Combinational RNAi gene therapy of hepatocellular carcinoma by targeting human EGFR and TERT

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 4, 2011, Pages 387-391

  Hu, Yurong ^a   Shen, Yingying ^a   Ji, Baofang ^a   Wang, Lei ^a   Zhang, Zhenzhong ^a   Zhang, Yun ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Combinational gene therapy; EGFR; Pegylated immuno lipopolyplexes; RNA interference; TERT

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOLIPOPOLYPLEX; LIPOPLEX; PU6 SHORT HAIRPIN EPIDERMAL GROWTH FACTOR RECEPTOR; PU6 SHORT HAIRPIN TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; EXPRESSION VECTOR; FEMALE; GENE TARGETING; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; GENE THERAPY; HUMANS; LIPOSOMES; LIVER NEOPLASMS; PHOSPHATIDYLETHANOLAMINES; PLASMIDS; POLYETHYLENE GLYCOLS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; RNA, SMALL INTERFERING; TELOMERASE;

EID: 79952281252     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.01.004     Document Type: Article

References (15)

1. L. Bai, R. Zhu, Z. Chen, L. Gao, X. Zhang, X. Wang, and C. Bai Potential role of short hairpin RNA targeting epidermal growth factor receptor in growth and sensitivity to drugs of human lung adenocarcinoma cells Biochem. Pharmacol. 71 2006 1265 1271 (Pubitemid 43357907)
2. A. Budiyanto, T. Bito, M. Kunisada, M. Ashida, M. Ichihashi, and M. Ueda Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells J. Invest. Dermatol. 121 2003 1088 1094 (Pubitemid 37430978)
3. F. Ciardiello Epidermal growth factor receptor tyrosine kinase inhibitors as anticancer agents Drugs 60 Suppl. 1 2000 25 32
4. F. Ciardiello, and G. Tortora A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor Clin. Cancer Res. 7 2001 2958 2970 (Pubitemid 32963812)
5. Y. Hu, K. Li, L. Wang, S. Yin, Z. Zhang, and Y. Zhang Pegylated immuno-lipopoplyplexes: a novel non-viral gene delivery system for liver cancer therapy J. Control. Release 144 2010 75 81
6. K. Kraemer, S. Fuessel, U. Schmidt, M. Kotzsch, B. Schwenzer, M.P. Wirth, and A. Meye Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells Clin. Cancer Res. 9 2003 3794 3800 (Pubitemid 37169250)
7. A. Lechel, M.P. Manns, and K.L. Rudolph Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma J. Hepatol. 41 2004 491 497 (Pubitemid 39158760)
8. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method Methods 25 2001 402 408 (Pubitemid 34164012)
9. Y. Maida, S. Kyo, T. Kanaya, Z. Wang, N. Yatabe, M. Tanaka, M. Nakamura, M. Ohmichi, N. Gotoh, S. Murakami, and M. Inoue Direct activation of telomerase by EGF though Ets-mediated transactivation of TERT via MAP kinase signaling pathway Oncogene 21 2002 4071 4079 (Pubitemid 34712874)
10. W.M. Merritt, M. Bar-Eli, and A.K. Sood The dicey role of dicer: implications for RNAi therapy Cancer Res. 70 2010 2571 2574
11. D.O. Moon, M.O. Kim, M.S. Heo, J.D. Lee, Y.H. Choi, and G.Y. Kim Gefitinib induces apoptosis and decreases telomerase activity in MDA-MB-231 human breast cancer cells Arch. Pharm. Res. 32 2009 1351 1360
12. K. Nagao, M. Tomimatsu, H. Endo, H. Hisatomi, and K. Hikiji Telomerase reverse transcriptase mRNA expression and telomerase activity in hepatocellular carcinoma J. Gastroenterol. 34 1999 83 87 (Pubitemid 29112340)
13. T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, and T.R. Cech Telomerase catalytic subunit homologs from fission yeast and human Science 277 1997 955 999
14. D.S. Salomon, R. Brandt, F. Ciardiello, and N. Normanno Epidermal growth factor-related peptides and their receptors in human malignancies Crit. Rev. Oncol. Hematol. 19 1995 183 232
15. Y. Zhang, and W.M. Pardridge Delivery of β-galactosidase to mouse brain via the blood-brain barrier transferring receptor J. Pharmacol. Exp. Ther. 313 2005 1075 1081 (Pubitemid 40727011)