Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling study

European Journal of Medicinal Chemistry

Volumn 42, Issue 5, 2007, Pages 614-626

  Abdel Aziz, Alaa A M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Apoptosis induction; DNA binding; Molecular modeling; N Substituted imides; Novel synthesis

Indexed keywords

2,3 PYRAZINEDICARBOXIMIDE DERIVATIVE; 2,3 PYRIDINEDICARBOXIMIDE DERIVATIVE; ACID ANHYDRIDE; AMINO ACID ESTER; BICYCLO[2.2.2] OCT 5 ENE 2,3 DICARBOXIMIDE DERIVATIVE; CYTOTOXIC AGENT; DICARBOXYLIC ACID DERIVATIVE; DIPHENYL 2 OXO 3 OXAZOLINYLPHOSPHONATE; ESTER DERIVATIVE; IMIDE; N BENZYLPHTHALIMIDE; PHOSPHONIC ACID DERIVATIVE; PHTHALIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CYCLIZATION; CYTOTOXICITY; DNA BINDING; MOLECULAR MODEL; NONHUMAN; QUANTUM MECHANICS; SUBSTITUTION REACTION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DNA; HUMANS; IMIDES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 34248220479     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.12.003     Document Type: Article

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