메뉴 건너뛰기




Volumn 43, Issue 6, 2013, Pages 596-607

RNAi therapeutics and applications of microRNAs in cancer treatment

Author keywords

Cancer; DDS; MicroRNA; RNA interference

Indexed keywords

ALN RSV 01; BEVASIRANIB; LIPOSOME; LOCKED NUCLEIC ACID; MICRORNA; MICRORNA 122; MIRAVIRSEN; NANOCARRIER; NANOPARTICLE; NUCLEIC ACID; OLIGONUCLEOTIDE; POLYETHYLENEIMINE; SMALL INTERFERING RNA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VIRUS VECTOR;

EID: 84878630603     PISSN: 03682811     EISSN: 14653621     Source Type: Journal    
DOI: 10.1093/jjco/hyt052     Document Type: Article
Times cited : (60)

References (114)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-11.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 4
    • 13444262170 scopus 로고    scopus 로고
    • Inhibition of respiratory viruses by nasally administered siRNA
    • Bitko V, Musiyenko A, Shulyayeva O, Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 2005;11:50-5.
    • (2005) Nat Med , vol.11 , pp. 50-55
    • Bitko, V.1    Musiyenko, A.2    Shulyayeva, O.3    Barik, S.4
  • 5
    • 33645165026 scopus 로고    scopus 로고
    • Viral-based modelling and correction of neurodegenerative diseases by RNA interference
    • Raoul C, Barker SD, Aebischer P. Viral-based modelling and correction of neurodegenerative diseases by RNA interference. Gene Ther 2006;13:487-95.
    • (2006) Gene Ther , vol.13 , pp. 487-495
    • Raoul, C.1    Barker, S.D.2    Aebischer, P.3
  • 6
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson BL, McCray PB. Current prospects for RNA interference-based therapies. Nat Rev Genet 2011;12:329-40.
    • (2011) Nat Rev Genet , vol.12 , pp. 329-340
    • Davidson, B.L.1    McCray, P.B.2
  • 7
    • 34547584514 scopus 로고    scopus 로고
    • Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo
    • Aigner A. Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo. Appl Microbiol Biotechnol 2007;76:9-21.
    • (2007) Appl Microbiol Biotechnol , vol.76 , pp. 9-21
    • Aigner, A.1
  • 8
    • 33745625836 scopus 로고    scopus 로고
    • Therapeutic potential of RNA interference against cancer
    • Takeshita F, Ochiya T. Therapeutic potential of RNA interference against cancer. Cancer Sci 2006;97:689-96.
    • (2006) Cancer Sci , vol.97 , pp. 689-696
    • Takeshita, F.1    Ochiya, T.2
  • 9
    • 36349032759 scopus 로고    scopus 로고
    • MicroRNAs in disease and potential therapeutic applications
    • Soifer HS, Rossi JJ, Sætrom P. MicroRNAs in disease and potential therapeutic applications. Mol Ther 2007;15:2070-9.
    • (2007) Mol Ther , vol.15 , pp. 2070-2079
    • Soifer, H.S.1    Rossi, J.J.2    Sætrom, P.3
  • 10
    • 22144477115 scopus 로고    scopus 로고
    • MicroRNAs in vertebrate development
    • Harfe BD. MicroRNAs in vertebrate development. Curr Opin Genet Dev 2005;15:410-5.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 410-415
    • Harfe, B.D.1
  • 11
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-97.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 12
    • 14644393684 scopus 로고    scopus 로고
    • Perspective: machines for RNAi
    • Tomari Y, Zamore PD. Perspective: machines for RNAi. Genes Dev 2005;19:517-29.
    • (2005) Genes Dev , vol.19 , pp. 517-529
    • Tomari, Y.1    Zamore, P.D.2
  • 13
    • 77952840963 scopus 로고    scopus 로고
    • Microprocessor of microRNAs: regulation and potential for therapeutic intervention
    • Beezhold KJ, Castranova V, Chen F. Microprocessor of microRNAs: regulation and potential for therapeutic intervention. Mol Cancer 2010;9:134.
    • (2010) Mol Cancer , vol.9 , pp. 134
    • Beezhold, K.J.1    Castranova, V.2    Chen, F.3
  • 14
    • 61849137222 scopus 로고    scopus 로고
    • Many roads to maturity: microRNA biogenesis pathways and their regulation
    • Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 2009;11:228-34.
    • (2009) Nat Cell Biol , vol.11 , pp. 228-234
    • Winter, J.1    Jung, S.2    Keller, S.3    Gregory, R.I.4    Diederichs, S.5
  • 15
    • 84878624750 scopus 로고    scopus 로고
    • Small RNAs with big impacts
    • Meltzer PS. Small RNAs with big impacts. Nature 2005;435:0-1.
    • (2005) Nature , vol.435 , pp. 0-1
    • Meltzer, P.S.1
  • 16
    • 73349125465 scopus 로고    scopus 로고
    • MicroRNAs in cancer: small molecules with a huge impact
    • Iorio MV, Croce CM. MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol 2009;27:5848-56.
    • (2009) J Clin Oncol , vol.27 , pp. 5848-5856
    • Iorio, M.V.1    Croce, C.M.2
  • 17
    • 58249106361 scopus 로고    scopus 로고
    • MicroRNA-like off-target transcript regulation by siRNAs is species specific
    • Burchard J, Jackson AL, Malkov V, et al. MicroRNA-like off-target transcript regulation by siRNAs is species specific. RNA 2009;15:308-15.
    • (2009) RNA , vol.15 , pp. 308-315
    • Burchard, J.1    Jackson, A.L.2    Malkov, V.3
  • 20
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 21
    • 0035694237 scopus 로고    scopus 로고
    • Identification of essential genes in cultured mammalian cells using small interfering RNAs
    • Harborth J, Elbashir SM, Bechert K, Tuschl T, Weber K. Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci 2001;114:4557-65.
    • (2001) J Cell Sci , vol.114 , pp. 4557-4565
    • Harborth, J.1    Elbashir, S.M.2    Bechert, K.3    Tuschl, T.4    Weber, K.5
  • 24
    • 84864354715 scopus 로고    scopus 로고
    • Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation
    • Zheng D, Giljohann DA, Chen DL, et al. Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation. Proc Natl Acad Sci USA 2012;109:11975-80.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 11975-11980
    • Zheng, D.1    Giljohann, D.A.2    Chen, D.L.3
  • 25
    • 77951132901 scopus 로고    scopus 로고
    • Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
    • Davis ME, Zuckerman JE, Choi CHJ, et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010;464:1067-70.
    • (2010) Nature , vol.464 , pp. 1067-1070
    • Davis, M.E.1    Zuckerman, J.E.2    Choi, C.H.J.3
  • 26
    • 65649085603 scopus 로고    scopus 로고
    • Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice
    • Judge AD, Robbins M, Levi J, et al. Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice. J Clin Invest 2009;119:661-73.
    • (2009) J Clin Invest , vol.119 , pp. 661-673
    • Judge, A.D.1    Robbins, M.2    Levi, J.3
  • 27
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann TS, Lee ACH, Akinc A, et al. RNAi-mediated gene silencing in non-human primates. Nature 2006;441:111-4.
    • (2006) Nature , vol.441 , pp. 111-114
    • Zimmermann, T.S.1    Lee, A.C.H.2    Akinc, A.3
  • 28
    • 31944441562 scopus 로고    scopus 로고
    • Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain
    • Chen Y, Chen H, Hoffmann A, et al. Adenovirus-mediated small-interference RNA for in vivo silencing of angiotensin AT1a receptors in mouse brain. Hypertension 2006;47:230-7.
    • (2006) Hypertension , vol.47 , pp. 230-237
    • Chen, Y.1    Chen, H.2    Hoffmann, A.3
  • 29
    • 84863686039 scopus 로고    scopus 로고
    • The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-a
    • Zhu S, Pan W, Song X, et al. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-a. Nat Med 2012;18:1077-86.
    • (2012) Nat Med , vol.18 , pp. 1077-1086
    • Zhu, S.1    Pan, W.2    Song, X.3
  • 30
    • 84862104289 scopus 로고    scopus 로고
    • Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo
    • Pihlmann M, Askou AL, Aagaard L, et al. Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo. J Gene Med 2012;14:328-38.
    • (2012) J Gene Med , vol.14 , pp. 328-338
    • Pihlmann, M.1    Askou, A.L.2    Aagaard, L.3
  • 31
    • 25144464388 scopus 로고    scopus 로고
    • Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice
    • Rodriguez-Lebron E, Denovan-Wright EM, Nash K, Lewin AS, Mandel RJ. Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice. Mol Ther 2005;12:618-33.
    • (2005) Mol Ther , vol.12 , pp. 618-633
    • Rodriguez-Lebron, E.1    Denovan-Wright, E.M.2    Nash, K.3    Lewin, A.S.4    Mandel, R.J.5
  • 32
    • 84868254278 scopus 로고    scopus 로고
    • miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma
    • Kasinski AL, Slack FJ. miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res 2012;72:5576-87.
    • (2012) Cancer Res , vol.72 , pp. 5576-5587
    • Kasinski, A.L.1    Slack, F.J.2
  • 33
    • 17644383664 scopus 로고    scopus 로고
    • Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
    • Raoul C, Abbas-Terki T, Bensadoun J-C, et al. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med 2005;11:423-8.
    • (2005) Nat Med , vol.11 , pp. 423-428
    • Raoul, C.1    Abbas-Terki, T.2    Bensadoun, J.-C.3
  • 34
    • 49249134278 scopus 로고    scopus 로고
    • Efficient delivery of RNA interference to peripheral neurons in vivo using herpes simplex virus
    • Anesti A-M, Peeters PJ, Royaux I, Coffin RS. Efficient delivery of RNA interference to peripheral neurons in vivo using herpes simplex virus. Nucleic Acids Res 2008;36:e86.
    • (2008) Nucleic Acids Res , vol.36
    • Anesti, A.-M.1    Peeters, P.J.2    Royaux, I.3    Coffin, R.S.4
  • 35
    • 27744519930 scopus 로고    scopus 로고
    • Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo
    • Saydam O, Glauser DL, Heid I, et al. Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo. Mol Ther 2005;12:803-12.
    • (2005) Mol Ther , vol.12 , pp. 803-812
    • Saydam, O.1    Glauser, D.L.2    Heid, I.3
  • 37
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems with the use of viral vectors for gene therapy
    • Thomas CE, Ehrhardt A, Kay MA. Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 2003;4:346-58.
    • (2003) Nat Rev Genet , vol.4 , pp. 346-358
    • Thomas, C.E.1    Ehrhardt, A.2    Kay, M.A.3
  • 38
    • 8844269115 scopus 로고    scopus 로고
    • Why do we need new gene therapy viral vectors? Characteristics, limitations and future perspectives of viral vector transduction
    • Tomanin R, Scarpa M. Why do we need new gene therapy viral vectors? Characteristics, limitations and future perspectives of viral vector transduction. Curr Gene Ther 2004;4:357-72.
    • (2004) Curr Gene Ther , vol.4 , pp. 357-372
    • Tomanin, R.1    Scarpa, M.2
  • 39
    • 0141552295 scopus 로고    scopus 로고
    • Gene silencing by systemic delivery of synthetic sirnas in adult mice
    • Sørensen DR, Leirdal M, Sioud M. Gene silencing by systemic delivery of synthetic sirnas in adult mice. J Mol Biol 2003;327:761-6.
    • (2003) J Mol Biol , vol.327 , pp. 761-766
    • Sørensen, D.R.1    Leirdal, M.2    Sioud, M.3
  • 40
    • 0037388638 scopus 로고    scopus 로고
    • Small interfering RNAs directed against b-catenin inhibit the in vitro and in vivo growth of colon cancer cells
    • Verma UN, Surabhi RM, Schmaltieg A, Schmaltieg A, Becerra C, Gaynor RB. Small interfering RNAs directed against b-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin Cancer Res 2003;9:1291-300.
    • (2003) Clin Cancer Res , vol.9 , pp. 1291-1300
    • Verma, U.N.1    Surabhi, R.M.2    Schmaltieg, A.3    Schmaltieg, A.4    Becerra, C.5    Gaynor, R.B.6
  • 41
    • 9344224580 scopus 로고    scopus 로고
    • Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer
    • Yano J, Hirabayashi K, Nakagawa S-I, et al. Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer. Clin Cancer Res 2004;10:7721-6.
    • (2004) Clin Cancer Res , vol.10 , pp. 7721-7726
    • Yano, J.1    Hirabayashi, K.2    Nakagawa, S-I.3
  • 42
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • Urban-Klein B, Werth S, Abuharbeid S, Czubayko F, Aigner A. RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther 2005;12:461-6.
    • (2005) Gene Ther , vol.12 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 43
    • 33746267422 scopus 로고    scopus 로고
    • RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts
    • Grzelinski M, Urban-Klein B, Martens T, et al. RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts. Hum Gene Ther 2006;17:751-66.
    • (2006) Hum Gene Ther , vol.17 , pp. 751-766
    • Grzelinski, M.1    Urban-Klein, B.2    Martens, T.3
  • 44
    • 34848868157 scopus 로고    scopus 로고
    • Growth arrest through modulation of the E2F pathway in human colon cancer cells
    • Tazawa H, Tsuchiya N, Izumiya M, Nakagama H. Growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA 2007;104:2-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2-7
    • Tazawa, H.1    Tsuchiya, N.2    Izumiya, M.3    Nakagama, H.4
  • 45
    • 3242733298 scopus 로고    scopus 로고
    • Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
    • Minakuchi Y, Takeshita F, Kosaka N, et al. Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res 2004;32:e109.
    • (2004) Nucleic Acids Res , vol.32
    • Minakuchi, Y.1    Takeshita, F.2    Kosaka, N.3
  • 46
    • 24744464786 scopus 로고    scopus 로고
    • Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
    • Takeshita F, Minakuchi Y, Nagahara S, et al. Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci USA 2005;102:12177-82.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12177-12182
    • Takeshita, F.1    Minakuchi, Y.2    Nagahara, S.3
  • 47
    • 74149083873 scopus 로고    scopus 로고
    • Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes
    • Takeshita F, Patrawala L, Osaki M, et al. Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol Ther 2010;18:181-7.
    • (2010) Mol Ther , vol.18 , pp. 181-187
    • Takeshita, F.1    Patrawala, L.2    Osaki, M.3
  • 48
    • 79960580777 scopus 로고    scopus 로고
    • Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing
    • Al-jamal KT, Gherardini L, Bardi G, Nunes A, Guo C, Bussy C. Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing. Proc Natl Acad Sci USA 2011;108:10952-7.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 10952-10957
    • Al-jamal, K.T.1    Gherardini, L.2    Bardi, G.3    Nunes, A.4    Guo, C.5    Bussy, C.6
  • 49
    • 33645720317 scopus 로고    scopus 로고
    • Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference
    • Geisbert TW, Hensley LE, Kagan E, et al. Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference. J Infect Dis 2006;193:1650-7.
    • (2006) J Infect Dis , vol.193 , pp. 1650-1657
    • Geisbert, T.W.1    Hensley, L.E.2    Kagan, E.3
  • 50
    • 79957900919 scopus 로고    scopus 로고
    • Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
    • Trang P, Wiggins JF, Daige CL, et al. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther 2011;19:1116-22.
    • (2011) Mol Ther , vol.19 , pp. 1116-1122
    • Trang, P.1    Wiggins, J.F.2    Daige, C.L.3
  • 51
    • 25444482607 scopus 로고    scopus 로고
    • Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
    • Hu-Lieskovan S, Heidel JD, Bartlett DW, Davis ME, Triche TJ. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 2005;65:8984-92.
    • (2005) Cancer Res , vol.65 , pp. 8984-8992
    • Hu-Lieskovan, S.1    Heidel, J.D.2    Bartlett, D.W.3    Davis, M.E.4    Triche, T.J.5
  • 52
    • 57149086661 scopus 로고    scopus 로고
    • Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression
    • Aleku M, Schulz P, Keil O, et al. Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3, inhibits cancer progression. Cancer Res 2008;68:9788-98.
    • (2008) Cancer Res , vol.68 , pp. 9788-9798
    • Aleku, M.1    Schulz, P.2    Keil, O.3
  • 53
    • 77956269093 scopus 로고    scopus 로고
    • Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy
    • Chen Y, Zhu X, Zhang X, Liu B, Huang L. Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther 2010;18:1650-6.
    • (2010) Mol Ther , vol.18 , pp. 1650-1656
    • Chen, Y.1    Zhu, X.2    Zhang, X.3    Liu, B.4    Huang, L.5
  • 55
    • 70249110439 scopus 로고    scopus 로고
    • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
    • Dassie JP, Liu X-Y, Thomas GS, et al. Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol 2009;27:839-49.
    • (2009) Nat Biotechnol , vol.27 , pp. 839-849
    • Dassie, J.P.1    Liu, X-Y.2    Thomas, G.S.3
  • 56
    • 70349971417 scopus 로고    scopus 로고
    • In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
    • Kortylewski M, Swiderski P, Herrmann A, et al. In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol 2009;27:925-32.
    • (2009) Nat Biotechnol , vol.27 , pp. 925-932
    • Kortylewski, M.1    Swiderski, P.2    Herrmann, A.3
  • 57
    • 38849166053 scopus 로고    scopus 로고
    • Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
    • Peer D, Park EJ, Morishita Y, Carman CV, Shimaoka M. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science 2008;319:627-30.
    • (2008) Science , vol.319 , pp. 627-630
    • Peer, D.1    Park, E.J.2    Morishita, Y.3    Carman, C.V.4    Shimaoka, M.5
  • 58
    • 33746863376 scopus 로고    scopus 로고
    • Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma
    • Kim WJ, Christensen LV, Jo S, et al. Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma. Mol Ther 2006;14:343-50.
    • (2006) Mol Ther , vol.14 , pp. 343-350
    • Kim, W.J.1    Christensen, L.V.2    Jo, S.3
  • 59
    • 35148815670 scopus 로고    scopus 로고
    • Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
    • Wolfrum C, Shi S, Jayaprakash KN, et al. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat Biotechnol 2007;25:1149-57.
    • (2007) Nat Biotechnol , vol.25 , pp. 1149-1157
    • Wolfrum, C.1    Shi, S.2    Jayaprakash, K.N.3
  • 60
    • 58249094519 scopus 로고    scopus 로고
    • Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene
    • Wu Y, Navarro F, Lal A, et al. Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe 2009;5:84-94.
    • (2009) Cell Host Microbe , vol.5 , pp. 84-94
    • Wu, Y.1    Navarro, F.2    Lal, A.3
  • 61
    • 69249215187 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse
    • Takanashi M, Oikawa K, Sudo K, et al. Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse. Gene Ther 2009;16:982-9.
    • (2009) Gene Ther , vol.16 , pp. 982-989
    • Takanashi, M.1    Oikawa, K.2    Sudo, K.3
  • 62
    • 77952675911 scopus 로고    scopus 로고
    • Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery
    • Chen Q, Butler D, Querbes W, et al. Lipophilic siRNAs mediate efficient gene silencing in oligodendrocytes with direct CNS delivery. J Controlled Release 2010;144:227-32.
    • (2010) J Controlled Release , vol.144 , pp. 227-232
    • Chen, Q.1    Butler, D.2    Querbes, W.3
  • 63
    • 84870570270 scopus 로고    scopus 로고
    • Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo
    • Wong SC, Klein JJ, Hamilton HL, et al. Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo. Nucleic Acid Ther 2012;22:380-90.
    • (2012) Nucleic Acid Ther , vol.22 , pp. 380-390
    • Wong, S.C.1    Klein, J.J.2    Hamilton, H.L.3
  • 64
    • 84862993281 scopus 로고    scopus 로고
    • Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma
    • Babar IA, Cheng CJ, Booth CJ, et al. Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci USA 2012;109:E1695-704.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Babar, I.A.1    Cheng, C.J.2    Booth, C.J.3
  • 65
    • 33747031960 scopus 로고    scopus 로고
    • Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
    • McNamara JO, Andrechek ER, Wang Y, et al. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol 2006;24:1005-15.
    • (2006) Nat Biotechnol , vol.24 , pp. 1005-1015
    • McNamara, J.O.1    Andrechek, E.R.2    Wang, Y.3
  • 66
    • 78751667739 scopus 로고    scopus 로고
    • An Aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4{Thorn} T cell decline in humanized mice
    • Neff CP, Zhou J, Remling L, et al. An Aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4{Thorn} T cell decline in humanized mice. Sci Trans Med 2011;3:1-20.
    • (2011) Sci Trans Med , vol.3 , pp. 1-20
    • Neff, C.P.1    Zhou, J.2    Remling, L.3
  • 68
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • Song E, Zhu P, Lee S-K, et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol 2005;23:709-17.
    • (2005) Nat Biotechnol , vol.23 , pp. 709-717
    • Song, E.1    Zhu, P.2    Lee, S-K.3
  • 69
    • 82855165061 scopus 로고    scopus 로고
    • EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma
    • Gao J, Yu Y, Zhang Y, et al. EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma. Biomaterials 2012;33:270-82.
    • (2012) Biomaterials , vol.33 , pp. 270-282
    • Gao, J.1    Yu, Y.2    Zhang, Y.3
  • 70
    • 34248679586 scopus 로고    scopus 로고
    • shRNA and siRNA delivery to the brain
    • Pardridge WM. shRNA and siRNA delivery to the brain. Adv Drug Del Rev 2007;59:141-52.
    • (2007) Adv Drug Del Rev , vol.59 , pp. 141-152
    • Pardridge, W.M.1
  • 71
    • 0026651984 scopus 로고
    • Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides
    • Citro G, Perrotti D, Cucco C, et al. Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides. Proc Natl Acad Sci USA 1992;89:7031-5.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7031-7035
    • Citro, G.1    Perrotti, D.2    Cucco, C.3
  • 72
    • 30644473108 scopus 로고    scopus 로고
    • Antibody-directed cell-type-specific delivery of siRNA
    • Vornlocher H-P. Antibody-directed cell-type-specific delivery of siRNA. Trends Mol Med 2006;12:1-3.
    • (2006) Trends Mol Med , vol.12 , pp. 1-3
    • Vornlocher, H-P.1
  • 73
  • 74
    • 84865682650 scopus 로고    scopus 로고
    • Single-stranded sirnas activate RNAi in animals
    • Lima Walt F, Prakash Thazha P, Murray Heather M, et al. Single-stranded sirnas activate RNAi in animals. Cell 2012;150:883-94.
    • (2012) Cell , vol.150 , pp. 883-894
    • Lima Walt, F.1    Prakash Thazha, P.2    Murray Heather, M.3
  • 75
    • 33644620908 scopus 로고    scopus 로고
    • Chemical modification of siRNAs to improve serum stability without loss of efficacy
    • Choung S, Kim YJ, Kim S, Park H-O, Choi Y-C. Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem Biophys Res Commun 2006;342:919-27.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 919-927
    • Choung, S.1    Kim, Y.J.2    Kim, S.3    Park, H-O.4    Choi, Y-C.5
  • 76
    • 84856431819 scopus 로고    scopus 로고
    • RNA therapeutics: beyond RNA interference and antisense oligonucleotides
    • Kole R, Krainer AR, Altman S. RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nat Rev Drug Discov 2012;11:125-40.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 125-140
    • Kole, R.1    Krainer, A.R.2    Altman, S.3
  • 77
    • 84865688581 scopus 로고    scopus 로고
    • Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression
    • Yu D, Pendergraff H, Liu J, et al. Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell 2012;150:895-908.
    • (2012) Cell , vol.150 , pp. 895-908
    • Yu, D.1    Pendergraff, H.2    Liu, J.3
  • 78
    • 0038385504 scopus 로고    scopus 로고
    • RNA interference in mammalian cells by chemically-modified RNA
    • Braasch DA, Jensen S, Liu Y, et al. RNA interference in mammalian cells by chemically-modified RNA. Biochemistry 2003;42:7967-75.
    • (2003) Biochemistry , vol.42 , pp. 7967-7975
    • Braasch, D.A.1    Jensen, S.2    Liu, Y.3
  • 79
    • 0032579375 scopus 로고    scopus 로고
    • Identification and partial purification of human double strand
    • Wu H, Macleod AR, Lima WF, Crooke ST. Identification and partial purification of human double strand. J Bio Chem 1998;273:2532-42.
    • (1998) J Bio Chem , vol.273 , pp. 2532-2542
    • Wu, H.1    Macleod, A.R.2    Lima, W.F.3    Crooke, S.T.4
  • 80
    • 77949512140 scopus 로고    scopus 로고
    • RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
    • Bennett CF, Swayze EE. RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol 2010;50:259-93.
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 259-293
    • Bennett, C.F.1    Swayze, E.E.2
  • 81
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004;101:2999-3004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3
  • 82
    • 56949096813 scopus 로고    scopus 로고
    • Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications
    • Rossi S, Sevignani C, Nnadi SC, Siracusa LD, Calin GA. Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications. Mamm Genome 2008;19:526-40.
    • (2008) Mamm Genome , vol.19 , pp. 526-540
    • Rossi, S.1    Sevignani, C.2    Nnadi, S.C.3    Siracusa, L.D.4    Calin, G.A.5
  • 83
    • 34249945067 scopus 로고    scopus 로고
    • MicroRNA genes are frequently located near mouse cancer susceptibility loci
    • Sevignani C, Calin GA, Nnadi SC, et al. MicroRNA genes are frequently located near mouse cancer susceptibility loci. Proc Natl Acad Sci USA 2007;104:8017-22.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8017-8022
    • Sevignani, C.1    Calin, G.A.2    Nnadi, S.C.3
  • 84
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • Saito Y, Liang G, Egger G, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006;9:435-43.
    • (2006) Cancer Cell , vol.9 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3
  • 85
    • 79955942571 scopus 로고    scopus 로고
    • Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma
    • Chen X, Wang J, Shen H, et al. Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma. Invest Ophthalmol Vis Sci 2011;52:1193-9.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 1193-1199
    • Chen, X.1    Wang, J.2    Shen, H.3
  • 86
    • 80051785482 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer
    • Tsai K-W, Wu C-W, Hu L-Y, et al. Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer. Int J Cancer 2011;129:2600-10.
    • (2011) Int J Cancer , vol.129 , pp. 2600-2610
    • Tsai, K-W.1    Wu, C-W.2    Hu, L-Y.3
  • 87
    • 33847763576 scopus 로고    scopus 로고
    • Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
    • Lujambio A, Ropero S, Ballestar E, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007;67:1424-9.
    • (2007) Cancer Res , vol.67 , pp. 1424-1429
    • Lujambio, A.1    Ropero, S.2    Ballestar, E.3
  • 88
    • 33745168962 scopus 로고    scopus 로고
    • microRNAs exhibit high frequency genomic alterations in human cancer
    • Zhang L, Huang J, Yang N, et al. microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci USA 2006;103:9136-41.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9136-9141
    • Zhang, L.1    Huang, J.2    Yang, N.3
  • 89
    • 61349127117 scopus 로고    scopus 로고
    • A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
    • Melo SA, Ropero S, Moutinho C, et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet 2009;41:365-70.
    • (2009) Nat Genet , vol.41 , pp. 365-370
    • Melo, S.A.1    Ropero, S.2    Moutinho, C.3
  • 90
    • 40749090479 scopus 로고    scopus 로고
    • Widespread deregulation of microRNA expression in human prostate cancer
    • Ozen M, Creighton CJ, Ozdemir M, Ittmann M. Widespread deregulation of microRNA expression in human prostate cancer. Oncogene 2008;27:1788-93.
    • (2008) Oncogene , vol.27 , pp. 1788-1793
    • Ozen, M.1    Creighton, C.J.2    Ozdemir, M.3    Ittmann, M.4
  • 91
    • 39149134593 scopus 로고    scopus 로고
    • Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
    • Marton S, Garcia MR, Robello C, et al. Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. Leukemia 2008;22:330-8.
    • (2008) Leukemia , vol.22 , pp. 330-338
    • Marton, S.1    Garcia, M.R.2    Robello, C.3
  • 93
    • 17344376224 scopus 로고    scopus 로고
    • The conformations of locked nucleic acids (LNA)
    • Petersen M, Nielsen CB, Nielsen KE, et al. The conformations of locked nucleic acids (LNA). J Mol Recognit 2000;13:44-53.
    • (2000) J Mol Recognit , vol.13 , pp. 44-53
    • Petersen, M.1    Nielsen, C.B.2    Nielsen, K.E.3
  • 94
    • 42249093319 scopus 로고    scopus 로고
    • LNA-mediated microRNA silencing in non-human primates
    • Elmén J, Lindow M, Schütz S, et al. LNA-mediated microRNA silencing in non-human primates. Nature 2008;452:896-9.
    • (2008) Nature , vol.452 , pp. 896-899
    • Elmén, J.1    Lindow, M.2    Schütz, S.3
  • 95
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • Lanford RE, Hildebrandt-Eriksen ES, Petri A, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010;327:198-201.
    • (2010) Science , vol.327 , pp. 198-201
    • Lanford, R.E.1    Hildebrandt-Eriksen, E.S.2    Petri, A.3
  • 97
    • 64549109671 scopus 로고    scopus 로고
    • Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells
    • Haraguchi T, Ozaki Y, Iba H. Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res 2009;37:e43.
    • (2009) Nucleic Acids Res , vol.37
    • Haraguchi, T.1    Ozaki, Y.2    Iba, H.3
  • 98
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krützfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005;438:685-9.
    • (2005) Nature , vol.438 , pp. 685-689
    • Krützfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 99
    • 82455186405 scopus 로고    scopus 로고
    • miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs
    • Fabbri E, Brognara E, Borgatti M, et al. miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs. Epigenomics 2011;3:733-45.
    • (2011) Epigenomics , vol.3 , pp. 733-745
    • Fabbri, E.1    Brognara, E.2    Borgatti, M.3
  • 100
    • 33645135862 scopus 로고    scopus 로고
    • Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?
    • Weiler J, Hunziker J, Hall J. Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther 2006;13:496-502.
    • (2006) Gene Ther , vol.13 , pp. 496-502
    • Weiler, J.1    Hunziker, J.2    Hall, J.3
  • 102
    • 78650858038 scopus 로고    scopus 로고
    • miR-301a as an NF-kB activator in pancreatic cancer cells
    • Lu Z, Li Y, Takwi A, et al. miR-301a as an NF-kB activator in pancreatic cancer cells. EMBO J. 2011;30:57-67.
    • (2011) EMBO J. , vol.30 , pp. 57-67
    • Lu, Z.1    Li, Y.2    Takwi, A.3
  • 103
    • 84859439441 scopus 로고    scopus 로고
    • Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a
    • Sakurai F, Furukawa N, Higuchi M, et al. Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a. Virus Res 2012;165:214-8.
    • (2012) Virus Res , vol.165 , pp. 214-218
    • Sakurai, F.1    Furukawa, N.2    Higuchi, M.3
  • 104
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji Q, Hao X, Zhang M, et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PloS One 2009;4:e6816.
    • (2009) PloS One , vol.4
    • Ji, Q.1    Hao, X.2    Zhang, M.3
  • 105
    • 77955022405 scopus 로고    scopus 로고
    • Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34
    • Wiggins JF, Ruffino L, Kelnar K, et al. Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res 2010;70:5923-30.
    • (2010) Cancer Res , vol.70 , pp. 5923-5930
    • Wiggins, J.F.1    Ruffino, L.2    Kelnar, K.3
  • 106
    • 34848868157 scopus 로고    scopus 로고
    • Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
    • Hiroshi Tazawa NT, Izumiya M, Nakagama H. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA 2007;104:15472.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15472
    • Hiroshi Tazawa, N.T.1    Izumiya, M.2    Nakagama, H.3
  • 107
    • 49749126791 scopus 로고    scopus 로고
    • Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer
    • Lodygin D, Tarasov V, Epanchintsev A, et al. Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 2008;7:2591-600.
    • (2008) Cell Cycle , vol.7 , pp. 2591-2600
    • Lodygin, D.1    Tarasov, V.2    Epanchintsev, A.3
  • 108
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002;99:15524-9.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 109
    • 42049103216 scopus 로고    scopus 로고
    • The let-7 microRNA reduces tumor growth in mouse models of lung cancer
    • Esquela-Kerscher A, Trang P, Wiggins JF, et al. The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 2008;7:759-64.
    • (2008) Cell Cycle , vol.7 , pp. 759-764
    • Esquela-Kerscher, A.1    Trang, P.2    Wiggins, J.F.3
  • 110
    • 79959847017 scopus 로고    scopus 로고
    • Dysregulation of microRNAs in cancer: playing with fire
    • Melo SA, Esteller M. Dysregulation of microRNAs in cancer: playing with fire. FEBS Lett 2011;585:2087-99.
    • (2011) FEBS Lett , vol.585 , pp. 2087-2099
    • Melo, S.A.1    Esteller, M.2
  • 111
    • 79955509397 scopus 로고    scopus 로고
    • miR-22 represses cancer progression by inducing cellular senescence
    • Xu D, Takeshita F, Hino Y, et al. miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol 2011;193: 409-24.
    • (2011) J Cell Biol , vol.193 , pp. 409-424
    • Xu, D.1    Takeshita, F.2    Hino, Y.3
  • 112
    • 79957902973 scopus 로고    scopus 로고
    • MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression
    • Osaki M, Takeshita F, Sugimoto Y, et al. MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. Mol Ther 2011;19:1123-30.
    • (2011) Mol Ther , vol.19 , pp. 1123-1130
    • Osaki, M.1    Takeshita, F.2    Sugimoto, Y.3
  • 113
    • 20044396377 scopus 로고    scopus 로고
    • Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication
    • Morrissey DV, Blanchard K, Shaw L, et al. Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication. Hepatology 2005;41:1349-56.
    • (2005) Hepatology , vol.41 , pp. 1349-1356
    • Morrissey, D.V.1    Blanchard, K.2    Shaw, L.3
  • 114
    • 34548735210 scopus 로고    scopus 로고
    • Dynamic polyconjugates for targeted in vivo delivery of siRNA to hepatocytes
    • Rozema DB, Lewis DL, Wakefield DH, et al. Dynamic polyconjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc Natl Acad Sci USA 2007;104:12982-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12982-12987
    • Rozema, D.B.1    Lewis, D.L.2    Wakefield, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.