Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study

European Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2010, Pages 4188-4198

  El Azab, Adel S ^a   Al Omar, Mohamed A ^a   Abdel Aziz, Alaa A M ^a   Abdel Aziz, Naglaa I ^b   El Sayed, Magda A A ^c   Aleisa, Abdulaziz M ^a   Sayed Ahmed, Mohamed M ^a   Abdel Hamide, Sami G ^d  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b MANSOURA UNIVERSITY   (Egypt)

^c Mansoura University 35516   (Egypt)

^d PRINCE SATTAM BIN ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Antitumor; Drug likeness; Molecular docking; Quinazoline; Synthesis

Indexed keywords

2 (6 CHLORO 2 P TOLYLQUINAZOLIN 4 YLTHIO) P FLOROPHENYLACETAMIDE; 2 (6 CHLORO 2 P TOLYLQUINAZOLIN 4 YLTHIO) P TOLYACETAMIDE; 2 (6 CHLORO 2 P TOLYLQUINAZOLIN 4 YLTHIO)ACETAMIDE; 2 (6 CHLORO 2 P TOLYLQUINAZOLIN 4 YLTHIO)ACETONITRILE; 2 (6 CHLORO 2 P TOLYLQUINAZOLIN 4 YLTHIO)ETHANOL; 2 (6 CHLORO 2 P TOLYLQUINAZOLIN 4 YLTHIO)PHENYLACETAMIDE; 3 AMINO 6 CHLORO 2 P TOLYLQUINAZOLIN 4 ONE; 3 AMINO 6 CHLORO 2 P TOLYLQUINAZOLIN 4 THIONE; 4 (ALLYLTHIO) 6 CHLORO 2 P TOLYLQUINAZOLINE; 4 (BENZYLSULFONYL) 6 CHLORO 2 P TOLYLQUINAZOLINE; 4 (BENZYLTHIO) 6 CHLORO 2 P TOLYLQUINAZOLINE; 5 CHLORO 2 (4 METHYLBENZAMIDO)BENZAMIDE; 5 CHLORO2 (4 METHYLBENZAMIDO)BENZOIC ACID; 6 CHLORO 2 P TOLYL BENZO[D][1,3]OXAZIN 4 ONE; 6 CHLORO 2 P TOLYL BENZO[D][1,3]OXAZIN 4 THION; 6 CHLORO 2 P TOLYLQUINAZOLIN 4 AMINE; 6 CHLORO 2 P TOLYLQUINAZOLIN 4 ONE; 6 CHLORO 2 P TOLYLQUINAZOLIN 4 THIONE; 6 CHLORO 3 METHYL 2 P TOLYLQUINAZOLIN 4 ONE; 6 CHLORO 4 (2 NITROPYRIDYLTHIO) 2 P TOLYLQUINAZOLINE; 6 CHLORO 4 (METHYLTHIO) 2 P TOLYLQUINAZOLINE; 6 CHLORO 4 HYDRAZINO 2 P TOLYLQUINAZOLINE; ANTINEOPLASTIC AGENT; BENZOYL N (6 CHLORO 2 P TOLYLQUINAZOLIN 4 YL) HYDROXYLAMINE; ETHYL(6 CHLORO 2 P TOLYLQUINAZOLIN 4 YLTHIO)ETHYL 4 (2 ACETAMIDO)BENZOATE; N (4 CHLORO 2 (HYDRAZINECARBONOTHIOYLPHENYL) 4 METHYLBENZAMIDE; N (6 CHLORO 2 P TOLYLQUINAZOLIN 4 YL)BENZAMIDE; N (6 CHLORO 2 P TOLYLQUINAZOLIN 4 YL)HYDROXYLAMINE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING SITE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIVER CANCER; MOLECULAR DOCKING; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROTEIN CONFORMATION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955553428     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.06.013     Document Type: Article

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