Structure-activity relationship study of tricyclic necroptosis inhibitors

Journal of Medicinal Chemistry

Volumn 50, Issue 8, 2007, Pages 1886-1895

  Jagtap, Prakash G ^a   Degterev, Alexei ^b,c   Choi, Sungwoon ^a   Keys, Heather ^c   Yuan, Junying ^b   Cuny, Gregory D ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (HYDROXYACETYL) 3,3A,4,5 TETRAHYDRO 3 (4 METHOXYPHENYL) 8 METHOXY 2H BENZ[G]INDAZOLE; 2 ACETYL 2,3,3A,4 TETRAHYDRO 3 (4 METHOXYPHENYL) 8 METHOXY[1]BENZOTHIOPYRANO[4,3 C]PYRAZOLE; 2 ACETYL 3,3A,4,5 TETRAHYDRO 3 (4 METHOXYPHENYL) 8 FLUORO 2H BENZ[G]INDAZOLE; 2 ACETYL 3,3A,4,5 TETRAHYDRO 3 (4 METHOXYPHENYL) 8 METHOXY 2H BENZ[G]INDAZOLE; 2 PROPIONYL 3,3A,4,5 TETRAHYDRO 3 (4 METHOXYPHENYL) 8 METHOXY 2H BENZ[G]INDAZOLE; AMIDE; BENZOPYRAN DERIVATIVE; CASPASE; HETEROCYCLIC COMPOUND; HYDANTOIN; INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; PYRAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRUCTURE; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

CASPASES; CELL LINE; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; INDAZOLES; NECROSIS; PYRAZOLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34247264421     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061016o     Document Type: Article

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