Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted- 4(3H)-quinazoline derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 327-333

  El Azab, Adel S ^a,b   Eltahir, Kamal E H ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Al Azhar University   (Egypt)

Author keywords

Anticonvulsant; Neurotoxicity; Quinazoline; Synthesis

Indexed keywords

1,2,4,5 TETRAZIN 3 ONE; 2 [2 [2 METHYL 3 (2 METHYLPHENYL) 4 (3H)QUINAZOLIN 8 YLOXY]ACETYL]HYDRAZINECARBODITHIOATE; 2 [2 [2 METHYL 3 (2 METHYLPHENYL) 4 (3H)QUINAZOLIN 8 YLOXY]ACETYL]HYDRAZINECARBOXAMIDE; 2 [3,4 DIHYDRO 2 METHYL 3 (2 METHYLPHENYL) 4 OXOQUINAZOLIN 8YLOXY]ACETIC ACID HYDRAZIDE; 4 [(2 METHYL) 3 (2 METHYLPHENYL) 4 (3H)QUINAZOLIN 8 YLOXY)PYRAZOLIDIN 3,5 DIONE; 8 (5 MERCAPTO 1,3,4 OXADIAZOL 2 YL)METHOXY)[2 METHYL 3 (2 METHYLPHENYL)] 4 (3H)QUINAZOLINONE; 8 [(4 AMINO 5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL)METHOXY 2 METHYL 3 (2 METHYLPHENYL)] 4 (3H)QUINAZOLINONE; 8 [(5 MERCAPTO 1,3,4 THIADIAZOL 2 YL)METHOXY] 2 METHYL 3 (2 METHYLPHENYL) 4 (3H) QUINAZOLINONE; [2 (2 METHYL) 3 (2 METHYLPHENYL) 4 (3H)QUINAZOLIN 8 YLOXY)N(2 PHENYLTHIAZOLIDIN 4 ON 3 YL)]ACETAMIDE; ANTICONVULSIVE AGENT; ETHYL 2 [2 (2 METHYL) 3 (2 METHYLPHENYL) 4 (3H)QUINAZOLIN 8 YLOXY)ACETYL]HYDRAZINCARBOXYLATE; ETHYL 2 [3,4 DIHYDRO 2 METHYL 3 (2 METHYLPHENYL) 4 OXOQUINAZOLIN 8 YLOXY]ACETATE; METHAQUALONE; METHYL 2 [2 [2 METHYL 3 (2 METHYLPHENYL) 4 (3H)QUINAZOLIN 8 YLOXY]ACETYL]HYDRAZINECARBODITHIOATE; N [(2 HYDROXYETHYL) 2 (2 METHYL 3 (2 METHYLPHENYL) 4 (3H)QUINAZOLIN 8 YLOXY)]ACETAMIDE; N [2 (2 METHYL) 3 (2 METHYLPHENYL) 4 (3H)QUINAZOLIN 8 YLOXY)ACETYL]BENZOHYDRAZIDE; N' (HYDRAZINECARBONOTHIOYL) 2 [(2 METHYL 3 (2 METHYLPHENYL) 4 (3H)QUINAZOLIN 8 YLOXY)ACETYL]ACETOHYDRAZIDE; QUINAZOLINE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANTICONVULSANT ACTIVITY; ARTICLE; CYCLIZATION; DRUG DESIGN; DRUG RESEARCH; LD 50; MAXIMAL ELECTROSHOCK SEIZURE; MOUSE; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; SEIZURE;

ANIMALS; ANTICONVULSANTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; MALE; METHAQUALONE; MICE; MODELS, CHEMICAL; NERVOUS SYSTEM; QUINAZOLINES; SEIZURES; VALPROIC ACID;

STRYCHNOS TOXIFERA;

EID: 84655175048     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.007     Document Type: Article

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