Design, synthesis and biological evaluation of 2-mercapto-3- phenethylquinazoline bearing anilide fragments as potential antitumor agents: Molecular docking study

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 13, 2013, Pages 3935-3941

  Al Suwaidan, Ibrahim A ^a   Alanazi, Amer M ^a   Abdel Aziz, Alaa A M ^a,b   Mohamed, Menshawy A ^c,d   El Azab, Adel S ^a,c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b University of Mansoura   (Egypt)

^c Cairo University   (Egypt)

^d PRINCE SATTAM BIN ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

In vitro antitumor evaluation; Molecular docking; NCI; Quinazoline; Synthesis

Indexed keywords

2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETAMIDE; 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)N PHENYLACETAMIDE; 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)N(3,4, 5 TRIMETHOXYPHENYL)ACETAMIDE; 2 [2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETAMIDO]BENZOIC ACID; 3 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)N(3,4,5 TRIMETHOXYPHENYL)PROPANAMIDE; 3,4,5 TRIMETHOXYPHENYL 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZO LIN 2 YLTHIO)ACETATE; 4 CHLOROPHENYL 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETATE; 5 CHLORO 2 [2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETAMIDO]BENZOIC ACID; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROURACIL; N BENZYL 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETAMIDE; N(4 ETHOXYPHENYL) 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETAMIDE; N(4 METHOXYPHENYL) 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETAMIDE; N(CHLOROPHENYL) 2 (4 OXO 3 PHENETHYL 3,4 DIHYDROQUINAZOLIN 2 YLTHIO)ACETAMIDE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; COLON CANCER; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; IN VITRO STUDY; KIDNEY CANCER; LUNG NON SMALL CELL CANCER; MELANOMA; MOLECULAR DOCKING; OVARY CANCER; PROSTATE CANCER;

ANILIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 84878849267     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.056     Document Type: Article

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