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Volumn 46, Issue 12, 2011, Pages 5754-5762
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New diarylureas and diarylamides containing 1,3,4-triarylpyrazole scaffold: Synthesis, antiproliferative evaluation against melanoma cell lines, ERK kinase inhibition, and molecular docking studies
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Author keywords
1,3,4 Triarylpyrazole; B RAF kinase; Diarylamide; Diarylurea; ERK kinase; Melanoma
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Indexed keywords
1 [4 [3 (4 CHLORO 3 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) 1H 1H PYRAZOL 1 YL]PHENYL] 3 (2,3 DICHLOROPHENYL)UREA;
1 [4 [3 (4 CHLORO 3 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL] 3 (3,4 DICHLOROPHENYL)UREA;
1 [4 [3 (4 CHLORO 3 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL] 3 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]UREA;
1 [4 [3 (4 CHLORO 3 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL] 3 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL]UREA;
1 [4 [3 (4 CHLORO 3 METHOXYPHENYL) 4 (PYRIDIN 4 YL) 1H 1 YL]PHENYL] 3 (2,3 DICHLOROPHENYL)UREA;
1 [4 [3 (4 CHLORO 3 METHOXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL] 3 (3,4 DICHLOROPHENYL)UREA;
1 [4 [3 (4 CHLORO 3 METHOXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL] 3 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL]UREA;
1 [4 [3 (4 CHLORO 3 METHOXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1YL]PHENYL] 3 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]UREA;
3,4 DICHLORO N[4 [3 (4 CHLORO 3 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL]BENZAMIDE;
3,4 DICHLORO N[4 [3 (4 CHLORO 3 METHOXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL]BENZAMIDE;
3,5 BIS(TRIFLUOROMETHYL) N[4 [3 (4 CHLORO 3 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL]BENZAMIDE;
3,5 BIS(TRIFLUOROMETHYL)N [4 [3 (4 CHLORO 3 METHOXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL]BENZAMIDE;
3,5 DICHLORO N[4 [3 (4 CHLORO 3 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL]BENZAMIDE;
3,5 DICHLORO N[4 [3 (4 CHLORO 3 METHOXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL]BENZAMIDE;
4 CHLORO 3 TRIFLUOROMETHYL N [4 [3 (4 CHLORO 3 HYDROXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL]BENZAMIDE;
4 CHLORO 3 TRIFLUOROMETHYL N [4 [3 (4 CHLORO 3 METHOXYPHENYL) 4 (PYRIDIN 4 YL) 1H PYRAZOL 1 YL]PHENYL]BENZAMIDE;
AMIDE;
ANTINEOPLASTIC AGENT;
B RAF KINASE;
MITOGEN ACTIVATED PROTEIN KINASE;
PYRAZOLE DERIVATIVE;
RAF PROTEIN;
SORAFENIB;
UNCLASSIFIED DRUG;
UREA DERIVATIVE;
ANTINEOPLASTIC ACTIVITY;
ANTIPROLIFERATIVE ACTIVITY;
ARTICLE;
CONCENTRATION RESPONSE;
DRUG POTENCY;
DRUG PROTEIN BINDING;
DRUG SCREENING;
DRUG SYNTHESIS;
ENZYME INHIBITION;
HUMAN;
HUMAN CELL;
IC 50;
MELANOMA CELL;
MOLECULAR DOCKING;
ANTINEOPLASTIC AGENTS;
CELL LINE, TUMOR;
CELL PROLIFERATION;
DRUG SCREENING ASSAYS, ANTITUMOR;
HUMANS;
MAP KINASE SIGNALING SYSTEM;
MELANOMA;
MODELS, MOLECULAR;
PROTEIN KINASE INHIBITORS;
PROTO-ONCOGENE PROTEINS B-RAF;
PYRAZOLES;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 80955131286
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2011.08.013 Document Type: Article |
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Times cited : (75)
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References (26)
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