메뉴 건너뛰기




Volumn 17, Issue 7, 2006, Pages 751-766

RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; ALPHA INTERFERON; MESSENGER RNA; PLEIOTROPHIN; POLYETHYLENEIMINE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 33746267422     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2006.17.751     Document Type: Article
Times cited : (219)

References (56)
  • 2
    • 33646190173 scopus 로고    scopus 로고
    • Gene silencing through RNA interference (RNAi) in vivo: Strategies based on the direct application of siRNAs
    • AIGNER, A. (2006). Gene silencing through RNA interference (RNAi) in vivo: Strategies based on the direct application of siRNAs. J. Biotechnol. 124, 12-25.
    • (2006) J. Biotechnol. , vol.124 , pp. 12-25
    • Aigner, A.1
  • 3
    • 0036953454 scopus 로고    scopus 로고
    • Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression
    • AIGNER, A., FISCHER, D., MERDAN, T., BRUS, C., KISSEL, T., and CZUBAYKO, F. (2002a). Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression. Gene Ther. 9, 1700-1707.
    • (2002) Gene Ther. , vol.9 , pp. 1700-1707
    • Aigner, A.1    Fischer, D.2    Merdan, T.3    Brus, C.4    Kissel, T.5    Czubayko, F.6
  • 4
    • 0036244546 scopus 로고    scopus 로고
    • Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development
    • AIGNER, A., RAY, P.E., CZUBAYKO, F., and WELLSTEIN, A. (2002b). Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development. Histochem. Cell Biol. 117, 1-11.
    • (2002) Histochem. Cell Biol. , vol.117 , pp. 1-11
    • Aigner, A.1    Ray, P.E.2    Czubayko, F.3    Wellstein, A.4
  • 6
    • 20444370291 scopus 로고    scopus 로고
    • Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy
    • ANABOUSI, S., LAUE, M., LEHR, C.M., BAKOWSKY, U., and EHRHARDT, C. (2005). Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy. Eur. J. Pharm. Biopharm. 60, 295-303.
    • (2005) Eur. J. Pharm. Biopharm. , vol.60 , pp. 295-303
    • Anabousi, S.1    Laue, M.2    Lehr, C.M.3    Bakowsky, U.4    Ehrhardt, C.5
  • 7
    • 78650476432 scopus 로고    scopus 로고
    • The proton sponge: A trick to enter cells the viruses did not exploit
    • BEHR, J.P. (1997). The proton sponge: A trick to enter cells the viruses did not exploit. Chimia 51, 34-36.
    • (1997) Chimia , vol.51 , pp. 34-36
    • Behr, J.P.1
  • 9
    • 0037184080 scopus 로고    scopus 로고
    • Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase
    • BOWDEN, E.T., STOICA, G.E., and WELLSTEIN, A. (2002). Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase. J. Biol. Chem. 277, 35862-35868.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35862-35868
    • Bowden, E.T.1    Stoica, G.E.2    Wellstein, A.3
  • 10
    • 0141925943 scopus 로고    scopus 로고
    • Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4
    • BROCKMANN, M.A., PAPADIMITRIOU, A., BRANDT, M., FILLBRANDT, R., WESTPHAL, M., and LAMSZUS, K. (2003a). Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4. Clin. Cancer Res. 9, 4578-4585.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4578-4585
    • Brockmann, M.A.1    Papadimitriou, A.2    Brandt, M.3    Fillbrandt, R.4    Westphal, M.5    Lamszus, K.6
  • 11
    • 0141675083 scopus 로고    scopus 로고
    • Improved method for the intracerebral engraftment of tumour cells and intratumoural treatment using a guide screw system in mice
    • discussion 781
    • BROCKMANN, M.A., WESTPHAL, M., and LAMSZUS, K. (2003b). Improved method for the intracerebral engraftment of tumour cells and intratumoural treatment using a guide screw system in mice. Acta Neurochir. (Wien) 145, 777-781; discussion 781.
    • (2003) Acta Neurochir. (Wien) , vol.145 , pp. 777-781
    • Brockmann, M.A.1    Westphal, M.2    Lamszus, K.3
  • 12
    • 0030904197 scopus 로고    scopus 로고
    • An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis
    • CHOUDHURI, R., ZHANG, H.T., DONNINI, S., ZICHE, M., and BICKNELL, R. (1997). An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis. Cancer Res. 57, 1814-1819.
    • (1997) Cancer Res. , vol.57 , pp. 1814-1819
    • Choudhuri, R.1    Zhang, H.T.2    Donnini, S.3    Ziche, M.4    Bicknell, R.5
  • 15
    • 0029855988 scopus 로고    scopus 로고
    • Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin
    • CZUBAYKO, F., SCHULTE, A.M., BERCHEM, G.J., and WELLSTEIN, A. (1996). Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin. Proc. Natl. Acad. Sci. U.S.A. 93, 14753-14758.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 14753-14758
    • Czubayko, F.1    Schulte, A.M.2    Berchem, G.J.3    Wellstein, A.4
  • 16
    • 0035404677 scopus 로고    scopus 로고
    • Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups
    • DAVIS, F.G., KUPELIAN, V., FREELS, S., MCCARTHY, B., and SURAWICZ, T. (2001). Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. J. Neurooncol. 3, 152-158.
    • (2001) J. Neurooncol. , vol.3 , pp. 152-158
    • Davis, F.G.1    Kupelian, V.2    Freels, S.3    McCarthy, B.4    Surawicz, T.5
  • 17
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • ELBASHIR, S.M., HARBORTH, J., LENDECKEL, W., YALCIN, A., WEBER, K., and TUSCHL, T. (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 18
    • 0027076643 scopus 로고
    • Pleiotrophin stimulates fibroblasts, endothelial and epithelial cells, and is expressed in human cancer
    • FANG, W.J., HARTMANN, N., CHOW, D., RIEGEL, A.T., and WELLSTEIN, A. (1992). Pleiotrophin stimulates fibroblasts, endothelial and epithelial cells, and is expressed in human cancer. J. Biol. Chem. 267, 25889-25897.
    • (1992) J. Biol. Chem. , vol.267 , pp. 25889-25897
    • Fang, W.J.1    Hartmann, N.2    Chow, D.3    Riegel, A.T.4    Wellstein, A.5
  • 19
    • 4143087473 scopus 로고    scopus 로고
    • Effect of polyethylene imine molecular weight and pegylation on organ distribution and pharmacokinetics of polyplexes with oligodeoxynucleotides in mice
    • FISCHER, D., OSBURG, B., PETERSEN, H., KISSEL, T., and BICKEL, U. (2004). Effect of polyethylene imine) molecular weight and pegylation on organ distribution and pharmacokinetics of polyplexes with oligodeoxynucleotides in mice. Drug Metab. Dispos. 32, 983-992.
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 983-992
    • Fischer, D.1    Osburg, B.2    Petersen, H.3    Kissel, T.4    Bickel, U.5
  • 20
    • 9144231998 scopus 로고    scopus 로고
    • RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas
    • GONDI, C.S., LAKKA, S.S., DINH, D.H., OLIVERO, W.C., GUJRATI, M., and RAO, J.S. (2004). RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas. Oncogene 23, 8486-8496.
    • (2004) Oncogene , vol.23 , pp. 8486-8496
    • Gondi, C.S.1    Lakka, S.S.2    Dinh, D.H.3    Olivero, W.C.4    Gujrati, M.5    Rao, J.S.6
  • 21
    • 0031860769 scopus 로고    scopus 로고
    • Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system
    • GOULA, D., REMY, J.S., ERBACHER, P., WASOWICZ, M., LEVI, G., ABDALLAH, B., and DEMENEIX, B.A. (1998). Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther. 5, 712-717.
    • (1998) Gene Ther. , vol.5 , pp. 712-717
    • Goula, D.1    Remy, J.S.2    Erbacher, P.3    Wasowicz, M.4    Levi, G.5    Abdallah, B.6    Demeneix, B.A.7
  • 22
    • 28044443697 scopus 로고    scopus 로고
    • Ribozyme-targeting reveals the rate-limiting role of pleiotrophin in glioblastoma
    • GRZELINSKI, M., BADER, N., CZUBAYKO, F., and AIGNER, A. (2005). Ribozyme-targeting reveals the rate-limiting role of pleiotrophin in glioblastoma. Int. J. Cancer 117, 942-951.
    • (2005) Int. J. Cancer , vol.117 , pp. 942-951
    • Grzelinski, M.1    Bader, N.2    Czubayko, F.3    Aigner, A.4
  • 23
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • HANNON, G.J., and ROSSI, J.J. (2004). Unlocking the potential of the human genome with RNA interference. Nature 431, 371-378.
    • (2004) Nature , vol.431 , pp. 371-378
    • Hannon, G.J.1    Rossi, J.J.2
  • 24
    • 0034612289 scopus 로고    scopus 로고
    • Glioblastoma multiforme: The terminator
    • HOLLAND, E.C. (2000). Glioblastoma multiforme: The terminator. Proc. Natl. Acad. Sci. U.S.A. 97, 6242-6244.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 6242-6244
    • Holland, E.C.1
  • 26
    • 0348014778 scopus 로고    scopus 로고
    • Unlocking the money-making potential of RNAi
    • HOWARD, K. (2003). Unlocking the money-making potential of RNAi. Nat. Biotechnol. 21, 1441-1446.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 1441-1446
    • Howard, K.1
  • 27
    • 0032005359 scopus 로고    scopus 로고
    • Growth factor-mediated angiogenesis in the malignant progression of glial tumors: A review
    • discussion 196
    • JENSEN, R.L. (1998). Growth factor-mediated angiogenesis in the malignant progression of glial tumors: A review. Surg. Neurol. 49, 189-195; discussion 196.
    • (1998) Surg. Neurol. , vol.49 , pp. 189-195
    • Jensen, R.L.1
  • 28
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • JUDGE, A.D., SOOD, V., SHAW, J.R., FANG, D., MCCLINTOCK, K., and MACLACHLAN, I. (2005). Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23, 457-462.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    Maclachlan, I.6
  • 29
    • 3242807724 scopus 로고    scopus 로고
    • Gene transfer with modified polyethylenimines
    • KICHLER, A. (2004). Gene transfer with modified polyethylenimines. J. Gene Med. 6(Suppl. 1), S3-S10.
    • (2004) J. Gene Med. , vol.6 , Issue.SUPPL. 1
    • Kichler, A.1
  • 30
    • 0029548635 scopus 로고
    • Pleiotrophin and midkine in normal development and tumor biology
    • KURTZ, A., SCHULTE, A.M., and WELLSTEIN, A. (1995). Pleiotrophin and midkine in normal development and tumor biology. Crit. Rev. Oncog. 6, 151-177.
    • (1995) Crit. Rev. Oncog. , vol.6 , pp. 151-177
    • Kurtz, A.1    Schulte, A.M.2    Wellstein, A.3
  • 32
    • 0025615372 scopus 로고
    • Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity
    • LI, Y.S., MILNER, P.G., CHAUHAN, A.K., WATSON, M.A., HOFFMAN, R.M., KODNER, C.M., MILBRANDT, J., and DEUEL, T.F. (1990). Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science 250, 1690-1694.
    • (1990) Science , vol.250 , pp. 1690-1694
    • Li, Y.S.1    Milner, P.G.2    Chauhan, A.K.3    Watson, M.A.4    Hoffman, R.M.5    Kodner, C.M.6    Milbrandt, J.7    Deuel, T.F.8
  • 34
    • 14644395513 scopus 로고    scopus 로고
    • Ribozyme targeting of the growth factor pleiotrophin in established tumors: A gene therapy approach
    • MALERCZYK, C., SCHULTE, A.M., CZUBAYKO, F., BELLON, L., MACEJAK, D., RIEGEL, A.T., and WELLSTEIN, A. (2005). Ribozyme targeting of the growth factor pleiotrophin in established tumors: A gene therapy approach. Gene Ther. 12, 339-346.
    • (2005) Gene Ther. , vol.12 , pp. 339-346
    • Malerczyk, C.1    Schulte, A.M.2    Czubayko, F.3    Bellon, L.4    Macejak, D.5    Riegel, A.T.6    Wellstein, A.7
  • 35
    • 0036846123 scopus 로고    scopus 로고
    • Pleiotrophin, an angiogenic and mitogenic growth factor, is expressed in human gliomas
    • MENTLEIN, R., and HELD-FEINDT, J. (2002). Pleiotrophin, an angiogenic and mitogenic growth factor, is expressed in human gliomas. J. Neurochem. 83, 747-753.
    • (2002) J. Neurochem. , vol.83 , pp. 747-753
    • Mentlein, R.1    Held-Feindt, J.2
  • 36
    • 0024801855 scopus 로고
    • A novel 17 kD heparin-binding growth factor (HBGF-8) in bovine uterus: Purification and N-terminal amino acid sequence
    • MILNER, P.G., LI, Y.S., HOFFMAN, R.M., KODNER, C.M., SIEGEL, N.R., and DEUEL, T.F. (1989). A novel 17 kD heparin-binding growth factor (HBGF-8) in bovine uterus: Purification and N-terminal amino acid sequence. Biochem. Biophys. Res. Commun. 165, 1096-1103.
    • (1989) Biochem. Biophys. Res. Commun. , vol.165 , pp. 1096-1103
    • Milner, P.G.1    Li, Y.S.2    Hoffman, R.M.3    Kodner, C.M.4    Siegel, N.R.5    Deuel, T.F.6
  • 37
    • 22544440004 scopus 로고    scopus 로고
    • Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin
    • MOOG-LUTZ, C., DEGOUTIN, J., GOUZI, J.Y., FROBERT, Y., BRUNET-DE CARVALHO, N., BUREAU, J., CREMINON, C., and VIGNY, M. (2005), Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin. J. Biol. Chem. 280, 26039-26048.
    • (2005) J. Biol. Chem. , vol.280 , pp. 26039-26048
    • Moog-Lutz, C.1    Degoutin, J.2    Gouzi, J.Y.3    Frobert, Y.4    Brunet-De Carvalho, N.5    Bureau, J.6    Creminon, C.7    Vigny, M.8
  • 39
    • 0036739307 scopus 로고    scopus 로고
    • Midkine and pleiotrophin: Two related proteins involved in development, survival, inflammation and tumorigenesis
    • MURAMATSU, T. (2002). Midkine and pleiotrophin: Two related proteins involved in development, survival, inflammation and tumorigenesis. J. Biochem. (Tokyo) 132, 359-371.
    • (2002) J. Biochem. (Tokyo) , vol.132 , pp. 359-371
    • Muramatsu, T.1
  • 40
    • 0033863232 scopus 로고    scopus 로고
    • Lipoplex formation under equilibrium conditions reveals a three-step mechanism
    • OBERLE, V., BAKOWSKY, U., ZUHORN, I.S., and HOEKSTRA, D. (2000). Lipoplex formation under equilibrium conditions reveals a three-step mechanism. Biophys. J. 79, 1447-1454.
    • (2000) Biophys. J. , vol.79 , pp. 1447-1454
    • Oberle, V.1    Bakowsky, U.2    Zuhorn, I.S.3    Hoekstra, D.4
  • 42
    • 0037134490 scopus 로고    scopus 로고
    • Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth
    • POWERS, C., AIGNER, A., STOICA, G.E., MCDONNELL, K., and WELLSTEIN, A. (2002). Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth. J. Biol. Chem. 277, 14153-14158.
    • (2002) J. Biol. Chem. , vol.277 , pp. 14153-14158
    • Powers, C.1    Aigner, A.2    Stoica, G.E.3    Mcdonnell, K.4    Wellstein, A.5
  • 43
    • 0024317792 scopus 로고
    • An 18-kD heparin-binding protein of developing brain that is distinct from fibroblast growth factors
    • RAUVALA, H. (1989). An 18-kD heparin-binding protein of developing brain that is distinct from fibroblast growth factors. EMBO J. 8, 2933-2941.
    • (1989) EMBO J. , vol.8 , pp. 2933-2941
    • Rauvala, H.1
  • 44
    • 0034564273 scopus 로고    scopus 로고
    • An antisense strategy for inhibition of human melanoma growth targets the growth factor pleiotrophin
    • SATYAMOORTHY, K., OKA, M., and HERLYN, M. (2000). An antisense strategy for inhibition of human melanoma growth targets the growth factor pleiotrophin. Pigment Cell Res. 13(Suppl. 8), 87-93.
    • (2000) Pigment Cell Res. , vol.13 , Issue.SUPPL. 8 , pp. 87-93
    • Satyamoorthy, K.1    Oka, M.2    Herlyn, M.3
  • 46
    • 14844303966 scopus 로고    scopus 로고
    • The prospect of silencing disease using RNA interference
    • SHANKAR, P., MANJUNATH, N., and LIEBERMAN, J. (2005). The prospect of silencing disease using RNA interference. JAMA 293, 1367-1373.
    • (2005) JAMA , vol.293 , pp. 1367-1373
    • Shankar, P.1    Manjunath, N.2    Lieberman, J.3
  • 47
    • 18044365415 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
    • SIOUD, M. (2005). Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J. Mol. Biol. 348, 1079-1090.
    • (2005) J. Mol. Biol. , vol.348 , pp. 1079-1090
    • Sioud, M.1
  • 48
    • 33646593191 scopus 로고    scopus 로고
    • RNA interference below the immune radar
    • SIOUD, M. (2006a). RNA interference below the immune radar. Nat. Biotechnol. 24, 521-522.
    • (2006) Nat. Biotechnol. , vol.24 , pp. 521-522
    • Sioud, M.1
  • 49
    • 33646544416 scopus 로고    scopus 로고
    • Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: A central role for 2′-hydroxyl uridines in immune responses
    • SIOUD, M. (2006b). Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: A central role for 2′-hydroxyl uridines in immune responses. Eur. J. Immunol. 36, 1222-1230.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1222-1230
    • Sioud, M.1
  • 51
    • 26944499005 scopus 로고    scopus 로고
    • The therapeutic potential of RNA interference
    • UPRICHARD, S.L. (2005). The therapeutic potential of RNA interference. FEBS Lett. 579, 5996-6007.
    • (2005) FEBS Lett. , vol.579 , pp. 5996-6007
    • Uprichard, S.L.1
  • 52
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • URBAN-KLEIN, B., WERTH, S., ABUHARBEID, S., CZUBAYKO, F., and AIGNER, A. (2005). RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther. 12, 461-466.
    • (2005) Gene Ther. , vol.12 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 53
    • 1842634414 scopus 로고    scopus 로고
    • Targeted nucleic acid delivery into tumors: New avenues for cancer therapy. Biomed
    • WAGNER, E., KIRCHEIS, R., and WALKER, G.F. (2004). Targeted nucleic acid delivery into tumors: New avenues for cancer therapy. Biomed. Pharmacother. 58, 152-161.
    • (2004) Pharmacother. , vol.58 , pp. 152-161
    • Wagner, E.1    Kircheis, R.2    Walker, G.F.3
  • 55
    • 0026808477 scopus 로고
    • A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine
    • WELLSTEIN, A., FANG, W.J., KHATRI, A., LU, Y., SWAIN, S.S., DICKSON, R.B., SASSE, J., RIEGEL, A.T., and LIPPMAN, M.E. (1992). A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine. J. Biol. Chem. 267, 2582-2587.
    • (1992) J. Biol. Chem. , vol.267 , pp. 2582-2587
    • Wellstein, A.1    Fang, W.J.2    Khatri, A.3    Lu, Y.4    Swain, S.S.5    Dickson, R.B.6    Sasse, J.7    Riegel, A.T.8    Lippman, M.E.9
  • 56
    • 0032951527 scopus 로고    scopus 로고
    • Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors
    • ZHANG, N., and DEUEL, T.F. (1999). Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors. Curr. Opin. Hematol. 6, 44-50.
    • (1999) Curr. Opin. Hematol. , vol.6 , pp. 44-50
    • Zhang, N.1    Deuel, T.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.