Antitumor activity of 3,4-dihydroquinazoline dihydrochloride in A549 xenograft nude mice

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6633-6636

  Jung, Soo Yeon ^a   Lee, So Hyung ^a   Kang, Han Byul ^a   Park, Hang Ah ^a   Chang, Sun Ki ^a   Kim, Jungahn ^a   Choo, Dong Joon ^a   Oh, Chun Rim ^b   Kim, Young Deuk ^b   Seo, Ji Hyung ^a   Lee, Kyung Tae ^a   Lee, Jae Yeol ^a  

^a Kyung Hee University   (South Korea)

^b DongWoo Syntech Co Ltd   (South Korea)

Author keywords

A549 Xenograft; Acute toxicity; Anticancer activity; Pharmacokinetics

Indexed keywords

4(3H) QUINAZOLINONE DERIVATIVE; DOXORUBICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BAGG ALBINO MOUSE; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN LNCAP; CONTROLLED STUDY; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; LD 50; MALE; MOUSE; NONHUMAN; NUDE MOUSE; RAT; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LETHAL DOSE 50; MICE; MICE, INBRED BALB C; MICE, NUDE; QUINAZOLINES; TRANSPLANTATION, HETEROLOGOUS;

MUS MUSCULUS;

EID: 77958070232     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.020     Document Type: Article

References (10)

1. P. Mariot, K. Vanoverberghe, N. Lalevee, M.F. Rossier, and N. Prevarskaya J. Biol. Chem. 277 2002 10824
2. P. Lory, I. Bidaud, and J. Chemin Cell Calcium 40 2006 135
3. P. Lory, and J. Chemin Expert Opin. Ther. Targets 11 2007 717 and references cited herein
4. J.H. Heo, H.N. Seo, Y.J. Choe, S. Kim, C.R. Oh, Y.D. Kim, H. Rhim, D.J. Choo, J. Kim, and J.Y. Lee Bioorg. Med. Chem. Lett. 18 2008 3899
5. S. Sunami, and M. Ohkubo Tetrahedron 65 2009 638
6. C. Sabot, K.A. Kumar, S. Meunier, and C. Mioskowski Tetrahedron Lett. 48 2007 3863
7. T.J. Mosmann Immunol. Methods 65 1983 55
8. K. Yamashita, S. Nakano, M. Kuwata, H. Yada, K. Irimura, H. Morinaga, and K. Morita J. Toxicol. Sci. 1989 1
9. R.P. Singh, G.U. Mallikarjuna, G. Sharma, S. Dhanalakshmi, A.K. Tyagi, D.C. Chan, C. Agarwal, and R. Agarwal Clin. Cancer Res. 10 2004 8641
10. W.E. Hardman, M.P. Moyer, and I.L. Cameron Cancer Lett. 151 2000 145