A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment

Leukemia Research

Volumn 34, Issue 10, 2010, Pages 1383-1389

  Annereau, J P ^a   Brel, V ^a   Dumontet, C ^b   Guminski, Y ^a   Imbert, T ^a   Broussas, M ^a   Vispe S ^a   Breand S ^a   Guilbaud, N ^a   Barret, J M ^a   Bailly, C ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Biomarker; Etoposide; F14512; Polyamine transporter; Spermine

Indexed keywords

CD45 ANTIGEN; ETOPOSIDE; F 14512; POLYAMINE; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; DRUG RESPONSE; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; LYMPHOCYTE; PATIENT SELECTION; POLYAMINE METABOLISM; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD34; BIOGENIC POLYAMINES; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; FLOW CYTOMETRY; FLUORESCENT DYES; HUMANS; LEUKEMIA, MYELOID, ACUTE; OXADIAZOLES; PODOPHYLLOTOXIN; SPERMINE;

EID: 77955892650     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.12.021     Document Type: Article

References (28)

1. Porter C.W., Sufrin J.R. Interference with polyamine biosynthesis and/or function by analogs of polyamines or methionine as a potential anticancer chemotherapeutic strategy. Anticancer Res 1986, 6:525-542.
2. Sjoerdsma A., Schechter P.J. Chemotherapeutic implications of polyamine biosynthesis inhibition. Clin Pharmacol Ther 1984, 35:287-300.
3. Hibasami H., Maekawa S., Murata T., Nakashima K. Antitumour effect of a new multienzyme inhibitor of polyamine synthetic pathway, methylglyoxal-bis (cyclopentylamidinohydrazone), against human and mouse leukemia cells. Cancer Res 1989, 49:2065-2068.
4. Casero R.A., Woster P.M. Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem 2001, 44:1-26.
5. Persson L., Holm I., Ask A., Heby O. Curative effect of dl-2-difluoromethylornithine on mice bearing mutant L1210 leukemia cells deficient in polyamine uptake. Cancer Res 1998, 48:4807-4811.
6. Bergeron R.J., Bharti N., Wiegand J., McManis J.S., Yao H., Prokai L. Polyamine-vectored iron chelators: the role of charge. J Med Chem 2005, 48:4120-4137.
7. Holley J.L., Mather A., Wheelhouse R.T., Cullis P.M., Hartley J.A., Bingham J.P., et al. Targeting of tumour cells and DNA by a chlorambucil-spermidine conjugate. Cancer Res 1992, 52:4190-4195.
8. Casero R.A., Woster P.M. Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem 2009, 52(15):4551-4573.
9. Barret J.M., Kruczynski A., Vispe S., Annereau J.P., Brel V., Guminski Y., et al. F14512, a potent antitumour agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system. Cancer Res 2008, 68:9845-9853.
10. Kruczynski A, Vandenberghe I, Pillon A, Pesnel S, Goetsch L, Barret JM, et al. Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system. Invest News Drugs 2009 Sep 24. [Epub ahead of print].
11. Evageliou N.F., Hogarty M.D. Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma. Clin Cancer Res 2009, 15:5956-5961.
12. Seiler N., Sarhan S., Grauffel C., Jones R., Knodgen B., Moulinoux J.P. Endogenous and exogenous polyamines in support of tumour growth. Cancer Res 1990, 50:5077-5083.
13. Uemura T., Yerushalmi H.F., Tsaprailis G., Stringer D.E., Pastorian K.E., Hawel L., et al. Identification and characterization of a diamine exporter in colon epithelial cells. J Biol Chem 2008, 283:26428-26435.
14. Belani C.P., Doyle L.A., Aisner J. Etoposide: current status and future perspectives in the management of malignant neoplasms. Cancer Chemother Pharmacol 1994, 34(Suppl.):S118-S126.
15. Hande K.R. Etoposide: four decades of development of a topoisomerase II inhibitor. Eur J Cancer 1988, 34:1514-1521.
16. Guminski Y., Grousseau M., Cugnasse S., Brel V., Annereau J.P., Vispe S., et al. Synthesis of conjugated spermine derivatives with 7-nitrobenzoxadiazole (NBD), rhodamine and bodipy, as new fluorescent probes for the polyamine transport system. Bioorg Med Chem Lett 2009, 19:2474-2477.
17. Lindsay G.S., Wallace H.M. Changes in polyamine catabolism in HL-60 human promyelogenous leukaemic cells in response to etoposide-induced apoptosis. Biochem J 1999, 337:83-87.
18. Ware B.R., Klein J.W., Zero K. Interaction of a fluorescent spermine derivative with a nucleic acid polyion. Langmuir 1988, 4:458-463.
19. Hu Z.B., Minden M.D., McCulloch E.A. Direct evidence for the participation of bc1-2 in the regulation of retinoic acid of the Ara-C sensitivity of leukemic stem cells. Leukemia 1995, 9:1667-2167.
20. Hassan H.T., Drexler H.G. Interleukins and colony stimulating factors in human myeloid leukemia cell lines. Leukemia Lymphoma 1995, 20:1-15.
21. Kollmannsberger C., Beyer J., Droz J.P., Harstrick A., Hartmann J.T., Biron P., et al. Secondary leukemia following high cumulative doses of etoposide in patients treated for advanced germ cell tumours. J Clin Oncol 1998, 16:3386-3391.
22. Soulet D., Gagnon B., Rivest S., Audette M., Poulin R. A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism. J Biol Chem 2004, 279:49355-49366.
23. Phanstiel O., Kaur N., Delcros J.G. Structure-activity investigations of polyamine-anthracene conjugates and their uptake via the polyamine transporter. Amino Acids 2007, 33:305-313.
24. Siddiqui A.Q., Merson-Davies L., Cullis P.M. The synthesis of novel polyamine-nitroimidazole conjugates designed to probe the structural specificities of the polyamine uptake system in A549 lung carcinoma cells. J Chem Soc Perkin Trans 1999, 1:3243-3252.
25. Cullis P.M., Green R.E., Merson-Davies L., Travis N. Probing the mechanism of transport and compartmentalisation of polyamines in mammalian cells. Chem Biol 1999, 6:717-729.
26. Wolf M., Bauder-Wust U., Pipkorn R., Eskerski H., Eisenhut M. Fluorophore-labeled spermidine derivatives as fluorescent markers in optical tumour imaging. Bioorg Med Chem Lett 2006, 16:3193-3196.
27. Felschow D.M., Mi Z., Stanek J., Frei J., Porter C.W. Selective labelling of cell-surface polyamine-binding proteins on leukaemic and solid-tumour cell types using a new polyamine photoprobe. Biochem J 1997, 328:889-895.
28. Aziz S.M., Yatin M., Worthen D.R., Lipke D.W., Crooks P.A. A novel technique for visualizing the intracellular localization and distribution of transported polyamines in cultured pulmonary artery smooth muscle cells. J Pharm Biomed Anal 1998, 17:307-320.