Mibefradil (Ro 40-5967) blocks multiple types of voltage-gated calcium channels in cultured rat spinal motoneurones

Cell Calcium

Volumn 22, Issue 4, 1997, Pages 299-311

  Viana, Félix ^a,c   Van Bosch, Ludo Den ^b   Missiaen, Ludwig ^a   Vandenberghe, Wim ^b   Droogmans, Guy ^a   Nilius, Bernd ^a   Robberecht, Wim ^b  

^a Laboratory of Physiology   (Georgia)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; AMILORIDE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; INDO 1; MIBEFRADIL; NICKEL;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DRUG POTENCY; FETUS; HEART MUSCLE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD MOTONEURON;

ANIMALIA; MAMMALIA;

EID: 0030685757     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0143-4160(97)90068-3     Document Type: Article

References (35)

1. 3H]-desmethoxyverapamil receptor, is devoid of the negative inotropic effects of verapamil in normal and failing rat hearts. Cardiovasc Drugs Ther 1990; 4: 731-736.
2. Billman G.E. Ro 40-5967, a novel calcium channel antagonist, protects against ventricular fibrillation. Eur J Pharmacol 1992; 229: 179-187.
3. Bakx A.L., van der Wall E.E., Braun S., Emanuelsson H., Bruschke A.V., Kobrin I., International Study Group. Effects of the new calcium antagonist mibefradil (Ro 40-5967) on exercise duration in patients with chronic stable angina pectoris: a multicenter, placebo-controlled study. Ro 40-5967 Am Heart J 1995; 130: 748-757
4. Bernink P.J., Prager G., Schelling A., Kobrin I., Mibefradil International Study Group. Antihypertensive properties of the novel calcium antagonist mibefradil (Ro 40-5967). A new generation of calcium antagonists? Hypertension 1996; 27: 426-432.
5. Billman G.E., Hamlin R.L. The effects of mibefradil, a novel calcium channel antagonist, on ventricular arrhythmias induced by myocardial ischemia and programmed electrical stimulation. J Pharmacol Exp Ther 1996; 277: 1517-1526.
6. Braun S., van der Wall E.E., Emanuelsson H., Kobrin I., The Mibefradil International Study Group. Effects of a new calcium antagonist, mibefradil (Ro 40-5967), on silent ischemia in patients with stable chronic angina pectoris: a multicenter placebo-controlled study. J Am Coll Cardiol 1996; 27: 317-322.
7. 2+ channels by Ro 40-5967 Circ Res 1994; 75: 144-148.
8. ++ channels. J Pharmacol Exp Ther 1994; 271: 1483-1488.
9. 2+ channel blocker with potent vasodilator but weak inotropic action. J Cardiovasc Pharmacol 1989; 13: 754-759.
10. Clozel J.P., Banken L, Osterrieder W. Effects of Ro 40-5967, a novel calcium antagonist, on myocardial function during ischemia induced by lowering coronary perfusion pressure in dogs: comparison with verapamil. J Cardiovasc Pharmacol 1989; 14: 713-721.
11. Portegies M.C., Schmitt R., Kraaij C.J. et al. Lack of negative inotropic effects of the new calcium antagonist Ro 40-5967 in patients with stable angina pectoris. J Cardiovasc Pharmacol 1991; 18: 746-751.
12. Roux S., Buhler M., Clozel J.P. Mechanism of the anti-ischemic effect of mibefradil, a selective T calcium channel blocker in dogs: comparison with amlodipine. J Cardiovasc Pharmacol 1996; 27: 132-139.
13. Schmitt R., Clozel J.P., Iberg N., Buhler ER. Mibefradil prevents neointima formation after vascular injury in rats. Possible role of the blockade of the T-type voltage-operated calcium channel. Arterioscler Thromb Vasc Biol 1995; 15: 1161-1165.
14. - channels in macrovascular endothelial cells. Br J Pharmacol 1997; 121: 547-555.
15. 2+ channel antagonist mibefradil (Ro 40-5967). Mol Pharmacol 1995; 48: 540-549.
16. Lacinova L., Welling A., Bosse E., Ruth P., Flockerzi V., Hofmann E Interaction of Ro 40-5967 and verapamil with the stably expressed alpha 1-subunit of the cardiac L-type calcium channel. J Pharmacol Exp Ther 1995; 274: 54-63.
17. Welling A., Lacinova L, Donatin K. et al. Expression of the L-type calcium channel with two different beta subunits and its modulation by Ro 40-5967. Pflügers Arch 1995; 429: 400-411.
18. 2+ inward currents by Ro 40-5967 and verapamil: relation to negative inotropy. Eur J Pharmacol 1991; 196: 205-207
19. Berger A.J., Takahashi T. Serotonin enhances a low-voltage-activated calcium current in rat spinal motoneurons. J Neurosci 1990; 10: 1922-1928.
20. Mynlieff M., Beam K.G. Characterization of voltage-dependent calcium currents in mouse motoneurons. J Neurophysiol 1992; 68: 85-92.
21. Viana E, Bayliss D.A., Berger A.J. Calcium conductances and their role in the firing behavior of neonatal rat hypoglossal motoneurons. J Neurophysiol 1993; 69: 2137-2149.
22. Bayliss D.A., Umemiya M., Berger A.J. Inhibition of N- and P-type calcium currents and the after-hyperpolarization in rat motoneurones by serotonin. J Physiol 1995; 485: 635-647.
23. 2+ channels in hypoglossal motoneurons. J Neurosci 1994; 14: 5652-5660.
24. Hivert B., Bouhanna S., Diochot S. et al. Embryonic rat motoneurons express a functional P-type voltage-dependent calcium channel. Int J Dev Neurosci 1995; 13: 429-436.
25. Camu W., Henderson C.E. Purification of embryonic rat motoneurons by panning on a monoclonal antibody to the low-affinity NGF receptor. J Neurosci Methods 1992; 44: 59-70.
26. Yan Q., Johnson E.M. An immunohistochemical study of the nerve growth factor receptor in developing rats. J Neurosci 1988; 8: 3481-3498.
27. Fonnum F. A rapid radiochemical method for the determination of choline acetyltransferase. J Neurochem 1975; 24: 407-409.
28. Hamill O.P., Marty A., Neher E. Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 1981; 391: 85-100.
29. Fox A.P., Nowycky M.C., Tsien R.W. Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J Physiol 1987; 394: 149-172.
30. 2+ in developing Xenopus neurons. Neurosci 1993; 13: 4936-4948.
31. Kokubun S., Reuter H. Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells. Proc Natl Acad Sci USA 1984; 81: 4824-4827.
32. Garcia K.D., Beam K.G. Reduction of calcium currents by Lambert-Eaton syndrome sera: motoneurons are preferentially affected, and L-type currents are spared. J Neurosci 1996; 16: 4903-4913.
33. McCobb D.P., Best P.M., Beam K.G. Development alters the expression of calcium currents in chick limb motoneurons. Neuron 1989; 2: 1633-1643.
34. Nishimaru N., Iizuka M., Ozaki S., Kudo N. Spontaneous motoneuronal activity mediated by glycine and GABA in the spinal cord of rat fetuses in vitro. J Physiol 1996; 497: 131-143.
35. 2+ channels: diversity of form and function. Curr Opin Neurobiol 1992; 2: 247-253.