Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo

Nucleic Acid Therapeutics

Volumn 22, Issue 6, 2012, Pages 399-404

  Wong, So C ^a   Klein, Jason J ^a   Hamilton, Holly L ^a   Chu, Qili ^a   Frey, Christina L ^a   Trubetskoy, Vladimir S ^a   Hegge, Julia ^a   Wakefield, Darren ^a   Rozema, David B ^a   Lewis, David L ^a  

^a Arrowhead Research Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; BLOOD CLOTTING FACTOR 7; CHOLESTEROL CONJUGATED SMALL INTERFERING RNA; LIGAND; LOW DENSITY LIPOPROTEIN RECEPTOR; MACROGOL; N ACETYLGALACTOSAMINE; POLYMER; POLYMER COMPOSED OF BUTYL AND AMINO VINYL ETHER; SMALL INTERFERING RNA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ASIALOGLYCOPROTEIN RECEPTOR; CHOLESTEROL; DRUG DERIVATIVE; LIPID; POLYVINYL DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; ENDOCYTOSIS; ENDOSOME; FEMALE; GENE EXPRESSION; GENE SILENCING; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; CYTOLOGY; DRUG EFFECT; GENE TRANSFER; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; METABOLISM; MOUSE MUTANT; RHESUS MONKEY; RNA INTERFERENCE;

MUS; PRIMATES;

ACETYLGALACTOSAMINE; ANIMALS; APOLIPOPROTEINS B; ASIALOGLYCOPROTEIN RECEPTOR; CHOLESTEROL; ENDOSOMES; FACTOR VII; FEMALE; GENE KNOCKDOWN TECHNIQUES; GENE TRANSFER TECHNIQUES; HEPATOCYTES; LIPIDS; LIVER; MACACA MULATTA; MALE; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; POLYVINYLS; RECEPTORS, LDL; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84870570270     PISSN: 21593337     EISSN: None     Source Type: Journal    
DOI: 10.1089/nat.2012.0389     Document Type: Article

References (18)

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