Cav3 T-type calcium channels

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling

Volumn 1, Issue 4, 2012, Pages 467-491

  Senatore, Adriano ^a   Zhorov, Boris S ^b   Spafford, J David ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; DIVALENT CATION; GUANINE NUCLEOTIDE BINDING PROTEIN; LIPID; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL CAV3; VOLTAGE GATED CALCIUM CHANNEL CAV3.1; VOLTAGE GATED CALCIUM CHANNEL CAV3.2; VOLTAGE GATED CALCIUM CHANNEL CAV3.3;

ALPHA HELIX; ALTERNATIVE RNA SPLICING; CALCIUM CURRENT; CELL PROLIFERATION; CHANNEL GATING; CHROMAFFIN CELL; COMPLEX FORMATION; DISEASE COURSE; DRUG EFFECT; EXCITATORY POSTSYNAPTIC POTENTIAL; EXOCYTOSIS; GENE INACTIVATION; GENOME ANALYSIS; HEART DISEASE; HIGH FREQUENCY OSCILLATION; INTRACELLULAR SIGNALING; ION CURRENT; LOSS OF FUNCTION MUTATION; MALIGNANT NEOPLASTIC DISEASE; MEMBRANE TRANSPORT; MOLECULAR EVOLUTION; NERVE CELL EXCITABILITY; NEUROPATHY; NOCICEPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; REVIEW; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE TONE; SURVIVAL RATE; TRANSCRIPTION REGULATION; VOLTAGE GATED CALCIUM CHANNEL CAV3 GENE;

EID: 84878801960     PISSN: 2190460X     EISSN: 21904618     Source Type: Journal    
DOI: 10.1002/wmts.41     Document Type: Review

References (238)

1. Hagiwara S, Ozawa S, Sand O. Voltage clamp analysis of two inward current mechanisms in the egg cell membrane of a starfish. J Gen Physiol 1975, 65:617-644.
2. Llinás R, Yarom Y. Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances. J Physiol 1981, 315:549-567.
3. Jahnsen H, Llinás R. Ionic basis for the electro-responsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro. J Physiol 1984, 349: 227-247.
4. Carbone E, Lux HD. A low voltage-activated calcium conductance in embryonic chick sensory neurons. Biophys J 1984, 46:413-418.
5. Tsien RW, Barret CF. A brief history of calcium channel discovery, Chapter 3. In: Zamponi GW, ed. Voltage-Gated Calcium Channels. Georgetown, TX; New York, NY: Landes Bioscience/Eurekah.com; Kluwer Academic/Plenum Publishers, c2005; 2005.
6. Perez-Reyes E. Molecular characterization of T-type calcium channels. Cell Calcium 2006, 40:89-96.
7. Twindow. J Neurosci 2010, 30: 99-109.
8. Shipe WD, Barrow JC, Yang ZQ, Lindsley CW, Yang FV, Schlegel KA, Shu Y, Rittle KE, Bock MG, Hartman GD, et al. Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist. J Med Chem 2008, 51: 3692-3695.
9. Tscherter A, David F, Ivanova T, Deleuze C, Renger JJ, Uebele VN, Shin HS, Bal T, Leresche N, Lambert RC. Minimal alterations in T-type calcium channel gating markedly modify physiological firing dynamics. J Physiol-London 2011, 589:1707-1724.
10. Ertel EA, Campbell KP, Harpold MM, Hofmann F, Mori Y, Perez-Reyes E, Schwartz A, Snutch TP, Tanabe T, Birnbaumer L, et al. Nomenclature of voltage-gated calcium channels. Neuron 2000, 25:533-535.
11. Liebeskind BJ, Hillis DM, Zakon HH. Evolution of sodium channels predates the origin of nervous systems in animals. PNAS 2011, 108:9154-9159.
12. Srivastava M, Begovic E, Chapman J, Putnam NH, Hellsten U, Kawashima T, Kuo A, Mitros T, Salamov A, Carpenter ML, et al. The Trichoplax genome and the nature of placozoans. Nature 2008, 454:955-960.
13. Marlow HQ, Srivastava M, Matus DQ, Rokhsar D, Martindale MQ. Anatomy and development of the nervous system of Nematostella vectensis, an anthozoan cnidarian. Dev Neurobiol 2009, 69:235-254.
14. Spafford JD, Chen L, Feng ZP, Smit AB, Zamponi GW. Expression and modulation of an invertebrate presynaptic calcium channel α1 subunit homolog. J Biol Chem 2003, 278:21178-21187.
15. Spafford JD, Dunn T, Smit AB, Syed NI, Zamponi GW. In vitro characterization of L-type calcium channels and their contribution to firing behavior in invertebrate respiratory neurons. J Neurophysiol 2006, 95: 42-52.
16. v3) from the central nervous system of Lymnaea stagnalis. J Biol Chem 2010, 285:7447-7458.
17. + conduction and selectivity. Science 1998, 280:69-77.
18. Long SB, Tao X, Campbell EB, MacKinnon R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature 2007, 450: 376-382.
19. Payandeh J, Scheuer T, Zheng N, Catterall WA. The crystal structure of a voltage-gated sodium channel. Nature 2011, 475:353-358.
20. Zhorov BS, Tikhonov DB. Potassium, sodium, calcium and glutamate-gated channels: pore architecture and ligand action. J Neurochem 2004, 88:782-799.
21. Talavera K, Nilius B. Biophysics and structure-function relationship of T-type Ca2+ channels. Cell Calcium 2006, 40:97-114.
22. Cheng R, Tikhonov D, Zhorov B. Structural modeling of calcium binding in the selectivity filter of the L-type calcium channel. Eur Biophys J 2010, 39:839-853.
23. Tikhonov DB, Zhorov BS. Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channels. J Biol Chem 2011, 286:2998-3006.
24. V3 T-type calcium channels. Channels 2010, 4:453-458.
25. + channels. PLoS Biol 2009, 7:47.
26. Yellen G. The voltage-gated potassium channels and their relatives. Nature 2002, 419:35-42.
27. 2+ channels. Physiol Rev 2010, 90:1461-1506.
28. Arikkath J, Campbell KP. Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol 2003, 13:298-307.
29. v3.3 channel is determined by the gating brake in the I-II loop. Pflugers Archiv Eur J Physiol 2011, 461:461-468.
30. + channels: from protein complexes to function. Physiol Rev 2010, 90:1437-1459.
31. Flores CA, Cid LP, Sepúlveda FV, Niemeyer MI. TMEM16 proteins: the long awaited calcium-activated chloride channels?. Braz J Med Biol Res 2009, 42:993-1001.
32. Lalonde M, Kelly M, Barnes S. Calcium-activated chloride channels in the retina. Channels 2008, 2: 252-260.
33. Clapham DE. Calcium signaling. Cell 2007, 131: 1047-1058.
34. v4 channel signaling complexes. Nat Neurosci 2010, 13: 333-337.
35. Wolfart J, Roeper J. Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons. J Neurosci 2002, 22:3404-3413.
36. Coulon P, Herr D, Kanyshkova T, Meuth P, Budde T, Pape HC. Burst discharges in neurons of the thalamic reticular nucleus are shaped by calcium-induced calcium release. Cell Calcium 2009, 46:333-346.
37. Costa RR, Varanda WA, Franci CR. A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells. Am J Physiol Cell Physiol 2010, 299: C316-C323.
38. 2+ release in developing myocardium. J Mol Cell Cardiol 2003, 35:515-523.
39. 2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol 2000, 524:415-422.
40. Perez-Reyes E. Molecular physiology of low-voltage-activated t-type calcium channels. Physiol Rev 2003, 83:117-161.
41. Cain SM, Snutch TP. Contributions of T-type calcium channel isoforms to neuronal firing. Channels 2010, 4:475-482.
42. 1I) to neuronal excitability. J Physiol 2002, 540:3-14.
43. 1I T-type calcium channel exhibits faster gating properties when overexpressed in neuroblastoma/glioma NG 108-15 cells. Eur J Neurosci 2001, 14:1678-1686.
44. Huguenard JR. Low-voltage-activated (T-type) calcium-channel genes identified. Trends Neurosci 1998, 21:451-452.
45. 2+ channels and NREM sleep. Cell Calcium 2006, 40:175-190.
46. 2+ current amplifies distal dendritic signaling in thalamic reticular neurons. J Neurosci 2010, 30:15419-15429.
47. 2+ channels: giving a boost to thalamic reticular neurons. J Neurosci 2011, 31:5551-5553.
48. 2+ influx into the dendrites of hippocampal pyramidal neurons. J Neurophysiol 1995, 74:1335-1342.
49. Markram H, Sakmann B. Calcium transients in dendrites of neocortical neurons evoked by single subthreshold excitatory postsynaptic potentials via low-voltage-activated calcium channels. PNAS 1994, 91:5207-5211.
50. v3 T-type calcium channel isoforms differentially distribute to somatic and dendritic compartments in rat central neurons. Eur J Neurosci 2006, 24:2581-2594.
51. Isope P, Murphy TH. Low threshold calcium currents in rat cerebellar Purkinje cell dendritic spines are mediated by T-type calcium channels. J Physiol 2005, 562:257-269.
52. 2+ channels via mGluR activation in the primary dendrite of mitral cells. J Neurophysiol 2010, 103:2557-2569.
53. 1G subunit of T-type calcium channel in the mouse dorsal lateral geniculate nucleus. J Comp Neurol 2010, 518:4362-4374.
54. v3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci 2009, 29:9668-9682.
55. Isope P, Hildebrand M, Snutch T. Contributions of T-type voltage-gated calcium channels to postsynaptic calcium signaling within Purkinje neurons. Cerebellum 2010. doi:10.1007/s12311-010-0195-4.
56. Rancz EA, Häusser M. Dendritic spikes mediate negative synaptic gain control in cerebellar Purkinje cells. PNAS 2010, 107:22284-22289.
57. 2+ channels in neurons. Pflugers Arch 2009, 457:1161-1172.
58. Blackmer T, Kuo SP, Bender KJ, Apostolides PF, Trussell LO. Dendritic calcium channels and their activation by synaptic signals in auditory coincidence detector neurons. J Neurophysiol 2009, 102: 1218-1226.
59. Lory P, Bidaud I, Chemin J. T-type calcium channels in differentiation and proliferation. Cell Calcium 2006, 40:135-146.
60. Chemin J, Monteil A, Briquaire C, Richard S, Perez-Reyes E, Nargeot J, Lory P. Overexpression of T-type calcium channels in HEK-293 cells increases intracellular calcium without affecting cellular proliferation. FEBS Lett 2000, 478:166-172.
61. 2+ current produces input signal amplification and bistability in cat and rat thalamocortical neurones. J Physiol 1997, 505:689-705.
62. 1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 2007, 292: L833-L844.
63. Zhou C, Wu S. T-type calcium channels in pulmonary vascular endothelium. Microcirculation 2006, 13:645-656.
64. House S, Potier M, Bisaillon J, Singer H, Trebak M. The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease. Pflugers Archiv: Eur J Physiol 2008, 456:769-785.
65. Taylor JT, Zeng XB, Pottle JE, Lee K, Wang AR, Yi SG, Scruggs JA, Sikka SS, Li M. Calcium signaling and T-type calcium channels in cancer cell cycling. World J Gastroenterol 2008, 267:4984-4991.
66. 2+ channels. Neuron 2001, 31:35-45.
67. 2+ channels. Science 2003, 302:1416-1418.
68. 1G-subunit of T-type calcium channels. PNAS 2004, 101:18195-18199.
69. Steger KA, Shtonda BB, Thacker C, Snutch TP, Avery L. The C. elegans T-type calcium channel CCA-1 boosts neuromuscular transmission. J Exp Biol 2005, 208:2191-2203.
70. 2+ channel plays a crucial role in stabilizing sleep. PNAS 2005, 102:1743-1748.
71. 1G T-type calcium channels. Circ Res 2006, 98:1422-1430.
72. v3.2 T-type channels. Genes Brain Behav 2007, 6:425-431.
73. v3.1 null mice. Mol Cells 2008, 25:242-246.
74. v3.1 is a tremor rhythm pacemaker in the inferior olive. PNAS 2010, 107:10731-10736.
75. Kraus RL, Li Y, Gregan Y, Gotter AL, Uebele VN, Fox SV, Doran SM, Barrow JC, Yang ZQ, Reger TS, et al. In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice. J Pharmacol Exp Therap 2010, 335:409-417.
76. v3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor. Biochem Biophys Res Commun 2011, 410:19-23.
77. Marder E, Goaillard J. Variability, compensation and homeostasis in neuron and network function. Nat Rev Neurosci 2006, 7:563-574.
78. 1H calcium channels induce neuritogenesis and expression of high-voltage-activated calcium channels in the NG108-15 cell line. J Neurosci 2002, 22:6856-6862.
79. Descoeur J, Pereira V, Pizzoccaro A, Francois A, Ling B, Maffre V, Couette B, Busserolles J, Courteix C, Noel J, et al. Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med 2011, 3:266-278.
80. Lewis BB, Wester MR, Miller LE, Nagarkar MD, Johnson MB, Saha MS. Cloning and characterization of voltage-gated calcium channel α1 subunits in Xenopus laevis during development. Dev Dyn 2009, 238:2891-2902.
81. 2+ channels in the embryonic heart of mice. Biomed Res 2010, 31: 301-305.
82. Talley EM, Cribbs LL, Lee JH, Daud A, Perez-Reyes E, Bayliss DA. Differential distribution of three members of a gene family encoding low voltage-activated (t-type) calcium channels. J Neurosci 1999, 19:1895-1911.
83. v3.2 T-type calcium channel mediate voltage-dependent facilitation and associate with cardiac hypertrophy and development. Channels 2010, 4:375-389.
84. 2+ channels in the heart. J Mol Cell Cardiol 2010, 48:65-70.
85. Chambard JM, Chabbert C, Sans A, Desmadryl G. Developmental changes in low and high voltage-activated calcium currents in acutely isolated mouse vestibular neurons. J Physiol 1999, 518:141-149.
86. McCobb DP, Best PM, Beam KG. Development alters the expression of calcium currents in chick limb motoneurons. Neuron 1989, 2:1633-1643.
87. Martin-Caraballo M, Greer JJ. Voltage-sensitive calcium currents and their role in regulating phrenic motoneuron electrical excitability during the perinatal period. J Neurobiol 2001, 46:231-248.
88. Bertolesi GE, Jollimore CAB, Shi C, Elbaum L, Denovan-Wright EM, Barnes S, Kelly MEM. Regulation of α1G T-type calcium channel gene (CACNA1G) expression during neuronal differentiation. Eur J Neurosci 2003, 17:1802-1810.
89. 2+ channel expression and its role in rat chromaffin cell responsiveness to acute hypoxia. J Physiol 2009, 587:1917-1929.
90. 2+ channels in embryonic chick nodose ganglion neurons. Dev Neurobiol 2007, 67: 1901-1914.
91. Desmadryl G, Hilaire C, Vigues S, Diochot S, Valmier J. Developmental regulation of T-, N- and L-type calcium currents in mouse embryonic sensory neurones. Eur J Neurosci 1998, 10:545-552.
92. v3.3 (α1I) isoforms reveal differences in their localization, expression, and neural development. Neuroscience 2003, 117:321-335.
93. v3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations. Proteins 2006, 64:320-342.
94. Zhong X, Liu JR, Kyle JW, Hanck DA, Agnew WS. A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies. Hum Mol Genet 2006, 15:1497-1512.
95. v3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. Neuroscience 2006, 141:259-268.
96. 2+ channel is required for pressure overload-induced cardiac hypertrophy in mice. Circ Res 2009, 104:522-530.
97. 2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. J Clin Invest 2009, 119:3787-3796.
98. Panner A, Cribbs LL, Zainelli GM, Origitano TC, Singh S, Wurster RD. Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells. Cell Calcium 2005, 37:105-119.
99. Cribbs L. T-type calcium channel expression and function in the diseased heart. Channels 2010, 4: 447-452.
100. Ernst WL, Zhang Y, Yoo JW, Ernst SJ, Noebels JL. Genetic enhancement of thalamocortical network activity by elevating α1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. J Neurosci 2009, 29:1615-1625.
101. v3.2 (α1H) channels in rat chromaffin cells. Biophys J 2006, 90: 1830-1841.
102. 1H T-type channels and low-threshold catecholamine secretion in rat chromaffin cells. J Physiol 2007, 584:149-165.
103. Carbone E, Giancippoli A, Marcantoni A, Guido D, Carabelli V. A new role for T-type channels in fast "low-threshold" exocytosis. Cell Calcium 2006, 40:147-154.
104. Del Toro R, Levitsky KL, López-Barneo J, Chiara MD. Induction of T-type calcium channel gene expression by chronic hypoxia. J Biol Chem 2003, 278:22316-22324.
105. 2+ channels in the heart. Cell Calcium 2006, 40:205-220.
106. 2+ channel isoform in murine atrial myocytes (AT-1 cells). Circ Res 2000, 86:636-642.
107. v3.1d) in developing mouse heart. Circ Res 2001, 88:403-407.
108. 2+ channel during fetal and postnatal rat heart development. J Mol Cell Cardiol 2002, 34: 533-546.
109. 2+ release sparks atrial pacemaker activity. Physiology 2001, 16:101-106.
110. 2+ channels in cardiac pacemaking. J Pharmacol Sci 2005, 99:197-204.
111. 2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circ Res 2008, 103:1109-1119.
112. Leuranguer V, Monteil A, Bourinet E, Dayanithi G, Nargeot J. T-type calcium currents in rat cardiomyocytes during postnatal development: contribution to hormone secretion. Am J Physiol Heart Circul Physiol 2000, 279:H2540-H2548.
113. Chen X, Wilson RM, Kubo H, Berretta RM, Harris DM, Zhang X, Jaleel N, MacDonnell SM, Bearzi C, Tillmanns J, et al. Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties. Circ Res 2007, 100:536-544.
114. 2+ sources and effects of altered activation of transmitter receptors. J Neurosci 2009, 29:15232-15244.
115. 2+ channels. J Neurochem 2009, 108:676-684.
116. Tarui T, Fukami K, Nagasawa K, Yoshida S, Sekiguchi F, Kawabata A. Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen sulfide. J Neurochem 2010, 114:512-519.
117. Zamponi G, Lory P, Perez-Reyes E. Role of voltage-gated calcium channels in epilepsy. Pflugers Arch 2010, 460:395-403.
118. 2+ channels and absence epilepsy. Cell Calcium 2006, 40:191-196.
119. Zhang Y, Mori M, Burgess DL, Noebels JL. Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci 2002, 22:6362-6371.
120. Chen Y, Lu J, Pan H, Zhang Y, Wu H, Xu K, Liu X, Jiang Y, Bao X, Yao Z, et al. Association between genetic variation of CACNA1H and childhood absence epilepsy. Ann Neurol 2003, 54:239-243.
121. Liang J, Zhang Y, Wang J, Pan H, Wu H, Xu K, Liu X, Jiang Y, Shen Y, Wu X. New variants in the CACNA1H gene identified in childhood absence epilepsy. Neurosci Lett 2006, 406:27-32.
122. Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E. Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J Neurosci 2005, 25:4844-4855.
123. 2+ channels: a paradigm for childhood absence epilepsy mutations. J Neurosci 2007, 27:322-330.
124. v3.2 T-type calcium channel mutations linked to childhood absence epilepsy. Epilepsia 2006, 47:655-658.
125. Lee J, Shin HS. T-type calcium channels and thalamocortical rhythms in sleep: a perspective from studies of T-type calcium channel knockout mice. CNS Neurol Disord Drug Targets 2007, 6:63-69.
126. Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. J Biol Chem 2006, 281:22085-22091.
127. Handforth A, Homanics GE, Covey DF, Krishnan K, Lee JY, Sakimura K, Martin FC, Quesada A. T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. Neuropharmacology 2010, 59:380-387.
128. Jevtovic-Todorovic V, Todorovic SM. The role of peripheral T-type calcium channels in pain transmission. Cell Calcium 2006, 40:197-203.
129. v3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. EMBO J 2005, 24:315-324.
130. Jagodic MM, Pathirathna S, Nelson MT, Mancuso S, Joksovic PM, Rosenberg ER, Bayliss DA, Jevtovic-Todorovic V, Todorovic SM. Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci 2007, 27:3305-3316.
131. Matsunami M, Kirishi S, Okui T, Kawabata A. Chelating luminal zinc mimics hydrogen sulfide-evoked colonic pain in mice: possible involvement of T-type calcium channels. Neuroscience 2011, 181:257-264.
132. Marger F, Gelot A, Alloui A, Matricon J, Ferrer JF, Barrere C, Pizzoccaro A, Muller E, Nargeot J, Snutch TP, et al. T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. PNAS 2011, 108:11268-11273.
133. 2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci 2010, 30:10360-10368.
134. 2+ channels controls pain sensory gating in the thalamus. J Neurosci 2008, 28:13331-13340.
135. 2+ for cancer cell proliferation and survival. Nat Rev Cancer 2008, 8:361-375.
136. 2+ channels inhibits human ovarian cancer cell proliferation. Cancer Invest 2011, 29:339-346.
137. v3.1 T-type calcium channels in cell proliferation in mouse preadipocytes. Am J Physiol Cell Physiol 2010, 298:C1414-C1423.
138. 2+ channels suppresses human breast cancer cell proliferation. Cancer Lett 2008, 267:116-124.
139. 2+ channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol Pharmacol 2002, 62:210-219.
140. v3.2) T-type calcium channel during neuroendocrine differentiation of human prostate cancer cells. J Biol Chem 2002, 277:10824-10833.
141. v3.1-expressed HEK293 cells. Brain Res 2005, 1054: 22-29.
142. v3.2 enhances membrane expression and regulates mechanically induced ATP release in MLO-Y4 osteocytes. J Bone Miner Res 2011, 26:2125-2139.
143. 2+ channel in hepatocellular carcinoma cell proliferation. Oncol Rep 2009, 22:1229-1235.
144. 2+ channels. Am J Physiol Cell Physiol 2011, 300:C576-C587.
145. 2+ channels in chicken nodose neurons. J Neurochem 2009, 108:246-259.
146. 2+ channel expression in chick nodose ganglion neurons. Dev Neurobiol 2007, 67: 1915-1931.
147. v3.2 T-type calcium channel via extracellularly regulated kinase pathway in cardiomyocytes. Endocrinology 2009, 150:879-888.
148. Murrin LC, Talbot JN. RanBPM, a scaffolding protein in the immune and nervous systems. J Neuroimmune Pharmacol 2007, 2:290-295.
149. 2+ channels by the ran binding protein RanBPM. Biochem Biophys Res Commun 2009, 378:15-20.
150. Wang D, Li Z, Messing EM, Wu G. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. J Biol Chem 2002, 277:36216-36222.
151. Fiedler B, Lohmann SM, Smolenski A, Linnemüller S, Pieske B, Schröder F, Molkentin JD, Drexler H, Wollert KC. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. PNAS 2002, 99:11363-11368.
152. 2O. Cell Calcium 2009, 46:293-302.
153. v3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide. Mol Pharmacol 2001, 60:603-610.
154. Ramracheya R, Ward C, Shigeto M, Walker JN, Amisten S, Zhang Q, Johnson PR, Rorsman P, Braun M. Membrane potential-dependent inactivation of voltage-gated ion channels in α-cells inhibits glucagon secretion from human islets. Diabetes 2010, 59:2198-2208.
155. 2+ channels governing generation of miniature and evoked excitatory synaptic currents in spinal laminae I and II. J Neurosci 1998, 18:8740-8750.
156. Bhandari B, Bansal P, Talwar P, Gupta SK. Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida. Reprod Biol Endocrinol 2010, 8:7.
157. Gupta SK, Bhandari B. Acrosome reaction: relevance of zona pellucida glycoproteins. Asian J Androl 2011, 13:97-105.
158. v3.2 deficient mice. J Cell Physiol 2007, 212:753-763.
159. Lin YC, Spencer AN. Calcium currents from jellyfish striated muscle cells: preservation of phenotype, characterisation of currents and channel localisation. J Exp Biol 2001, 204:3717-3726.
160. 2+ currents in ventricular muscle cells of the lymnaea heart. J Neurophysiol 1999, 82:2428-2440.
161. Liu P, Ge Q, Chen B, Salkoff L, Kotlikoff MI, Wang ZW. Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cells. J Physiol 2011, 589:101-117.
162. Shtonda B, Avery L. CCA-1, EGL-19 and EXP-2 currents shape action potentials in the Caenorhabditis elegans pharynx. J Exp Biol 2005, 208:2177-2190.
163. SoRelle R. Withdrawal of Posicor from market. Circulation 1998, 98:831-832.
164. Nilius B, Talavera K, Verkhratsky A. T-type calcium channels: the never ending story. Cell Calcium 2006, 40:81-88.
165. Randall AD, Tsien RW. Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology 1997, 36: 879-893.
166. Viana F, Van den Bosch L, Missiaen L, Vandenberghe W, Droogmans G, Nilius B, Robberecht W. Mibefradil (Ro 40-5967) blocks multiple types of voltage-gated calcium channels in cultured rat spinal motoneurones. Cell Calcium 1997, 22:299-311.
167. v1.2. Circ Res 2006, 98:105-110.
168. 2+ channels in vascular smooth muscle: multiple functions. Cell Calcium 2006, 40:221-230.
169. 2+ channels in regulation of vasomotor tone in mesenteric arterioles?. Can J Physiol Pharmacol 2009, 87:8-20.
170. v3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol 2011, 589:135-148.
171. Loutzenhiser R, Chilton L, Trottier G. Membrane potential measurements in renal afferent and efferent arterioles: actions of angiotensin II. Am J Physiol Renal Physiol 1997, 273:F307-F314.
172. 2+ oscillations in smooth muscle cells from overactive human bladders. Cell Calcium 2009, 45:456-464.
173. Young RC, Smith LH, McLaren MD. T-type and L-type calcium currents in freshly dispersed human uterine smooth muscle cells. Am J Obstet Gynecol 1993, 169:785-792.
174. Lee SE, Ahn DS, Lee YH. Role of T-type Ca channels in the spontaneous phasic contraction of pregnant rat uterine smooth muscle. Kor J Physiol Pharmacol 2009, 13:241-249.
175. Chemin J, Traboulsie A, Lory P. Molecular pathways underlying the modulation of T-type calcium channels by neurotransmitters and hormones. Cell Calcium 2006, 40:121-134.
176. Iftinca MC, Zamponi GW. Regulation of neuronal T-type calcium channels. Trends Pharmacol Sci 2009, 30:32-40.
177. Iftinca M, Hamid J, Chen L, Varela D, Tadayonnejad R, Altier C, Turner RW, Zamponi GW. Regulation of T-type calcium channels by Rho-associated kinase. Nat Neurosci 2007, 10:854-860.
178. v3.2 T-type channels revisited. Mol Pharmacol 2010, 77:136-138.
179. Cerda O, Baek JH, Trimmer JS. Mining recent brain proteomic databases for ion channel phosphosite nuggets. J Gen Physiol 2011, 137:3-16.
180. βγ dimers. J Biol Chem 2009, 284:7465-7473.
181. Twitchell W, Brown S, Mackie K. Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol 1997, 78:43-50.
182. Chemin J, Monteil A, Perez-Reyes E, Nargeot J, Lory P. Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. EMBO J 2001, 20:7033-7040.
183. 2+ channel α1G. J Gen Physiol 2004, 124:225-238.
184. Schmitt H, Meves H. Modulation of neuronal calcium channels by arachidonic acid and related substances. J Membr Biol 1995, 145:233-244.
185. Huc S, Monteil A, Bidaud I, Barbara G, Chemin J, Lory P. Regulation of T-type calcium channels: signalling pathways and functional implications. Biochim Biophys Acta 2009, 1793:947-952.
186. Zhang Y, Cribbs LL, Satin J. Arachidonic acid modulation of α1H, a cloned human T-type calcium channel. Am J Physiol Heart Circ Physiol 2000, 278:H184-H193.
187. v3 T-type calcium channels by protein kinases C and A in mammalian cells. J Biol Chem 2007, 282:32710-32718.
188. 2+ currents in mouse spermatogenic cells and the zona pellucida-induced sperm acrosome reaction. Dev Biol 2001, 236:210-219.
189. 1G, a human brain T calcium channel α1 subunit. Neurosci Lett 1999, 274:143-146.
190. v3.1/α1G T-type calcium channel. BMC Mol Biol 2009, 10:53.
191. v3.2 expressed in pregnant human uterus. Cell Physiol Biochem 2005, 16:245-254.
192. 1 subunit. Neurosci Lett 1999, 269:121-124.
193. 2+ channel gating properties. Biophys J 2001, 80:1238-1250.
194. McRory JE, Santi CM, Hamming KS, Mezeyova J, Sutton KG, Baillie DL, Stea A, Snutch TP. Molecular and functional characterization of a family of rat brain T-type calcium channels. J Biol Chem 2001, 276:3999-4011.
195. Monteil A, Chemin J, Leuranguer V, Altier C, Mennessier G, Bourinet E, Lory P, Nargeot J. Specific properties of T-type calcium channels generated by the human α1I subunit. J Biol Chem 2000, 275:16530-16535.
196. v3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy. J Neurosci 2009, 29:371-380.
197. v3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. J Neurosci 2008, 28:13341-13353.
198. Baumgart JP, Vitko I, Bidaud I, Kondratskyi A, Lory P, Perez-Reyes E. I-II Loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PLoS One 2008, 3:e2976.
199. Kahn RA. Toward a model for Arf GTPases as regulators of traffic at the Golgi. FEBS Lett 2009, 583:3872-3879.
200. Aromolaran KA, Benzow KA, Koob MD, Piedras-Renteria ES. The Kelch-like protein 1 modulates P/Q-type calcium current density. Neuroscience 2007, 145:841-850.
201. 1H channels via the recycling endosome. Channels 2009, 3:402-412.
202. Aromolaran KA, Benzow KA, Cribbs LL, Koob MD, Piedras-Renteria ES. T-type current modulation by the actin-binding protein Kelch-like 1. Am J Physiol Cell Physiol 2010, 298:C1353-C1362.
203. v3.1 calcium channels. FEBS Lett 2008, 582:3765-3770.
204. v3.3 calcium channels. J Neurophysiol 2004, 92:3399-3407.
205. Dubel SJ, Altier C, Chaumont S, Lory P, Bourinet E, Nargeot J. Plasma membrane expression of T-type calcium channel α(1) subunits is modulated by high voltage-activated auxiliary subunits. J Biol Chem 2004, 279:29263-29269.
206. v3.1 calcium current. J Physiol 2008, 586:5349-5366.
207. v3.1 channel expression in mouse C2C12 myoblasts. J Cell Physiol 2006, 209:448-456.
208. v3.1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol 2011, 300:C517-C525.
209. 2+ channel expression in PC-3 human prostate carcinoma cells. Biochem Biophys Res Commun 2010, 403:24-29.
210. v3.1 channels by glucocorticoids. Cell Mol Neurobiol 2009, 29:1265-1273.
211. Bosch MA, Hou J, Fang Y, Kelly MJ, Ronnekleiv OK. 17β-estradiol regulation of the mRNA expression of T-type calcium channel subunits: role of estrogen receptor α and estrogen receptor β. J Comp Neurol 2009, 512:347-358.
212. Kuwahara K, Saito Y, Takano M, Arai Y, Yasuno S, Nakagawa Y, Takahashi N, Adachi Y, Takemura G, Horie M, et al. NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J 2003, 22:6310-6321.
213. 2+ channels in neonatal rat heart. J Mol Cell Cardiol 2007, 42:1045-1053.
214. v3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. J Neurosci 2010, 30:4957-4969.
215. 2 sensing in chromaffin cells: new duties for T-type channels. J Physiol 2009, 587:1859-1860.
216. 2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells. J Neurosci 2010, 30: 10763-10772.
217. Wen XJ, Xu SY, Chen ZX, Yang CX, Liang H, Li H. The roles of T-type calcium channel in the development of neuropathic pain following chronic compression of rat dorsal root ganglia. Pharmacology 2010, 85:295-300.
218. Jung SY, Lee SH, Kang HB, Park HA, Chang SK, Kim J, Choo DJ, Oh CR, Kim YD, Seo JH, et al. Antitumor activity of 3, 4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice. Bioorg Med Chem Lett 2010, 20:6633-6636.
219. Toyota M, Ho C, Ohe-Toyota M, Baylin SB, Issa JP. Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5′ CpG island in human tumors. Cancer Res 1999, 59:4535-4541.
220. Ueki T, Toyota M, Sohn T, Yeo CJ, Issa JP, Hruban RH, Goggins M. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res 2000, 60:1835-1839.
221. Shen L, Ahuja N, Shen Y, Habib NA, Toyota M, Rashid A, Issa JP. DNA methylation and environmental exposures in human hepatocellular carcinoma. J Natl Cancer Inst 2002, 94:755-761.
222. Zamponi GW, Lewis RJ, Todorovic SM, Arneric SP, Snutch TP. Role of voltage-gated calcium channels in ascending pain pathways. Brain Res Rev 2009, 60:84-89.
223. Todorovic SM, Jevtovic-Todorovic V. Regulation of T-type calcium channels in the peripheral pain pathway. Channels 2007, 1:238-245.
224. Swayne L, Bourinet E. Voltage-gated calcium channels in chronic pain: emerging role of alternative splicing. Pflügers Archiv Eur J Physiol 2008, 456: 459-466.
225. Todorovic SM, Jevtovic-Todorovic V, Meyenburg A, Mennerick S, Perez-Reyes E, Romano C, Olney JW, Zorumski CF. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron 2001, 31:75-85.
226. Jagodic MM, Pathirathna S, Joksovic PM, Lee W, Nelson MT, Naik AK, Su P, Jevtovic-Todorovic V, Todorovic SM. Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol 2008, 99:3151-3156.
227. Traboulsie A, Chemin J, Chevalier M, Quignard JF, Nargeot J, Lory P. Subunit-specific modulation of T-type calcium channels by zinc. J Physiol 2007, 578:159-171.
228. v3.2 T-type calcium channels. J Biol Chem 2006, 281:4823-4830.
229. v3.2 T-type calcium channels. J Biol Chem 2010, 285:3271-3281.
230. v3.2 calcium channel. FEBS Lett 2007, 581:5774-5780.
231. Tarohda T, Ishida Y, Kawai K, Yamamoto M, Amano R. Regional distributions of manganese, iron, copper, and zinc in the brains of 6-hydroxydopamine-induced parkinsonian rats. Anal Bioanal Chem 2005, 383:224-234.
232. Tarohda T, Yamamoto M, Amamo R. Regional distribution of manganese, iron, copper, and zinc in the rat brain during development. Anal Bioanal Chem 2004, 380:240-246.
233. Mathie A, Sutton GL, Clarke CE, Veale EL. Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol Ther 2006, 111:567-583.
234. Nelson MT, Woo J, Kang HW, Vitko I, Barrett PQ, Perez-Reyes E, Lee JH, Shin HS, Todorovic SM. Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. J Neurosci 2007, 27:8250-8260.
235. 2+ channels in the rat and mouse thalamus. J Physiol 2006, 574: 415-430.
236. v3.3 gating kinetics: implications for thalamocortical activity. J Neurophysiol 2007, 98:2274-2284.
237. Giordanetto F, Knerr L, Wållberg A. T-type calcium channels inhibitors: a patent review. Expert Opin Ther Pat 2011, 21:85-101.
238. Destexhe A, Neubig M, Ulrich D, Huguenard J. Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci 1998, 18:3574-3588.