang, C. Z.; Searle, J.; He, T. C.; Yuan, C. S.; Du, W. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53 Cancer Lett. 2011, 301, 185-192
-
(2011)
Cancer Lett.
, vol.301
, pp. 185-192
-
-
Li, B.1
Zhao, J.2
Wang, C.Z.3
Searle, J.4
He, T.C.5
Yuan, C.S.6
Du, W.7
-
103
-
-
64749084915
-
Honokiol, a multifunctional antiangiogenic and antitumor agent
-
Fried, L. E.; Arbiser, J. L. Honokiol, a multifunctional antiangiogenic and antitumor agent Antioxid. Redox Signaling 2009, 11, 1139-1148
-
(2009)
Antioxid. Redox Signaling
, vol.11
, pp. 1139-1148
-
-
Fried, L.E.1
Arbiser, J.L.2
-
104
-
-
84878799839
-
Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis
-
Xu, H. L.; Tang, W.; Du, G. H.; Kokudo, N. Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis Drug Discovery Ther. 2011, 5, 202-210
-
(2011)
Drug Discovery Ther.
, vol.5
, pp. 202-210
-
-
Xu, H.L.1
Tang, W.2
Du, G.H.3
Kokudo, N.4
-
105
-
-
77952816915
-
Honokiol induces paraptosis and apoptosis and exhibits schedule-dependent synergy in combination with imatinib in human leukemia cells
-
Wang, Y.; Yang, Z.; Zhao, X. Honokiol induces paraptosis and apoptosis and exhibits schedule-dependent synergy in combination with imatinib in human leukemia cells Toxicol. Mech. Methods 2010, 20, 234-241
-
(2010)
Toxicol. Mech. Methods
, vol.20
, pp. 234-241
-
-
Wang, Y.1
Yang, Z.2
Zhao, X.3
-
106
-
-
66449088004
-
A glycosylated antitumor ether lipid kills cells via paraptosis-like cell death
-
Samadder, P.; Bittman, R.; Byun, H. S.; Arthur, G. A glycosylated antitumor ether lipid kills cells via paraptosis-like cell death Biochem. Cell Biol. 2009, 87, 401-414
-
(2009)
Biochem. Cell Biol.
, vol.87
, pp. 401-414
-
-
Samadder, P.1
Bittman, R.2
Byun, H.S.3
Arthur, G.4
-
107
-
-
82655162060
-
Paraptosis-like cell death induced by yessotoxin
-
Korsnes, M. S.; Espenes, A.; Hetland, D. L.; Hermansen, L. C. Paraptosis-like cell death induced by yessotoxin Toxicol. in Vitro 2011, 25, 1764-1770
-
(2011)
Toxicol. in Vitro
, vol.25
, pp. 1764-1770
-
-
Korsnes, M.S.1
Espenes, A.2
Hetland, D.L.3
Hermansen, L.C.4
-
108
-
-
84864372423
-
Yessotoxin as a tool to study induction of multiple cell death pathways
-
Korsnes, M. S. Yessotoxin as a tool to study induction of multiple cell death pathways Toxins 2012, 4, 568-579
-
(2012)
Toxins
, vol.4
, pp. 568-579
-
-
Korsnes, M.S.1
-
109
-
-
4344685333
-
The PARP superfamily
-
Ame, J. C.; Spemlehauer, C.; de Murcia, G. The PARP superfamily BioEssays 2004, 26, 882-893
-
(2004)
BioEssays
, vol.26
, pp. 882-893
-
-
Ame, J.C.1
Spemlehauer, C.2
De Murcia, G.3
-
110
-
-
84859965899
-
A phase II study of the PARP inhibitor ABT-888 plus temozolomide in patients with heavily pretreated, metastatic colorectal cancer
-
Pishvaian, M. J; Slack, R.; Witkiewicz, A.; He, A. R.; Hwang, J. J.; Hankin, A.; Dorsch-Vogel, K.; Kuda, D.; McAndrew, T.; Weiner, L. M.; Marshall, J.; Brody, J. R. A phase II study of the PARP inhibitor ABT-888 plus temozolomide in patients with heavily pretreated, metastatic colorectal cancer J. Clin. Oncol. 2011, 29 (Suppl.) 3502
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.SUPPL.
, pp. 3502
-
-
Pishvaian, M.J.1
Slack, R.2
Witkiewicz, A.3
He, A.R.4
Hwang, J.J.5
Hankin, A.6
Dorsch-Vogel, K.7
Kuda, D.8
McAndrew, T.9
Weiner, L.M.10
Marshall, J.11
Brody, J.R.12
-
111
-
-
84865737317
-
Role of PARP inhibitors in cancer biology and therapy
-
Davar, D.; Beumer, J. H.; Hamieh, L.; Tawbi, H. Role of PARP inhibitors in cancer biology and therapy Curr. Med. Chem. 2012, 19, 3907-3921
-
(2012)
Curr. Med. Chem.
, vol.19
, pp. 3907-3921
-
-
Davar, D.1
Beumer, J.H.2
Hamieh, L.3
Tawbi, H.4
-
112
-
-
77953764486
-
Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. from concept to clinic
-
Ferraris, D. V. Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic J. Med. Chem. 2010, 53, 4561-4584
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4561-4584
-
-
Ferraris, D.V.1
-
113
-
-
78650705729
-
Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose) polymerase-1-dependent parthanatos cell death
-
Chiu, L. Y.; Ho, F. M.; Shiah, S. G.; Chang, Y.; Lin, W. W. Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose)polymerase-1-dependent parthanatos cell death Biochem. Pharmacol. 2011, 81, 459-470
-
(2011)
Biochem. Pharmacol.
, vol.81
, pp. 459-470
-
-
Chiu, L.Y.1
Ho, F.M.2
Shiah, S.G.3
Chang, Y.4
Lin, W.W.5
-
114
-
-
35148894301
-
First and final report of a phase II study of the poly(ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM)
-
Plummer, R. First and final report of a phase II study of the poly(ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM) J. Clin. Oncol 2006, 24 (Suppl.) 8013
-
(2006)
J. Clin. Oncol
, vol.24
, Issue.SUPPL.
, pp. 8013
-
-
Plummer, R.1
-
115
-
-
80355136313
-
Phase II trial of the poly(ADPribose) polymerase (PARP) inhibitor AG-014699 in BRCA 1 and 2-mutated, advanced ovarian and/or locally advanced or metastatic breast cancer
-
Drew, Y.; Ledermann, J. A; Jones, A.; Hall, G.; Jayson, G. C.; Highley, M.; Rea, D.; Glasspool, R. M.; Halford, S. E. R.; Crosswell, G.; Colebrook, S.; Boddy, A. V.; Curtin, N. J.; Plummer, E. R. Phase II trial of the poly(ADPribose) polymerase (PARP) inhibitor AG-014699 in BRCA 1 and 2-mutated, advanced ovarian and/or locally advanced or metastatic breast cancer J. Clin. Oncol. 2011, 29 (Suppl.) 3104
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.SUPPL.
, pp. 3104
-
-
Drew, Y.1
Ledermann, J.A.2
Jones, A.3
Hall, G.4
Jayson, G.C.5
Highley, M.6
Rea, D.7
Glasspool, R.M.8
Halford, S.E.R.9
Crosswell, G.10
Colebrook, S.11
Boddy, A.V.12
Curtin, N.J.13
Plummer, E.R.14
-
116
-
-
50349092363
-
Active Ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis
-
Overmeyer, J. H.; Kaul, A.; Johnson, E. E.; Maltese, W. A. Active Ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis Mol. Cancer Res. 2008, 6, 965-977
-
(2008)
Mol. Cancer Res.
, vol.6
, pp. 965-977
-
-
Overmeyer, J.H.1
Kaul, A.2
Johnson, E.E.3
Maltese, W.A.4
-
117
-
-
78649670089
-
Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6
-
Bhanot, H.; Young, A. M.; Overmeyer, J. H.; Maltese, W. A. Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6 Mol. Cancer Res. 2010, 8, 1358-1374
-
(2010)
Mol. Cancer Res.
, vol.8
, pp. 1358-1374
-
-
Bhanot, H.1
Young, A.M.2
Overmeyer, J.H.3
Maltese, W.A.4
-
118
-
-
84858032579
-
Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death
-
Robinson, M. W.; Overmeyer, J. H.; Young, A. M.; Erhardt, P. W.; Maltese, W. A. Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death J. Med. Chem. 2012, 55, 1940-1956
-
(2012)
J. Med. Chem.
, vol.55
, pp. 1940-1956
-
-
Robinson, M.W.1
Overmeyer, J.H.2
Young, A.M.3
Erhardt, P.W.4
Maltese, W.A.5
-
119
-
-
77955892650
-
A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment
-
Annereau, J. P.; Brel, V.; Dumontet, C.; Guminski, Y.; Imbert, T.; Broussas, M.; Vispe, S.; Breand, S.; Guilbaud, N.; Barret, J. M.; Bailly, C. A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment Leuk. Res. 2010, 34, 1383-1389
-
(2010)
Leuk. Res.
, vol.34
, pp. 1383-1389
-
-
Annereau, J.P.1
Brel, V.2
Dumontet, C.3
Guminski, Y.4
Imbert, T.5
Broussas, M.6
Vispe, S.7
Breand, S.8
Guilbaud, N.9
Barret, J.M.10
Bailly, C.11
-
120
-
-
79151481154
-
Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system
-
Kruczynski, A.; Vandenberghe, I.; Pillon, A.; Pesnel, S.; Goetsch, L.; Barret, J. M.; Guminski, Y.; Le, P. A.; Imbert, T.; Bailly, C.; Guilbaud, N. Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system Invest. New Drugs 2011, 29, 9-21
-
(2011)
Invest. New Drugs
, vol.29
, pp. 9-21
-
-
Kruczynski, A.1
Vandenberghe, I.2
Pillon, A.3
Pesnel, S.4
Goetsch, L.5
Barret, J.M.6
Guminski, Y.7
Le, P.A.8
Imbert, T.9
Bailly, C.10
Guilbaud, N.11
-
121
-
-
80555131125
-
Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II
-
Brel, V.; Annereau, J. P.; Vispé, S.; Kruczynski, A.; Bailly, C.; Guilbaud, N. Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II Biochem. Pharmacol. 2011, 82, 1843-1852
-
(2011)
Biochem. Pharmacol.
, vol.82
, pp. 1843-1852
-
-
Brel, V.1
Annereau, J.P.2
Vispé, S.3
Kruczynski, A.4
Bailly, C.5
Guilbaud, N.6
-
122
-
-
0025363276
-
Studies on the mechanisms of autophagy: Formation of the autophagic vacuole
-
Dunn, W. A., Jr. Studies on the mechanisms of autophagy: formation of the autophagic vacuole J. Cell Biol. 1990, 110, 1923-1933
-
(1990)
J. Cell Biol.
, vol.110
, pp. 1923-1933
-
-
Dunn Jr., W.A.1
-
123
-
-
0642318239
-
Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells
-
Suarez, Y.; Gonzalez, L.; Cuadrado, A.; Berciano, M.; Lafarga, M.; Munoz, A. Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells Mol. Cancer Ther. 2003, 2, 863-872
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 863-872
-
-
Suarez, Y.1
Gonzalez, L.2
Cuadrado, A.3
Berciano, M.4
Lafarga, M.5
Munoz, A.6
-
124
-
-
34548502668
-
Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: Semisynthetic modifications and antifungal lead-exploration studies
-
Shilabin, A. G.; Shilabin, A. G.; Kasanah, N.; Wedge, D. E.; Hamann, M. T. Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies J. Med. Chem. 2007, 50, 4340-4350
-
(2007)
J. Med. Chem.
, vol.50
, pp. 4340-4350
-
-
Shilabin, A.G.1
Shilabin, A.G.2
Kasanah, N.3
Wedge, D.E.4
Hamann, M.T.5
-
125
-
-
79955907533
-
Chemistry and biology of kahalalides
-
Gao, J.; Hamann, M. T. Chemistry and biology of kahalalides Chem. Rev. 2011, 111, 3208-3235
-
(2011)
Chem. Rev.
, vol.111
, pp. 3208-3235
-
-
Gao, J.1
Hamann, M.T.2
-
126
-
-
84870702650
-
Oncosis: An important non-apoptotic mode of cell death
-
Weerasinghe, P.; Buja, L. M. Oncosis: an important non-apoptotic mode of cell death Exp. Mol. Pathol. 2012, 93, 302-308
-
(2012)
Exp. Mol. Pathol.
, vol.93
, pp. 302-308
-
-
Weerasinghe, P.1
Buja, L.M.2
-
127
-
-
0031047146
-
The pathway of cell death: Oncosis, apoptosis and necrosis
-
Trump, B. E.; Berezesky, I. K.; Chang, S. H.; Phelps, P. C. The pathway of cell death: oncosis, apoptosis and necrosis Toxicol. Pathol. 1997, 25, 82-88
-
(1997)
Toxicol. Pathol.
, vol.25
, pp. 82-88
-
-
Trump, B.E.1
Berezesky, I.K.2
Chang, S.H.3
Phelps, P.C.4
-
128
-
-
61349167751
-
Phase II study of weekly kahalalide F in patients with advanced malignant melanoma
-
Martín-Algarra, S.; Espinosa, E.; Rubió, J.; López López, J. J.; Manzano, J. L.; Carrión, L. A.; Plazaola, A.; Tanovic, A.; Paz-Ares, L. Phase II study of weekly kahalalide F in patients with advanced malignant melanoma Eur. J. Cancer 2009, 45, 732-735
-
(2009)
Eur. J. Cancer
, vol.45
, pp. 732-735
-
-
Martín-Algarra, S.1
Espinosa, E.2
Rubió, J.3
López López, J.J.4
Manzano, J.L.5
Carrión, L.A.6
Plazaola, A.7
Tanovic, A.8
Paz-Ares, L.9
-
129
-
-
79957655142
-
Ascorbate and endocytosed motexafin gadolinium induce lysosomal rupture
-
Berndt, C.; Kurz, T.; Bannenberg, S.; Jacob, R.; Holmgren, A.; Brunk, U. T. Ascorbate and endocytosed motexafin gadolinium induce lysosomal rupture Cancer Lett. 2011, 307, 119-123
-
(2011)
Cancer Lett.
, vol.307
, pp. 119-123
-
-
Berndt, C.1
Kurz, T.2
Bannenberg, S.3
Jacob, R.4
Holmgren, A.5
Brunk, U.T.6
-
130
-
-
82955233755
-
Safety and feasibility of motexafin gadolinium administration with whole brain radiation therapy and stereotactic radiosurgery boost in the treatment of brain metastases: A multi-institutional phase II trial
-
McHaffie, D. R.; Chabot, P.; Dagnault, A.; Suh, J. H.; Fortin, M. A.; Chang, E.; Timmerman, R.; Souhami, L.; Grecula, J.; Nabid, A.; Schultz, C.; Werner-Wasik, M.; Gaspar, L. E.; Brachman, D.; Mody, T.; Mehta, M. P. Safety and feasibility of motexafin gadolinium administration with whole brain radiation therapy and stereotactic radiosurgery boost in the treatment of brain metastases: a multi-institutional phase II trial J. Neuro-Oncol. 2011, 105, 301-308
-
(2011)
J. Neuro-Oncol.
, vol.105
, pp. 301-308
-
-
McHaffie, D.R.1
Chabot, P.2
Dagnault, A.3
Suh, J.H.4
Fortin, M.A.5
Chang, E.6
Timmerman, R.7
Souhami, L.8
Grecula, J.9
Nabid, A.10
Schultz, C.11
Werner-Wasik, M.12
Gaspar, L.E.13
Brachman, D.14
Mody, T.15
Mehta, M.P.16
-
131
-
-
33846805629
-
Novel cell death pathways induced by N -(4-hydroxyphenyl)retinamide: Therapeutic implications
-
Venè, R.; Arena, G.; Poggi, A.; D'Arrigo.; Mormino, M.; Noonan, D. M.; Albini, A.; Tosetti, F. Novel cell death pathways induced by N -(4-hydroxyphenyl)retinamide: therapeutic implications Mol. Cancer Ther. 2007, 6, 286-298
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 286-298
-
-
Venè, R.1
Arena, G.2
Poggi, A.3
D'Arrigo4
Mormino, M.5
Noonan, D.M.6
Albini, A.7
Tosetti, F.8
-
132
-
-
14944353655
-
Phase II study of fenretinide (NSC 374551) in adults with recurrent malignant gliomas: A North American brain tumor consortium study
-
Puduvalli, V. K.; Alfred Yung, W. K.; Hess, K. R.; Kuhn, J. G.; Groves, M. D.; Levin, V. A.; Zwiebel, J.; Chang, S. M.; Cloughesy, T. F.; Junck, L.; Wen, P.; Lieberman, F.; Conrad, C. A; Gilbert, M. R.; Meyers, C. A.; Liu, V.; Mehta, M. P.; Nicholas, K. M.; Prados, M. Phase II study of fenretinide (NSC 374551) in adults with recurrent malignant gliomas: a North American brain tumor consortium study J. Clin. Oncol. 2004, 22, 4282-4289
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 4282-4289
-
-
Puduvalli, V.K.1
Alfred Yung, W.K.2
Hess, K.R.3
Kuhn, J.G.4
Groves, M.D.5
Levin, V.A.6
Zwiebel, J.7
Chang, S.M.8
Cloughesy, T.F.9
Junck, L.10
Wen, P.11
Lieberman, F.12
Conrad, C.A.13
Gilbert, M.R.14
Meyers, C.A.15
Liu, V.16
Mehta, M.P.17
Nicholas, K.M.18
Prados, M.19
-
133
-
-
43949093441
-
Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation
-
Ostenfeld, M. S.; Høyer-Hansen, M.; Bastholm, L.; Fehrenbacher, N.; Olsen, O. D.; Groth-Pedersen, L.; Puustinen, P.; Kirkegaard-Sørensen, T.; Nylandsted, J.; Farkas, T.; Jäättelä, M. Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation Autophagy 2008, 4, 487-499
-
(2008)
Autophagy
, vol.4
, pp. 487-499
-
-
Ostenfeld, M.S.1
Høyer-Hansen, M.2
Bastholm, L.3
Fehrenbacher, N.4
Olsen, O.D.5
Groth-Pedersen, L.6
Puustinen, P.7
Kirkegaard-Sørensen, T.8
Nylandsted, J.9
Farkas, T.10
Jäättelä, M.11
-
134
-
-
25444483322
-
Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress
-
Ostenfeld, M. S.; Fehrenbacher, N.; Høyer-Hansen, M.; Thomsen, C.; Farkas, T.; Jäättelä, M. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress Cancer Res. 2005, 65, 8975-8983
-
(2005)
Cancer Res.
, vol.65
, pp. 8975-8983
-
-
Ostenfeld, M.S.1
Fehrenbacher, N.2
Høyer-Hansen, M.3
Thomsen, C.4
Farkas, T.5
Jäättelä, M.6
-
135
-
-
33746023970
-
Biphosphinic palladacycle complex mediates lysosomal-membrane permeabilization and cell death in K562 leukaemia cells
-
Barbosa, C. M. V.; Oliveira, C. R.; Nascimento, F. D.; Smith, M. C. M.; Fausto, D. M.; Soufen, M. A.; Sena, E.; Araújo, R. C.; Tersariol, I. L. S.; Bincoletto, C.; Caires, A. C. F. Biphosphinic palladacycle complex mediates lysosomal-membrane permeabilization and cell death in K562 leukaemia cells Eur. J. Pharmacol. 2006, 542, 37-47
-
(2006)
Eur. J. Pharmacol.
, vol.542
, pp. 37-47
-
-
Barbosa, C.M.V.1
Oliveira, C.R.2
Nascimento, F.D.3
Smith, M.C.M.4
Fausto, D.M.5
Soufen, M.A.6
Sena, E.7
Araújo, R.C.8
Tersariol, I.L.S.9
Bincoletto, C.10
Caires, A.C.F.11
-
136
-
-
77649189381
-
Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo
-
Du, J. H.; Zhang, H. De; Ma, Z. J.; Ji, K. M. Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo Cancer Chemother. Pharmacol. 2010, 65, 895-902
-
(2010)
Cancer Chemother. Pharmacol.
, vol.65
, pp. 895-902
-
-
Du, J.H.1
Zhang, H.D.2
Ma, Z.J.3
Ji, K.M.4
-
137
-
-
79954448902
-
Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells
-
Sun, L.; Zhao, Y.; Yuan, H.; Li, X.; Cheng, A.; Lou, H. Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells Cancer Chemother. Pharmacol. 2011, 67, 813-821
-
(2011)
Cancer Chemother. Pharmacol.
, vol.67
, pp. 813
-
-
Sun, L.1
Zhao, Y.2
Yuan, H.3
Li, X.4
Cheng, A.5
Lou, H.6
|