Synthesis and biological evaluation of novel 6-nitro-5-substituted aminoquinolines as local anesthetic and anti-arrhythmic agents: Molecular modeling study

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 9, 2005, Pages 3175-3183

  Goda, Fatma E ^a   Abdel Aziz, Alaa A M ^a   Ghoneim, Hamdy A ^a  

^a MANSOURA UNIVERSITY   (Egypt)

Author keywords

6 Nitro quinoline; Antiarrhythmic agents; Local anesthetics; Molecular modeling; Xylocaine

Indexed keywords

AMINOQUINOLINE DERIVATIVE; ANESTHETIC AGENT; ANTIARRHYTHMIC AGENT; LIDOCAINE;

ACUTE TOXICITY; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ARRHYTHMIA; LETHAL DOSE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PAIN; SUBSTITUTION REACTION;

EID: 16244383545     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.02.050     Document Type: Article

References (24)

1. W. Foye, T. Leme, and D. Williams Principles of Medicinal Chemistry P.305 1995 Williams & Wikins, Media PA USA
2. J.M. Ritchie, and N.M. Green Local Anesthetics A.G. Gilman L.S. Goodman T.W. Rall F. Murad Goodman and Gilman's The Pharmacological Bases of Therapeutics 1985 Macmillan New York 302
3. M. Verderame Handbook of CNS Agents and Local Anesthetics 1986 CRC FL, USA p 336
4. B. Greorge, W. Barbara, and O. Dinana J. Heterocycl. Chem. 29 1992 33
5. A.M. AL-Obaid Alex J. Pharm. Sci. 6 1992 43
6. A.M. Al-Obaid Arzneim -Forsch 45 1995 627
7. A.M. Al-Obaid Boll. Chim. Pharmacutico. 135 1996 415
8. A.M. Al-Obaid, H.I. El-Subbagh, O.A. Shabanah, and M.A. Mahran Die Pharmazie 53 1998 24
9. A.K. Shakya, G.K. Patnaik, and P. Mishra Eur. J. Med. Chem. 27 1992 67
10. G.B. Phillips, T.K. Morgan, W.C. Lumma, R.P. Gomez, J.M. Lind, T. Argentieri, and M.E. Sullivan J. Med. Chem. 35 1992 743
11. G. Caliendo, G. Greco, P. Grieco, R. Mattace, R. Meli, E. Novellino, E. Perissutti, and V. Santagda Eur. J. Med. Chem. 31 1996 99
12. M.E. El.Sherbeny, M.A. Al-Obaid, and H.A. El-Kashef Saudi Pharmaceut. J. 6 1998 228
13. S. Profeta, and N.L. Allinger J. Am. Chem. Soc. 107 1985 1907
14. N.L. Allinger J. Am. Chem. Soc. 99 1977 8127
15. HyperChem version 5.1 Hypercube, Inc
16. A.W. Hanson, and D.W. Banner Acta Cryst. B30 1974 2486 and references cited therein
17. P.S. Farmer Drug Des. 10 1980 119
18. M. Remko, S. Schreiner, and B.M. Rode J. Mol. Struct. (Theochem) 307 1994 35
19. M.J.S. Dewar, E.G. Zoebisch, E.F. Healy, and J.J.P. Stewart J. Am. Chem. Soc. 107 1985 3902
20. L.A. LaPlanche, G. Vanderkooi, H. Jasmani, and M.M. Suki Magn. Reson. Chem. 23 1985 945
21. G.L. Patrick An Introduction to Medicinal Chemistry 1995 Oxford University Press p 130
22. Staff Department of pharmacology, University of Edinburgh, pharmacological Experiments on IntactPreparation, Churchill Living press, London 1971
23. K. El-Tahir, H.A. El-Obeid, K.A. Al-Rashood, A.E. Madani, and A.M. Ageel Pharm. Res. 6 1989 252
24. J.T. Litchfield, and T. Wilcoxon J. Pharmacol. Exp. Ther. 96 1949 99