Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 10, 2012, Pages 3306-3316

  El Sayed, Magda A A ^a   Abdel Aziz, Naglaa I ^b   Abdel Aziz, Alaa A M ^b,c   El Azab, Adel S ^c,d   Eltahir, Kamal E H ^c  

^a Mansoura University 35516   (Egypt)

^b MANSOURA UNIVERSITY   (Egypt)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d Al Azhar University   (Egypt)

Author keywords

Anti inflammatory; COX 2 inhibitors; Molecular modeling; Pyrazole; Pyrazoline; Synthesis

Indexed keywords

1 (4 CHLOROPHENYL) 2 (2 HYDROXYBENZYLIDENE) 4,4,4 TRIFLUOROBUTANE 1,3 DIONE; 1 (4 CHLOROPHENYL) 2 (3 NITROBENZYLIDENE) 4,4,4 TRIFLUOROBUTANE 1,3 DIONE; 1 (4 CHLOROPHENYL) 2 (3,4 DIMETHOXYBENZYLIDENE) 4,4,4 TRIFLUOROBUTANE 1,3 DIONE; 1 (4 CHLOROPHENYL) 2 (4 HYDROXYBENZYLIDENE) 4,4,4 TRIFLUOROBUTANE 1,3 DIONE; 1 (4 CHLOROPHENYL) 2 (4 METHOXYBENZYLIDENE) 4,4,4 TRIFLUOROBUTANE 1,3 DIONE; 1 (4 CHLOROPHENYL) 2 [(FURAN 2 YL)METHYLENE] 4,4,4 TRIFLUOROBUTANE 1,3 DIONE; 2 [5 (4 CHLOROPHENYL) 1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL YL]METHYLENE MALONITRILE; 2 [[3 (4 CHLOROPHENYL) 5 (TRIFLUOROMETHYL) 4H PYRAZOL 4 YLIDENE]METHYL]PHENOL; 2 CHLORO N [[5 (4 CHLOROPHENYL) 1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]METHYLENE]ANILINE; 3 (4 CHLOROPHENYL) 4 (3 NITROBENZYLIDENE) 5 (TRIFLUOROMETHYL) 4H PYRAZOLE; 3 (4 CHLOROPHENYL) 4 (3,4 DIMETHOXYBENZYLIDENE) 5 (TRIFLUOROMETHYL) 4H PYRAZOLE; 3 (4 CHLOROPHENYL) 4 (4 METHOXYBENZYLIDENE) 5 (TRIFLUOROMETHYL) 4H PYRAZOLE; 3 (4 CHLOROPHENYL) 4 [(FURAN 2 YL)METHYLENE] 5 (TRIFLUOROMETHYL) 4H PYURAZOLE; 3,5 BI(TRIFLUOROMETHYL) N [[5 (4 CHLOROPHENYL) 1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4YL]METHYLENE]ANILINE; 4 [[3 (4 CHLOROPHENYL) 5 (TRIFLUOROMETHYL) 4H PYRAZOL 4 YLIDENE]METHYL]PHENOL; 4 BENZYL 3 (4 CHLOROPHENYL) 5 (TRIFLUOROMETHYL) 1H PYRAZOLE; 4 BROMO N [[5 (4 CHLOROPHENYL) 1 PHENYL 3 (TRIFLUOROMETHYL) 1H PYRAZOL 4 YL]METHYLENE]ANILINE; 5' (4 BROMOPHENYL) 5 FLUORO 2',4' DIHYDROSPIRO(INDOL 3,3' PYRAZOL) 2(1H) ONE; 5' (4 METHYLPHENYL) 5 FLUORO 2',4' DIHYDROSPIRO(INDOL 3,3' PYRAZOL) 2(1H) ONE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; PYRAZOLE DERIVATIVE; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; IN VIVO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PAW EDEMA; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BINDING SITES; CYCLOOXYGENASE 2 INHIBITORS; DISEASE MODELS, ANIMAL; DRUG DESIGN; ENZYME ACTIVATION; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROTEIN BINDING; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS;

OVIS; RATTUS;

EID: 84860425971     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.044     Document Type: Article

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