Role of voltage-gated calcium channels in ascending pain pathways

Brain Research Reviews

Volumn 60, Issue 1, 2009, Pages 84-89

  Zamponi, Gerald W ^a   Lewis, Richard J ^b   Todorovic, Slobodan M ^c   Arneric, Stephen P ^d   Snutch, Terrance P ^e  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF VIRGINIA   (United States)

^d Neuromed Pharmaceuticals   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Burst firing; Conotoxin; Dorsal root ganglion; N type channel; T type channel

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL T TYPE; CALCIUM CHANNEL T TYPE CAV3.2; CLONIDINE; CONOTOXIN; DULOXETINE; ETHOSUXIMIDE; GLUTAMIC ACID; MIBEFRADIL; MORPHINE; OMEGA CONOTOXIN CVID; OMEGA CONOTOXIN MVIIA; SUBSTANCE P; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; XEN 2174;

ALTERNATIVE RNA SPLICING; AMNESIA; BEHAVIOR DISORDER; CANCER PAIN; CLINICAL TRIAL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GENE; GENE EXPRESSION; HUMAN; HYPOTENSION; N TYPE CALCIUM CHANNEL GENE; NERVE ENDING; NEUROPATHIC PAIN; NEUROTRANSMISSION; NONHUMAN; OXIDATION REDUCTION REACTION; PAIN; PAIN RECEPTOR; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW; SENSORY NERVE; SPINAL CORD DORSAL HORN; UNRULY BEHAVIOR; UNSPECIFIED SIDE EFFECT;

AFFERENT PATHWAYS; ANALGESICS; ANIMALS; CALCIUM CHANNELS; GANGLIA, SPINAL; HUMANS; ION CHANNEL GATING; NERVOUS SYSTEM; NOCICEPTORS; PAIN; POSTERIOR HORN CELLS; SENSORY RECEPTOR CELLS;

EID: 63449128852     PISSN: 01650173     EISSN: 18726321     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2008.12.021     Document Type: Review

References (51)

1. Altier C., and Zamponi G.W. Targeting Ca2+ channels to treat pain: T-type versus N-type. Trends Pharmacol. Sci. 25 (2004) 465-470
2. Altier C., Dale C.S., Kisilevsky A.E., Chapman K., Castiglioni A.J., Matthews E.A., Evans R.M., Dickenson A.H., Lipscombe D., Vergnolle N., and Zamponi G.W. Differential role of N-type calcium channel splice isoforms in pain. J. Neurosci. 27 (2007) 6363-6373
3. Barton M.E., Eberle E.J., and Shannon H.E. The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione and mibefradil. Eur. J. Pharmacol. 521 (2005) 79-85
4. Bell T.J., Thaler C., Castiglioni A.J., Helton T.D., and Lipscombe D. Cell-specific alternative splicing increases calcium channel current density in the pain pathway. Neuron 41 (2004) 127-138
5. Bourinet E., Soong T.W., Stea T., and Snutch T.P. Determinants of the G-protein-dependent opioid modulation of neuronal calcium channels. Proc. Natl. Acad. Sci. USA 93 (1996) 1486-1491
6. V3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. EMBO J. 24 (2005) 315-324
7. V2.2 controls expression and gating of N-type calcium channels. J. Physiol. 576 (2006) 119-134
8. v3.2 T-type channels. Genes Brain Behav. 6 (2007) 425-431
9. Devor M., Janig W., and Michaelis M. Modulation of activity in dorsal root ganglion neurons by sympathetic activation in nerve injured rats. J. Neurophysiol. 71 (1994) 38-47
10. Dogrul A., Gardell L.R., Ossipov M.H., Tulunay F.C., Lai J., and Porreca F. Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain 105 (2003) 159-168
11. Flatters S.J., and Bennett G.J. Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheralneuropathy. Pain 109 (2004) 150-161
12. Gray A.C., Raingo J., and Lipscombe D. Neuronal calcium channels: splicing for optimal performance. Cell Calcium 42 (2007) 409-417
13. Hatakeyama S., Wakamori M., Ino M., Miyamoto N., Takahashi E., Yoshinaga T., Sawada K., Imoto K., Tanaka I., Yoshizawa T., Nishizawa Y., Mori Y., Niidome T., and Shoji S. Differential nociceptive responses in mice lacking the alpha(1B) subunit of N-type Ca(2+) channels. NeuroReport 12 (2001) 2423-2427
14. Hildebrand M.E., and Snutch T.P. Contributions of T-type Ca channels to the pathophysiology of pain signaling. Drug Discovery Today: Disease Mechanisms 3 (2006) 335-341
15. Jagodic M.M., Pathirathna S., Nelson M.T., Mancuso S., Joksovic P.M., Rosenberg E.R., Bayliss D.A., Jevtovic-Todorovic V., and Todorovic S.M. Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J. Neurosci. 27 (2007) 3305-3316
16. Jagodic M.M., Pathirathna S., Joksovic P.M., Lee W., Nelson M.T., Naik A.K., Su P., Jevtovic-Todorovic V., and Todorovic S.M. Up-regulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J. Neurophysiol. 99 (2008) 3151-3156
17. Julius D., and Basbaum A.I. Molecular mechanisms of nociception. Nature 413 (2001) 203-210
18. Kajander K.C., and Bennett G.J. Onset of a painful peripheral neuropathy in rat: a partial and differential deafferation and spontaneous discharge in Aβ and Aδ primary afferent neurons. J. Neurophysiol. 68 (1992) 734-744
19. Krarup C. An update on electrophysiological studies in neuropathy. Curr. Opin. Neurol. 16 (2003) 603-612
20. Lewis R.J., Nielsen K.J., Craik D.J., Loughnan M.L., Adams D.A., Sharpe I.A., Luchian T., Adams D.J., Bond T., Thomas L., Jones A., Matheson J.L., Drinkwater R., Andrews P.R., and Alewood P.F. Novel ω-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J. Biol. Chem. 275 (2000) 35335-35344
21. Lipscombe D. Neuronal proteins custom designed by alternative splicing. Curr. Opin. Neurobiol. 5 (2005) 358-363
22. Malmberg A.B., and Yaksh T.L. Effect of continuous intrathecal infusion of ω-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain 60 (1995) 83-90
23. Martin T.J., and Eisenach J.C. Pharmacology of opioid and nonopioid analgesics in chronic pain states. J. Pharmacol. Exp. Ther. 299 (2001) 811-817
24. Matthews E.A., and Dickenson A.H. Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats. Eur. J. Pharmacol. 415 (2001) 141-149
25. Matthews E.A., Bee L.A., Stephens G.J., and Dickenson A.H. The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur. J. Neurosci. 25 (2007) 3561-3569
26. 2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. J. Neurosci. 25 (2005) 8766-8775
27. Nelson M.T., Woo J., Kang H.-W., Barrett P.Q., Vitko J., Perez-Reyes E., Lee J.-H., Shin H.-S., and Todorovic S.M. Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. J. Neurosci. 27 (2007) 8250-8260
28. Newton P.M., Orr C.J., Wallace M.J., Kim C., Shin H.S., and Messing R.O. Deletion of N-type calcium channels alters ethanol reward and reduces ethanol consumption in mice. J. Neurosci. 24 (2004) 9862-9869
29. Newton P.M., Zeng L., Wang V., Connolly J., Wallace M.J., Kim C.K., Shin H.S., Belardetti F., Snutch T.P., and Messing R.O. A blocker of N- and T-type voltage-gated calcium channels attenuates ethanol-induced intoxication, place preference, self-administration, and reinstatement. J Neurosci. 28 (2008) 11712-11719
30. Nielsen C.K., Lewis R.J., Alewood D., Drinkwater R., Palant E., Patterson M., Yaksh T.L., McCumber D., and Smith M.T. Anti-allodynic efficacy of the χ-conopeptide, Xen2174, in rats with neuropathic pain. Pain 118 (2005) 112-124
31. Paczkowski F.A., Sharpe I.A., Dutertre S., and Lewis R.J. Conopeptide and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model. J. Biol. Chem. 282 (2007) 17837-17844
32. Pathirathna S., Todorovic S.M., Covey D.F., and Jevtovic-Todorovic V. Differential effects of endogenous cysteine analogues on thermal nociception in intact rats. Pain 125 (2006) 53-64
33. Pertovaara A. Noradrenergic pain modulation. Prog. Neurobiol. 80 (2006) 53-83
34. Petersen M., Zhang J., Zhang J.-M., and LaMotte R.H. Abnormal spontaneous activity and responses to norepinepherine in dissociated dorsal root ganglion cells after chronic nerve constriction. Pain 67 (1996) 391-397
35. Porreca F., Ossipov M.H., and Gebhart G.F. Chronic pain and medullary descending facilitation. Trends Neurosci. 25 (2002) 319-325
36. Raingo J., Castiglioni A.J., and Lipscombe D. Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors. Nat. Neurosci. 10 (2007) 285-292
37. Saegusa H., Kurihara T., Zong S., Minowa O., Kazuno A., Han W., Matsuda Y., Yamanaka H., Osanai M., Noda T., and Tanabe T. Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 6132-6137
38. Saegusa H., Kurihara T., Zong S., Kazuno A., Matsuda Y., Nonaka T., Han W., Toriyama H., and Tanabe T. Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J. 20 (2001) 2349-2356
39. Schaible H.G., and Richter F. Pathophysiology of pain. Langenbecks Arch. Surg. 389 (2004) 237-243
40. Sekizawa S.-I., French A.S., and Torkkeli P.H. Low-voltage-activated calcium current does not regulate the firing behaviour in paired mechanosensory neurons with different adaptation properties. J. Neurophysiol. 83 (2000) 746-753
41. Sharpe I.A., Gehrmann J., Loughnan M.L., Thomas L., Adams D.A., Atkins A., Palant E., Craik D.J., Adams D.F., Alewood P.F., and Lewis R.J. Two new classes of conopeptides inhibit the a1-adrenoceptor and noradrenaline transporter. Nat. Neurosci. 4 (2001) 902-907
42. Shin H.S., Cheong E.J., Choi S., Lee J., and Na H.S. T-type Ca2+ channels as therapeutic targets in the nervous system. Curr. Opin. Pharmacol. 8 (2008) 33-41
43. Smith M., Cabot P.J., Ross F.B., Robertson A.D., and Lewis R.J. The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices. Pain 96 (2002) 119-127
44. Smith P.A. Neuropathic pain: drug targets for current and future interventions. Drug News Perspect. 17 (2004) 5-17
45. Snutch T.P. Targeting chronic and neuropathic pain: the N-type calcium channel comes of age. NeuroRx 2 (2005) 662-670
46. Song X.-J., Hu S.-J., Greenquist K.W., Zhang J.-M., and LaMotte R.H. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J. Neurophysiol. 82 (1999) 3347
47. Staats P.S., Yearwood T., Charapata S.G., Presley R.W., Wallace M.S., Byas-Smith M., Fisher R., Bryce D.A., Mangieri E.A., Luther R.R., Mayo M., McGuire D., and Ellis D. Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA 291 (2004) 63-70
48. Todorovic S.M., Jevtovic-Todorovic V., Meyenburg A., Mennerick S., Perez-Reyes E., Romano C., Olney J.W., and Zorumski C.F. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron 31 (2001) 75-85
49. Todorovic S.M., Meyenburg A., and Jevtovic-Todorovic V. Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res. 951 (2002) 336-340
50. Todorovic S.M., and Jevtovic-Todorovic V. The role of T-type calcium channels in peripheral and central pain processing. CNS Neurol. Disord. Drug Targets 5 (2006) 639-653
51. Zhang J.-M., Song X.-J., and LaMotte R.H. Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesic produced by chronic compression of the dorsal root ganglion. J. Neurophysiol. 82 (1999) 3359-3366