Synthesis and antitumor activity of some 2, 3-disubstituted quinazolin-4(3H)-ones and 4, 6- disubstituted- 1, 2, 3, 4-tetrahydroquinazolin- 2H-ones

European Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2010, Pages 6058-6067

  Abdel Gawad, Nagwa M ^a   Georgey, Hanan H ^a   Youssef, Riham M ^a   El Sayed, Nehad A ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Antitumor screening; Quinazolinone; Synthesis; Thiadiazole

Indexed keywords

2 (1H IMIDAZOL 1 YL) 3 (4 METHOXYPHENYL)QUINAZOLIN 4(3H) ONE; 2 (1H IMIDAZOL 1 YL) 3 PHENYLQUINAZOLIN 4(3H) ONE; 2 [2 (4 CHLOROPHENYL) 2 OXO ETHYLTHIO] 3 (4 METHOXYPHENYL)QUINAZOLIN 4(3H) ONE; 2 [2 (4 CHLOROPHENYL)2 OXO ETHYLTHIO] 3 (4 METHOXYPHENYL)QUINAZOLIN 4(3H) ONE; 2 [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YLAMINO] 3 PHENYLQUINAZOLIN 4(3H) ONE; 2 [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YLAMINO] 3 PHENYLQUINAZOLIN 4(3H) ONE; 3 (4 CHLOROPHENYL) 2 (1H IMIDAZOL 1 YL)QUINAZOLIN 4(3H) ONE; 3 (4 CHLOROPHENYL) 2 [2 (4 CHLOROPHENYL) 2 OXO ETHYLTHIO]QUINAZOLIN 4(3H) ONE; 3 (4 CHLOROPHENYL) 2 [2 (4 ETHOXYPHENYL) 2 OXO ETHYLTHIO]QUINAZOLIN 4(3H) ONE; 3 (4 CHLOROPHENYL) 2 [2 (4 METHOXYPHENYL) 2 OXO ETHYLTHIO]QUINAZOLIN 4(3H) ONE; 3 (4 METHOXYPHENYL) 2 [2 (4 METHOXYPHENYL) 2 OXO ETHYLTHIO]QUINAZOLIN 4(3H) ONE; 3 ETHYL 2 (6 HYDROXY 2 MERCAPTOPYRIMIDIN 4 YLAMINO)QUINAZOLINE 4(3H) ONE; 3 ETHYL 2 [2 (4 METHOXYPHENYL) 2 OXO ETHYLTHIO]QUINAZOLIN 4(3H) ONE; 3,4 DIHYDROQUINAZOLIN 2(1H) ONE DERIVATIVE; 4 (4 CHLOROPHENYL) 2 OXO N (PYRIDIN 2 YL) 1,2,3,4 TETRAHYDROQUINAZOLINE 6 CARBOXAMIDE; 4 (4 CHLOROPHENYL) 6 (PYRIDIN 2 YLAMINOMETHYL) 3,4 DIHYDROQUINAZOLIN 2(1H) ONE; 4 (4 METHOXYPHENYL) 2 OXO N (PYRIDIN 2 YL) 1,2,3,4 TETRAHYDROQUINAZOLINE 6 CARBOXAMIDE; 4 [3 (4 CHLOROPHENYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YLAMINO]BENZENE SULFONAMIDE; 4 [3 (4 METHOXYPHENYL) 4 OXO 3,4 DIHYDROQUINAZOLIN 2 YLAMINO]BENZENE SULFONAMIDE; 4,6 1,2,3,4 TETRAHYDROQUINAZOLIN 2H ONE DERIVATIVE; ANTINEOPLASTIC AGENT; QUINAZOLIN 4(3H) ONE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; QUINAZOLINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649323240     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.10.008     Document Type: Article

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