Identification and partial purification of human double strand RNase activity. A novel terminating mechanism for oligoribonucleotide antisense drugs

Journal of Biological Chemistry

Volumn 273, Issue 5, 1998, Pages 2532-2542

  Wu, Hongjiang ^a   MacLeod, A Robert ^a,b   Lima, Walt F ^a   Crooke, Stanley T ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b METHYLGENE INC   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; DOUBLE STRANDED RNA; PROTEINASE; RIBONUCLEASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL FREE SYSTEM; CYTOTOXICITY; DNA REPLICATION; DNA RNA HYBRIDIZATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME PURIFICATION; GENETIC REGULATION; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL;

ANIMALS; CELL NUCLEUS; CYTOSOL; ENDORIBONUCLEASES; ESCHERICHIA COLI PROTEINS; GENES, RAS; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; RATS; RIBONUCLEASE III; RNA, DOUBLE-STRANDED; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

EID: 0032579375     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.5.2532     Document Type: Article

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