Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4335-4343

  Kashaw, Sushil K ^a   Kashaw, Varsha ^a   Mishra, Pradeep ^a   Jain, N K ^a   Stables, J P ^b  

^a DR H S GOUR UNIVERSITY   (India)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

4(3H) Quinazolinones; CNS depressants activity; MES; Subcutaneous pentylenetetrazole induced seizure

Indexed keywords

1 (2 ETHYL 4 OXO 4H QUINAZOLIN 3 YL) 3 (4 METHOXY PHENYL)UREA; 1 (2 ETHYL 4 OXO 4H QUINAZOLIN 3 YL) 3 (4 NITRO PHENYL)UREA; 1 (2 ETHYL 4 OXO 4H QUINAZOLIN 3 YL) 3 4 TOLYL UREA; 1 (2 ETHYL 4 OXO 4H QUINAZOLIN 3 YL) 3 PHENYL UREA; 1 (4 BROMO PHENYL) 3 (4 OXO 2 PHENYL 4H QUINAZOLIN 3 YL)UREA; 1 (4 CHLORO PHENYL) 3 (4 OXO 2 PHENYL 4H QUINAZOLIN 3 YL)UREA; 1 (4 ETHOXY PHENYL) 3 (2 ETHYL 4 OXO 4H QUINAZOLIN 3 YL)UREA; 1 (4 METHOXY PHENYL) 3 (4 OXO 2 PHENYL 4H QUINAZOLIN 3 YL)UREA; 1 (4 NITRO PHENYL) 3 (4 OXO 2 PHENYL 4H QUINAZOLIN 3 YL)UREA; ANTICONVULSIVE AGENT; HYPNOTIC SEDATIVE AGENT; PENTETRAZOLE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM DEPRESSION; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTRIC SHOCK; FORCED SWIMMING TEST; IMMOBILIZATION; LOCOMOTION; MALE; NEUROTOXICITY; NONHUMAN; RAT; SEIZURE; SPECTROSCOPY;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; MALE; MICE; MOLECULAR STRUCTURE; PENTYLENETETRAZOLE; QUINAZOLINONES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 70349770548     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.05.008     Document Type: Article

References (25)

1. Plescinba S., Daidone G., Raffa D., Bajardi M.L., Caruso A., Cutuli V., and Amico-Roxas M. Farmaco 47 (1992) 465-475
2. Mukerji D.D., Nautiyal S.R., Prasad C.R., and Dhawan B.N. Indian J. Med. Res. 71 (1980) 480-482
3. Misra S., Satsangi R.K., and Tiwari S.S. Pol. J. Pharmacol. Pharm. 34 (1982) 441-447
4. Husain M.I., and Gupta K.B. Indian J. Pharm. Sci. 44 (1982) 37-42
5. Chaurasia M.R., and Sharma S.K. J. Indian Chem. Soc. 59 (1982) 370-376
6. Kumar P., Dhawan K.N., Vrat S., Bhargava K.P., and Kishore K. Arch. Pharm. 316 (1983) 759-763
7. Fisnerova L., Brunova B., Kocfeldova Z., Tikalova J., Maturova E., and Grimova J. Collect. Czech. Chem. Commun. 56 (1991) 2373-2381
8. Saxena S., Verma M., Saxena A.K., and Shanker K. Indian J. Pharm. Sci. 53 (1991) 48-52
9. Dimmock J.R., Pandeya S.N., Quail J.W., Pugazhenthi U., Allen T.M., Kao G.Y., Balzarini J., and Declerq E. Eur. J. Med. Chem. 30 (1995) 303
10. Dimmock J.R., Puthucode R.N., Smith J.M., Hetheriengton M., Quail J.M., Pugazhenthi U., Lechler T., and Stables J.P. J. Med. Chem. 39 (1996) 3984-3997
11. Pandeya S.N., Yogeeswari P., and Stables J.P. Eur. J. Med. Chem. 35 (2000) 879-886
12. Pandeya S.N., Raja A.S., and Stables J.P. J. Pharm. Pharmaceut. Sci. 5 (2002) 266-271
13. Boltze K.H., Dell H.D., Lehwald H., Loranz D., and Ruberg-schweer M. Arzneimittelforschung/Drug Res. 13 (1963) 688-692
14. Wolfe J.F., Rathman T.L., Sleevi M.C., Campbell J.A., and Greenwood T.D. J. Med. Chem. 33 (1990) 161-166
15. Jatav V., Mishra P., Kashaw S., and Stables J.P. Eur. J. Med. Chem. 43 (2008) 135-141
16. Jatav V., Jain S.K., Kashaw S.K., and Mishra P. Indian J. of Pharm. Sci. 07 (2006) 360-362
17. Aggarwal N., and Mishra P. J. Pharm. Pharmaceut. Sci. 7 (2004) 260-264
18. Aggarwal N., and Mishra P. J. Zhejiang Univ. 6B (2005) 617-621
19. Jatav V., Mishra P., Kashaw S., and Stables J.P. Eur. J. Med. Chem. 43 (2008) 1945-1954
20. White H.S., Johnson M., Wolf H.H., and Kupferberg H.J. Ital J. Neurol. Sci. 16 (1995) 73-77
21. White H.S., Woodhead J.H., and Franklin M.R. General principals: experimental selection, quantification and evaluation of antiepileptic drugs. Antiepileptic Drug (1995), Raven Press, New York 99-110
22. Swinyard E.A., Clark L.D., Miyahara J.T., and Wolf H.H. J. Physiol. 132 (1961) 97-102
23. Dunham M.S., and Miya T.A. J. Am. Pharm. Assoc. Sci. 46 (1957) 208-209
24. Boissier J.R., and Simon P. Arch. Int. Pharmacodyn. Ther. 158 (1965) 212-214
25. Porsolt R.D., Anton G., Blanet N., and Jalbre M. Eur. J. Pharmacol. 47 (1978) 379-386