Role of T-type Ca2+ channels in the heart

Cell Calcium

Volumn 40, Issue 2, 2006, Pages 205-220

  Vassort, Guy ^a   Talavera, Karel ^b   Alvarez, Julio L ^c  

^a HÔPITAL ARNAUD DE VILLENEUVE   (France)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c INSTITUTO DE CARDIOLOGÍA Y CIRUGÍA CARDIOVASCULAR   (Cuba)

Author keywords

Calcium channels; Cardiomyocytes; Excitation contraction coupling; Heart; Pacemaker; T type calcium channels

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; AMIODARONE; AMLODIPINE; ANGIOTENSIN II; ANTIARRHYTHMIC AGENT; ARANIDIPINE; BEPRIDIL; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM ANTAGONIST; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; CALCIUM ION; CINNARIZINE; DIHYDROPYRIDINE DERIVATIVE; EFONIDIPINE; ENDOTHELIN; FELODIPINE; FLUNARIZINE; ISOPRENALINE; ISRADIPINE; NIFEDIPINE; NIGULDIPINE; NISOLDIPINE; NITRENDIPINE; PHENYTOIN; PRAJMALINE; QUINIDINE; SOMATOMEDIN C; TETRANDRINE; UNINDEXED DRUG;

ARRHYTHMOGENESIS; ARTICLE; BIOPHYSICS; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL KINETICS; CHEMOSENSITIVITY; DRUG MECHANISM; ELECTRIC ACTIVITY; EMBRYO CELL; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART DEVELOPMENT; HEART FUNCTION; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART VENTRICLE REMODELING; HEART VENTRICLE WALL; HORMONE RELEASE; HUMAN; MEMBRANE CHANNEL; NONHUMAN; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PUBLICATION; SINUS NODE; SPECIES; TISSUE DISTRIBUTION;

EID: 33745391787     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceca.2006.04.025     Document Type: Article

References (151)

1. Hagiwara S., Ozawa S., and Sand O. Voltage clamp analysis of two inward current mechanisms in the egg cell membrane of a starfish. J. Gen. Physiol. 65 (1975) 617-644
2. Bean B.P. Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology. J. Gen. Physiol. 86 (1985) 1-30
3. Nilius B., Hess P., Lansman J.B., and Tsien R.W. A novel type of cardiac calcium channel in ventricular cells. Nature 316 (1985) 443-446
4. Reuter H. The dependence of slow inward current in Purkinje fibres on the extracellular calcium-concentration. J. Physiol. 192 (1967) 479-492
5. Rougier O., Vassort G., Garnier D., Gargouil Y.M., and Coraboeuf E. Existence and role of a slow inward current during the frog atrial action potential. Pflugers Arch. 308 (1969) 91-110
6. Perez-Reyes E. Molecular physiology of low-voltage-activated T-type calcium channels. Physiol. Rev. 83 (2003) 117-161
7. Vassort G., and Alvarez J. Cardiac T-type calcium current: pharmacology and roles in cardiac tissues. J. Cardiovasc. Electrophysiol. 5 (1994) 376-393
8. Yeoman M.S., Brezden B.L., and Benjamin P.R. LVA and HVA Ca(2+) currents in ventricular muscle cells of the Lymnaea heart. J. Neurophysiol. 82 (1999) 2428-2440
9. 2+ currents in canine cardiac Purkinje cells. Am. J. Physiol. 256 (1989) H1478-H1492
10. Bogdanov K.Y., Ziman B.D., Spurgeon H.A., and Lakatta E.G. L- and T-type calcium currents differ in finch and rat ventricular cardiomyocytes. J. Mol. Cell Cardiol. 27 (1995) 2581-2593
11. Alvarez J.L., and Vassort G. Properties of the low threshold Ca current in single frog atrial cardiomyocytes. A comparison with the high threshold Ca current. J. Gen. Physiol. 100 (1992) 519-545
12. Bonvallet R. A low threshold calcium current recorded at physiological Ca concentrations in single frog atrial cells. Pflugers Arch. 408 (1987) 540-542
13. Xu X.P., and Best P.M. Increase in T-type calcium current in atrial myocytes from adult rats with growth hormone-secreting tumors. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 4655-4659
14. Tytgat J., Vereecke J., and Carmeliet E. Mechanism of cardiac T-type Ca channel blockade by amiloride. J. Pharmacol. Exp. Ther. 254 (1990) 546-551
15. 2+ channels in guinea-pig heart cells. J. Physiol. 456 (1992) 247-265
16. Xu X., and Best P.M. Postnatal changes in T-type calcium current density in rat atrial myocytes. J. Physiol. 454 (1992) 657-672
17. 2+ currents in single canine Purkinje cells. Circ. Res. 65 (1989) 1735-1750
18. Tseng G.N., and Boyden P.A. Different effects of intracellular Ca and protein kinase C on cardiac T and L Ca currents. Am. J. Physiol. 261 (1991) H364-H379
19. 2+ current is expressed in hypertrophied adult feline left ventricular myocytes. Circ. Res. 73 (1993) 777-782
20. 2+ currents in single atrial myocytes. Am. J. Physiol. 259 (1990) H1842-H1850
21. Pascarel C., Brette F., and Le Guennec J.Y. Enhancement of the T-type calcium current by hyposmotic shock in isolated guinea-pig ventricular myocytes. J. Mol. Cell Cardiol. 33 (2001) 1363-1369
22. Furukawa T., Ito H., Nitta J., Tsujino M., Adachi S., Hiroe M., Marumo F., Sawanobori T., and Hiraoka M. Endothelin-1 enhances calcium entry through T-type calcium channels in cultured neonatal rat ventricular myocytes. Circ. Res. 71 (1992) 1242-1253
23. 2+ channel blockade by oxodipine and elgodipine in rat cardiomyocytes. Eur. J. Pharmacol. 357 (1998) 93-105
24. Zhou Z., and Lipsius S.L. T-type calcium current in latent pacemaker cells isolated from cat right atrium. J. Mol. Cell Cardiol. 26 (1994) 1211-1219
25. Leuranguer V., Monteil A., Bourinet E., Dayanithi G., and Nargeot J. T-type calcium currents in rat cardiomyocytes during postnatal development: contribution to hormone secretion. Am. J. Physiol. Heart Circ. Physiol. 279 (2000) H2540-H2548
26. Martinez M.L., Heredia M.P., and Delgado C. Expression of T-type Ca(2+) channels in ventricular cells from hypertrophied rat hearts. J. Mol. Cell Cardiol. 31 (1999) 1617-1625
27. 2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts. Circ. Res. 75 (1994) 149-155
28. Kawano S., and DeHaan R.L. Low-threshold current is major calcium current in chick ventricle cells. Am. J. Physiol. 256 (1989) H1505-H1508
29. Fermini B., and Nathan R.D. Removal of sialic acid alters both T- and L-type calcium currents in cardiac myocytes. Am. J. Physiol. 260 (1991) H735-H743
30. Droogmans G., and Nilius B. Kinetic properties of the cardiac T-type calcium channel in the guinea-pig. J. Physiol. 419 (1989) 627-650
31. 2+ release contributes to automaticity in cat atrial pacemaker cells. J. Physiol. 524 Pt 2 (2000) 415-422
32. Mentrard D., Vassort G., and Fischmeister R. Calcium-mediated inactivation of the calcium conductance in cesium-loaded frog heart cells. J. Gen. Physiol. 83 (1984) 105-131
33. Alvarez J.L., Rubio L.S., and Vassort G. Facilitation of T-type calcium current in bullfrog atrial cells: voltage-dependent relief of a G protein inhibitory tone. J. Physiol. 491 Pt 2 (1996) 321-334
34. Wolfe J.T., Wang H., Howard J., Garrison J.C., and Barrett P.Q. T-type calcium channel regulation by specific G-protein betagamma subunits. Nature 424 (2003) 209-213
35. Alvarez J.L., Artiles A., Talavera K., and Vassort G. Modulation of voltage-dependent facilitation of the T-type calcium current by sodium ion in isolated frog atrial cells. Pflugers Arch. 441 (2000) 39-48
36. McDonald T.F., Pelzer S., Trautwein W., and Pelzer D.J. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol. Rev. 74 (1994) 365-507
37. Bonvallet R., and Rougier O. Existence of two calcium currents recorded at normal calcium concentrations in single frog atrial cells. Cell Calcium 10 (1989) 499-508
38. Hagiwara N., Irisawa H., and Kameyama M. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J. Physiol. 395 (1988) 233-253
39. Talavera K., Alvarez J.L., and Vassort G. A model of Ca ion permeation through the cardiac T-type Ca-channel. Biophys. J. 74 (1988) A108
40. Hess P., Lansman J.B., and Tsien R.W. Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature 311 (1984) 538-544
41. 2+. J. Physiol. 430 (1990) 159-188
42. Bois P., and Lenfant J. Evidence for two types of calcium currents in frog cardiac sinus venosus cells. Pflugers Arch. 417 (1991) 591-596
43. Yunker A.M. Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels. J. Bioenerg. Biomembr. 35 (2003) 577-598
44. Cohen C.J., Spires S., and Van Skiver D. Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J. Gen. Physiol. 100 (1992) 703-728
45. Alvarez J.L., and Vassort G. Dual action of prajmalium on the Ca currents in frog isolated cardiomyocytes. J. Mol. Cell Cardiol. 23 (1991) 627-638
46. Rubio L.S., Garrido G., Llanes L., and Alvarez J.L. Effects of tetrandrine on Ca(2+)- and Na(+)-currents of single bullfrog cardiomyocytes. J. Mol. Cell Cardiol. 25 (1993) 801-813
47. Tytgat J., Nilius B., and Carmeliet E. Modulation of the T-type cardiac Ca channel by changes in proton concentration. J. Gen. Physiol. 96 (1990) 973-990
48. Wu L., Karpinski E., Wang R., and Pang P.K. Modification by solvents of the action of nifedipine on calcium channel currents in neuroblastoma cells. Naunyn. Schmiedebergs Arch. Pharmacol. 345 (1992) 478-484
49. Wu L., Wang R., Karpinski E., and Pang P.K. Bay K-8644 in different solvents acts as a transient calcium channel antagonist and a long-lasting calcium channel agonist. J. Pharmacol. Exp. Ther. 260 (1992) 966-973
50. Mitra R., and Morad M. Two types of calcium channels in guinea pig ventricular myocytes. Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 5340-5344
51. 2+ channel?. Trends Neurosci. 12 (1989) 128-130
52. Tytgat J., Nilius B., Vereecke J., and Carmeliet E. The T-type Ca channel in guinea-pig ventricular myocytes is insensitive to isoproterenol. Pflugers Arch. 411 (1988) 704-706
53. J.A. Kim, J.Y. Park, H.W. Kang, S.U. Huh, S.W. Jeong, J.H. Lee, Augmentation of Cav3.2 T-type calcium channel activity by cAMP-dependent protein kinase A, J. Pharmacol. Exp. Ther., 2006, in press.
54. Larsen J.K., Mitchell J.W., and Best P.M. Quantitative analysis of the expression and distribution of calcium channel alpha 1 subunit mRNA in the atria and ventricles of the rat heart. J. Mol. Cell Cardiol. 34 (2002) 519-532
55. Ferron L., Capuano V., Deroubaix E., Coulombe A., and Renaud J.F. Functional and molecular characterization of a T-type Ca(2+) channel during fetal and postnatal rat heart development. J. Mol. Cell Cardiol. 34 (2002) 533-546
56. Chu P.J., and Best P.M. Molecular cloning of calcium channel alpha(2)delta-subunits from rat atria and the differential regulation of their expression by IGF-1. J. Mol. Cell Cardiol. 35 (2003) 207-215
57. 2+ channel in murine hearts during the embryonic period. Am. J. Physiol. Heart Circ. Physiol. 286 (2004) H2257-H2263
58. Monteil A., Chemin J., Bourinet E., Mennessier G., Lory P., and Nargeot J. Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels. J. Biol. Chem. 275 (2000) 6090-6100
59. 2+ channel gene family. Circ. Res. 83 (1998) 103-109
60. Qu Y., and Boutjdir M. Gene expression of SERCA2a and L- and T-type Ca channels during human heart development. Pediatr. Res. 50 (2001) 569-574
61. 2+ channels in embryonic stem cell-derived cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H2770-H2779
62. 2+ channels from Cav3.2 to Cav3.1 during differentiation of embryonic stem cells to cardiac cell lineage. Circ. J. 69 (2005) 1284-1289
63. Satin J., and Cribbs L.L. Identification of a T-type Ca(2+) channel isoform in murine atrial myocytes (AT-1 cells). Circ. Res. 86 (2000) 636-642
64. 2+ channels in murine HL-1 cells. J. Mol. Cell Cardiol. 36 (2004) 111-119
65. 2+ currents in cultured newborn rat ventricular myocytes. J. Mol. Cell Cardiol. 30 (1998) 1095-1103
66. Chemin J., Monteil A., Briquaire C., Richard S., Perez-Reyes E., Nargeot J., and Lory P. Overexpression of T-type calcium channels in HEK-293 cells increases intracellular calcium without affecting cellular proliferation. FEBS Lett. 478 (2000) 166-172
67. Huang B., Qin D., and El-Sherif N. Early down-regulation of K+ channel genes and currents in the postinfarction heart. J. Cardiovasc. Electrophysiol. 11 (2000) 1252-1261
68. Izumi T., Kihara Y., Sarai N., Yoneda T., Iwanaga Y., Inagaki K., Onozawa Y., Takenaka H., Kita T., and Noma A. Reinduction of T-type calcium channels by endothelin-1 in failing hearts in vivo and in adult rat ventricular myocytes in vitro. Circulation 108 (2003) 2530-2535
69. 2+ current in heart cells of the cardiomyopathic hamster. Mol. Cell Biochem. 176 (1997) 199-204
70. Yasui K., Niwa N., Takemura H., Opthof T., Muto T., Horiba M., Shimizu A., Lee J.K., Honjo H., Kamiya K., and Kodama I. Pathophysiological significance of T-type Ca(2+) channels: expression of T-type Ca(2+) channels in fetal and diseased heart. J. Pharmacol. Sci. 99 (2005) 205-210
71. 2+ currents in cells that survived in the epicardial border zone of canine healed infarcted heart. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H1046-H1054
72. 2+ currents in myocytes surviving in the epicardial border zone of the 5-day infarcted canine heart. Circ. Res. 77 (1995) 1180-1191
73. Gaborit N., Steenman M., Lamirault G., Le Meur N., Le Bouter S., Lande G., Leger J., Charpentier F., Christ T., Dobrev D., Escande D., Nattel S., and Demolombe S. Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation 112 (2005) 471-481
74. Yang Z., Shen W., Rottman J.N., Wikswo J.P., and Murray K.T. Rapid stimulation causes electrical remodeling in cultured atrial myocytes. J. Mol. Cell Cardiol. 38 (2005) 299-308
75. Yue L., Feng J., Gaspo R., Li G.R., Wang Z., and Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ. Res. 81 (1997) 512-525
76. Fareh S., Benardeau A., Thibault B., and Nattel S. The T-type Ca(2+) channel blocker mibefradil prevents the development of a substrate for atrial fibrillation by tachycardia-induced atrial remodeling in dogs. Circulation 100 (1999) 2191-2197
77. 2+ channels and pharmacological blockade: potential pathophysiological relevance. Cardiovasc. Drugs Ther. 11 (1997) 723-739
78. Ohashi N., Mitamura H., Tanimoto K., Fukuda Y., Kinebuchi O., Kurita Y., Shiroshita-Takeshita A., Miyoshi S., Hara M., Takatsuki S., and Ogawa S. A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling. J. Cardiovasc. Pharmacol. 44 (2004) 386-392
79. Levine T.B., Bernink P.J., Caspi A., Elkayam U., Geltman E.M., Greenberg B., McKenna W.J., Ghali J.K., Giles T.D., Marmor A., Reisin L.H., Ammon S., and Lindberg E. Effect of mibefradil, a T-type calcium channel blocker, on morbidity and mortality in moderate to severe congestive heart failure: the MACH-1 study. Mortality assessment in congestive heart failure trial. Circulation 101 (2000) 758-764
80. Aiba S., and Creazzo T.L. Calcium currents in hearts with persistent truncus arteriosus. Am. J. Physiol. 262 (1992) H1182-H1190
81. Li D., Melnyk P., Feng J., Wang Z., Petrecca K., Shrier A., and Nattel S. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation 101 (2000) 2631-2638
82. Han W., Chartier D., Li D., and Nattel S. Ionic remodeling of cardiac Purkinje cells by congestive heart failure. Circulation 104 (2001) 2095-2100
83. 2+ channel and insulin-like growth factor genes in rat atria. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H829-H838
84. Fares N., Gomez J.P., and Potreau D. T-type calcium current is expressed in dedifferentiated adult rat ventricular cells in primary culture. CR Acad. Sci. III 319 (1996) 569-576
85. Lalevee N., Rebsamen M.C., Barrere-Lemaire S., Perrier E., Nargeot J., Benitah J.P., and Rossier M.F. Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes. Cardiovasc. Res. 67 (2005) 216-224
86. Benitah J.P., and Vassort G. Aldosterone upregulates Ca(2+) current in adult rat cardiomyocytes. Circ. Res. 85 (1999) 1139-1145
87. Ferron L., Capuano V., Ruchon Y., Deroubaix E., Coulombe A., and Renaud J.F. Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels. Circ. Res. 93 (2003) 1241-1248
88. Kuwahara K., Takano M., and Nakao K. Pathophysiological significance of T-type Ca(2+) channels: transcriptional regulation of T-type Ca(2+) channel-regulation of CACNA1H by neuron-restrictive silencer factor. J. Pharmacol. Sci. 99 (2005) 211-213
89. 2+ channels are involved in high glucose-induced rat neonatal cardiomyocyte proliferation. Pediatr. Res. 57 (2005) 550-556
90. Zhang L.M., Wang Z., and Nattel S. Effects of sustained beta-adrenergic stimulation on ionic currents of cultured adult guinea pig cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. 282 (2002) H880-H889
91. Kawano S., and DeHaan R.L. Developmental changes in the calcium currents in embryonic chick ventricular myocytes. J. Membr. Biol. 120 (1991) 17-28
92. Nilius B. Possible functional significance of a novel type of cardiac Ca channel. Biomed. Biochim. Acta 45 (1986) K37-K45
93. Doerr T., Denger R., and Trautwein W. Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp. Pflugers Arch. 413 (1989) 599-603
94. Escande D., Coraboeuf E., and Planche C. Abnormal pacemaking is modulated by sarcoplasmic reticulum in partially-depolarized myocardium from dilated right atria in humans. J. Mol. Cell Cardiol. 19 (1987) 231-241
95. 2+ release from sarcoplasmic reticulum in the regulation of sinoatrial node automaticity. Heart Vessels 11 (1996) 234-241
96. Hancox J.C., Levi A.J., and Brooksby P. Intracellular calcium transients recorded with Fura-2 in spontaneously active myocytes isolated from the atrioventricular node of the rabbit heart. Proc. Biol. Sci. 255 (1994) 99-105
97. 2+ exchange current in isolated toad pacemaker cells. J. Physiol. 508 Pt 1 (1998) 153-166
98. 2+ channels. Science 302 (2003) 1416-1418
99. Madle A., Linhartova K., and Koza J. Effects of the T-type calcium channel blockade with oral mibefradil on the electrophysiologic properties of the human heart. Med. Sci. Monit. 7 (2001) 74-77
100. Ono K., and Iijima T. Pathophysiological significance of T-type Ca(2+) channels: properties and functional roles of T-type Ca(2+) channels in cardiac pacemaking. J. Pharmacol. Sci. 99 (2005) 197-204
101. 2+ transients under action potential clamp in guinea pig ventricular myocytes. Am. J. Physiol. 261 (1991) C393-C397
102. Pitt B., Zannad F., Remme W.J., Cody R., Castaigne A., Perez A., Palensky J., and Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N. Engl. J. Med. 341 (1999) 709-717
103. Cittadini A., Monti M.G., Isgaard J., Casaburi C., Stromer H., Di Gianni A., Serpico R., Saldamarco L., Vanasia M., and Sacca L. Aldosterone receptor blockade improves left ventricular remodeling and increases ventricular fibrillation threshold in experimental heart failure. Cardiovasc. Res. 58 (2003) 555-564
104. Le Menuet D., Viengchareun S., Muffat-Joly M., Zennaro M.C., and Lombes M. Expression and function of the human mineralocorticoid receptor: lessons from transgenic mouse models. Mol. Cell Endocrinol. 217 (2004) 127-136
105. 2+ channel in development of tension in heart muscle. J. Mol. Cell Cardiol. 19 (1987) 527-553
106. 2+ release from the sarcoplasmic reticulum in guinea-pig ventricular myocytes. J. Physiol. 508 Pt 2 (1998) 439-451
107. 2+ channels can contribute to excitation-contraction coupling in cardiac Purkinje cells. Biophys. J. 74 (1998) 1830-1839
108. 2+ currents in human atrial cells. Receptors Channels 3 (1995) 71-81
109. Aggarwal R., Shorofsky S.R., Goldman L., and Balke C.W. Tetrodotoxin-blockable calcium currents in rat ventricular myocytes; a third type of cardiac cell sodium current. J. Physiol. 505 Pt 2 (1997) 353-369
110. + channels in guinea pig ventricular myocytes. Am. J. Physiol. 273 (1997) H128-H137
111. 2+-channel antagonists reduce contractility in guinea pig cardiac myocytes. J. Cardiovasc. Pharmacol. 32 (1998) 323-330
112. 2+ channels, in single myocytes and intact muscle of guinea-pig heart. J. Physiol. Pharmacol. 49 (1998) 577-590
113. 2+ release in developing myocardium. J. Mol. Cell Cardiol. 35 (2003) 515-523
114. 2+ transients in beating rat hearts. Am. J. Physiol. Heart Circ. Physiol. 286 (2004) H971-H978
115. Thibault G., Amiri F., and Garcia R. Regulation of natriuretic peptide secretion by the heart. Annu. Rev. Physiol. 61 (1999) 193-217
116. Wen J.F., Cui X., Ahn J.S., Kim S.H., Seul K.H., Kim S.Z., Park Y.K., Lee H.S., and Cho K.W. Distinct roles for L- and T-type Ca(2+) channels in regulation of atrial ANP release. Am. J. Physiol. Heart Circ. Physiol. 279 (2000) H2879-H2888
117. Campbell D.L., Giles W.R., and Shibata E.F. Ion transfer characteristics of the calcium current in bull-frog atrial myocytes. J. Physiol. 403 (1988) 239-266
118. 2+ current in cardiac myocytes. Am. J. Physiol. 256 (1989) C1267-C1272
119. + modulates the cAMP-dependent regulation of ion channels in the heart. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 6946-6950
120. Balke C.W., and Wier W.G. Modulation of L-type calcium channels by sodium ions. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 4417-4421
121. Alvarez J.L., Salinas-Stefanon E., Orta G., Ferrer T., Talavera K., Galan L., and Vassort G. Occurrence of a tetrodotoxin-sensitive calcium current in rat ventricular myocytes after long-term myocardial infarction. Cardiovasc. Res. 63 (2004) 653-661
122. Heubach J.F., Kohler A., Wettwer E., and Ravens U. T-Type and tetrodotoxin-sensitive Ca(2+) currents coexist in guinea pig ventricular myocytes and are both blocked by mibefradil. Circ. Res. 86 (2000) 628-635
123. Wang H.S., and Cohen I.S. Calcium channel heterogeneity in canine left ventricular myocytes. J. Physiol. 547 (2003) 825-833
124. Dubel S.J., Altier C., Chaumont S., Lory P., Bourinet E., and Nargeot J. Plasma membrane expression of T-type calcium channel alpha(1) subunits is modulated by high voltage-activated auxiliary subunits. J. Biol. Chem. 279 (2004) 29263-29269
125. Marionneau C., Couette B., Liu J., Li H., Mangoni M.E., Nargeot J., Lei M., Escande D., and Demolombe S. Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J. Physiol. 562 (2005) 223-234
126. Liu Y., Zeng W., Delmar M., and Jalife J. Ionic mechanisms of electronic inhibition and concealed conduction in rabbit atrioventricular nodal myocytes. Circulation 88 (1993) 1634-1646
127. 2+ current in cultured ventricular guinea pig myocytes. Physiol. Res. 53 (2004) 369-377
128. Perez-Reyes E., Cribbs L.L., Daud A., Lacerda A.E., Barclay J., Williamson M.P., Fox M., Rees M., and Lee J.H. Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 391 (1998) 896-900
129. Nuss H.B., and Marban E. Electrophysiological properties of neonatal mouse cardiac myocytes in primary culture. J. Physiol. 479 Pt 2 (1994) 265-279
130. Cribbs L.L., Martin B.L., Schroder E.A., Keller B.B., Delisle B.P., and Satin J. Identification of the T-type calcium channel (Ca(v)3.1d) in developing mouse heart. Circ. Res. 88 (2001) 403-407
131. Wetzel G.T., Chen F., and Klitzner T.S. L- and T-type calcium channels in acutely isolated neonatal and adult cardiac myocytes. Pediatr. Res. 30 (1991) 89-94
132. 2+ currents in shark ventricular myocytes. Am. J. Physiol. 269 (1995) H1695-H1703
133. Chrachri A., Odblom M., and Williamson R. G protein-mediated FMRFamidergic modulation of calcium influx in dissociated heart muscle cells from squid, Loligo forbesii. J. Physiol. 525 Pt 2 (2000) 471-482
134. Baker K., Warren K.S., Yellen G., and Fishman M.C. Defective "pacemaker" current (Ih) in a zebrafish mutant with a slow heart rate. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 4554-4559
135. Han W., Bao W., Wang Z., and Nattel S. Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscle. Circ. Res. 91 (2002) 790-797
136. Maltsev V.A., Wobus A.M., Rohwedel J., Bader M., and Hescheler J. Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents. Circ. Res. 75 (1994) 233-244
137. De Paoli P., Cerbai E., Koidl B., Kirchengast M., Sartiani L., and Mugelli A. Selectivity of different calcium antagonists on T- and L-type calcium currents in guinea-pig ventricular myocytes. Pharmacol. Res. 46 (2002) 491-497
138. 2+ channel cloned from human heart. Naunyn. Schmiedebergs Arch. Pharmacol. 361 (2000) 590-599
139. 2+ antagonist. Pharmacology 61 (2000) 57-61
140. 2+ currents by efonidipine: possible mechanism for its chronotropic effect. Eur. J. Pharmacol. 349 (1998) 351-357
141. Tanaka H., Komikado C., Shimada H., Takeda K., Namekata I., Kawanishi T., and Shigenobu K. The R(-)-enantiomer of efonidipine blocks T-type but not L-type calcium current in guinea pig ventricular myocardium. J. Pharmacol. Sci. 96 (2004) 499-501
142. 2+ currents in atrial myocytes. Pflugers Arch. 420 (1992) 410-412
143. Liu Q.Y., Karpinski E., and Pang P.K. Tetrandrine inhibits both T and L calcium channel currents in ventricular cells. J. Cardiovasc. Pharmacol. 20 (1992) 513-519
144. Rivet M., Bois P., Cognard C., and Raymond G. Phenytoin preferentially inhibits L-type calcium currents in whole-cell patch-clamped cardiac and skeletal muscle cells. Cell Calcium 11 (1990) 581-588
145. El-Bizri N., Bkaily G., Wang S., Jacques D., Regoli D., D'Orleans-Juste P., and Sukarieh R. Bradykinin induced a positive chronotropic effect via stimulation of T- and L-type calcium currents in heart cells. Can J. Physiol. Pharmacol. 81 (2003) 247-258
146. 2+ channels by calmodulin-dependent protein kinase II. Am. J. Physiol. 267 (1994) F183-F189
147. 2+ current. Am. J. Physiol. 260 (1991) H759-H769
148. Camara A.K., Begic Z., Kwok W.M., and Bosnjak Z.J. Differential modulation of the cardiac L- and T-type calcium channel currents by isoflurane. Anesthesiology 95 (2001) 515-524
149. Chuang R.S., Jaffe H., Cribbs L., Perez-Reyes E., and Swartz K.J. Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. Nat. Neurosci. 1 (1998) 668-674
150. Le Grand B., Deroubaix E., Coulombe A., and Coraboeuf E. Stimulatory effect of ouabain on T- and L-type calcium currents in guinea pig cardiac myocytes. Am. J. Physiol. 258 (1990) H1620-H1623
151. Xiao G.Q., Hu K., and Boutjdir M. Direct inhibition of expressed cardiac l- and t-type calcium channels by igg from mothers whose children have congenital heart block. Circulation 103 (2001) 1599-1604