The "Trojan horse" model-delivery of anti-HBV small interfering RNAs by a recombinant HBV vector

Biochemical and Biophysical Research Communications

Volumn 390, Issue 3, 2009, Pages 619-623

  Shlomai, Amir ^a   Lubelsky, Yoav ^a   Har Noy, Ofir ^a   Shaul, Yosef ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Hepatitis B virus; Recombinant virus; RNAi; shRNA

Indexed keywords

CORE PROTEIN; GREEN FLUORESCENT PROTEIN; LUCIFERASE; PLASMID VECTOR; RECOMBINANT HEPATITIS B VIRUS VECTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS VECTOR;

ARTICLE; CELL CULTURE; CELL STRAIN HEPG2; CONTROLLED STUDY; GENE CASSETTE; GENE EXPRESSION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

CELL LINE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HUMANS; LIVER; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EQUIDAE; HEPATITIS B VIRUS;

EID: 70449710774     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.10.016     Document Type: Article

References (12)

1. Seeger C., and Mason W.S. Hepatitis B virus biology. Microbiol. Mol. Biol. Rev. 64 (2000) 51-68
2. Ganem D., and Prince A.M. Hepatitis B virus infection-natural history and clinical consequences. N. Engl. J. Med. 350 (2004) 1118-1129
3. McMahon B.J. Epidemiology and natural history of hepatitis B. Semin. Liver Dis. 25 (2005) 3-8
4. Perrillo R. Benefits and risks of interferon therapy for hepatitis B. Hepatology 49 (2009) S103-S111
5. Feld J.J., Wong D.K., and Heathcote E.J. Endpoints of therapy in chronic hepatitis B. Hepatology 49 (2009) S96-S102
6. Levrero M., Pollicino T., Petersen J., Belloni L., Raimondo G., and Dandri M. Control of cccDNA function in hepatitis B virus infection. J. Hepatol. 51 (2009) 581-592
7. Shlomai A., and Shaul Y. RNA interference-small RNAs effectively fight viral hepatitis. Liver Int. 24 (2004) 526-531
8. Morrissey D.V., Blanchard K., Shaw L., Jensen K., Lockridge J.A., Dickinson B., McSwiggen J.A., Vargeese C., Bowman K., Shaffer C.S., Polisky B.A., and Zinnen S. Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication. Hepatology 41 (2005) 1349-1356
9. Crowther C., Ely A., Hornby J., Mufamadi M.S., Salazar F., Marion P., and Arbuthnot P. Efficient inhibition of hepatitis B virus replication in vivo using peg-modified adenovirus vectors. Hum. Gene Ther. 19 (2008) 1325-1332
10. Chen Y., Cheng G., and Mahato R.I. RNAi for treating hepatitis B viral infection. Pharm. Res. 25 (2008) 72-86
11. Shlomai A., and Shaul Y. Inhibition of hepatitis B virus expression and replication by RNA interference. Hepatology 37 (2003) 764-770
12. Lewis D.L., and Wolff J.A. Delivery of siRNA and siRNA expression constructs to adult mammals by hydrodynamic intravascular injection. Methods Enzymol. 392 (2005) 336-350