Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2379-2391

  Al Obaid, Abdulrahman M ^a   Abdel Hamide, Sami G ^a   El Kashef, Hassan A ^b   Abdel Aziz, Alaa A M ^a   El Azab, Adel S ^a   Al Khamees, Hamad A ^a   El Subbagh, Hussein I ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

2 Thieno 4(3H) quinazolinones; Antitumor agents; Molecular modeling; Synthesis

Indexed keywords

2 (2 THIENO) 3 (2 CHLOROETHYL) 4 OXO 6 IODO 3H QUINAZOLINE; 2 (2 THIENO) 3 (3 OXOBUTYRYL)AMINO 6 IODO 3,4 DIHYDROQUINAZOLIN 3 ONE; 2 (2 THIENO) 3 ARYLIDENEAMINO 6 IODO 3,4 DIHYDROQUINAZOLIN 4 ONE DERIVATIVE; 2 (2 THIENO) 4 (4 SULFONAMIDOBENZYLAMINO) 6 IODOQUINAZOLINE; 2 (2 THIENO) 4 (ETHOXYCARBONYLMETHYLOXY) 6 IODO 3,4 DIHYDRO QUINAZOLINE; 2 (2 THIENO) 4 [4 SULFONAMIDOBENZYLAMINO] 6 IODO QUINAZOLINE; 2 (2 THIENO) 4 ALKYLTHIO 6 IODO QUINAZOLINE DERIVATIVE; 2 (2 THIENO) 4 CHLORO 6 IODO QUINAZOLINE; 2 (2 THIENO) 6 IODO 3 (4 SULPHONAMIDO BENZYL) 3H QUINAZOLIN 4 ONE; 2 (2 THIENO) 6 IODO 3,4 DIHYDRO QUINAZOLIN 4 ONE; 2 (2 THIENO) 6 IODO 3,4 DIHYDRO QUINAZOLIN 4 THIONE; 2 (2 THIENO) 6 IODO 3HYDROXY 3,4 DIHYDRO QUINAZOLIN 4 ONE; 2 (2 THIENO) 6IODO 4H 3,1 BENZOXAZIN 4 ONE; 2 (2 THIENYLCARBONYLAMINO) 5 IODO BENZOIC ACID; 2 (2 THIENYLCARBONYLAMINO) 5 IODO N(4 HYDROXYPHENYL) BENZAMIDE; 2 (2-THIENO) 6 IODO 3 PHENYLAMINO 3,4 DIHYDRO QUINA ZOLIN 4 ONE; 2 THIENO 4(3H) QUINAZOLINE DERIVATIVE; 4 [2 (2 THIENO) 6 IODO 3H QUINAZOLIN 4 YL OXY] ACETYL HYDRAZINE; FLUOROURACIL; N (PHENYL) N' [2 (2 THIENO) 4 OXO 6 IODO 3H QUINAZOLIN 3 YL] THIOUREA; N (PHENYL) N' [2 (2 THIENO) 4 OXO 6 IODO 3H QUINAZOLIN 3 YL] UREA; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG STRUCTURE; IN VITRO STUDY; MOLECULAR MODEL; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEOPLASMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINAZOLINES; STEREOISOMERISM;

EID: 64249139659     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.015     Document Type: Article

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