Synthesis and antitumor evaluation of novel diarylsulfonylurea derivatives: Molecular modeling applications

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 689-697

  El Sherbeny, Magda A ^a   Abdel Aziz, Alaa A M ^b   Ahmed, Musa A ^c  

^a MANSOURA UNIVERSITY   (Egypt)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF BENGHAZI   (Libyan Arab Jamahiriya)

Author keywords

Antitumor; Arylsulfonylurea; Molecular modeling; Synthesis

Indexed keywords

2 [3 (PHENYLSULFONYL)UREIDO] 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOHYDRAZIDE; 3 PHENYLSULFONYL 6,7,8,9 TETRAHYDRO 5H CYCLOHEPTA[10,20:4,5]THIENO[2,3 D]PYRIMIDINE 2,4(1H,3H)DIONE; ANTINEOPLASTIC AGENT; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTRICITY; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIPOPHILICITY; MOLECULAR MODEL; PHARMACOPHORE; PREDICTION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STATIC ELECTRICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 73549104042     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.014     Document Type: Article

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