Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor

Biochemical and Biophysical Research Communications

Volumn 410, Issue 1, 2011, Pages 19-23

  Chang, Ki Young ^a   Park, Young Gyun ^a   Park, Hye Yeon ^a   Homanics, Gregg E ^b   Kim, Jeongjin ^a   Kim, Daesoo ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

CaV3.1 T type Ca2+ channel; Double knockout mice; Essential tremor; GABAA receptor 1 subunit knockout; Motor coordination

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; CALCIUM CHANNEL; PROPRANOLOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBELLUM ATROPHY; CONTROLLED STUDY; ESSENTIAL TREMOR; GENETIC MODEL; IN VIVO STUDY; LEARNING; MOTOR CONTROL; MOTOR COORDINATION; MOUSE; MUTANT; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PURKINJE CELL;

AGE FACTORS; ANIMALS; CALCIUM CHANNELS, T-TYPE; CEREBELLAR ATAXIA; CEREBELLUM; DISEASE MODELS, ANIMAL; ESSENTIAL TREMOR; HUMANS; MICE; MICE, KNOCKOUT; MODELS, GENETIC; MOTOR ACTIVITY; PURKINJE CELLS; RECEPTORS, GABA-A;

MUS;

EID: 79959374582     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.05.082     Document Type: Article

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