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Volumn 169, Issue 6, 2013, Pages 1774-1789

RNA interference - A silent but an efficient therapeutic tool

Author keywords

Cancer; Cardiovascular diseases; Diabetes mellitus; Gene silencing; MiRNA; Ocular diseases; RNAi; ShRNA; SiRNA; Therapeutic tool; Viral diseases

Indexed keywords

CANCER; CARDIO-VASCULAR DISEASE; DIABETES MELLITUS; GENE SILENCING; MIRNA; OCULAR DISEASE; RNAI; SHRNA; SIRNA; THERAPEUTIC TOOLS; VIRAL DISEASE;

EID: 84878581041     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-013-0098-1     Document Type: Article
Times cited : (31)

References (143)
  • 1
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense rna in post transcriptional gene silencing in plants
    • Hamilton, A. J., & Baulcombe, D. C. (1999). A species of small antisense RNA in post transcriptional gene silencing in plants. Science, 286, 950-952.
    • (1999) Science , vol.286 , pp. 950-952
    • Hamilton, A.J.1    Baulcombe, D.C.2
  • 2
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded rna directs the atp-dependent cleavage of mrna at 21 to 23 nucleotide intervals
    • Zamore, P. D., Tuschl, T., Sharp, P. A., & Bartel, D. P. (2000). RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell, 101, 25-33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 3
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of rna interference
    • Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001). Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 409, 363-366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 4
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22- nucleotide rnas
    • Elbashir, S. M., Lendeckel, W., & Tuschl, T. (2001). RNA interference is mediated by 21- and 22- nucleotide RNAs. Genes & Development, 15, 188-200.
    • (2001) Genes & Development , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 6
    • 26944497194 scopus 로고    scopus 로고
    • Structural domains in rnai
    • Collins, R., & Cheng, X. (2005). Structural domains in RNAi. FEBS Letters, 579, 5841-5849.
    • (2005) FEBS Letters , vol.579 , pp. 5841-5849
    • Collins, R.1    Cheng, X.2
  • 7
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering rna structure in the rna interference pathway
    • Nykanen, A., Haley, B., & Zamore, P. D. (2001). ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell, 107, 309-321.
    • (2001) Cell , vol.107 , pp. 309-321
    • Nykanen, A.1    Haley, B.2    Zamore, P.D.3
  • 8
    • 0142165224 scopus 로고    scopus 로고
    • Functional sirnas and mirnas exhibit strand bias
    • Khvorova, A., Reynolds, A., & Jayasena, S. D. (2003). Functional siRNAs and miRNAs exhibit strand bias. Cell, 115, 209-216.
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 9
    • 0037123639 scopus 로고    scopus 로고
    • RNA-dependent rna polymerases, viruses and rnasilencing
    • Ahlquist, P. (2002). RNA-dependent RNA polymerases, viruses and RNAsilencing. Science, 296, 1270-1273.
    • (2002) Science , vol.296 , pp. 1270-1273
    • Ahlquist, P.1
  • 10
    • 84856723932 scopus 로고    scopus 로고
    • The n domain of argonaute drives duplex unwinding during risc assembly
    • Kwak, P. B., & Tomari, Y. (2012). The N domain of Argonaute drives duplex unwinding during RISC assembly. Nature Structural and Molecular Biology, 19, 145-152.
    • (2012) Nature Structural and Molecular Biology , vol.19 , pp. 145-152
    • Kwak, P.B.1    Tomari, Y.2
  • 11
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of sirna into ago2-containing rnai enzyme complexes
    • Matranga, C., Tomari, Y., Shin, C., Bartel, D. P., & Zamore, P. D. (2005). Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell, 123, 607-620.
    • (2005) Cell , vol.123 , pp. 607-620
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.P.4    Zamore, P.D.5
  • 12
    • 27744506761 scopus 로고    scopus 로고
    • Argonaute2 cleaves the anti-guide strand of sirna during risc activation
    • Rand, T. A., Petersen, S., Du, F., &Wang, X. (2005). Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell, 123, 621-629.
    • (2005) Cell , vol.123 , pp. 621-629
    • Rand, T.A.1    Petersen, S.2    Du, F.3    Wang, X.4
  • 13
    • 78650306521 scopus 로고    scopus 로고
    • Small rna sorting: Matchmaking for argonautes
    • Czech, B., & Hannon, G. J. (2011). Small RNA sorting: matchmaking for Argonautes. Nature Reviews Genetics, 12, 19-31.
    • (2011) Nature Reviews Genetics , vol.12 , pp. 19-31
    • Czech, B.1    Hannon, G.J.2
  • 14
    • 58449134534 scopus 로고    scopus 로고
    • Small silencing rnas: An expanding universe
    • Ghildiyal, M., & Zamore, P. D. (2009). Small silencing RNAs: an expanding universe. Nature Reviews Genetics, 10, 94-108.
    • (2009) Nature Reviews Genetics , vol.10 , pp. 94-108
    • Ghildiyal, M.1    Zamore, P.D.2
  • 15
    • 0036251639 scopus 로고    scopus 로고
    • Effective expression of small interfering rna in human cells
    • Paul, C. P., Good, P. D., Winer, I., & Engelke, D. R. (2002). Effective expression of small interfering RNA in human cells. Nature Biotechnology, 20, 505-508.
    • (2002) Nature Biotechnology , vol.20 , pp. 505-508
    • Paul, C.P.1    Good, P.D.2    Winer, I.3    Engelke, D.R.4
  • 16
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering rnas in mammalian cells
    • Brummelkamp, T. R., Bernards, R., & Agami, R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 17
    • 0037440160 scopus 로고    scopus 로고
    • Short hairpin type of dsrnas that are controlled by trna(val) promoter significantly induce rnai-mediated gene silencing in the cytoplasm of human cells
    • Kawasaki, H., & Taira, K. (2003). Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Research, 31, 700-707.
    • (2003) Nucleic Acids Research , vol.31 , pp. 700-707
    • Kawasaki, H.1    Taira, K.2
  • 21
    • 12544255565 scopus 로고    scopus 로고
    • Recognition and cleavage of primary microrna precursors by the nuclear processing enzyme drosha
    • Zeng, Y., Yi, R., & Cullen, B. (2005). Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO Journal, 24, 138-148.
    • (2005) EMBO Journal , vol.24 , pp. 138-148
    • Zeng, Y.1    Yi, R.2    Cullen, B.3
  • 25
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of premicrornas and short hairpin rnas
    • Yi, R., Qin, Y., Macara, I. G., & Cullen, B. R. (2003). Exportin-5 mediates the nuclear export of premicroRNAs and short hairpin RNAs. Genes & Development, 17, 3011-3016.
    • (2003) Genes & Development , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 27
  • 31
    • 0141552295 scopus 로고    scopus 로고
    • Gene silencing by systemic delivery of synthetic sirnas in adult mice
    • Sorensen, D. R., Leirdal, M., & Sioud, M. (2003). Gene silencing by systemic delivery of synthetic siRNAs in adult mice. Journal of Molecular Biology, 327, 761-766.
    • (2003) Journal of Molecular Biology , vol.327 , pp. 761-766
    • Sorensen, D.R.1    Leirdal, M.2    Sioud, M.3
  • 33
    • 84855851049 scopus 로고    scopus 로고
    • Supramolecular assemblies in functional sirna delivery: Where do we stand?
    • Hamidreza, M., Abadi, A., Landry, B., Sun, C., Tang, T., & Uluda, H. (2012). Supramolecular assemblies in functional siRNA delivery: where do we stand? Biomaterials, 33, 2546-2569.
    • (2012) Biomaterials , vol.33 , pp. 2546-2569
    • Hamidreza, M.1    Abadi, A.2    Landry, B.3    Sun, C.4    Tang, T.5    Uluda, H.6
  • 37
    • 84864324577 scopus 로고    scopus 로고
    • A review of nanocarriers for the delivery of small interfering rna
    • Kesharwani, P., Gajbhiye, V., & Jain, N. K. (2012). A review of nanocarriers for the delivery of small interfering RNA. Biomaterials, 33, 7138-7150.
    • (2012) Biomaterials , vol.33 , pp. 7138-7150
    • Kesharwani, P.1    Gajbhiye, V.2    Jain, N.K.3
  • 38
    • 77954362096 scopus 로고    scopus 로고
    • Aptamer-targeted cell-specific rna interference
    • Zhou, J., & Rossi, J. J. (2010). Aptamer-targeted cell-specific RNA interference. Silence, 4, 1-10.
    • (2010) Silence , vol.4 , pp. 1-10
    • Zhou, J.1    Rossi, J.J.2
  • 40
    • 79957671438 scopus 로고    scopus 로고
    • RNA interference therapy via functionalized scaffolds
    • Monaghan, M., & Pandit, A. (2011). RNA interference therapy via functionalized scaffolds. Advanced Drug Delivery Reviews, 63, 197-208.
    • (2011) Advanced Drug Delivery Reviews , vol.63 , pp. 197-208
    • Monaghan, M.1    Pandit, A.2
  • 41
  • 42
    • 34249947638 scopus 로고    scopus 로고
    • Matrices and scaffolds for dna delivery in tissue engineering
    • De Laporte, L., & Shea, L. D. (2007). Matrices and scaffolds for DNA delivery in tissue engineering. Advanced Drug Delivery Reviews, 59, 292-307.
    • (2007) Advanced Drug Delivery Reviews , vol.59 , pp. 292-307
    • De Laporte, L.1    Shea, L.D.2
  • 43
    • 77649339137 scopus 로고    scopus 로고
    • Non-viral polyplexes: Scaffold mediated delivery for gene therapy
    • O'Rorke, S., Keeney, M., & Pandit, A. (2010). Non-viral polyplexes: scaffold mediated delivery for gene therapy. Progress in Polymer Science, 35, 441-458.
    • (2010) Progress in Polymer Science , vol.35 , pp. 441-458
    • O'Rorke, S.1    Keeney, M.2    Pandit, A.3
  • 44
    • 0037089589 scopus 로고    scopus 로고
    • Short hairpin rnas (shrnas) induce sequence-specific silencing in mammalian cells
    • Paddison, P. J., Caudy, A. A., Bernstein, E., Hannon, G. J., & Conklin, D. S. (2002). Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes & Development, 16, 948-958.
    • (2002) Genes & Development , vol.16 , pp. 948-958
    • Paddison, P.J.1    Caudy, A.A.2    Bernstein, E.3    Hannon, G.J.4    Conklin, D.S.5
  • 47
    • 0036245628 scopus 로고    scopus 로고
    • U6 promoter driven sirnas with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells
    • Miyagishi, M., & Taira, K. (2002). U6 promoter driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nature Biotechnology, 20, 497-500.
    • (2002) Nature Biotechnology , vol.20 , pp. 497-500
    • Miyagishi, M.1    Taira, K.2
  • 48
    • 4644245083 scopus 로고    scopus 로고
    • Inducible silencing of killer/dr5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil
    • Wang, S., & El-Deiry, W. S. (2004). Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil. Cancer Research, 64, 6666-6672.
    • (2004) Cancer Research , vol.64 , pp. 6666-6672
    • Wang, S.1    El-Deiry, W.S.2
  • 50
    • 0036787671 scopus 로고    scopus 로고
    • SiRNA-mediated gene silencing in vitro and in vivo
    • Xia, H., Mao, Q., Paulson, H. L., & Davidson, B. L. (2002). siRNA-mediated gene silencing in vitro and in vivo. Nature Biotechnology, 20, 1006-1010.
    • (2002) Nature Biotechnology , vol.20 , pp. 1006-1010
    • Xia, H.1    Mao, Q.2    Paulson, H.L.3    Davidson, B.L.4
  • 52
    • 33747587442 scopus 로고    scopus 로고
    • Multiple shrnas expressed by an inducible pol ii promoter can knock down the expression of multiple target genes
    • Xia, X. G., Zhou, H., & Xu, Z. (2006). Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes. Biotechniques, 41, 64-68.
    • (2006) Biotechniques , vol.41 , pp. 64-68
    • Xia, X.G.1    Zhou, H.2    Xu, Z.3
  • 53
    • 33747603277 scopus 로고    scopus 로고
    • Multi-mirna hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown
    • Sun, D., Melegari, M., Sridhar, S., Rogler, C. E., & Zhu, L. (2006). Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown. Biotechniques, 41, 59-63.
    • (2006) Biotechniques , vol.41 , pp. 59-63
    • Sun, D.1    Melegari, M.2    Sridhar, S.3    Rogler, C.E.4    Zhu, L.5
  • 54
    • 78049287281 scopus 로고    scopus 로고
    • Unity and diversity in the human adenoviruses: Exploiting alternative entry pathways for gene therapy
    • Hall, K., Blair Zajdel, M. E., & Blair, G. E. (2010). Unity and diversity in the human adenoviruses: exploiting alternative entry pathways for gene therapy. Biochemical Journal, 431, 321-336.
    • (2010) Biochemical Journal , vol.431 , pp. 321-336
    • Hall, K.1    Blair Zajdel, M.E.2    Blair, G.E.3
  • 55
    • 20444498521 scopus 로고    scopus 로고
    • Use of adenovirusdelivered sirna to target oncoprotein p28gank in hepatocellular carcinoma
    • Li, H., Fu, X., Chen, Y., Hong, Y., Tan, Y., Cao, H., Wu, M., & Wang, H. (2005). Use of adenovirusdelivered siRNA to target oncoprotein p28GANK in hepatocellular carcinoma. Gastroenterology, 128, 2029-2041.
    • (2005) Gastroenterology , vol.128 , pp. 2029-2041
    • Li, H.1    Fu, X.2    Chen, Y.3    Hong, Y.4    Tan, Y.5    Cao, H.6    Wu, M.7    Wang, H.8
  • 56
    • 28244448285 scopus 로고    scopus 로고
    • ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features
    • Osada, H., Tatematsu, Y., Yatabe, Y., Horio, Y., & Takahashi, T. (2005). ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features. Cancer Research, 65, 10680-10685.
    • (2005) Cancer Research , vol.65 , pp. 10680-10685
    • Osada, H.1    Tatematsu, Y.2    Yatabe, Y.3    Horio, Y.4    Takahashi, T.5
  • 58
    • 80054068742 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors
    • Schaser, T., Wrede, C., Duerner, L., Sliva, K., Cichutek, K., Schnierle, B., & Buchholz, C. J. (2011). RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors. Gene Therapy, 18, 953-960.
    • (2011) Gene Therapy , vol.18 , pp. 953-960
    • Schaser, T.1    Wrede, C.2    Duerner, L.3    Sliva, K.4    Cichutek, K.5    Schnierle, B.6    Buchholz, C.J.7
  • 59
    • 77649273815 scopus 로고    scopus 로고
    • Recent advances in lentiviral vector development and applications
    • Matrai, J., Chuah, M. K., & VandenDriessche, T. (2010). Recent advances in lentiviral vector development and applications. Molecular Therapy, 18, 477-490.
    • (2010) Molecular Therapy , vol.18 , pp. 477-490
    • Matrai, J.1    Chuah, M.K.2    Vandendriessche, T.3
  • 61
    • 14844283156 scopus 로고    scopus 로고
    • In vivo gene silencing of cd81 by lentiviral expression of small interference rnas suppresses cocaine-induced behaviour
    • Bahi, A., Boyer, F., Kolira, M., & Dreyer, J. L. (2005). In vivo gene silencing of CD81 by lentiviral expression of small interference RNAs suppresses cocaine-induced behaviour. Journal of Neurochemistry, 92, 1243-1255.
    • (2005) Journal of Neurochemistry , vol.92 , pp. 1243-1255
    • Bahi, A.1    Boyer, F.2    Kolira, M.3    Dreyer, J.L.4
  • 63
    • 77953251302 scopus 로고    scopus 로고
    • Viral vectors for gene transfer: Current status of gene therapeutics
    • Heilbronn, R., & Weger, S. (2010). Viral vectors for gene transfer: current status of gene therapeutics. Handbook of Experimental Pharmacology, 197, 143-170.
    • (2010) Handbook of Experimental Pharmacology , vol.197 , pp. 143-170
    • Heilbronn, R.1    Weger, S.2
  • 64
    • 65749110883 scopus 로고    scopus 로고
    • Small silencing rnas: State-of-the-art
    • Grimm, D. (2009). Small silencing RNAs: state-of-the-art. Advanced Drug Delivery Reviews, 61, 672-703.
    • (2009) Advanced Drug Delivery Reviews , vol.61 , pp. 672-703
    • Grimm, D.1
  • 65
    • 21244490473 scopus 로고    scopus 로고
    • Adeno-associated virus (aav) vectors in the cns
    • McCown, T. J. (2005). Adeno-associated virus (AAV) vectors in the CNS. Current Gene Therapy, 5, 333-338.
    • (2005) Current Gene Therapy , vol.5 , pp. 333-338
    • McCown, T.J.1
  • 67
    • 2942527527 scopus 로고    scopus 로고
    • RNA interference as a new strategy against viral hepatitis
    • Radhakrishnan, S., Layden, T., & Gartel, A. (2004). RNA interference as a new strategy against viral hepatitis. Virology, 323, 173-181.
    • (2004) Virology , vol.323 , pp. 173-181
    • Radhakrishnan, S.1    Layden, T.2    Gartel, A.3
  • 68
    • 0036726313 scopus 로고    scopus 로고
    • Stable suppression of tumorigenicity by virus mediated rna interference
    • Brummelkamp, T. R., Bernards, R., & Agami, R. (2002). Stable suppression of tumorigenicity by virus mediated RNA interference. Cancer Cell, 2, 243-247.
    • (2002) Cancer Cell , vol.2 , pp. 243-247
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 69
    • 0041335551 scopus 로고    scopus 로고
    • Silencing of h-ras gene expression by retrovirusmediated sirna decreases transformation efficiency and tumour growth in a model of human ovarian cancer
    • Yang, G., Thompson, J., Fang, B., & Liu, J. (2003). Silencing of H-ras gene expression by retrovirusmediated siRNA decreases transformation efficiency and tumour growth in a model of human ovarian cancer. Oncogene, 22, 5694-5701.
    • (2003) Oncogene , vol.22 , pp. 5694-5701
    • Yang, G.1    Thompson, J.2    Fang, B.3    Liu, J.4
  • 70
    • 0037329372 scopus 로고    scopus 로고
    • RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines
    • Cioca, D., Aoki, Y., & Kiyosawa, K. (2003). RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines. Cancer Gene Therapy, 10, 125-133.
    • (2003) Cancer Gene Therapy , vol.10 , pp. 125-133
    • Cioca, D.1    Aoki, Y.2    Kiyosawa, K.3
  • 72
    • 2442668068 scopus 로고    scopus 로고
    • A small interfering rna targeting vascular endothelial growth factor as cancer therapeutics
    • Takei, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S., & Muramatsu, T. (2004). A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Research, 64, 3365-3370.
    • (2004) Cancer Research , vol.64 , pp. 3365-3370
    • Takei, Y.1    Kadomatsu, K.2    Yuzawa, Y.3    Matsuo, S.4    Muramatsu, T.5
  • 73
    • 25444482607 scopus 로고    scopus 로고
    • Sequence-specific knockdown of ews-fli1 by targeted, non viral delivery of small interfering rna inhibits tumor growth in a murine model of metastatic ewing's sarcoma
    • Hu-Lieskovan, S., Heidel, J. D., Bartlett, D. W., Davis, M. E., & Triche, T. J. (2005). Sequence-specific knockdown of EWS-FLI1 by targeted, non viral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Research, 65, 8984-8992.
    • (2005) Cancer Research , vol.65 , pp. 8984-8992
    • Hu-Lieskovan, S.1    Heidel, J.D.2    Bartlett, D.W.3    Davis, M.E.4    Triche, T.J.5
  • 74
    • 84872184208 scopus 로고    scopus 로고
    • Ewing's sarcoma: Development of rna interference-based therapy for advanced disease
    • Simmons, O., Maples, P. B., Senzer, N., & Nemunaitis, J. (2012). Ewing's sarcoma: development of RNA interference-based therapy for advanced disease. ISRN Oncology, 2012, 1-13.
    • (2012) ISRN Oncology , vol.2012 , pp. 1-13
    • Simmons, O.1    Maples, P.B.2    Senzer, N.3    Nemunaitis, J.4
  • 75
    • 84864742732 scopus 로고    scopus 로고
    • Knockdown of akt2 expression by rna interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to the anticancer drug vm-26 in u87 glioma cells
    • Cui, Y., Wang, Q., Wang, J. Y., Dong, Y., Luo, C., Hu, G., & Lu, Y. (2012). Knockdown of AKT2 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to the anticancer drug VM-26 in U87 glioma cells. Brain Research, 1469, 1-9.
    • (2012) Brain Research , vol.1469 , pp. 1-9
    • Cui, Y.1    Wang, Q.2    Wang, J.Y.3    Dong, Y.4    Luo, C.5    Hu, G.6    Lu, Y.7
  • 76
    • 81455158692 scopus 로고    scopus 로고
    • The abcc4 gene is a promising target for pancreatic cancer therapy
    • Zhang, Z.,Wang, J., Shen, B., Peng, C., & Zheng, M. (2012). The ABCC4 gene is a promising target for pancreatic cancer therapy. Gene, 491, 94-199.
    • (2012) Gene , vol.491 , pp. 94-199
    • Zhang, Z.1    Wang, J.2    Shen, B.3    Peng, C.4    Zheng, M.5
  • 77
    • 84855991351 scopus 로고    scopus 로고
    • ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer
    • Zhou, W., Wang, L., Gou, S., Wang, T. L., Zhang, M., Liu, T., & Wang, C. (2012). ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer. Cancer Letters, 316, 178-186.
    • (2012) Cancer Letters , vol.316 , pp. 178-186
    • Zhou, W.1    Wang, L.2    Gou, S.3    Wang, T.L.4    Zhang, M.5    Liu, T.6    Wang, C.7
  • 87
    • 17144400759 scopus 로고    scopus 로고
    • Targeting 2a protease by rna interference attenuates coxsackie viral cytopathogenicity and promotes survival in highly susceptible mice
    • Merl, S., Michaelis, C., Jaschke, B., Vorpahl, M., Seidl, S., & Wessely, R. (2005). Targeting 2A protease by RNA interference attenuates coxsackie viral cytopathogenicity and promotes survival in highly susceptible mice. Circulation, 111, 1583-1592.
    • (2005) Circulation , vol.111 , pp. 1583-1592
    • Merl, S.1    Michaelis, C.2    Jaschke, B.3    Vorpahl, M.4    Seidl, S.5    Wessely, R.6
  • 88
    • 77952688315 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of an rnai-based therapy directed against respiratory syncytial virus
    • Devincenzo, J., Williams, R. L., Wilkinson, T., Cehelsky, J., Nochur, S., Walsh, E., Meyers, R., Gollob, J., & Vaishnaw, A. (2010). A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. PNAS, 107, 8800-8805.
    • (2010) PNAS , vol.107 , pp. 8800-8805
    • Devincenzo, J.1    Williams, R.L.2    Wilkinson, T.3    Cehelsky, J.4    Nochur, S.5    Walsh, E.6    Meyers, R.7    Gollob, J.8    Vaishnaw, A.9
  • 89
    • 13444262170 scopus 로고    scopus 로고
    • Inhibition of respiratory viruses by nasally administered sirna
    • Bitko, V., Musiyenko, A., Shulyayeva, O., & Barik, S. (2005). Inhibition of respiratory viruses by nasally administered siRNA. Nature Medicine, 11, 50-55.
    • (2005) Nature Medicine , vol.11 , pp. 50-55
    • Bitko, V.1    Musiyenko, A.2    Shulyayeva, O.3    Barik, S.4
  • 90
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of hcv rna replication in cell culture
    • Blight, K. J., Kolykhalov, A. A., & Rice, C. M. (2000). Efficient initiation of HCV RNA replication in cell culture. Science, 290, 1972-1974.
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 91
  • 92
    • 0036190918 scopus 로고    scopus 로고
    • Selectable subgenomic and genome-length dicistronic rnas derived from an infectious molecular clone of the hcv-n strain of hepatitis c virus replicate efficiently in cultured huh7 cells
    • Ikeda, M., Yi, M., Li, K., & Lemon, S. M. (2002). Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells. Journal of Virology, 76, 2997-3006.
    • (2002) Journal of Virology , vol.76 , pp. 2997-3006
    • Ikeda, M.1    Yi, M.2    Li, K.3    Lemon, S.M.4
  • 93
    • 0035032237 scopus 로고    scopus 로고
    • Enhancement of hepatitis c virus rna replication by cell culture-adaptive mutations
    • Krieger, N., Lohmann, V., & Bartenschlager, R. (2001). Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations. Journal of Virology, 75, 4614-4624.
    • (2001) Journal of Virology , vol.75 , pp. 4614-4624
    • Krieger, N.1    Lohmann, V.2    Bartenschlager, R.3
  • 98
    • 0036721314 scopus 로고    scopus 로고
    • Potent and specific inhibition of human immunodeficiency virus type 1 replication by rna interference
    • Coburn, G. A., & Cullen, B. R. (2002). Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. Journal of Virology, 76, 9225-9331.
    • (2002) Journal of Virology , vol.76 , pp. 9225-9331
    • Coburn, G.A.1    Cullen, B.R.2
  • 99
    • 0036891843 scopus 로고    scopus 로고
    • RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication
    • Surabhi, R. M., & Gaynor, R. B. (2002). RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication. Journal of Virology, 76, 12963-12973.
    • (2002) Journal of Virology , vol.76 , pp. 12963-12973
    • Surabhi, R.M.1    Gaynor, R.B.2
  • 102
    • 0037173610 scopus 로고    scopus 로고
    • Modulation of hiv-1 replication by rna interference
    • Jacque, J. M., Triques, K., & Stevenson, M. (2002). Modulation of HIV-1 replication by RNA interference. Nature, 418, 435-438.
    • (2002) Nature , vol.418 , pp. 435-438
    • Jacque, J.M.1    Triques, K.2    Stevenson, M.3
  • 103
    • 0037032933 scopus 로고    scopus 로고
    • Suppression of chemokine receptor expression by rna interference allows for inhibition of hiv-1 replication
    • Martinez, M. A., Gutierrez, A., Armand-Ugon, M., Blanco, J., Parera, M., Gomez, J., Clotet, B., & Esté, J. A. (2002). Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication. AIDS, 16, 2385-2390.
    • (2002) AIDS , vol.16 , pp. 2385-2390
    • Martinez, M.A.1    Gutierrez, A.2    Armand-Ugon, M.3    Blanco, J.4    Parera, M.5    Gomez, J.6    Clotet, B.7    Esté, J.A.8
  • 104
    • 0036839458 scopus 로고    scopus 로고
    • Inhibition of hiv-1 infection by small interfering rna-mediated rna interference
    • Capodici, J., Kariko, K., & Weissman, D. (2002). Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. Journal of Immunology, 169, 5196-5201.
    • (2002) Journal of Immunology , vol.169 , pp. 5196-5201
    • Capodici, J.1    Kariko, K.2    Weissman, D.3
  • 105
    • 0041903758 scopus 로고    scopus 로고
    • Inhibition of hiv-1 by lentiviral vector-transduced sirnas in t lymphocytes differentiated in scid-hu mice and cd34+ progenitor cell derived macrophages
    • Banerjea, A., Li, M. J., Bauer, G., Remling, L., Lee, N. S., Rossi, J., & Akkina, R. (2003). Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell derived macrophages. Molecular Therapy, 8, 62-71.
    • (2003) Molecular Therapy , vol.8 , pp. 62-71
    • Banerjea, A.1    Li, M.J.2    Bauer, G.3    Remling, L.4    Lee, N.S.5    Rossi, J.6    Akkina, R.7
  • 107
    • 0142124143 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 escape from rna interference
    • Boden, D., Pusch, O., Lee, F., Tucker, L., & Ramratnam, B. (2003). Human immunodeficiency virus type 1 escape from RNA interference. Journal of Virology, 77, 11531-11535.
    • (2003) Journal of Virology , vol.77 , pp. 11531-11535
    • Boden, D.1    Pusch, O.2    Lee, F.3    Tucker, L.4    Ramratnam, B.5
  • 109
    • 21744446220 scopus 로고    scopus 로고
    • Targeting angiogenesis, the underlying disorder in neovascular agerelated macular degeneration
    • Ng, E. W., & Adamis, A. (2005). Targeting angiogenesis, the underlying disorder in neovascular agerelated macular degeneration. Canadian Journal of Ophthalmology, 40, 352-368.
    • (2005) Canadian Journal of Ophthalmology , vol.40 , pp. 352-368
    • Ng, E.W.1    Adamis, A.2
  • 110
    • 77956955088 scopus 로고    scopus 로고
    • Lentivirus-mediated rna interference of vascular endothelial growth factor in monkey eyes with iris neovascularisation
    • Yuan, M. K., Tao, Y., Yu, W. Z., Kai, W., & Jiang, Y. R. (2010). Lentivirus-mediated RNA interference of vascular endothelial growth factor in monkey eyes with iris neovascularisation. Molecular Vision, 16, 1743-1753.
    • (2010) Molecular Vision , vol.16 , pp. 1743-1753
    • Yuan, M.K.1    Tao, Y.2    Yu, W.Z.3    Kai, W.4    Jiang, Y.R.5
  • 111
    • 0038748037 scopus 로고    scopus 로고
    • Small interfering rna (sirna) targeting vegf effectively inhibits ocular neovascularization in a mouse model
    • Reich, S. J., Fosnot, J., Kuroki, A., Tang, W., Yang, X., Maguire, A. M., Bennett, J., & Tolentino, M. J. (2003). Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Molecular Vision, 9, 210-216.
    • (2003) Molecular Vision , vol.9 , pp. 210-216
    • Reich, S.J.1    Fosnot, J.2    Kuroki, A.3    Tang, W.4    Yang, X.5    Maguire, A.M.6    Bennett, J.7    Tolentino, M.J.8
  • 113
    • 16244377103 scopus 로고    scopus 로고
    • A crucial test
    • Check, E. (2005). A crucial test. Nature Medicine, 11, 243-244.
    • (2005) Nature Medicine , vol.11 , pp. 243-244
    • Check, E.1
  • 115
    • 0036796264 scopus 로고    scopus 로고
    • Cathepsin b expression and downregulation by gene silencing and antisense dna in human chondrocytes
    • Zwicky, R., Muntener, K., Goldring, M. B., & Baici, A. (2002). Cathepsin B expression and downregulation by gene silencing and antisense DNA in human chondrocytes. Biochemical Journal, 367, 209-217.
    • (2002) Biochemical Journal , vol.367 , pp. 209-217
    • Zwicky, R.1    Muntener, K.2    Goldring, M.B.3    Baici, A.4
  • 116
    • 0346013210 scopus 로고    scopus 로고
    • Potentials for rnai in sarcoma research and therapy: Ewing's sarcoma as a model
    • Kovar, H., Ban, J., & Pospisilova, S. (2003). Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model. Seminars in Cancer Biology, 13, 275-281.
    • (2003) Seminars in Cancer Biology , vol.13 , pp. 275-281
    • Kovar, H.1    Ban, J.2    Pospisilova, S.3
  • 117
    • 33749661948 scopus 로고    scopus 로고
    • Identification of target genes in their native cellular context: An analysis of ews/fli in ewing's sarcoma
    • Owen, L. A., & Lessnick, S. L. (2006). Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma. Cell Cycle, 5, 2049-2053.
    • (2006) Cell Cycle , vol.5 , pp. 2049-2053
    • Owen, L.A.1    Lessnick, S.L.2
  • 119
    • 33746480903 scopus 로고    scopus 로고
    • NF-κb as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
    • Roman-Blas, J. A., & Jimenez, S. A. (2006). NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthritis and Cartilage, 14, 839-848.
    • (2006) Osteoarthritis and Cartilage , vol.14 , pp. 839-848
    • Roman-Blas, J.A.1    Jimenez, S.A.2
  • 120
    • 17244378648 scopus 로고    scopus 로고
    • Effects of treatment with small interfering rna on joint inflammation in mice with collagen-induced arthritis
    • Schiffelers, R. M., Xu, J., Storm, G., Woodle, M. C., & Scaria, P. V. (2005). Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. Arthritis and Rheumatism, 52, 1314-1318.
    • (2005) Arthritis and Rheumatism , vol.52 , pp. 1314-1318
    • Schiffelers, R.M.1    Xu, J.2    Storm, G.3    Woodle, M.C.4    Scaria, P.V.5
  • 121
    • 84865306003 scopus 로고    scopus 로고
    • RNA therapeutics targeting osteoclast-mediated excessive bone resorption
    • Wang, Y., & Grainger, D. W. (2012). RNA therapeutics targeting osteoclast-mediated excessive bone resorption. Advanced Drug Delivery Reviews, 64, 1341-1357.
    • (2012) Advanced Drug Delivery Reviews , vol.64 , pp. 1341-1357
    • Wang, Y.1    Grainger, D.W.2
  • 122
    • 66549125217 scopus 로고    scopus 로고
    • MicroRNAs: Regulating a change of heart
    • Barringhaus, K. G., & Zamore, P. D. (2009). MicroRNAs: regulating a change of heart. Circulation, 119, 2217-2224.
    • (2009) Circulation , vol.119 , pp. 2217-2224
    • Barringhaus, K.G.1    Zamore, P.D.2
  • 124
    • 67651154718 scopus 로고    scopus 로고
    • MicroRNA-195 suppresses tumorigenicity and regulates g1/s transition of human hepatocellular carcinoma cells
    • Xu, T., Zhu, Y., Xiong, Y., Ge, Y. Y., Yun, J. P., & Zhuang, S. M. (2009). MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology, 50, 113-121.
    • (2009) Hepatology , vol.50 , pp. 113-121
    • Xu, T.1    Zhu, Y.2    Xiong, Y.3    Ge, Y.Y.4    Yun, J.P.5    Zhuang, S.M.6
  • 127
    • 33847038668 scopus 로고    scopus 로고
    • MicroRNAs play an essential role in the development of cardiac hypertrophy
    • Sayed, D., Hong, C., Chen, I. Y., Lypowy, J., & Abdellatif, M. (2007). MicroRNAs play an essential role in the development of cardiac hypertrophy. Circulation Research, 100, 416-424.
    • (2007) Circulation Research , vol.100 , pp. 416-424
    • Sayed, D.1    Hong, C.2    Chen, I.Y.3    Lypowy, J.4    Abdellatif, M.5
  • 128
  • 129
    • 36248978699 scopus 로고    scopus 로고
    • MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    • Lynn, F. C., Skewes-Cox, P., Kosaka, Y., McManus, M. T., Harfe, B. D., & German, M. S. (2007). MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes, 56, 2938-2945.
    • (2007) Diabetes , vol.56 , pp. 2938-2945
    • Lynn, F.C.1    Skewes-Cox, P.2    Kosaka, Y.3    McManus, M.T.4    Harfe, B.D.5    German, M.S.6
  • 130
    • 58149350343 scopus 로고    scopus 로고
    • MiR-375 targets 30-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells
    • El Ouaamari, A., Baroukh, N., Martens, G. A., Lebrun, P., Pipeleers, D., & Van Obberghen, E. (2008). MiR-375 targets 30-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells. Diabetes, 57, 2708-2717.
    • (2008) Diabetes , vol.57 , pp. 2708-2717
    • El Ouaamari, A.1    Baroukh, N.2    Martens, G.A.3    Lebrun, P.4    Pipeleers, D.5    Van Obberghen, E.6
  • 132
    • 58249107416 scopus 로고    scopus 로고
    • Identification of glucose regulated mirnas from pancreatic beta cells reveals a role for mir-30d in insulin transcription
    • Tang, X., Muniappan, L., Tang, G., & Ozcan, S. (2009). Identification of glucose regulated miRNAs from pancreatic beta cells reveals a role for miR-30d in insulin transcription. RNA, 15, 287-293.
    • (2009) RNA , vol.15 , pp. 287-293
    • Tang, X.1    Muniappan, L.2    Tang, G.3    Ozcan, S.4
  • 133
    • 48349087101 scopus 로고    scopus 로고
    • AAV8- mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in nod mice
    • Rehman, K. K., Trucco, M.,Wang, Z., Xiao, X., & Robbins, P. D. (2008). AAV8- mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Molecular Therapy, 16, 1409-1416.
    • (2008) Molecular Therapy , vol.16 , pp. 1409-1416
    • Rehman, K.K.1    Trucco, M.2    Wang, Z.3    Xiao, X.4    Robbins, P.D.5
  • 134
    • 84855950313 scopus 로고    scopus 로고
    • Directing stem cell fate by controlled rna interference
    • Yau, W. W. Y., Rujitanaroj, P., Lam, L., & Chew, S. Y. (2012). Directing stem cell fate by controlled RNA interference. Biomaterials, 33, 2608-2628.
    • (2012) Biomaterials , vol.33 , pp. 2608-2628
    • Yau, W.W.Y.1    Rujitanaroj, P.2    Lam, L.3    Chew, S.Y.4
  • 137
    • 0037388638 scopus 로고    scopus 로고
    • Small interfering rnas directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells
    • Verma, U. N., Surabhi, R. M., Schmaltieg, A., Becerra, C., & Gaynor, R. B. (2003). Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clinical Cancer Research, 4, 1291-1300.
    • (2003) Clinical Cancer Research , vol.4 , pp. 1291-1300
    • Verma, U.N.1    Surabhi, R.M.2    Schmaltieg, A.3    Becerra, C.4    Gaynor, R.B.5
  • 141
    • 64549098232 scopus 로고    scopus 로고
    • Therapeutic targeting of gene expression by sirnas directed against bcr-abl transcripts in a patient with imatinib-resistant chronic myeloid leukemia
    • Koldehoff, M., & Elmaagacli, A. H. (2009). Therapeutic targeting of gene expression by siRNAs directed against BCR-ABL transcripts in a patient with imatinib-resistant chronic myeloid leukemia. Methods in Molecular Biology, 487, 451-466.
    • (2009) Methods in Molecular Biology , vol.487 , pp. 451-466
    • Koldehoff, M.1    Elmaagacli, A.H.2
  • 142
    • 39649085607 scopus 로고    scopus 로고
    • Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity
    • Dannull, J., Lesher, D. T., Holzknecht, R., Qi, W., Hanna, G., Seigler, H., Tyler, D. S., & Pruitt, S. K. (2007). Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity. Blood, 110, 4341-4350.
    • (2007) Blood , vol.110 , pp. 4341-4350
    • Dannull, J.1    Lesher, D.T.2    Holzknecht, R.3    Qi, W.4    Hanna, G.5    Seigler, H.6    Tyler, D.S.7    Pruitt, S.K.8
  • 143
    • 79951827479 scopus 로고    scopus 로고
    • RNA interference, rsv, and lung transplantation: A promising future for sirna therapeutics
    • Astor, T. L. (2011). RNA interference, RSV, and lung transplantation: a promising future for siRNA therapeutics. American Journal of Respiratory and Critical Care Medicine, 183, 427-428.
    • (2011) American Journal of Respiratory and Critical Care Medicine , vol.183 , pp. 427-428
    • Astor, T.L.1


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