Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels

Journal of Neuroscience

Volumn 27, Issue 31, 2007, Pages 8250-8260

  Nelson, Michael T ^a   Woo, Jiwan ^c   Kang, Ho Won ^b   Vitko, Iuliia ^a   Barrett, Paula Q ^a   Perez Reyes, Edward ^a   Lee, Jung Ha ^b   Shin, Hee Sup ^c   Todorovic, Slobodan M ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b Sogang University   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

Author keywords

Action potential; C fiber; Calcium current; Dorsal root ganglion; Nociception; Pain; Sensitization; Zinc

Indexed keywords

AMINO ACID; CALCIUM CHANNEL T TYPE; HISTIDINE; PROTEIN DERIVATIVE; REDUCING AGENT; ZINC;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NERVE CELL EXCITABILITY; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION; SPINAL GANGLION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CELL LINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY; REDUCING AGENTS; ZINC;

EID: 34547693209     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1800-07.2007     Document Type: Article

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