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Volumn 316, Issue 2, 2012, Pages 178-186

ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer

Author keywords

GSK 3 ; Molecular targeted therapy; Pancreatic neoplasia; RNA interference

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; PROTEIN BCL 2; SHORT HAIRPIN RNA; VASCULOTROPIN;

EID: 84855991351     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.10.033     Document Type: Article
Times cited : (55)

References (39)
  • 3
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: tricks of the trade for a multi-tasking kinase
    • Doble B., Woodgett J. GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell Sci. 2003, 116:1175-1186.
    • (2003) J. Cell Sci. , vol.116 , pp. 1175-1186
    • Doble, B.1    Woodgett, J.2
  • 4
    • 8744271562 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?
    • Patel S., Doble B., Woodgett J.R. Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?. Biochem. Soc. Trans. 2004, 32:803-808.
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 803-808
    • Patel, S.1    Doble, B.2    Woodgett, J.R.3
  • 6
    • 12144266241 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
    • Bachelder R.E., Yoon S.O., Franci C., de Herreros A.G., Mercurio A.M. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J. Cell. Biol. 2005, 168:29-33.
    • (2005) J. Cell. Biol. , vol.168 , pp. 29-33
    • Bachelder, R.E.1    Yoon, S.O.2    Franci, C.3    de Herreros, A.G.4    Mercurio, A.M.5
  • 7
    • 33845806853 scopus 로고    scopus 로고
    • Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice
    • Wang Y., Lam J.B., Lam K.S., Liu J., Lam M.C., Hoo R.L., Wu D., Cooper G.J., Xu A. Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Res. 2006, 66:11462-11470.
    • (2006) Cancer Res. , vol.66 , pp. 11462-11470
    • Wang, Y.1    Lam, J.B.2    Lam, K.S.3    Liu, J.4    Lam, M.C.5    Hoo, R.L.6    Wu, D.7    Cooper, G.J.8    Xu, A.9
  • 8
    • 20444475324 scopus 로고    scopus 로고
    • Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells
    • Ghosh J.C., Altieri D.C. Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells. Clin. Cancer Res. 2005, 11:4580-4588.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4580-4588
    • Ghosh, J.C.1    Altieri, D.C.2
  • 9
    • 55049086241 scopus 로고    scopus 로고
    • Growth control of multiple myeloma cells through inhibition of glycogen synthase kinase-3
    • Zhou Y., Uddin S., Zimmerman T., Kang J.A., Ulaszek J., Wickrema A. Growth control of multiple myeloma cells through inhibition of glycogen synthase kinase-3. Leuk. Lymphoma 2008, 49:1945-1953.
    • (2008) Leuk. Lymphoma , vol.49 , pp. 1945-1953
    • Zhou, Y.1    Uddin, S.2    Zimmerman, T.3    Kang, J.A.4    Ulaszek, J.5    Wickrema, A.6
  • 10
    • 57349143530 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy
    • Luo J. Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy. Cancer Lett. 2009, 273:194-200.
    • (2009) Cancer Lett. , vol.273 , pp. 194-200
    • Luo, J.1
  • 11
    • 42449112592 scopus 로고    scopus 로고
    • The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways
    • Gao X., Zhang H., Takahashi T., Hsieh J., Liao J., Steinberg G.K., Zhao H. The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways. J. Neurochem. 2008, 105:943-955.
    • (2008) J. Neurochem. , vol.105 , pp. 943-955
    • Gao, X.1    Zhang, H.2    Takahashi, T.3    Hsieh, J.4    Liao, J.5    Steinberg, G.K.6    Zhao, H.7
  • 14
    • 0032955426 scopus 로고    scopus 로고
    • Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase
    • Lesort M., Jope R.S., Johnson G.V. Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase. J. Neurochem. 1999, 72:576-584.
    • (1999) J. Neurochem. , vol.72 , pp. 576-584
    • Lesort, M.1    Jope, R.S.2    Johnson, G.V.3
  • 15
    • 72549086625 scopus 로고    scopus 로고
    • Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase
    • Mai W., Kawakami K., Shakoori A., Kyo S., Miyashita K., Yokoi K., Jin M., Shimasaki T., Motoo Y., Minamoto T. Deregulated GSK3{beta} sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase. Clin. Cancer Res. 2009, 15:6810-6819.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6810-6819
    • Mai, W.1    Kawakami, K.2    Shakoori, A.3    Kyo, S.4    Miyashita, K.5    Yokoi, K.6    Jin, M.7    Shimasaki, T.8    Motoo, Y.9    Minamoto, T.10
  • 17
    • 0036920227 scopus 로고    scopus 로고
    • Expression, localization, and activity of glycogen synthase kinase 3beta during mouse skin tumorigenesis
    • Leis H., Segrelles C., Ruiz S., Santos M., Paramio J.M. Expression, localization, and activity of glycogen synthase kinase 3beta during mouse skin tumorigenesis. Mol. Carcinog. 2002, 35:180-185.
    • (2002) Mol. Carcinog. , vol.35 , pp. 180-185
    • Leis, H.1    Segrelles, C.2    Ruiz, S.3    Santos, M.4    Paramio, J.M.5
  • 18
    • 0141678112 scopus 로고    scopus 로고
    • TNM staging for malignancies of the digestive tract: 2003 changes and beyond
    • Greene F.L. TNM staging for malignancies of the digestive tract: 2003 changes and beyond. Semin. Surg. Oncol. 2003, 21:23-29.
    • (2003) Semin. Surg. Oncol. , vol.21 , pp. 23-29
    • Greene, F.L.1
  • 19
    • 77955409200 scopus 로고    scopus 로고
    • Constitutive activation of glycogen synthase kinase-3beta correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer
    • Cho Y.J., Kim J.H., Yoon J., Cho S.J., Ko Y.S., Park J.W., Lee H.S., Lee H.E., Kim W.H., Lee B.L. Constitutive activation of glycogen synthase kinase-3beta correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer. BMC Gastroenterol. 2010, 10:91.
    • (2010) BMC Gastroenterol. , vol.10 , pp. 91
    • Cho, Y.J.1    Kim, J.H.2    Yoon, J.3    Cho, S.J.4    Ko, Y.S.5    Park, J.W.6    Lee, H.S.7    Lee, H.E.8    Kim, W.H.9    Lee, B.L.10
  • 20
    • 29344467392 scopus 로고    scopus 로고
    • Overexpression of stefin A in human esophageal squamous cell carcinoma cells inhibits tumor cell growth, angiogenesis, invasion, and metastasis
    • Li W., Ding F., Zhang L., Liu Z., Wu Y., Luo A., Wu M., Wang M., Zhan Q. Overexpression of stefin A in human esophageal squamous cell carcinoma cells inhibits tumor cell growth, angiogenesis, invasion, and metastasis. Clin. Cancer Res. 2005, 11:8753-8762.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 8753-8762
    • Li, W.1    Ding, F.2    Zhang, L.3    Liu, Z.4    Wu, Y.5    Luo, A.6    Wu, M.7    Wang, M.8    Zhan, Q.9
  • 21
    • 33749015218 scopus 로고    scopus 로고
    • Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation
    • Ougolkov A.V., Fernandez-Zapico M.E., Bilim V.N., Smyrk T.C., Chari S.T., Billadeau D.D. Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. Clin. Cancer Res. 2006, 12:5074-5081.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5074-5081
    • Ougolkov, A.V.1    Fernandez-Zapico, M.E.2    Bilim, V.N.3    Smyrk, T.C.4    Chari, S.T.5    Billadeau, D.D.6
  • 22
    • 16844374033 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells
    • Ougolkov A.V., Fernandez-Zapico M.E., Savoy D.N., Urrutia R.A., Billadeau D.D. Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res. 2005, 65:2076-2081.
    • (2005) Cancer Res. , vol.65 , pp. 2076-2081
    • Ougolkov, A.V.1    Fernandez-Zapico, M.E.2    Savoy, D.N.3    Urrutia, R.A.4    Billadeau, D.D.5
  • 23
    • 77953312514 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 beta: can it be a target for oral cancer
    • Mishra R. Glycogen synthase kinase 3 beta: can it be a target for oral cancer. Mol. Cancer 2010, 9:144.
    • (2010) Mol. Cancer , vol.9 , pp. 144
    • Mishra, R.1
  • 24
    • 33746239119 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells
    • Cao Q., Lu X., Feng Y.J. Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells. Cell Res. 2006, 16:671-677.
    • (2006) Cell Res. , vol.16 , pp. 671-677
    • Cao, Q.1    Lu, X.2    Feng, Y.J.3
  • 25
    • 80052052253 scopus 로고    scopus 로고
    • Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer
    • Zhang J., Koenig A., Harrison A., Ugolkov A., Fernandez-Zapico M., Couch F., Billadeau D. Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer. Oncogene 2011, 30:3705-3715.
    • (2011) Oncogene , vol.30 , pp. 3705-3715
    • Zhang, J.1    Koenig, A.2    Harrison, A.3    Ugolkov, A.4    Fernandez-Zapico, M.5    Couch, F.6    Billadeau, D.7
  • 26
    • 27944490875 scopus 로고    scopus 로고
    • VEGF as a therapeutic target in cancer
    • Ferrara N. VEGF as a therapeutic target in cancer. Oncology 2005, 69(Suppl. 3):11-16.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 11-16
    • Ferrara, N.1
  • 27
    • 14044278776 scopus 로고    scopus 로고
    • Glycogen-synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells
    • Skurk C., Maatz H., Rocnik E., Bialik A., Force T., Walsh K. Glycogen-synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells. Circ. Res. 2005, 96:308-318.
    • (2005) Circ. Res. , vol.96 , pp. 308-318
    • Skurk, C.1    Maatz, H.2    Rocnik, E.3    Bialik, A.4    Force, T.5    Walsh, K.6
  • 29
    • 60549083256 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    • Semenza G.L. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin. Cancer Biol. 2009, 19:12-16.
    • (2009) Semin. Cancer Biol. , vol.19 , pp. 12-16
    • Semenza, G.L.1
  • 30
    • 80052607424 scopus 로고    scopus 로고
    • Overexpression of carbonic anhydrase and HIF-1alpha in Wilms tumours
    • Dungwa J.V., Hunt L.P., Ramani P. Overexpression of carbonic anhydrase and HIF-1alpha in Wilms tumours. BMC Cancer 2011, 11:390.
    • (2011) BMC Cancer , vol.11 , pp. 390
    • Dungwa, J.V.1    Hunt, L.P.2    Ramani, P.3
  • 32
    • 35248814408 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in cancer
    • Maynard M.A., Ohh M. The role of hypoxia-inducible factors in cancer. Cell Mol. Life Sci. 2007, 64:2170-2180.
    • (2007) Cell Mol. Life Sci. , vol.64 , pp. 2170-2180
    • Maynard, M.A.1    Ohh, M.2
  • 33
    • 34247583794 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner
    • Flugel D., Gorlach A., Michiels C., Kietzmann T. Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner. Mol. Cell Biol. 2007, 27:3253-3265.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 3253-3265
    • Flugel, D.1    Gorlach, A.2    Michiels, C.3    Kietzmann, T.4
  • 34
    • 79953793443 scopus 로고    scopus 로고
    • Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer
    • Ulahannan S.V., Brahmer J.R. Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer. Cancer Invest. 2011, 29:325-337.
    • (2011) Cancer Invest. , vol.29 , pp. 325-337
    • Ulahannan, S.V.1    Brahmer, J.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.