Killing of tumor cells: A drama in two acts

Biochemical Pharmacology

Volumn 82, Issue 10, 2011, Pages 1304-1310

  Giansanti, Vincenzo ^a   Tillhon, Micol ^a   Mazzini, Giuliano ^a,b   Prosperi, Ennio ^a,b   Lombardi, Paolo ^c   Scovassi, A Ivana ^a  

^a CNR   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c Naxospharma Srl   (Italy)

Author keywords

Apoptosis; Autophagy; Cancer; Chemotherapy

Indexed keywords

APOPTOSIS; AUTOPHAGY; CANCER GROWTH; CANCER SURVIVAL; CELL KILLING; CONFERENCE PAPER; HUMAN; NONHUMAN; PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR CELL; ANTIPROLIFERATIVE ACTIVITY; AUTOLYSOSOME; AUTOPHAGOSOME; CANCER RESISTANCE; CANCER THERAPY; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; DRUG POTENTIATION; ENZYME ACTIVITY; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; GENE EXPRESSION REGULATION; HUMANS; NEOPLASMS;

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; 2 METHOXYESTRADIOL; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 METHYLADENINE; BAFILOMYCIN; BERBERINE; CASPASE; CHLOROQUINE; DNA VACCINE; EVEROLIMUS; INHIBITOR OF APOPTOSIS PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MONENSIN; OBATOCLAX; ORIDONIN; RESVERATROL; SPERMIDINE; SURVIVIN; TAMOXIFEN; UNCLASSIFIED DRUG; VALPROIC ACID; VINBLASTINE; WYE 125132;

EID: 80054684146     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.05.023     Document Type: Conference Paper

References (86)

1. V. Pavet, M.M. Portal, J.C. Moulin, R. Herbrecht, and H. Gronemeyer Towards novel paradigms for cancer therapy Oncogene 30 2011 1 20
2. U. Fischer, K. Janssen, and K. Schulze-Osthoff Cutting-edge apoptosis-based therapeutics: a panacea for cancer? BioDrugs 21 2007 273 297 (Pubitemid 47529468)
3. L. Yang Disfunction of the apoptotic pathway in cancer cells M. Sluyser, Application of apoptosis to cancer treatment 2005 Springer 1 28
4. P. Huang, and A. Oliff Signaling pathways in apoptosis as potential targets for cancer therapy Trends Cell Biol. 11 2001 343 348 (Pubitemid 32728175)
5. B. Levine, and G. Kroemer Autophagy in the pathogenesis of disease Cell 132 2008 27 42
6. G.M. Fimia, and M. Piacentini Regulation of autophagy in mammals and its interplay with apoptosis Cell. Mol. Life Sci. 67 2010 1581 1588
7. D. Glick, S. Barth, and K.F. Macleod Autophagy: cellular and molecular mechanisms J. Pathol. 221 2010 3 12
8. G. Kroemer, G. Marino, and B. Levine Autophagy and the integrated stress response Mol. Cell 40 2010 280 293
9. J.D. Rabinowitz, and E. White Autophagy and metabolism Science 330 2010 1344 1348
10. Z. Yang, and D.J. Klionsky Eaten alive: a history of macroautophagy Nat. Cell Biol. 12 2010 814 822
11. J. Li, and J. Yuan Caspases in apoptosis and beyond Oncogene 27 2008 6194 6206
12. A.U. Luthi, S.J. Martin, and The CASBAH: a searchable database of caspase substrates Cell Death Differ. 14 2007 641 650 (Pubitemid 46444502)
13. S. Ghavami, M. Hashemi, S.R. Ande, B. Yeganeh, W. Xiao, and M. Eshraghi Apoptosis and cancer: mutations within caspase genes J. Med. Genet. 46 2009 497 510
14. S. Kumar Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? Nat. Rev. Cancer 9 2009 897 903
15. S.F. Shariat, S. Desai, W. Song, T. Khan, J. Zhao, and C. Nguyen Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer Cancer Res. 61 2001 2562 2571 (Pubitemid 32685840)
16. L.T. Jia, L.H. Zhang, C.J. Yu, J. Zhao, Y.M. Xu, and J.H. Gui Specific tumoricidal activity of a secreted proapoptotic protein consisting of HER2 antibody and constitutively active caspase-3 Cancer Res. 63 2003 3257 3262 (Pubitemid 36735880)
17. M. D'Amelio, E. Tino, and F. Cecconi The apoptosome: emerging insights and new potential targets for drug design Pharm. Res. 25 2008 740 751
18. K.S. Putt, G.W. Chen, J.M. Pearson, J.S. Sandhorst, M.S. Hoagland, and J.T. Kwon Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy Nat. Chem. Biol. 2 2006 543 550 (Pubitemid 44413237)
19. T.T. Tan, and E. White Therapeutic targeting of death pathways in cancer: mechanisms for activating cell death in cancer cells Adv. Exp. Med. Biol. 615 2008 81 104
20. S. Fulda Caspase-8 in cancer biology and therapy Cancer Lett. 281 2009 128 133
21. G.S. Salvesen, and C.S. Duckett IAP proteins: blocking the road to death's door Nat. Rev. Mol. Cell Biol. 3 2002 401 410 (Pubitemid 34685698)
22. S.M. Srinivasula, and J.D. Ashwell IAPs: what's in a name? Mol. Cell 30 2008 123 135 (Pubitemid 351626688)
23. H. Yamamoto, C.Y. Ngan, and M. Monden Cancer cells survive with survivin Cancer Sci. 99 2008 1709 1714
24. N. Zaffaroni, M. Pennati, and M.G. Daidone Survivin as a target for new anticancer interventions J. Cell. Mol. Med. 9 2005 360 372
25. D.C. Altieri Targeted therapy by disabling crossroad signaling networks: the survivin paradigm Mol. Cancer Ther. 5 2006 478 482
26. M. Pennati, M. Folini, and N. Zaffaroni Targeting survivin in cancer therapy: fulfilled promises and open questions Carcinogenesis 28 2007 1133 1139 (Pubitemid 47062670)
27. D.C. Altieri New wirings in the survivin networks Oncogene 27 2008 6276 6284
28. S.M. Schmidt, K. Schag, M.R. Muller, M.M. Weck, S. Appel, and L. Kanz Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells Blood 102 2003 571 576 (Pubitemid 36841977)
29. U.B. Hofmann, H. Voigt, M.H. Andersen, P.T. Straten, J.C. Becker, and A.O. Eggert Identification and characterization of survivin-derived H-2Kb-restricted CTL epitopes Eur. J. Immunol. 39 2009 1419 1424
30. A. Lladser, K. Ljungberg, H. Tufvesson, M. Tazzari, A.K. Roos, and A.F. Quest Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection against mouse melanoma Cancer Immunol. Immunother. 59 2010 81 92
31. D.C. Altieri Survivin and IAP proteins in cell-death mechanisms Biochem. J 430 2010 199 205
32. M. Gyrd-Hansen, and P. Meier IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer Nat. Rev. Cancer 10 2010 561 574
33. R.K. Kanwar, C.H. Cheung, J.Y. Chang, and J.R. Kanwar Recent advances in anti-survivin treatments for cancer Curr. Med. Chem. 17 2010 1509 1515
34. J. Lopez, and P. Meier To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death Curr. Opin. Cell Biol. 22 2010 872 881
35. B. Levine Cell biology: autophagy and cancer Nature 446 2007 745 747 (Pubitemid 46582063)
36. N. Mizushima Autophagy: process and function Genes Dev. 21 2007 2861 2873 (Pubitemid 350133435)
37. Z. Xie, and D.J. Klionsky Autophagosome formation: core machinery and adaptations Nat. Cell Biol. 9 2007 1102 1109 (Pubitemid 47500484)
38. C. Behrends, M.E. Sowa, S.P. Gygi, and J.W. Harper Network organization of the human autophagy system Nature 466 2010 68 76
39. A.G. Jegga, L. Schneider, X. Ouyang, and J. Zhang Systems biology of the autophagy-lysosomal pathway Autophagy 7 2011 477 489
40. M. Mehrpour, A. Esclatine, I. Beau, and P. Codogno Overview of macroautophagy regulation in mammalian cells Cell Res. 20 2010 748 762
41. V. Giansanti, A. Torriglia, and A.I. Scovassi Conversation between apoptosis and autophagy: "Is it your turn or mine?" Apoptosis 16 2011 321 333
42. D.G McEwan, and I. Dikic The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation Trends Cell Biol. 21 2011 195 201
43. N. Hosokawa, T. Hara, T. Kaizuka, C. Kishi, A. Takamura, and Y. Miura Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy Mol. Biol. Cell 20 2009 1981 1991
44. C.H. Jung, C.B. Jun, S.H. Ro, Y.M. Kim, N.M. Otto, and J. Cao ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery Mol. Biol. Cell 20 2009 1992 2003
45. Y. Wei, S. Pattingre, S. Sinha, M. Bassik, and B. Levine JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy Mol. Cell 30 2008 678 688 (Pubitemid 351818252)
46. E. Zalckvar, H. Berissi, L. Mizrachy, Y. Idelchuk, I. Koren, and M. Eisenstein DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy EMBO Rep. 10 2009 285 292
47. E. Shvets, E. Fass, R. Scherz-Shouval, and Z. Elazar The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes J. Cell Sci. 121 2008 2685 2695
48. S.J. Cherra, 3rd, S.M. Kulich, G. Uechi, M. Balasubramani, and J. Mountzouris Regulation of the autophagy protein LC3 by phosphorylation J. Cell Biol. 190 2010 533 539
49. E. Morselli, G. Marino, M.V. Bennetzen, T. Eisenberg, E. Megalou, and S. Schroeder Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome J. Cell Biol. 192 2011 615 629
50. A. Iwata, B.E. Riley, J.A. Johnston, and R.R. Kopito HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin J. Biol. Chem. 280 2005 40282 40292 (Pubitemid 41779165)
51. J.Y. Lee, H. Koga, Y. Kawaguchi, W. Tang, E. Wong, and Y.S. Gao HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy EMBO J. 29 2010 969 980
52. C. Kraft, M. Peter, and K. Hofmann Selective autophagy: ubiquitin-mediated recognition and beyond Nat. Cell Biol. 12 2010 836 841
53. T.L. Thurston, G. Ryzhakov, S. Bloor, N. von Muhlinen, and F. Randow The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria Nat. Immunol. 10 2009 1215 1221
54. C. Burman, and N.T. Ktistakis Regulation of autophagy by phosphatidylinositol 3-phosphate FEBS Lett. 584 2010 1302 1312
55. A. Kihara, T. Noda, N. Ishihara, and Y. Ohsumi Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae J. Cell Biol. 152 2001 519 530 (Pubitemid 34280235)
56. K. Obara, T. Noda, K. Niimi, and Y. Ohsumi Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae Genes Cells 13 2008 537 547 (Pubitemid 351761772)
57. K. Obara, and Y. Ohsumi Dynamics and function of PtdIns(3)P in autophagy Autophagy 4 2008 952 954
58. E. Itakura, C. Kishi, K. Inoue, and N. Mizushima Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG Mol. Biol. Cell 19 2008 5360 5372
59. I. Vergne, E. Roberts, R.A. Elmaoued, V. Tosch, M.A. Delgado, and T. Proikas-Cezanne Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy EMBO J. 28 2009 2244 2258
60. R.A. Lockshin, and Z. Zakeri Apoptosis, autophagy, and more Int. J. Biochem. Cell Biol. 36 2004 2405 2419 (Pubitemid 39119755)
61. H.M. Shen, and P. Codogno Autophagic cell death: Loch Ness monster or endangered species? Autophagy 7 2011 457 465
62. T.P. Neufeld TOR-dependent control of autophagy: biting the hand that feeds Curr. Opin. Cell Biol. 22 2010 157 168
63. R.J. Dowling, I. Topisirovic, B.D. Fonseca, and N. Sonenberg Dissecting the role of mTOR: lessons from mTOR inhibitors Biochim. Biophys. Acta 1804 2010 433 439
64. Z. Yang, Z. Lei, B. Li, Y. Zhou, G.M. Zhang, and Z.H. Feng Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signaling Cancer Sci. 101 2010 494 500
65. W. Zhuang, B. Li, L. Long, L. Chen, Q. Huang, and Z. Liang Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity Int. J. Cancer 2011 10.1002/ijc.25975
66. R. Crazzolara, A. Cisterne, M. Thien, J. Hewson, R. Baraz, and K.F. Bradstock Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia Blood 113 2009 3297 3306
67. C.I. Lin, E.E. Whang, D.B. Donner, J. Du, J. Lorch, and F. He Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer Mol. Cancer Res. 8 2010 1217 1226
68. K. Yu, C. Shi, L. Toral-Barza, J. Lucas, B. Shor, and J.E. Kim Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 Cancer Res. 70 2010 621 631
69. Q.W. Fan, C. Cheng, C. Hackett, M. Feldman, B.T. Houseman, and T. Nicolaides Akt and autophagy cooperate to promote survival of drug-resistant glioma Sci. Signal. 3 2010 ra81
70. T.J. Liu, D. Koul, T. LaFortune, N. Tiao, R.J. Shen, and S.M. Maira NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas Mol. Cancer Ther. 8 2009 2204 2210
71. S. Thomas, K.T. Thurn, E. Bicaku, D.C. Marchion, and P.N. Munster Addition of a histone deacetylase inhibitor redirects tamoxifen-treated breast cancer cells into apoptosis, which is opposed by the induction of autophagy Breast Cancer Res. Treat. 2011 10.1007/s10549-011-1364-y
72. A. Puissant, G. Robert, N. Fenouille, F. Luciano, J.P. Cassuto, and S. Raynaud Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation Cancer Res. 70 2010 1042 1052
73. R.A. Gonzalez-Polo, P. Boya, A.L. Pauleau, A. Jalil, N. Larochette, and S. Souquere The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death J. Cell Sci. 118 2005 3091 3102 (Pubitemid 41149913)
74. U.E. Martinez-Outschoorn, D. Whitaker-Menezes, S. Pavlides, B. Chiavarina, G. Bonuccelli, and T. Casey The autophagic tumor stroma model of cancer or "battery-operated tumor growth": a simple solution to the autophagy paradox Cell Cycle 9 2010 4297 4306
75. G.M. Balaburski, R.D. Hontz, and M.E. Murphy p53 and ARF: unexpected players in autophagy Trends Cell Biol. 20 2010 363 369
76. M.C. Maiuri, E. Tasdemir, A. Criollo, E. Morselli, J.M. Vicencio, and R. Carnuccio Control of autophagy by oncogenes and tumor suppressor genes Cell Death Differ. 16 2009 87 93
77. K. Fujiwara, S. Daido, A. Yamamoto, R. Kobayashi, T. Yokoyama, and H. Aoki Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy J. Biol. Chem. 283 2008 388 397
78. P.M. Yang, and C.C. Chen Life or death? Autophagy in anticancer therapies with statins and histone deacetylase inhibitors Autophagy 7 2011 107 108
79. F. Strappazzon, M. Vietri-Rudan, S. Campello, F. Nazio, F. Florenzano, and G.M. Fimia Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy EMBO J. 30 2011 1195 1208
80. M. Parks, M. Tillhon, F. Don, E. Prosperi, and A.I. Scovassi 2-Methoxyestradiol: new perspectives in colon carcinoma treatment Mol. Cell. Endocrinol. 331 2011 119 128
81. N. Heidari, M.A. Hicks, and H. Harada GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy Cell Death Dis. 1 2010 e76
82. C.Y. Li, E.Q. Wang, Y. Cheng, J.K. Bao, and Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics Int. J. Biochem. Cell Biol. 43 2011 701 704
83. N. Wang, Y. Feng, M. Zhu, C.M. Tsang, K. Man, and Y. Tong Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism J. Cell. Biochem. 111 2010 1426 1436
84. O. Kepp, L. Galluzzi, M. Lipinski, J. Yuan, and G. Kroemer Cell death assays for drug discovery Nat. Rev. Drug Discov. 10 2011 221 237
85. M. Salazar, S. Hernandez-Tiedra, S. Torres, M. Lorente, M. Guzman, and G. Velasco Detecting autophagy in response to ER stress signals in cancer Methods Enzymol. 489 2011 297 317
86. Y. Chen, and D.J. Klionsky The regulation of autophagy - unanswered questions J. Cell Sci. 124 2011 161 170