A glycosylated antitumor ether lipid kills cells via paraptosis-like cell death

Biochemistry and Cell Biology

Volumn 87, Issue 2, 2009, Pages 401-414

  Samadder, Pranati ^a   Bittman, Robert ^b   Byun, Hoe Sup ^b   Arthur, Gilbert ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Apoptosis; Autophagy; Cell death; Glycosylated antitumor ether lipid; Paraptosis

Indexed keywords

ANTI-TUMOR; ANTICANCER PROPERTIES; APOPTOSIS; AUTOPHAGY; CASPASE; CASPASE INHIBITORS; CHINESE HAMSTER OVARY CELLS; GLYCOSYLATED; GLYCOSYLATED ANTITUMOR ETHER LIPID; GREEN FLUORESCENT PROTEIN FUSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE EMBRYONIC FIBROBLASTS; PARAPTOSIS; PROTEIN MARKERS; WILD TYPES; WORTMANNIN;

AMINES; CELL CULTURE; CELL DEATH; ETHERS; GLYCEROL; LIPIDS;

CELL MEMBRANES;

1 O HEXADECYL 2 O METHY 3 O (2' AMINO 2' DEOXY BETA DEXTRO GLUCOPYRANOSYL) SN GLYCEROL; 3 METHYLADENINE; ANTINEOPLASTIC AGENT; CASPASE; CASPASE INHIBITOR; CELL PROTEIN; EDELFOSINE; ETHER LIPID; GREEN FLUORESCENT PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; PROTEIN ATG5; PROTEIN LC3 II; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL VACUOLE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MOUSE EMBRYO; NONHUMAN; PROTEIN EXPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CASPASES; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCOLIPIDS; GLYCOSYLATION; GREEN FLUORESCENT PROTEINS; HUMANS; MAP KINASE KINASE KINASE 5; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICROTUBULE-ASSOCIATED PROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECOMBINANT FUSION PROTEINS; VACUOLES;

CRICETULUS GRISEUS;

EID: 66449088004     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/O08-147     Document Type: Article

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