RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 5, 2003, Pages 2783-2788

  Wilson, Joyce A ^a   Jayasena, Sumedha ^b   Khvorova, Anastasia ^a,e   Sabatinos, Sarah ^a,c   Rodrigue Gervais, Ian Gaël ^d   Arya, Sudha ^a   Sarangi, Farida ^a   Harris Brandts, Marees ^a   Beaulieu, Sylvie ^d   Richardson, Christopher D ^a,c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b AMGEN INC   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

^e Dharmacon Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SINGLE STRANDED RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; BICISTRONIC EXPRESSION VECTOR; CISTRON; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE THERAPY; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPLICATION TEMPLATE; REPLICON; RNA DEGRADATION; RNA INTERFERENCE; RNA PURIFICATION; RNA SYNTHESIS; VIRUS GENOME; VIRUS INFECTION; VIRUS REPLICATION;

ANTIBODIES, MONOCLONAL; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPORATION; GENETIC VECTORS; HEPATITIS C; HUMANS; LIVER; MODELS, GENETIC; MUTATION; PLASMIDS; RNA; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA, VIRAL; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0344321890     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.252758799     Document Type: Article

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