Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1648-1655

  Abdel Aziz, Alaa A M ^a,b   Eltahir, Kamal E H ^a   Asiri, Yousif A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Anti inflammatory activities; COX 2 inhibitors; Cyclic imides; Molecular docking

Indexed keywords

1 (3,4,5 TRIMETHOXYPHENYL)PYRROLIDINE 2,5 DIONE; 2 (3,4,5 TRICHLOROPHENYL) 1H BENZO[DE]ISOQUINOLINE 1,3 (2H) DIONE; 2 (3,4,5 TRIMETHOXYPHENYL) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3,4,5 TRIMETHOXYPHENYL)ISOINDOLINE 1,3 DIONE; 4 [5 (4 BROMOPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 4,5,6,7 TETRABROMO 2 (3,4,5 TRIMETHOXYPHENYL)ISOINDOLINE 1,3 DIONE; 4,5,6,7 TETRACHLORO 2 (3,4,5 TRIMETHOXYPHENYL)ISOINDOLINE 1,3 DIONE; 4,5,6,7,8,8 HEXACHLORO 2 (3,4,5 TRIMETHOXYPHENYL) 3A,4,7,7ATETRAHYDRO 1H 4,7 METHANOISOINDOLE 1,3(2H) DIONE; 5 METHYL 2 (3,4,5 TRIMETHOXYPHENYL)ISOINDOLINE 1,3 DIONE; 5 NITRO 2 (3,4,5 TRIMETHOXYPHENYL)ISOINDOLINE 1,3 DIONE; 5 TERT BUTYL 2 (3,4,5 TRIMETHOXYPHENYL)ISOINDOLINE 1,3 DIONE; 5,6 DICHLORO 2 (3,4,5 TRIMETHOXYPHENYL)ISOINDOLINE 1,3 DIONE; 6 (3,4,5 TRICHLOROPHENYL) 5H DIBENZO[C,E]AZEPINE 5,7(6H) DIONE; 6 (3,4,5 TRIMETHOXYPHENYL) 5H DIBENZO[C,E]AZEPINE 5,7 (6H) DIONE; CELECOXIB; CIS 2 (3,4,5 TRIMETHOXYPHENYL) 3A,4,7,7A TETRAHYDRO 1H ISOINDOLE 1,3(2H) DIONE; CYCLIC IMIDE DERIVATIVE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; IMIDE; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HYDROGEN BOND; MALE; MOLECULAR DOCKING; NONHUMAN; PAW EDEMA; RAT; SUBSTITUTION REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DISEASE MODELS, ANIMAL; EDEMA; HYDROGEN BONDING; IMIDES; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; SHEEP; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953170516     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.013     Document Type: Article

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