Design, synthesis and biological evaluation of chrysin long-chain derivatives as potential anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 3, 2010, Pages 1117-1123

  Lv, Peng Cheng ^a   Wang, Kai Rui ^a   Li, Qing Shan ^a   Chen, Jin ^a   Sun, Juan ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Anticancer; Chrysin; EGFR; HT 29; Long chain derivatives

Indexed keywords

ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; CHRYSIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; HEXADECYL 2 (5 HYDROXY 4 OXO 2 PHENYL 4H CHROMEN 7 YLOXY)ACETATE; N HEXADECYL 2 (5 HYDROXY 4 OXO 2 PHENYL 4H CHROMEN 7 YLOXY)ACETAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; MITOSIS INHIBITION; MOLECULAR DOCKING; PROTEIN STRUCTURE; SIMULATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONOIDS; HUMANS; LIVER NEOPLASMS; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 75149149892     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.048     Document Type: Article

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