Durable Protection from Herpes Simplex Virus-2 Transmission Following Intravaginal Application of siRNAs Targeting Both a Viral and Host Gene

Cell Host and Microbe

Volumn 5, Issue 1, 2009, Pages 84-94

  Wu, Yichao ^a   Navarro, Francisco ^a   Lal, Ashish ^a   Basar, Emre ^a   Pandey, Rajendra K ^b   Manoharan, Muthiah ^b   Feng, Yang ^c   Lee, Sandra J ^c   Lieberman, Judy ^a   Palliser, Deborah ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ALNYLAM PHARMACEUTICALS   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

MICROBIO; RNA

Indexed keywords

CHOLESTEROL; NECTIN 1; RNA; SMALL INTERFERING RNA; VIRUS RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; FEMALE; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HOST; MICROSCOPY; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TISSUE SECTION; VAGINA; VIRUS GENE; VIRUS TRANSMISSION;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIVIRAL AGENTS; CELL ADHESION MOLECULES; DISEASE TRANSMISSION, INFECTIOUS; FEMALE; GENE SILENCING; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; MICE; MICE, INBRED BALB C; RNA, SMALL INTERFERING; SURVIVAL ANALYSIS; VAGINA;

HUMAN HERPESVIRUS 2; MUS;

EID: 58249094519     PISSN: 19313128     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chom.2008.12.003     Document Type: Article

References (35)

1. Bitko V., Musiyenko A., Shulyayeva O., and Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat. Med. 11 (2005) 50-55
2. Choung S., Kim Y.J., Kim S., Park H.O., and Choi Y.C. Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem. Biophys. Res. Commun. 342 (2006) 919-927
3. Cocchi F., Menotti L., Mirandola P., Lopez M., and Campadelli-Fiume G. The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells. J. Virol. 72 (1998) 9992-10002
4. Corey L., Wald A., Celum C.L., and Quinn T.C. The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics. J. Acquir. Immune Defic. Syndr. 35 (2004) 435-445
5. Fan Z., Beresford P.J., Oh D.Y., Zhang D., and Lieberman J. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 112 (2003) 659-672
6. Galen B., Cheshenko N., Tuyama A., Ramratnam B., and Herold B.C. Access to nectin favors herpes simplex virus infection at the apical surface of polarized human epithelial cells. J. Virol. 80 (2006) 12209-12218
7. Gao M., and Knipe D.M. Genetic evidence for multiple nuclear functions of the herpes simplex virus ICP8 DNA-binding protein. J. Virol. 63 (1989) 5258-5267
8. Geraghty R.J., Krummenacher C., Cohen G.H., Eisenberg R.J., and Spear P.G. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280 (1998) 1618-1620
9. Jones C.A., Taylor T.J., and Knipe D.M. Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model. Virology 278 (2000) 137-150
10. Kaplan E., and Meier P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53 (1958) 457-481
11. Kleinman M.E., Yamada K., Takeda A., Chandrasekaran V., Nozaki M., Baffi J.Z., Albuquerque R.J., Yamasaki S., Itaya M., Pan Y., et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452 (2008) 591-597
12. Krummenacher C., Nicola A.V., Whitbeck J.C., Lou H., Hou W., Lambris J.D., Geraghty R.J., Spear P.G., Cohen G.H., and Eisenberg R.J. Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry. J. Virol. 72 (1998) 7064-7074
13. Linehan M.M., Richman S., Krummenacher C., Eisenberg R.J., Cohen G.H., and Iwasaki A. In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa. J. Virol. 78 (2004) 2530-2536
14. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother. Rep. 50 (1966) 163-170
15. Montgomery R.I., Warner M.S., Lum B.J., and Spear P.G. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87 (1996) 427-436
16. Morrison L.A., Da Costa X.J., and Knipe D.M. Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital challenge. Virology 243 (1998) 178-187
17. Novina C.D., Murray M.F., Dykxhoorn D.M., Beresford P.J., Riess J., Lee S.K., Collman R.G., Lieberman J., Shankar P., and Sharp P.A. siRNA-directed inhibition of HIV-1 infection. Nat. Med. 8 (2002) 681-686
18. Palliser D., Chowdhury D., Wang Q.Y., Lee S.J., Bronson R.T., Knipe D.M., and Lieberman J. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 439 (2006) 89-94
19. Parr M.B., Kepple L., McDermott M.R., Drew M.D., Bozzola J.J., and Parr E.L. A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2. Lab. Invest. 70 (1994) 369-380
20. Plasterk R.H. RNA silencing: the genome's immune system. Science 296 (2002) 1263-1265
21. Robbins M., Judge A., Ambegia E., Choi C., Yaworski E., Palmer L., McClintock K., and Maclachlan I. Misinterpreting the therapeutic effects of siRNA caused by immune stimulation. Hum. Gene Ther. (2008) 10.1089/hum.2008.131 in press. Published online August 19, 2008
22. Schlee M., Hornung V., and Hartmann G. siRNA and isRNA: two edges of one sword. Mol. Ther. 14 (2006) 463-470
23. Serwadda D., Gray R.H., Sewankambo N.K., Wabwire-Mangen F., Chen M.Z., Quinn T.C., Lutalo T., Kiwanuka N., Kigozi G., Nalugoda F., et al. Human immunodeficiency virus acquisition associated with genital ulcer disease and herpes simplex virus type 2 infection: a nested case-control study in Rakai, Uganda. J. Infect. Dis. 188 (2003) 1492-1497
24. Shukla D., Dal Canto M.C., Rowe C.L., and Spear P.G. Striking similarity of murine nectin-1alpha to human nectin-1alpha (HveC) in sequence and activity as a glycoprotein D receptor for alphaherpesvirus entry. J. Virol. 74 (2000) 11773-11781
25. Song E., Lee S.K., Dykxhoorn D.M., Novina C., Zhang D., Crawford K., Cerny J., Sharp P.A., Lieberman J., Manjunath N., et al. Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J. Virol. 77 (2003) 7174-7181
26. Soutschek J., Akinc A., Bramlage B., Charisse K., Constien R., Donoghue M., Elbashir S., Geick A., Hadwiger P., Harborth J., et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432 (2004) 173-178
27. Spang A.E., Godowski P.J., and Knipe D.M. Characterization of herpes simplex virus 2 temperature-sensitive mutants whose lesions map in or near the coding sequences for the major DNA-binding protein. J. Virol. 45 (1983) 332-342
28. Suzuki K., Hu D., Bustos T., Zlotogora J., Richieri-Costa A., Helms J.A., and Spritz R.A. Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia. Nat. Genet. 25 (2000) 427-430
29. Taylor J.M., Lin E., Susmarski N., Yoon M., Zago A., Ware C.F., Pfeffer K., Miyoshi J., Takai Y., and Spear P.G. Alternative entry receptors for herpes simplex virus and their roles in disease. Cell Host Microbe 2 (2007) 19-28
30. Wald A. Herpes simplex virus type 2 transmission: risk factors and virus shedding. Herpes 11 Suppl 3 (2004) 130A-137A
31. Wald A., and Link K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J. Infect. Dis. 185 (2002) 45-52
32. Whitley R.J. Field's Virology. In: Knipe D.M., and Howley P.M. (Eds) (2001), Lippincott, Williams and Wilkins, Philadelphia 2461-2510
33. Zhang Y., Cristofaro P., Silbermann R., Pusch O., Boden D., Konkin T., Hovanesian V., Monfils P.R., Resnick M., Moss S.F., et al. Engineering mucosal RNA interference in vivo. Mol. Ther. 14 (2006) 336-342
34. Zhao X., Deak E., Soderberg K., Linehan M., Spezzano D., Zhu J., Knipe D.M., and Iwasaki A. Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J. Exp. Med. 197 (2003) 153-162
35. Zimmermann T.S., Lee A.C., Akinc A., Bramlage B., Bumcrot D., Fedoruk M.N., Harborth J., Heyes J.A., Jeffs L.B., John M., et al. RNAi-mediated gene silencing in non-human primates. Nature 441 (2006) 111-114